Abstract:
:Individuals with lower limb amputation need a secure suspension system for their prosthetic devices. A new coupling system was developed that is capable of suspending the prosthesis. The system's safety is ensured through an acoustic alarm system. This article explains how the system works and provides an in vivo evaluation of the device with regard to pistoning during walking. The system was designed to be used with silicone liners and is based on the requirements of prosthetic suspension systems. Mechanical testing was performed using a universal testing machine. The pistoning during walking was measured using a motion analysis system. The new coupling device produced significantly less pistoning compared to a common suspension system (pin/lock). The safety alarm system would buzz if the suspension was going to fail. The new coupling system could securely suspend the prostheses in transtibial amputees and produced less vertical movement than the pin/lock system.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Eshraghi A,Osman NA,Gholizadeh H,Ahmadian J,Rahmati B,Abas WAdoi
10.1038/srep02270subject
Has Abstractpub_date
2013-01-01 00:00:00pages
2270issn
2045-2322pii
srep02270journal_volume
3pub_type
杂志文章abstract::Antagonist pleiotropy, where a gene exerts a beneficial effect at early stages and a deleterious effect later on in an animal's life, may explain the evolutionary persistence of devastating genetic diseases such as Huntington's disease (HD). To date, however, there is little direct experimental evidence to support thi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37102-8
更新日期:2019-01-10 00:00:00
abstract::Sensorimotor transformation is indispensable to the accurate motion of the human body in daily life. For instance, when we grasp an object, the distance from our hands to an object needs to be calculated by integrating multisensory inputs, and our motor system needs to appropriately activate the arm and hand muscles t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09648
更新日期:2015-04-29 00:00:00
abstract::Herein, we have fabricated rutile TiO2 nanorod-coupled α-Fe2O3 by a wet-chemical process. It is demonstrated that the visible activities for photoelectrochemical water oxidation and for degrading pollutant of α-Fe2O3 are greatly enhanced after coupling a proper amount of rutile nanorods. The enhanced activity is attri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06180
更新日期:2014-08-26 00:00:00
abstract::This study was to investigate effects of progesterone vaginal sustained-release gel and intramuscular injection of progesterone on frozen-thawed embryos transfer in 3013 patients receiving vaginal progesterone sustained-release gel and progesterone injection in artificial cycle for frozen-thawed embryo transfer. All p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51717-5
更新日期:2019-10-24 00:00:00
abstract::Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated the effects of liraglutide on HSC phenotype and hepatic microvascular function using diverse pre-clinical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02866-y
更新日期:2017-06-12 00:00:00
abstract::Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Recent studies have implicated cancer stem cells within glioblastoma (glioma stem cells, GSCs) as mediators of therapeutic resistance and tumor progression. In this study, we investigated the role of the transforming growth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51270-1
更新日期:2019-10-10 00:00:00
abstract::Plasmonically enhanced metal-insulator-metal (MIM) type structures are popular among perfect absorbers and photodetectors in which the field enhancement (for increased absorption) mechanism is directly coupled with collection (photocurrent) processes. In this work we propose a device structure that decouples absorptio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42349
更新日期:2017-02-09 00:00:00
abstract::Due to their unique properties, Weyl semimetals (WSMs) are promising materials for the future electronics. Currently, the two types (I and II) of WSMs are discovered experimentally. These types of WSMs differ from each other in their topological properties. In this paper we showed that a coexistence of types I and II ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32104-y
更新日期:2018-09-12 00:00:00
abstract::To examine patterns of human immunodeficiency virus (HIV) cause-specific deaths, risk factors, and the effect of interactions on mortality, we conducted a retrospective cohort study in Zhejiang, China, from 2006 to 2013. All data were downloaded from the acquired immune deficiency syndrome (AIDS) Prevention and Contro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42366
更新日期:2017-02-15 00:00:00
abstract::Land use change is one of the important aspects of the regional ecological restoration research. With remote sensing (RS) image in 2003, 2007 and 2012, using geographic information system (GIS) technologies, the land use pattern changes in Yimeng Mountain ecological restoration area in China and its driving force fact...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11038
更新日期:2015-06-05 00:00:00
abstract::Parasite death via ion channel activations is the hallmark of anthelmintic and antiparasitic drugs. Glutamate gated chloride channel (GluCl) is a prominent targets for drug selection and design in parasitology. We report several iodine-fluorine based lead activators of GluCl by computational studies and structure-acti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38561-3
更新日期:2019-02-14 00:00:00
abstract::Preventing ischemia-related cell damage is a priority when preserving tissue for transplantation. Perfusion protocols have been established for a variety of applications and proven to be superior to procedures used in clinical routine. Extracorporeal perfusion of muscle tissue though cumbersome is highly desirable sin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11956
更新日期:2015-07-06 00:00:00
abstract::Chronic kidney disease (CKD) progresses to end-stage renal failure via renal tubulointerstitial fibrosis. Malnutrition, inflammation, and arteriosclerosis interact to exacerbate the poor prognosis of CKD, and their effective management is thus essential. The traditional Japanese medicine Rikkunshito (RKT) exerts appet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58214-0
更新日期:2020-02-05 00:00:00
abstract::Advanced glycation end products (AGEs) are sugar-modified biomolecules that accumulate in the body with advancing age, and are implicated in the development of multiple age-associated structural and functional abnormities and diseases. It has been well documented that AGEs signal via their receptor RAGE to activate se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18822
