当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Evidence of a Causal Role for mid-Ventrolateral Prefrontal Cortex Based Functional Networks in Retrieving High-Fidelity Memory.

Evidence of a Causal Role for mid-Ventrolateral Prefrontal Cortex Based Functional Networks in Retrieving High-Fidelity Memory.

Abstract：

:Functional neuroimaging studies have implicated regions of both ventrolateral prefrontal cortex (VLPFC) and angular gyrus in processes associated with retrieving goal-relevant information, which increases the fidelity and richness of long-term memory (LTM). To further investigate the roles of these cortical regions as nodes in functional networks with memory regions of the medial temporal lobe (MTL), we used fMRI-guided, 1 Hz repetitive transcranial magnetic stimulation (rTMS) to perturb normal neuronal function. The aim was to test the causal roles of left mid-VLPFC and left angular gyrus (AG) in MTL-VLPFC-parietal networks that have been associated with high-fidelity memory retrieval. rTMS treatments were administered immediately before blocks in an old/new recognition test, which was based on a mnemonic similarity task requiring discrimination of previously studied pictures of common objects. Capability for mnemonic discrimination was evaluated after each of three conditions: placebo control (rTMS at somatosensory cortex), mid-VLPFC target (rTMS at left pars triangularis) and parietal target (rTMS at left AG). The results showed the effect of rTMS perturbation of mid-VLPFC diminished subsequent discrimination-based memory performance, relative to placebo control, and no significant effect of perturbation of AG. These findings show a causal role for functional networks with left mid-VLPFC in high-fidelity retrieval.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wais PE,Montgomery O,Stark CEL,Gazzaley A

doi

10.1038/s41598-018-33164-w

subject

Has Abstract

pub_date

2018-10-05 00:00:00

pages

14877

issue

1

issn

2045-2322

pii

10.1038/s41598-018-33164-w

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD.

    abstract：:Both chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics compared to those without COPD. In this study, we retrospectively analyz...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02405-9

    authors： Xiao D,Li F,Pan H,Liang H,Wu K,He J

    更新日期：2017-05-18 00:00:00

  • The establishment of the infant intestinal microbiome is not affected by rotavirus vaccination.

    abstract：:The microbial colonization of the intestine during the first months of life constitutes the most important process for the microbiota-induced host-homeostasis. Alterations in this process may entail a high-risk for disease in later life. However, the potential factors affecting this process in the infant are not well ...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep07417

    authors： Ang L,Arboleya S,Lihua G,Chuihui Y,Nan Q,Suarez M,Solís G,de los Reyes-Gavilán CG,Gueimonde M

    更新日期：2014-12-10 00:00:00

  • Air-like plasmonics with ultralow-refractive-index silica aerogels.

    abstract：:The coupling of the surface plasmon near-field into the sensing medium is key to the sensitivity of surface plasmon-based sensing devices. A low-index dielectric is necessary for the sensing medium to support a highly-penetrating surface plasmon evanescent field that extends well into the dielectric medium. The air-li...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-38859-2

    authors： Kim Y,Baek S,Gupta P,Kim C,Chang K,Ryu SP,Kang H,Kim WS,Myoung J,Park W,Kim K

    更新日期：2019-02-19 00:00:00

  • VISTA: VIsual Semantic Tissue Analysis for pancreatic disease quantification in murine cohorts.

    abstract：:Mechanistic disease progression studies using animal models require objective and quantifiable assessment of tissue pathology. Currently quantification relies heavily on staining methods which can be expensive, labor/time-intensive, inconsistent across laboratories and batch, and produce uneven staining that is prone ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78061-3

    authors： Ternes L,Huang G,Lanciault C,Thibault G,Riggers R,Gray JW,Muschler J,Chang YH

    更新日期：2020-12-01 00:00:00

  • Efficient Optical Energy Harvesting in Self-Accelerating Beams.

    abstract：:We report the experimental observation of energetically confined self-accelerating optical beams propagating along various convex trajectories. We show that, under an appropriate transverse compression of their spatial spectra, these self-accelerating beams can exhibit a dramatic enhancement of their peak intensity an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13197

    authors： Bongiovanni D,Hu Y,Wetzel B,Robles RA,Mendoza González G,Marti-Panameño EA,Chen Z,Morandotti R

    更新日期：2015-08-24 00:00:00

  • Information measure for long-range correlated sequences: the case of the 24 human chromosomes.

