Abstract：
:Advanced glycation end products (AGEs) are sugar-modified biomolecules that accumulate in the body with advancing age, and are implicated in the development of multiple age-associated structural and functional abnormities and diseases. It has been well documented that AGEs signal via their receptor RAGE to activate several cellular programs including NF-κB, leading to inflammation. A large number of stimuli can activate NF-κB; yet different stimuli, or the same stimulus for NF-κB in different cellular settings, produce a very different transcriptional landscape and physiological outcome. The NF-κB barcode hypothesis posits that cellular network dynamics generate signal-specific post-translational modifications, or a "barcode" to NF-κB, and that a signature "barcode" mediates a specific gene expression pattern. In the current study, we established that AGE-RAGE signaling results in NF-κB activation that directs collagen Ia1 and Ia2 expression. We further demonstrated that AGE-RAGE signal induces phosphorylation of RelA at three specific residues, T254, S311, and S536. These modifications are required for transcription of collagen I genes and are a consequence of cellular network dynamics. The increase of collagen content is a hallmark of arterial aging, and our work provides a potential mechanistic link between RAGE signaling, NF-κB activation, and aging-associated arterial alterations in structure and function.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Peng Y,Kim JM,Park HS,Yang A,Islam C,Lakatta EG,Lin Ldoi
10.1038/srep18822subject
Has Abstractpub_date
2016-01-05 00:00:00pages
18822issn
2045-2322pii
srep18822journal_volume
6pub_type
杂志文章abstract：:There has been a developing technology in algae with pharmaceuticals wastewater. However, the effect and the underlying mechanism of pharmaceuticals on algae are not well understood. To investigate the effect and mechanism of pharmaceuticalson microalgae, four pharmaceuticals of clofibric acid (CLF), ciprofloxacin (CI...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36609-4
更新日期：2019-02-07 00:00:00
abstract：:Chronic venous disease (CVD) is a multifactorial condition representing one of the most common disorders among populations of Western countries. The heritability of about 17% suggests genetic risk factors in CVD etiology. However, so far the genetic causes are unknown. We undertook the hitherto first genome-wide assoc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45652
更新日期：2017-04-04 00:00:00
abstract：:Most ice polymorphs have order-disorder "pairs" in terms of hydrogen positions, which contributes to the rich variety of ice polymorphs; in fact, three recently discovered polymorphs- ices XIII, XIV, and XV-are ordered counter forms to already identified disordered phases. Despite the considerable effort to understand...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28920
更新日期：2016-07-04 00:00:00
abstract：:Domoic acid (DA, 1), a potent neurotoxin that causes amnesic shellfish poisoning, has been found in diatoms and red algae. While biosynthetic pathway towards DA from geranyl diphosphate and L-glutamate has been previously proposed, its late stage is still unclear. Here, six novel DA related compounds, 7'-methyl-isodom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18651-w
更新日期：2018-01-10 00:00:00
abstract：:Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PID...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31198
更新日期：2016-08-09 00:00:00
abstract：:The differential conductance of graphene is shown to exhibit a zero-bias anomaly at low temperatures, arising from a suppression of the quantum corrections due to weak localization and electron interactions. A simple rescaling of these data, free of any adjustable parameters, shows that this anomaly exhibits a univers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62313-3
更新日期：2020-03-27 00:00:00
abstract：:A hematite photoanode showing a stable, record-breaking performance of 4.32 mA/cm² photoelectrochemical water oxidation current at 1.23 V vs. RHE under simulated 1-sun (100 mW/cm²) irradiation is reported. This photocurrent corresponds to ca. 34% of the maximum theoretical limit expected for hematite with a band gap o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02681
更新日期：2013-01-01 00:00:00
abstract：:The endogenous peptide C-type natriuretic peptide (CNP) binds its receptor, guanylyl cyclase B (GCB), and is expressed by endothelial cells in diverse tissues. Because the endothelial cells of visceral adipose tissue have recently been reported to play a role in lipid metabolism and inflammation, we investigated the e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10240-1
更新日期：2017-08-29 00:00:00
abstract：:Species in the genus Suaeda have few diagnostic characters and substantial morphological plasticity. Hence, regional floras do not provide clear taxonomic information for Suaeda spp. in East Asia. In order to assess the taxonomy of four species in the genus Suaeda (S. australis, S. maritima, S. japonica, and S. hetero...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78041-7
更新日期：2020-12-01 00:00:00
abstract：:In dentistry, the wet-bonding approach relies on water to maintain demineralized collagen expanded for proper resin infiltration; nevertheless, hydrolytic instability of the resin-dentin interface is inevitable with current bonding techniques. Considering dimethyl sulfoxide's (DMSO) ability to "biomodify" collagen and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34726-8
更新日期：2018-11-15 00:00:00
abstract：:Brood is a very valuable part of an ant colony and behaviours increasing its number with minimum investment is expected to be favoured by natural selection. Brood theft has been well documented in ants belonging to the subfamilies Myrmicinae and Formicinae. In this study we report opportunistic brood theft in the cont...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36166
更新日期：2016-10-31 00:00:00
abstract：:Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cystic Fibrosis (CF) that develop CF related diabetes (CFRD). CF is caused by a mutat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00098-8
更新日期：2017-03-07 00:00:00