更新日期:2016-01-05 00:00:00
abstract::Novelty seeking (NS) is a personality trait reflecting excitement in response to novel stimuli. High NS is usually a predictor of risky behaviour such as drug abuse. However, the relationships between NS and risk-related cognitive processes, including individual risk preference and the brain activation associated with...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep10534
更新日期:2015-06-11 00:00:00
abstract::Ionic currents, whether measured as conductance amplitude or as ion channel transcript numbers, can vary many-fold within a population of identified neurons. In invertebrate neuronal types multiple currents can be seen to vary while at the same time their magnitudes are correlated. These conductance amplitude correlat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38405-6
更新日期:2019-02-08 00:00:00
abstract::Invasive plant species often form dense mono-dominant stands in areas they have invaded, while having only sparse distribution in their native ranges, and the reasons behind this phenomenon are a key point of research in invasive species biology. Differences in species composition between native and invasive ranges ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16376-4
更新日期:2017-11-22 00:00:00
abstract::Neurokinin B (NKB) is a hypothalamic neuropeptide binding preferentially to the neurokinin 3 receptor. Expression of the gene encoding NKB is elevated in postmenopausal women. Furthermore, rodent studies suggest that NKB signalling may mediate menopausal hot flushes. However, the effects of NKB administration on hot f...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/srep08466
更新日期:2015-02-16 00:00:00
abstract::We used swept-source (SS) optical coherence tomography (OCT) and OCT angiography (OCTA) to investigate the effects of moderate physical exercise on retinal and choroidal vessel densities (VDs) and thicknesses in children. One eye in each of 40 myopic children (mean age, 11.70 years) and 18 emmetropic children (mean ag...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81770-y
更新日期:2021-01-21 00:00:00
abstract::Neuroticism is a personality trait, which is an important risk factor for psychiatric disorders. Recent genome-wide studies reported about 600 genes potentially influencing neuroticism. Little is known about the mechanisms of their action. Here, we aimed to conduct a more detailed analysis of genes that can regulate t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82123-5
更新日期:2021-01-28 00:00:00
abstract::Interactions and coordination between conspecific individuals have produced a remarkable variety of collective behaviours. This co-operation occurs in vertebrate and invertebrate animals and is well expressed in the group flight of birds, fish shoals and highly organized activities of social insects. How individuals i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51012-3
更新日期:2019-10-17 00:00:00
abstract::Vaccine trials and cohort studies in Plasmodium falciparum endemic areas indicate that naturally-acquired and vaccine-induced antibodies to merozoite surface protein 2 (MSP2) are associated with resistance to malaria. These data indicate that PfMSP2 has significant potential as a component of a multi-antigen malaria v...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45440-4
更新日期:2019-06-21 00:00:00
abstract::The epithelial-to-mesenchymal transition (EMT) is one of mechanisms that induce renal interstitial fibrosis. Understanding EMT in renal fibrosis has important therapeutic implications for patients with kidney disease. Alpha-lipoic acid (ALA) is a natural compound with antioxidant properties. Studies for ALA are perfor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46065
更新日期:2017-04-05 00:00:00
abstract::Glycosyltransferases (GTs) are bidirectional biocatalysts catalyzing the glycosylation of diverse molecules. However, the extensive applications of GTs in glycosides formation are limited due to their requirements of expensive nucleotide diphosphate (NDP)-sugars or NDP as the substrates. Here, in an effort to characte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24277-3
更新日期:2018-04-12 00:00:00
abstract::Advances in microfluidics technology has enabled many discoveries on microbial mechanisms and phenotypes owing to its exquisite controls over biological and chemical environments. However, emulating accurate ecologically relevant flow environments (e.g. microbes around a rising oil droplet) in microfluidics remains ch...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50153-9
更新日期:2019-09-24 00:00:00
abstract::Aberrant immune responses characterize autoimmune disorders like Rheumatoid Arthritis (RA) wherein lymphocytes are recognized as key players. Role of CD8+ T cells in RA has been less defined however we found that these cells are activated in RA patients with increased expression of cytolytic granules and inflammatory ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01033-7
更新日期:2017-04-19 00:00:00
abstract::In arthropods, retinoid X receptor (RXR) is a highly conserved nuclear hormone receptor. By forming a heterodimeric complex with the ecdysone receptor (EcR), RXR is known to be vital importance for various physiological processes. However, in comparison to EcR, the RXR signaling pathway and its roles in crustacean rep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23654
更新日期:2016-03-24 00:00:00
abstract::Malaria in India, while decreasing, remains a serious public health problem, and the contribution of submicroscopic and asymptomatic infections to its persistence is poorly understood. We conducted community surveys and clinic studies at three sites in India differing in their eco-epidemiologies: Chennai (Tamil Nadu),...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53386-w
更新日期:2019-11-19 00:00:00
abstract::Steep-slope transistors allow to scale down the supply voltage and the energy per computed bit of information as compared to conventional field-effect transistors (FETs), due to their sub-60 mV/decade subthreshold swing at room temperature. Currently pursued approaches to achieve such a subthermionic subthreshold swin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00359-6
更新日期:2017-03-23 00:00:00
abstract::Exploiting pattern formation - such as that observed in nature - in the context of micro/nanotechnology could have great benefits if coupled with the traditional top-down lithographic approach. Here, we demonstrate an original and simple method to produce unique, localized and controllable self-organised patterns on e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14787
更新日期:2015-10-06 00:00:00