当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > A core extended naphtalene diimide G-quadruplex ligand potently inhibits herpes simplex virus 1 replication.

A core extended naphtalene diimide G-quadruplex ligand potently inhibits herpes simplex virus 1 replication.

Abstract：

:G-quadruplexes (G4s) are nucleic acids secondary structures, epigenetic regulators in cells and viruses. In herpes simplex virus 1 (HSV-1)-infected cells, G4s are massively present during viral replication. We here aimed at investigating the possibility to target the HSV-1 G4s by a core extended naphtalene diimide (c-exNDI) G4 ligand. Biophysical and biomolecular analysis proved that c-exNDI stabilized the HSV-1 G4s in a concentration dependent manner. In MS competition assays, c-exNDI preferentially recognized HSV-1 G4s over cellular telomeric G4s, the most represented G4s within cells; other less abundant cellular G4s were also recognized. Treatment of HSV-1 infected cells with c-exNDI at low nanomolar concentrations induced significant virus inhibition with no cytotoxicity. The mechanism of action was ascribed to G4-mediated inhibition of viral DNA replication, with consequent impairment of viral genes transcription. Our data suggest that the observed potent antiviral activity and low cytotoxicity mainly depend on a combination of c-exNDI affinity for HSV-1 G4s and their massive presence during infection. HSV-1 G4s may thus represent new effective antiviral targets: the fact that no current antiherpetic drug exploits them and their presence at the viral genome, responsible for both active and latent HSV infections, makes them particularly attracting.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Callegaro S,Perrone R,Scalabrin M,Doria F,Palù G,Richter SN

doi

10.1038/s41598-017-02667-3

subject

Has Abstract

pub_date

2017-05-24 00:00:00

pages

2341

issue

1

issn

2045-2322

pii

10.1038/s41598-017-02667-3

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Insulating phase at low temperature in ultrathin La0.8Sr0.2MnO3 films.

    abstract：:Metal-insulator transition is observed in the La0.8Sr0.2MnO3 thin films with thickness larger than 5 unit cells. Insulating phase at lower temperature appeared in the ultrathin films with thickness ranging from 6 unit cells to 10 unit cells and it is found that the Mott variable range hopping conduction dominates in t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22382

    authors： Feng Y,Jin KJ,Gu L,He X,Ge C,Zhang QH,He M,Guo QL,Wan Q,He M,Lu HB,Yang G

    更新日期：2016-03-01 00:00:00

  • Comparing distress of mouse models for liver damage.

    abstract：:In order to foster animal welfare as well as high quality of research, many countries regulate by law that the severity of animal experiments must be evaluated and considered when performing biomedical research. It is well accepted that multiple parameters rather than a single readout parameter should be applied to de...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76391-w

    authors： Tang G,Seume N,Häger C,Kumstel S,Abshagen K,Bleich A,Vollmar B,Talbot SR,Zhang X,Zechner D

    更新日期：2020-11-13 00:00:00

  • Interface instability modes in freezing colloidal suspensions: revealed from onset of planar instability.

    abstract：:Freezing colloidal suspensions widely exists in nature and industry. Interface instability has attracted much attention for the understandings of the pattern formation in freezing colloidal suspensions. However, the interface instability modes, the origin of the ice banding or ice lamellae, are still unclear. In-situ ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23358

    authors： Wang L,You J,Wang Z,Wang J,Lin X

    更新日期：2016-03-21 00:00:00

  • Bark and wood tissues of American elm exhibit distinct responses to Dutch elm disease.

    abstract：:Tolerance to Dutch elm disease (DED) has been linked to the rapid and/or high induction of disease-responsive genes after infection with the fungus Ophiostoma novo-ulmi. Although the fungal infection by O. novo-ulmi primarily takes places in xylem vessels, it is still unclear how xylem contributes to the defense again...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07779-4

    authors： Sherif SM,Erland LA,Shukla MR,Saxena PK

    更新日期：2017-08-02 00:00:00

  • Kinetic analysis of effects of temperature and time on the regulation of venom expression in Bungarus multicinctus.

    abstract：:Venom gland is a highly efficient venom production system to maintain their predatory arsenal. Venom toxins mRNA has been shown to increase abruptly in snake after venom expenditure, while the dynamics of venom accumulation during synthesis are poorly understood. Here, PacBio long-read sequencing, Illumina RNA sequenc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70565-2

    authors： Yin X,Guo S,Gao J,Luo L,Liao X,Li M,Su H,Huang Z,Xu J,Pei J,Chen S

    更新日期：2020-08-24 00:00:00

  • Magnetic properties in α-MnO₂ doped with alkaline elements.

