Abstract：
:Regional abnormalities in brain structure and function, as well as disrupted connectivity, have been found repeatedly in adolescents with conduct disorder (CD). Yet, the large-scale brain topology associated with CD is not well characterized, and little is known about the systematic neural mechanisms of CD. We employed graphic theory to investigate systematically the structural connectivity derived from cortical thickness correlation in a group of patients with CD (N = 43) and healthy controls (HCs, N = 73). Nonparametric permutation tests were applied for between-group comparisons of graphical metrics. Compared with HCs, network measures including global/local efficiency and modularity all pointed to hypo-functioning in CD, despite of preserved small-world organization in both groups. The hubs distribution is only partially overlapped with each other. These results indicate that CD is accompanied by both impaired integration and segregation patterns of brain networks, and the distribution of highly connected neural network 'hubs' is also distinct between groups. Such misconfiguration extends our understanding regarding how structural neural network disruptions may underlie behavioral disturbances in adolescents with CD, and potentially, implicates an aberrant cytoarchitectonic profiles in the brain of CD patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jiang Y,Liu W,Ming Q,Gao Y,Ma R,Zhang X,Situ W,Wang X,Yao S,Huang Bdoi
10.1038/srep37053subject
Has Abstractpub_date
2016-11-14 00:00:00pages
37053issn
2045-2322pii
srep37053journal_volume
6pub_type
杂志文章,随机对照试验abstract：:The importance of microbial natural products has been widely demonstrated in the search for new antibiotics. However, the functional role of microbial metabolites in nature remains to be deciphered. Several natural products are known to mediate microbial interactions through metabolic exchange. One approach to investi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05532-5
更新日期：2017-07-14 00:00:00
abstract：:Enamel proteins form a scaffold for growing hydroxyapatite crystals during enamel formation. They are then almost completely degraded during enamel maturation, resulting in a protein content of only 1% (w/v) in mature enamel. Nevertheless, this small amount of remaining proteins has important effects on the mechanical...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15194
更新日期：2015-10-15 00:00:00
abstract：:The revolutionary RNA-guided endonuclease CRISPR/Cas9 system has proven to be a powerful tool for gene editing in a plethora of organisms. Here, utilizing this system we developed an efficient protocol for the generation of heritable germline mutations in the parasitoid jewel wasp, Nasonia vitripennis, a rising insect...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00990-3
更新日期：2017-04-19 00:00:00
abstract：:Nanoscale wavelength-converted optical components are promising components for communication and optical information processing in integrated photonic system. In this work, we report a facile strategy for realizing continuously tunable wavelength-converted wave-guiding in dye-doped nanofibers. The nanofibers with diam...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01674
更新日期：2013-01-01 00:00:00
abstract：:There is a scarcity of data of zinc transporter-8 autoantibody (ZnT8A) on mixed populations such as Brazilian. Therefore, we evaluated the relevance of ZnT8A for type 1 diabetes (T1D) diagnosis and the role of ZnT8 coding gene (SLC30A8) in T1D predisposition. Patients with T1D (n = 629; diabetes duration = 11 (6-16) y...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00307-4
更新日期：2017-03-16 00:00:00
abstract：:The biogeographic history of lichenized fungi remains unrevealed because those organisms rarely fossilize due to their delicate, often tiny and quickly rotting thalli. Also the ecology and factors limiting occurrence of numerous taxa, especially those restricted in their distribution to tropical areas are poorly recog...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38779
更新日期：2016-12-08 00:00:00
abstract：:A range of chemistries were explored for the efficient covalent conjugation of DNA to poly(N-isopropylacrylamide) (poly(NIPAM)) in organic solvents. Amide coupling and thiol-ene Michael addition were found to be ineffective for the synthesis of the desired products. However, the inverse electron-demand Diels-Alder (DA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39192
更新日期：2016-12-16 00:00:00
abstract：:In this work, the coexistence of Write Once Read Many Memory (WORM) and memristor can be achieved in a single device of Poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT: PSS) and Polyvinyl Alcohol (PVA) blend organic memory system. In memristor mode, the bistable resistance states of the device can be cy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38816
更新日期：2016-12-12 00:00:00
abstract：:Genetic divergences among mammalian strains are presented phenotypically in various aspects of physical appearance such as body shape and facial features. Yet how genetic diversity is expressed in brain function still remains unclear. Functional connectivity has been shown to be a valuable approach in characterizing t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21697
更新日期：2016-02-22 00:00:00
abstract：:We successfully realised plasmon-driven selective reduction reactions of 2-amino-5-nitrobenzenethiol (2A-5-NBT) to 3,3'-dimercapto-4,4'-diaminoazobenzene , an azobenzene derivative, using surface-enhanced Raman scattering (SERS) spectroscopy, and supported by the theoretical calculations. The SERS spectra demonstrated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10269
更新日期：2015-06-01 00:00:00
abstract：:Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12511
更新日期：2015-07-27 00:00:00
abstract：:The plasmodial CTP:phosphocholine cytidylyltransferase (PfCCT) is a promising antimalarial target, which can be inhibited to exploit the need for increased lipid biosynthesis during the erythrocytic life stage of Plasmodium falciparum. Notable structural and regulatory differences of plasmodial and mammalian CCTs offe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27183-w
更新日期：2018-06-12 00:00:00
abstract：:Oxygen tolerance of selenium-containing [NiFeSe] hydrogenases (Hases) is attributable to the high reducing power of the selenocysteine residue, which sustains the bimetallic Ni-Fe catalytic center in the large subunit. Genes encoding [NiFeSe] Hases are inherited by few sulphate-reducing δ-proteobacteria globally distr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19742
更新日期：2016-01-28 00:00:00