    abstract：:A new approach to estimate the Shannon entropy of a long-range correlated sequence is proposed. The entropy is written as the sum of two terms corresponding respectively to power-law (ordered) and exponentially (disordered) distributed blocks (clusters). The approach is illustrated on the 24 human chromosome sequences...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02721

    authors： Carbone A

    更新日期：2013-01-01 00:00:00

  • Population pharmacokinetics of peginterferon α2a in patients with chronic hepatitis B.

    abstract：:There were significant differences in response and pharmacokinetic characteristics to the peginterferon α2a treatment among Chronic Hepatitis B (CHB) patients. The aim of this study is to identify factors which could significantly impact the peginterferon α2a pharmacokinetic characteristics in CHB patients. There were...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08205-5

    authors： Bi J,Li X,Liu J,Chen D,Li S,Hou J,Zhou Y,Zhu S,Zhao Z,Qin E,Wei Z

    更新日期：2017-08-11 00:00:00

  • Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation.

    abstract：:Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We inves...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-16391-5

    authors： Fiorito G,Polidoro S,Dugué PA,Kivimaki M,Ponzi E,Matullo G,Guarrera S,Assumma MB,Georgiadis P,Kyrtopoulos SA,Krogh V,Palli D,Panico S,Sacerdote C,Tumino R,Chadeau-Hyam M,Stringhini S,Severi G,Hodge AM,Giles GG,Mar

    更新日期：2017-11-24 00:00:00

  • Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.

    abstract：:Nonalcoholic fatty liver disease (NAFLD) is a rising cause of hepatocellular carcinoma (HCC). We examined whether inherited pathogenic variants in candidate genes (n = 181) were enriched in patients with NAFLD-HCC. To this end, we resequenced peripheral blood DNA of 142 NAFLD-HCC, 59 NAFLD with advanced fibrosis, and ...

    journal_title：Scientific reports

    pub_type： 杂志文章,多中心研究

    doi：10.1038/s41598-019-39998-2

    authors： Pelusi S,Baselli G,Pietrelli A,Dongiovanni P,Donati B,McCain MV,Meroni M,Fracanzani AL,Romagnoli R,Petta S,Grieco A,Miele L,Soardo G,Bugianesi E,Fargion S,Aghemo A,D'Ambrosio R,Xing C,Romeo S,De Francesco R,Reeves

    更新日期：2019-03-06 00:00:00

  • People Can Create Iconic Vocalizations to Communicate Various Meanings to Naïve Listeners.

    abstract：:The innovation of iconic gestures is essential to establishing the vocabularies of signed languages, but might iconicity also play a role in the origin of spoken words? Can people create novel vocalizations that are comprehensible to naïve listeners without prior convention? We launched a contest in which participants...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20961-6

    authors： Perlman M,Lupyan G

    更新日期：2018-02-08 00:00:00

  • Association between maternal blood lipids levels during pregnancy and risk of small-for-gestational-age infants.

    abstract：:Dyslipidemia in pregnancy are associated with risk of adverse outcomes. As an adverse pregnancy outcome, small-for-gestational-age has been extensively studied in Western countries. However, similar studies have rarely been conducted in Asian countries. Data were derived from 5695 pairs of non-diabetic mothers and neo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76845-1

    authors： Chen Q,Chen H,Xi F,Sagnelli M,Zhao B,Chen Y,Yang M,Xu D,Jiang Y,Chen G,Luo Q

    更新日期：2020-11-16 00:00:00

  • TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2.

    abstract：:TLR4 is implicated in diseases associated with chronic low-grade inflammation, yet homeostatic signaling mechanisms that prevent and/or are affected by chronic TLR4 activation are largely uncharacterized. We recently reported that LPS/TLR4 activates in human leukocytes signaling intermediates (SI), abbreviated TLR4-SI...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43347-8

    authors： Zhang Z,Amorosa LF,Petrova A,Coyle S,Macor M,Nair M,Lee LY,Haimovich B

    更新日期：2019-05-07 00:00:00

  • (t, n) Threshold d-Level Quantum Secret Sharing.

    abstract：:Most of Quantum Secret Sharing(QSS) are (n, n) threshold 2-level schemes, in which the 2-level secret cannot be reconstructed until all n shares are collected. In this paper, we propose a (t, n) threshold d-level QSS scheme, in which the d-level secret can be reconstructed only if at least t shares are collected. Comp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06486-4

    authors： Song XL,Liu YB,Deng HY,Xiao YG

    更新日期：2017-07-25 00:00:00

  • Allocation of photosynthesized carbon in an intensively farmed winter wheat-soil system as revealed by 14CO2 pulse labelling.