    abstract：:α-MnO2 nanotubes were fabricated using a hydrothermal technique. Li, Na and K ions were introduced into MnO2 nanotubes to tailor their magnetic properties. It was found that with a doping concentration lower than 12 at%, the nanotubes showed ferromagnetic-like ordering at low temperature (<50 K), while antiferromagnet...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09094

    authors： Tseng LT,Lu Y,Fan HM,Wang Y,Luo X,Liu T,Munroe P,Li S,Yi J

    更新日期：2015-03-13 00:00:00

  • Identification of endoxylanase XynE from Clostridium thermocellum as the first xylanase of glycoside hydrolase family GH141.

    abstract：:Enzymes that cleave polysaccharides in lignocellulose, i. e., cellulases, xylanases, and accessory enzymes, play crucial roles in the natural decomposition of plant-derived biomass and its efficient and sustainable processing into biofuels or other bulk chemicals. The analysis of open reading frame cthe_2195 from the ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11598-y

    authors： Heinze S,Mechelke M,Kornberger P,Liebl W,Schwarz WH,Zverlov VV

    更新日期：2017-09-11 00:00:00

  • Formation of neocortical memory circuits for unattended written word forms: neuromagnetic evidence.

    abstract：:To master linguistic communication, humans must acquire large vocabularies quickly and effortlessly. Efficient word learning might be facilitated by the ability to rapidly acquire novel word forms even outside the focus of attention, occurring within minutes of repetitive exposure and suggesting fast and automatic lex...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34029-y

    authors： Partanen EJ,Leminen A,Cook C,Shtyrov Y

    更新日期：2018-10-25 00:00:00

  • Recent loss of closed forests is associated with Ebola virus disease outbreaks.

    abstract：:Ebola virus disease (EVD) is a contagious, severe and often lethal form of hemorrhagic fever in humans. The association of EVD outbreaks with forest clearance has been suggested previously but many aspects remained uncharacterized. We used remote sensing techniques to investigate the association between deforestation ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14727-9

    authors： Olivero J,Fa JE,Real R,Márquez AL,Farfán MA,Vargas JM,Gaveau D,Salim MA,Park D,Suter J,King S,Leendertz SA,Sheil D,Nasi R

    更新日期：2017-10-30 00:00:00

  • Forest edge disturbance increases rattan abundance in tropical rain forest fragments.

    abstract：:Human-induced forest fragmentation poses one of the largest threats to global diversity yet its impact on rattans (climbing palms) has remained virtually unexplored. Rattan is arguably the world's most valuable non-timber forest product though current levels of harvesting and land-use change place wild populations at ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06590-5

    authors： Campbell MJ,Edwards W,Magrach A,Laurance SG,Alamgir M,Porolak G,Laurance WF

    更新日期：2017-07-20 00:00:00

  • Structural Studies of Epithelial Mesenchymal Transition Breast Tissues.

    abstract：:At the supramolecular level, the proliferation of invasive ductal carcinoma through breast tissue is beyond the range of standard histopathology identification. Using synchrotron small angle x-ray scattering (SAXS) techniques, determining nanometer scale structural changes in breast tissue has been demonstrated to all...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-58932-5

    authors： Mohd Sobri SN,Abdul Sani SF,Sabtu SN,Looi LM,Chiew SF,Pathmanathan D,Chio-Srichan S,Bradley DA

    更新日期：2020-02-06 00:00:00

  • Y-chromosomal connection between Hungarians and geographically distant populations of the Ural Mountain region and West Siberia.

    abstract：:Hungarians who live in Central Europe today are one of the westernmost Uralic speakers. Despite of the proposed Volga-Ural/West Siberian roots of the Hungarian language, the present-day Hungarian gene pool is highly similar to that of the surrounding Indo-European speaking populations. However, a limited portion of sp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44272-6

    authors： Post H,Németh E,Klima L,Flores R,Fehér T,Türk A,Székely G,Sahakyan H,Mondal M,Montinaro F,Karmin M,Saag L,Yunusbayev B,Khusnutdinova EK,Metspalu E,Villems R,Tambets K,Rootsi S

    更新日期：2019-05-24 00:00:00

  • Signal mingle: Micropatterns of BMP-2 and fibronectin on soft biopolymeric films regulate myoblast shape and SMAD signaling.

    abstract：:In vivo, bone morphogenetic protein 2 (BMP-2) exists both in solution and bound to the extracellular matrix (ECM). While these two modes of presentation are known to influence cell behavior distinctly, their role in the niche microenvironment and their functional relevance in the genesis of a biological response has s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41479

    authors： Fitzpatrick V,Fourel L,Destaing O,Gilde F,Albigès-Rizo C,Picart C,Boudou T

