Abstract：
:Caspase-2 is known to be involved in oxidative-stress mediated neuronal cell death. In this study, we demonstrated that rotenone-induced neuronal cell death is mediated by caspase-2 activation via PIDDosome formation. Our newly designed TAT-fused peptides, which contains wild-type helix number3 (H3) from RAIDD and PIDD, blocked the PIDDosome formation in vitro. Furthermore, peptides inhibited rotenone-induced caspase-2-dependent apoptosis in neuronal cells. These results suggest that PIDD- or RAIDD-targeted peptides might be effective at protecting against rotenone-induced neurotoxicity. Our peptides are novel neuronal cell apoptosis inhibitors that might serve as a prototype for development of drugs for the treatment of neurodegenerative diseases.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jang TH,Lim IH,Kim CM,Choi JY,Kim EA,Lee TJ,Park HHdoi
10.1038/srep31198subject
Has Abstractpub_date
2016-08-09 00:00:00pages
31198issn
2045-2322pii
srep31198journal_volume
6pub_type
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