abstract：:Nanocarrier systems for the encapsulation of agrochemicals can contribute to sustainable agriculture, but few nanosystems have been developed for plant growth regulators (PGRs). The present study evaluated the effects of seed priming using alginate/chitosan (nanoALG/CS) and chitosan/tripolyphosphate (nanoCS/TPP) conta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43494-y
更新日期：2019-05-09 00:00:00
abstract：:We consider synchronization properties of arrays of spin-torque nano-oscillators coupled via an RC load. We show that while the fully synchronized state of identical oscillators may be locally stable in some parameter range, this synchrony is not globally attracting. Instead, regimes of different levels of composition...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04918-9
更新日期：2017-07-05 00:00:00
abstract：:Alcohol and nicotine are the most widely co-abused drugs. Both modify the activity of dopaminergic (DA) neurons of the Ventral Tegmental Area (VTA) and lead to an increase in DA release in the Nucleus Accumbens, thereby affecting the reward system. Evidences support the hypothesis that distinct nicotinic acetylcholine...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45116
更新日期：2017-03-23 00:00:00
abstract：:We previously identified novel bioactive polysaccharides from Bactrocera cucurbitae and Antheraea yamamai that activate innate immunity in RAW264 murine macrophages. However, in terms of potential applications in the cultivation of prawns, there were problems with the availability of these insects. However, we have no...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27241-3
更新日期：2018-06-11 00:00:00
abstract：:Area under a receiver-operating-characteristic (AUROC) curve is widely used in medicine to summarize the ability of a continuous predictive marker to predict a binary outcome. This study illustrated how a U-shaped or inverted U-shaped continuous predictor would affect the shape and magnitude of its AUROC curve in pred...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10408-9
更新日期：2017-08-31 00:00:00
abstract：:Congenital ptosis may be associated with abnormalities of visual development and function, including amblyopia, strabismus and refractive errors. However, the prevalence estimates of these abnormalities vary widely. We performed a systematic review and meta-analysis to estimate the prevalence of amblyopia, strabismus ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-26671-3
更新日期：2018-05-29 00:00:00
abstract：:Whether age has any impact on the risk of lymph node (LN) metastasis in patients with early-stage non-small cell lung cancer (NSCLC) remains controversial. Therefore, we aimed to objectively compare the risk of LN metastasis between elderly and young patients so as to justify for age-different extent of surgical resec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66509-5
更新日期：2020-06-12 00:00:00
abstract：:Diffusion tensor imaging (DTI) studies have detected white matter microstructural changes in essential tremor (ET). However, it is still unclear whether these changes are related to cognitive deficits, which have been described in ET patients. DTI-derived fractional anisotropy, mean diffusivity (MD), axial diffusivity...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02596-1
更新日期：2017-06-07 00:00:00
abstract：:Liraglutide, a glucagon-like peptide-1 receptor (GLP-1R) agonist, is widely used to treat diabetes. However, its effect on pulmonary arterial hypertension (PAH) is unknown. In this study, we investigated its effects on rats with monocrotaline (MCT)-induced PAH and mechanisms on rat pulmonary artery smooth muscle cells...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31788
更新日期：2016-09-01 00:00:00
abstract：:Despite the increasing number of studies conducted recently to evaluate the association between HPV infections and the risk of prostate cancer, the results remain inconclusive. Furthermore, the prevalence and distribution of overall and individual HPV types worldwide in prostate cancer has not been reported until now....
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep14667
更新日期：2015-10-06 00:00:00
abstract：:Human KHDRBS1/Sam68 is an oncogenic splicing factor involved in signal transduction and pre-mRNA splicing. We explored the molecular mechanism of KHDRBS1 to be a prognostic marker in four different cancers. Within specific cancer, including kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), acut...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47558-x
更新日期：2019-07-31 00:00:00
abstract：:The integral membrane-bound Nrf1 transcription factor fulfils important functions in maintaining cellular homeostasis and organ integrity, but how it is controlled vectorially is unknown. Herein, creative use of Gal4-based reporter assays with protease protection assays (GRAPPA), and double fluorescence protease prote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02006
更新日期：2013-01-01 00:00:00
abstract：:Communication between vascular plants through volatile organic compounds (VOCs) impacts on ecosystem functioning. However, nothing is known about that between non-vascular plants. To investigate plant-plant VOCs interaction in bryophytes we exposed rare peatland moss Hamatocaulis vernicosus to VOCs of its common compe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64108-y
更新日期：2020-05-04 00:00:00
abstract：:Externally manipulating memories by presenting conditioned stimuli (CS) during sleep is a new approach to investigating memory processing during sleep. However, whether presenting a CS during REM or NREM sleep enhances or extinguishes fear memory has not been clearly delineated. In this study, mice underwent trace fea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46247
更新日期：2017-04-12 00:00:00
abstract：:Mapping the structure of the mammalian brain at cellular resolution is a challenging task and one that requires capturing key anatomical features at the appropriate level of analysis. Although neuroscientific methods have managed to provide significant insights at the micro and macro level, in order to obtain a whole-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50137-9
更新日期：2019-09-25 00:00:00
abstract：:CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. Reducing mosaic mutations is particularly important for gene therapy and precision genome editing. Although the mechanisms underlying the CRSIPR...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42081
更新日期：2017-02-03 00:00:00
abstract：:Computed Tomography derived Fractional Flow Reserve (CTFFR) is an emerging non-invasive imaging modality to assess functional significance of coronary stenosis. We performed a meta-analysis to compare the diagnostic performance of CTFFR to invasive Fractional Flow reserve (FFR). Electronic search was performed to iden...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-29910-9
更新日期：2018-08-01 00:00:00
