Abstract:
:This paper proposes new ways to assess handwriting, a critical skill in any child's school journey. Traditionally, a pen and paper test called the BHK test (Concise Evaluation Scale for Children's Handwriting) is used to assess children's handwriting in French-speaking countries. Any child with a BHK score above a certain threshold is diagnosed as 'dysgraphic', meaning that they are then eligible for financial coverage for therapeutic support. We previously developed a version of the BHK for tablet computers which provides rich data on the dynamics of writing (acceleration, pressure, and so forth). The underlying model was trained on dysgraphic and non-dysgraphic children. In this contribution, we deviate from the original BHK for three reasons. First, in this instance, we are interested not in a binary output but rather a scale of handwriting difficulties, from the lightest cases to the most severe. Therefore, we wish to compute how far a child's score is from the average score of children of the same age and gender. Second, our model analyses dynamic features that are not accessible on paper; hence, the BHK is useful in this instance. Using the PCA (Principal Component Analysis) reduced the set of 53 handwriting features to three dimensions that are independent of the BHK. Nonetheless, we double-checked that, when clustering our data set along any of these three axes, we accurately detected dysgraphic children. Third, dysgraphia is an umbrella concept that embraces a broad variety of handwriting difficulties. Two children with the same global score can have totally different types of handwriting difficulties. For instance, one child could apply uneven pen pressure while another one could have trouble controlling their writing speed. Our new test not only provides a global score, but it also includes four specific score for kinematics, pressure, pen tilt and static features (letter shape). Replacing a global score with a more detailed profile enables the selection of remediation games that are very specific to each profile.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Asselborn T,Chapatte M,Dillenbourg Pdoi
10.1038/s41598-020-60011-8subject
Has Abstractpub_date
2020-02-21 00:00:00pages
3140issue
1issn
2045-2322pii
10.1038/s41598-020-60011-8journal_volume
10pub_type
杂志文章abstract::This paper reports a facile and green method for conversion of graphene oxide (GO) into graphene by low-temperature heating (80 °C) in the presence of a glass wafer. Compared to conventional GO chemical reduction methods, the presented approach is easy-scalable, operationally simple, and based on the use of a non-toxi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32488-x
更新日期:2018-09-20 00:00:00
abstract::In this work, cerium-diethyldithiocarbamate (Ce-DEDTC) complex was synthesized as a novel anti-corrosion pigment. The structure of the synthesized pigment was characterized by employing Fourier transfer infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, inductively coupled plasma optical emission sp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61946-8
更新日期:2020-03-19 00:00:00
abstract::This study presents analysis of four chimney samples in terms of glycerol dialkyl glycerol tetraether lipids (GDGTs), representing different growing stages of sulfide chimneys at the Deyin hydrothermal field, the southern mid-Atlantic ridge. The modified Bligh-Dyer method was used for lipid extraction and purification...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26166-1
更新日期:2018-05-23 00:00:00
abstract::In this paper, for the first time, the switchable two-color quantum dot laser has been realized considering solution process technology, which has both simultaneous and lonely lasing capability exploiting selective energy contacts. Furthermore, both channels can be modulated independently, which is a significant featu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60859-w
更新日期:2020-03-24 00:00:00
abstract::Listeria monocytogenes is well known for having the ability to cross the placental barrier, leading to fetal infections and abortion. However, the mechanisms leading to infectious abortion are poorly understood. In this study, we demonstrate that interferon γ-induced GTPase (IGTP) contributes to the invasion of L. mon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08195
更新日期:2015-02-03 00:00:00
abstract::Kelp forests are in decline globally and large-scale intervention could be required to halt the loss of these valuable ecosystems. To date kelp forest restoration has had limited success and been expensive and unable to address the increasing scale of ecosystem deterioration. Here we developed and tested a new approac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60553-x
更新日期:2020-03-04 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. In this study, we screened for chemicals capable of inhibiting TGF-β1-induced collagen production in cultured f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03676-y
更新日期:2017-06-13 00:00:00
abstract::In order to ensure successful development, cells of the early mammalian embryo must differentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or primitive endoderm (PE) specification within the ICM. Here, we deciphered the mechanism that assures the correct order of these sequenti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15427-0
更新日期:2017-11-09 00:00:00
abstract::Zika virus (ZIKV) is a recently re-emerged flavivirus transmitted to humans by mosquito bites but also from mother to fetus and by sexual intercourse. We here show that primary human endometrial stromal cells (HESC) are highly permissive to ZIKV infection and support its in vitro replication. ZIKV envelope expression ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44286
更新日期:2017-03-10 00:00:00
abstract::Terrestrial arthropod fauna have been suggested as a key indicator of ecological integrity in forest systems. Because phenotypic identification is expert-limited, a shift towards DNA metabarcoding could improve scalability and democratize the use of forest floor arthropods for biomonitoring applications. The objective...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54532-0
更新日期:2019-12-03 00:00:00
abstract::Dynamical polarization of nuclear spin ensembles is of central importance for magnetic resonance studies, precision sensing and for applications in quantum information theory. Here we propose a scheme to generate long-lived singlet pairs in an unpolarized nuclear spin ensemble which is dipolar coupled to the electron ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00603-z
更新日期:2017-04-03 00:00:00
abstract::Acrolein, a highly toxic α, β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. One of the most promising methods for detecting acrolein involves the use of antibodies that can recognize the acrolein-lysine conjugate, 3-formyl-3, 4-dehydropi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35872
更新日期:2016-10-26 00:00:00