abstract：:Spatially targeted, genetically-specific strategies for sustained inhibition of nociceptors may help transform pain science and clinical management. Previous optogenetic strategies to inhibit pain have required constant illumination, and chemogenetic approaches in the periphery have not been shown to inhibit pain. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30570
更新日期：2016-08-03 00:00:00
abstract：:The profiles of time-contrast (TC) -curves from popular MRI injectors derived at the injection site of the attached tube-line system were compared. Variations of TC-profiles were previously reported to potentially influence image quality in time critical MRI measurements. TC-curves from five injectors obtained during ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76536-x
更新日期：2020-11-11 00:00:00
abstract：:This paper proposes new ways to assess handwriting, a critical skill in any child's school journey. Traditionally, a pen and paper test called the BHK test (Concise Evaluation Scale for Children's Handwriting) is used to assess children's handwriting in French-speaking countries. Any child with a BHK score above a cer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60011-8
更新日期：2020-02-21 00:00:00
abstract：:Studies of locomotor activity in Svalbard reindeer reported the temporary absence of diel rhythms under Arctic photic conditions. However, using Lomb-Scargle periodogram analyses with high statistical power we found diel or circadian rhythmicity throughout the entire year in measures of behaviour, temperature in the r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32778-4
更新日期：2018-09-27 00:00:00
abstract：:The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo. Luciferase reporter based initia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19341
更新日期：2016-01-18 00:00:00
abstract：:Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNA...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28281
更新日期：2016-09-06 00:00:00
abstract：:Saccharomyces cerevisiae strains vary in their ability to develop and enhance sensory attributes of alcoholic beverages and are often found growing in mixed strain fermentations; however, quantifying individual strains is challenging due to quantification inaccuracies, low marker longevity, and compromised kinetics. W...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06971
更新日期：2014-11-10 00:00:00
abstract：:Protein electrochemistry represents a powerful technique for investigating the function and structure of proteins. Currently available biochemical assays provide limited information related to the conformational state of proteins and high costs. This work provides novel insights into the electrochemical investigation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53994-6
更新日期：2019-11-22 00:00:00
abstract：:Antibiotics in feed select for resistant strains and is thus a threat to human health. In this study, the effect of a multi-strain probiotic and antibiotics on the growth and health of broilers was studied. Equal numbers of broilers received on a daily basis either a multi-strain probiotic or a combination of sulphadi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12866-7
更新日期：2017-10-16 00:00:00
abstract：:Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in sepsis due to infection with Gram-negative bacteria but not other microbes. Herein, we provided IκB kinase β (IKKβ) in innate immune process as a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41180
更新日期：2017-02-01 00:00:00
abstract：:Genes with similar roles in the cell cluster on chromosomes, thus benefiting from coordinated regulation. This allows gene function to be inferred by transferring annotations from genomic neighbors, following the guilt-by-association principle. We performed a systematic search for co-occurrence of >1000 gene functions...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55984-0
更新日期：2019-12-20 00:00:00
abstract：:Periconceptional supplementation with folic acid reduces the occurrence of neural tube defects (NTDs). The association between maternal abnormalities in homocysteine metabolism (e.g., hyperhomocysteinaemia, folate deficiency and low vitamin B12) and the risk of NTDs-affected pregnancies has been widely evaluated in re...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep08510
更新日期：2015-03-02 00:00:00
abstract：:The discovery of graphene kicked off the curtain of atom-type two-dimensional (2D) materials. Layered metal-organic frameworks (MOFs) as parallel molecule-based 2D materials are more designable and more diverse, and magnetism may be induced by their metal ion nodes. However, the multifunctional 2D plane-like MOFs are ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11006-5
更新日期：2017-09-11 00:00:00
abstract：:In vivo, bone morphogenetic protein 2 (BMP-2) exists both in solution and bound to the extracellular matrix (ECM). While these two modes of presentation are known to influence cell behavior distinctly, their role in the niche microenvironment and their functional relevance in the genesis of a biological response has s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41479
更新日期：2017-01-30 00:00:00
abstract：:All real networks are different, but many have some structural properties in common. There seems to be no consensus on what the most common properties are, but scale-free degree distributions, strong clustering, and community structure are frequently mentioned without question. Surprisingly, there exists no simple gen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09421
更新日期：2015-04-29 00:00:00
abstract：:Filamentous fungi grow exclusively at their tips, where many growth-related fungal processes, such as enzyme secretion and invasion into host cells, take place. Hyphal tips are also a site of active metabolism. Understanding metabolic dynamics within the tip region is therefore important for biotechnology and medicine...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80270-9
更新日期：2021-01-14 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42948-7
更新日期：2019-05-02 00:00:00
abstract：:Angiogenesis is essential in tumor biology and is regulated by vascular endothelial growth factor (VEGF) ligands and receptors. Here we aimed to discover genetic variants associated with levels of circulating angiogenic proteins in cancer patients. Plasma was collected at baseline in 216 pancreatic and 114 colorectal ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34506-4
更新日期：2018-11-05 00:00:00