    abstract：:Understanding the rhizodeposited carbon (C) dynamics of winter wheat (Triticum aestivum L.), is crucial for soil fertility and C sequestration. Pot-grown winter wheat was pulse labelled with 14CO2 at the key growth stages. 14C in the shoots, roots and soil was measured at 5 or 2 days after 14C-labelling (DAL 5/2) at e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21547-y

    authors： Sun Z,Chen Q,Han X,Bol R,Qu B,Meng F

    更新日期：2018-02-16 00:00:00

  • Design principles of biologically fabricated avian nests.

    abstract：:Materials and construction methods of nests vary between bird species and at present, very little is known about the relationships between architecture and function in these structures. This study combines computational and experimental techniques to study the structural biology of nests fabricated by the edible nest ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41245-7

    authors： Jessel HR,Chen S,Osovski S,Efroni S,Rittel D,Bachelet I

    更新日期：2019-03-18 00:00:00

  • Covariance statistics and network analysis of brain PET imaging studies.

    abstract：:The analysis of structural and functional neuroimaging data using graph theory has increasingly become a popular approach for visualising and understanding anatomical and functional relationships between different cerebral areas. In this work we applied a network-based approach for brain PET studies using population-b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39005-8

    authors： Veronese M,Moro L,Arcolin M,Dipasquale O,Rizzo G,Expert P,Khan W,Fisher PM,Svarer C,Bertoldo A,Howes O,Turkheimer FE

    更新日期：2019-02-21 00:00:00

  • Clean Power Generation from the Intractable Natural Coalfield Fires: Turn Harm into Benefit.

    abstract：:The coal fires, a global catastrophe for hundreds of years, have been proved extremely difficult to control, and hit almost every coal-bearing area globally. Meanwhile, underground coal fires contain tremendous reservoir of geothermal energy. Approximately one billion tons of coal burns underground annually in the wor...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05622-4

    authors： Shi B,Su H,Li J,Qi H,Zhou F,Torero JL,Chen Z

    更新日期：2017-07-13 00:00:00

  • Gut-spilling in chordates: evisceration in the tropical ascidian Polycarpa mytiligera.

    abstract：:The ejection of internal organs, i.e., evisceration, is a well-known phenomenon in sea-cucumbers. We report the ability of a member of the Chordate phyla, the tropical ascidian Polycarpa mytiligera, to eviscerate and regenerate its gut within 12 days, and to rebuild its branchial sac within 19 days. Evisceration occur...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09614

    authors： Shenkar N,Gordon T

    更新日期：2015-04-16 00:00:00

  • A diver-operated hyperspectral imaging and topographic surveying system for automated mapping of benthic habitats.

    abstract：:We developed a novel integrated technology for diver-operated surveying of shallow marine ecosystems. The HyperDiver system captures rich multifaceted data in each transect: hyperspectral and color imagery, topographic profiles, incident irradiance and water chemistry at a rate of 15-30 m2 per minute. From surveys in ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07337-y

    authors： Chennu A,Färber P,De'ath G,de Beer D,Fabricius KE

    更新日期：2017-08-02 00:00:00

  • Impact of Adsorption on Gas Transport in Nanopores.

    abstract：:Given the complex nature of the interaction between gas and solid atoms, the development of nanoscale science and technology has engendered a need for further understanding of gas transport behavior through nanopores and more tractable models for large-scale simulations. In the present paper, we utilize molecular dyna...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23629

    authors： Wu T,Zhang D

    更新日期：2016-03-29 00:00:00

  • Effect of alcohol consumption on kidney function: population-based cohort study.

    abstract：:The association between alcohol consumption and kidney function is intriguing, but study results are mixed and controversial. We examined the association of alcohol consumption with the overall change in kidney function over 12 years. We analyzed data from a population-based cohort that was part of the Korean Genome a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81777-5

    authors： Lee YJ,Cho S,Kim SR

    更新日期：2021-01-27 00:00:00

  • Linked color imaging can improve the visibility of superficial non-ampullary duodenal epithelial tumors.

    abstract：:The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of whi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77726-3

    authors： Okimoto K,Maruoka D,Matsumura T,Tokunaga M,Kaneko T,Oura H,Akizue N,Ohta Y,Saito K,Arai M,Kato J,Kato N

    更新日期：2020-11-26 00:00:00

  • Hierarchically-structured silver nanoflowers for highly conductive metallic inks with dramatically reduced filler concentration.