    更新日期：2017-01-30 00:00:00

  • Switchable Multi-Color Solution-Processed QD-laser.

    abstract：:In this paper, for the first time, the switchable two-color quantum dot laser has been realized considering solution process technology, which has both simultaneous and lonely lasing capability exploiting selective energy contacts. Furthermore, both channels can be modulated independently, which is a significant featu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-60859-w

    authors： Matloub S,Amini P,Rostami A

    更新日期：2020-03-24 00:00:00

  • Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport.

    abstract：:Abnormal dopaminergic transmission has been implicated as a risk determinant of HIV-1-associated neurocognitive disorders. HIV-1 Tat protein increases synaptic dopamine (DA) levels by directly inhibiting DA transporter (DAT) activity, ultimately leading to dopaminergic neuron damage. Through integrated computational m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39048

    authors： Quizon PM,Sun WL,Yuan Y,Midde NM,Zhan CG,Zhu J

    更新日期：2016-12-14 00:00:00

  • Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells.

    abstract：:Attachment of nanoparticles (NPs) to the surface of carrier red blood cells (RBCs) profoundly alters their interactions with the host organism, decelerating NP clearance from the bloodstream while enabling NP transfer from the RBC surface to the vascular cells. These changes in pharmacokinetics of NPs imposed by carri...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19897-8

    authors： Pan DC,Myerson JW,Brenner JS,Patel PN,Anselmo AC,Mitragotri S,Muzykantov V

    更新日期：2018-01-25 00:00:00

  • Serum neurofilament light chain predicts long term clinical outcomes in multiple sclerosis.

    abstract：:Serum neurofilament light chain (NfL) is emerging as an important biomarker in multiple sclerosis (MS). Our objective was to evaluate the prognostic value of serum NfL levels obtained close to the time of MS onset with long-term clinical outcomes. In this prospective cohort study, we identified patients with serum col...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-67504-6

    authors： Thebault S,Abdoli M,Fereshtehnejad SM,Tessier D,Tabard-Cossa V,Freedman MS

    更新日期：2020-06-25 00:00:00

  • Sex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite).

    abstract：:Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated the sex-related pharmacokinetics of metapristone in both rats and dogs, and explored the related ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17225-0

    authors： Chen W,Xiao Y,Chen J,Liu J,Shao J,Li T,Zhu Y,Ma J,Gao Y,Wang J,Xu J,Lu Y,Jia L

    更新日期：2017-12-07 00:00:00

  • miR-494 induces EndMT and promotes the development of HCC (Hepatocellular Carcinoma) by targeting SIRT3/TGF-β/SMAD signaling pathway.

    abstract：:EndMT has an important effect on metastasis and progression of tumor. This work will elucidate the effect of miR-494 on EndMT and development of HCC. Therefore, the differential miRNA expression among non-tumorous, para-tumorous and tumorous tissues was analyzed. Moreover, luciferase activities of SIRT3 3'UTR treated ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43731-4

    authors： Zhang J,Zhu Y,Hu L,Yan F,Chen J

    更新日期：2019-05-10 00:00:00

  • Berberine decreases plasma triglyceride levels and upregulates hepatic TRIB1 in LDLR wild type mice and in LDLR deficient mice.

    abstract：:TRIB1 is a GWAS locus associated with plasma cholesterol and triglycerides (TG) levels. In mice, liver-specific overexpression of TRIB1 lowers plasma lipid levels. Berberine (BBR) is a natural lipid lowering drug that reduces plasma LDL-cholesterol (LDL-C), total cholesterol (TC) and TG in hyperlipidemic patients and ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52253-y

    authors： Singh AB,Liu J

    更新日期：2019-10-30 00:00:00

  • A label-free optical whole-cell Escherichia coli biosensor for the detection of pyrethroid insecticide exposure.

    abstract：:There is a growing need for low-cost, portable technologies for the detection of threats to the environment and human health. Here we propose a label-free, optical whole-cell Escherichia coli biosensor for the detection of 3-phenoxybenzoic acid (3-PBA), a biomarker for monitoring human exposure to synthetic pyrethroid...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48907-6

    authors： Riangrungroj P,Bever CS,Hammock BD,Polizzi KM

    更新日期：2019-08-28 00:00:00

  • A novel library of -arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in vitro and in vivo studies.

    abstract：:α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin) via scaffold hopping and bioisosteric modification of known inhibitors of α-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13798-y

    authors： Luthra T,Agarwal R,Estari M,Adepally U,Sen S

    更新日期：2017-10-16 00:00:00

  • Fluorescent Biocompatible Platinum-Porphyrin-Doped Polymeric Hybrid Particles for Oxygen and Glucose Biosensing.