abstract::Papillary thyroid carcinoma (PTC) displays strong but so far largely uncharacterized heritability. Here we studied genetic predisposition in a family with six affected individuals. We genotyped all available family members and conducted whole exome sequencing of blood DNA from two affected individuals. Haplotype analy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10566
更新日期:2015-07-02 00:00:00
abstract::Small for gestational age (SGA) is an established risk factor for cerebral palsy (CP) in term infants. However, there is conflicting data on the association between SGA and CP in moderate to late preterm infants. The aim of the article was to explore the relationship between SGA and CP in the moderate to late preterm ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析,评审
doi:10.1038/srep38853
更新日期:2016-12-13 00:00:00
abstract::Mitochondria distribution in cells controls cellular physiology in health and disease. Here we describe the mitochondrial morphology and positioning found in the different stages of the lytic cycle of the eukaryotic single-cell parasite Toxoplasma gondii. The lytic cycle, driven by the tachyzoite life stage, is respon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42746
更新日期:2017-02-16 00:00:00
abstract::Electron heating is a fundamental and multidisciplinary phenomenon in partially ionized gases, from the planet's ionosphere to laboratory-scale plasmas. Plasmas produced at ambient or reduced pressures have recently shown potential for scientific and industrial applications. However, electron heating, which is strongl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27945-6
更新日期:2018-07-05 00:00:00
abstract::Hematopoietic stem cells (HSCs) maintain the entire blood system throughout life and are utilized in therapeutic approaches for blood diseases. Prospective isolation of highly purified HSCs is crucial to understand the molecular mechanisms underlying regulation of HSCs. The zebrafish is an elegant genetic model for th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50672-5
更新日期:2019-10-02 00:00:00
abstract::Diabetes mellitus accelerates vascular calcification (VC) and increases the risk of end-stage renal disease (ESRD). Nevertheless, the impact of VC in renal disease progression in type 2 diabetes mellitus (T2DM) is poorly understood. We addressed the effect of VC and mechanisms involved in renal dysfunction in a murine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55501-3
更新日期:2020-01-09 00:00:00
abstract::Because of the small particle number of intracellular species participating in genetic circuits, stochastic fluctuations are inevitable. This intracellular noise is detrimental to precise regulation. To maintain the proper function of a cell, some natural motifs attenuate the noise at the protein level. In many biolog...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39611-6
更新日期:2019-03-04 00:00:00
abstract::Helicobacter pylori is presumed to infect gastric tissue via the oral cavity in childhood, whereas risk factors for H. pylori infection in the oral cavity are unknown. In this study, we analysed the effects of Streptococcus mutans, a major cariogenic bacterial species, on H. pylori colonisation in the oral cavity, as ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69368-2
更新日期:2020-07-27 00:00:00
abstract::Triple-negative breast cancer (TNBC) is sometimes mistaken for fibroadenoma due to its tendency to show benign morphology on breast ultrasound (US) albeit its aggressive nature. This study aims to develop a radiomics score based on US texture analysis for differential diagnosis between TNBC and fibroadenoma, and to ev...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31906-4
更新日期:2018-09-10 00:00:00
abstract::Zebrafish (Danio rerio), largely used as a model for studying developmental processes, has also emerged as a valuable system for modelling human inflammatory diseases. However, in a context where even mice have been questioned as a valid model for these analysis, a systematic study evaluating the reproducibility of hu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41905
更新日期:2017-02-03 00:00:00
abstract::The threshold size for enlarged abdominal lymph nodes (E-ALNs), a common pediatric disorder, has yet to be standardized. According to the maximum short-axis diameter, this study divided ALNs into Grade A (≥ 10 mm), Grade B (8-10 mm), Grade C (5-8 mm), and Grade D (< 5 mm, normal). To identify the threshold size for E-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81339-9
更新日期:2021-01-19 00:00:00
abstract::We fabricate a nonlinear optical device based on a fiber pigtail cross-section coated with a single-layer graphene grown by chemical vapor deposition (CVD) method. Using the fabricated graphene-assisted nonlinear optical device and employing Nyquist 16-ary quadrature amplitude modulation (16-QAM) signal, we experiment...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22379
更新日期:2016-03-02 00:00:00
abstract::The incidence of resistant Candida isolates, especially Candida albicans, has increased continuously. To overcome the resistance, research on antifungal agent sensitizers has attracted considerable attention. Omeprazole and lansoprazole were found to inhibit the growth of sensitive C. albicans and hyphae formation in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57174-4
更新日期:2020-01-16 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24178-5
更新日期:2018-04-17 00:00:00
abstract::High-throughput single-stranded DNA sequencing (ssDNA-seq) of cell-free DNA from plasma and other bodily fluids is a powerful method for non-invasive prenatal testing, and diagnosis of cancers and other diseases. Here, we developed a facile ssDNA-seq method, which exploits a novel template-switching activity of thermo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09064-w
更新日期:2017-08-21 00:00:00
abstract::The suprachiasmatic nucleus (SCN) central clock comprises two coupled oscillators, with light entraining the retinorecipient vasoactive intestinal peptide (VIP)-positive ventrolateral oscillator, which then entrains the arginine vasopressin (AVP)-positive dorsomedial oscillator. While glucose availability is known to ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00699-3
更新日期:2017-04-04 00:00:00
abstract::Endothelium-dependent flow-mediated dilation (ED-FMD), a biophysical marker of endothelial dysfunction, is apparently impaired in patients with systemic lupus erythematosus (SLE) but such observation is inconsistent. Here, we assessed and compared the brachial artery ED-FMD (baED-FMD) using ultrasonography between SLE...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-07574-1
更新日期:2017-08-04 00:00:00
abstract::17β-estradiol (E2) regulates diverse physiological effects, including cell proliferation, by binding to estrogen receptor α (ERα). ERα is both a transcription factor that drives E2-sensitive gene expression and an extra-nuclear localized receptor that triggers the activation of diverse kinase cascades. While E2 trigge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23727
更新日期:2016-03-24 00:00:00