    abstract：:Silver has long been employed as an electrically conductive component, and morphology-dependent properties have been actively investigated. Here we present a novel scalable synthesis method of flower-shaped silver nanoparticles (silver nanoflowers, Ag NFs). The preferential affinity of citrate molecules on (111) surfa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34894

    authors： C MA,K P F,Singh S,Baik S

    更新日期：2016-10-07 00:00:00

  • A transgenic mouse model expressing an ERα folding biosensor reveals the effects of Bisphenol A on estrogen receptor signaling.

    abstract：:Estrogen receptor-α (ERα) plays an important role in normal and abnormal physiology of the human reproductive system by interacting with the endogenous ligand estradiol (E2). However, other ligands, either analogous or dissimilar to E2, also bind to ERα. This may create unintentional activation of ER signaling in repr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34788

    authors： Sekar TV,Foygel K,Massoud TF,Gambhir SS,Paulmurugan R

    更新日期：2016-10-10 00:00:00

  • Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system.

    abstract：:Astrocyte reactivation has been discovered to be an important contributor to several neurological diseases. In vitro models involving human astrocytes have the potential to reveal disease-specific mechanisms of these cells and to advance research on neuropathological conditions. Here, we induced a reactive phenotype i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53414-9

    authors： Hyvärinen T,Hagman S,Ristola M,Sukki L,Veijula K,Kreutzer J,Kallio P,Narkilahti S

    更新日期：2019-11-15 00:00:00

  • Continuous and automatic mortality risk prediction using vital signs in the intensive care unit: a hybrid neural network approach.

    abstract：:Mortality risk prediction can greatly improve the utilization of resources in intensive care units (ICUs). Existing schemes in ICUs today require laborious manual input of many complex parameters. In this work, we present a scheme that uses variations in vital signs over a 24-h period to make mortality risk assessment...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78184-7

    authors： Baker S,Xiang W,Atkinson I

    更新日期：2020-12-04 00:00:00

  • An efficient full-length cDNA amplification strategy based on bioinformatics technology and multiplexed PCR methods.

    abstract：:A novel strategy for amplification full-length cDNA and promoter sequences has been developed using bioinformatics technology and multiplexed PCR methods in this study. The amplification of 3' ends of cDNA is performed according to the modified classic 3' RACE techniques, therein the more efficient and effective oligo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19420

    authors： Chen N,Wang WM,Wang HL

    更新日期：2016-01-13 00:00:00

  • Pre-symptomatic modified phytohormone profile is associated with lower phytoplasma titres in an Arabidopsis seor1ko line.

    abstract：:The proteins AtSEOR1 and AtSEOR2 occur as conjugates in the form of filaments in sieve elements of Arabidopsis thaliana. A reduced phytoplasma titre found in infected defective-mutant Atseor1ko plants in previous work raised the speculation that non-conjugated SEOR2 is involved in the phytohormone-mediated suppression...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71660-0

    authors： Bernardini C,Pagliari L,De Rosa V,Almeida-Trapp M,Santi S,Martini M,Buoso S,Loschi A,Loi N,Chiesa F,Mithöfer A,van Bel AJE,Musetti R

    更新日期：2020-09-08 00:00:00

  • Toxicology Study of Single-walled Carbon Nanotubes and Reduced Graphene Oxide in Human Sperm.

    abstract：:Carbon-based nanomaterials such as single-walled carbon nanotubes and reduced graphene oxide are currently being evaluated for biomedical applications including in vivo drug delivery and tumor imaging. Several reports have studied the toxicity of carbon nanomaterials, but their effects on human male reproduction have ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30270

    authors： Asghar W,Shafiee H,Velasco V,Sah VR,Guo S,El Assal R,Inci F,Rajagopalan A,Jahangir M,Anchan RM,Mutter GL,Ozkan M,Ozkan CS,Demirci U

    更新日期：2016-08-19 00:00:00

  • The different effects of twin boundary and grain boundary on reducing tension-compression yield asymmetry of Mg alloys.

    abstract：:In the present study, a coarse grained AZ31 plate was refined by twin boundaries (TBs) and grain boundaries (GBs), respectively. A comparative study about the different effects of grain refinements by GBs and by TBs on tension-compression yield asymmetry was performed. Our results show that both the refinements by GBs...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29283

    authors： Yu H,Xin Y,Chapuis A,Huang X,Xin R,Liu Q

    更新日期：2016-07-04 00:00:00