    abstract：:Near infrared (NIR) fluorophores like Pt-porphyrin along with analyte specific enzymes require co-encapsulation in biocompatible and biodegradable carriers in order to be transformed into implantable biosensors for efficient and continuous monitoring of analytes in patients. The main objective of this research is to d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41326-7

    authors： Pandey G,Chaudhari R,Joshi B,Choudhary S,Kaur J,Joshi A

    更新日期：2019-03-22 00:00:00

  • Genome wide association study and genomic prediction for stover quality traits in tropical maize (Zea mays L.).

    abstract：:Maize is rapidly replacing traditionally cultivated dual purpose crops of South Asia, primarily due to the better economic remuneration. This has created an impetus for improving maize for both grain productivity and stover traits. Molecular techniques can largely assist breeders in determining approaches for effectiv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80118-2

    authors： Vinayan MT,Seetharam K,Babu R,Zaidi PH,Blummel M,Nair SK

    更新日期：2021-01-12 00:00:00

  • Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome.

    abstract：:Rett syndrome (RTT) is a neurodevelopmental disorder mainly caused by mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding protein 2 (MeCP2), located on the X chromosome. Many RTT patients have breathing abnormalities, such as apnea and breathing irregularity, and respiratory infection is th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12293-8

    authors： Kida H,Takahashi T,Nakamura Y,Kinoshita T,Hara M,Okamoto M,Okayama S,Nakamura K,Kosai KI,Taniwaki T,Yamashita Y,Matsuishi T

    更新日期：2017-09-20 00:00:00

  • Asymptotic Gaussian law for noninteracting indistinguishable particles in random networks.

    abstract：:For N indistinguishable bosons or fermions impinged on a M-port Haar-random unitary network the average probability to count n 1, … n r particles in a small number r ≪ N of binned-together output ports takes a Gaussian form as N ≫ 1. The discovered Gaussian asymptotic law is the well-known asymptotic law for distingui...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00044-8

    authors： Shchesnovich VS

    更新日期：2017-02-16 00:00:00

  • The Brain Metabolome of Male Rats across the Lifespan.

    abstract：:Comprehensive and accurate characterization of brain metabolome is fundamental to brain science, but has been hindered by technical limitations. We profiled the brain metabolome in male Wistar rats at different ages (day 1 to week 111) using high-sensitivity and high-resolution mass spectrometry. Totally 380 metabolit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24125

    authors： Zheng X,Chen T,Zhao A,Wang X,Xie G,Huang F,Liu J,Zhao Q,Wang S,Wang C,Zhou M,Panee J,He Z,Jia W

    更新日期：2016-04-11 00:00:00

  • Membrane topologies of the PGLa antimicrobial peptide and a transmembrane anchor sequence by Dynamic Nuclear Polarization/solid-state NMR spectroscopy.

    abstract：:Dynamic Nuclear Polarization (DNP) has been introduced to overcome the sensitivity limitations of nuclear magnetic resonance (NMR) spectroscopy also of supported lipid bilayers. When investigated by solid-state NMR techniques the approach typically involves doping the samples with biradicals and their investigation at...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20895

    authors： Salnikov ES,Aisenbrey C,Aussenac F,Ouari O,Sarrouj H,Reiter C,Tordo P,Engelke F,Bechinger B

    更新日期：2016-02-15 00:00:00

  • Cardiac kinematic parameters computed from video of in situ beating heart.

    abstract：:Mechanical function of the heart during open-chest cardiac surgery is exclusively monitored by echocardiographic techniques. However, little is known about local kinematics, particularly for the reperfused regions after ischemic events. We report a novel imaging modality, which extracts local and global kinematic para...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46143

    authors： Fassina L,Rozzi G,Rossi S,Scacchi S,Galetti M,Lo Muzio FP,Del Bianco F,Colli Franzone P,Petrilli G,Faggian G,Miragoli M

    更新日期：2017-04-11 00:00:00

  • Evaluation of real-world early response of DMO to aflibercept therapy to inform future clinical trial design of novel investigational agents.

    abstract：:New clinical trials for diabetic macular oedema (DMO) are being designed to prove superiority over aflibercept when this agent is already very effective in improving visual acuity (VA) and DMO. The aim of this study was to determine the optimal inclusion-exclusion criteria for trials to aim for superiority in visual o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73571-6

    authors： Halim S,Gurudas S,Chandra S,Greenwood J,Sivaprasad S

    更新日期：2020-10-05 00:00:00