Plasticity of the inner cell mass in mouse blastocyst is restricted by the activity of FGF/MAPK pathway.

abstract：:Traffic-related air pollution is known to be associated with skin aging manifestations. We previously found that the use of fossil fuels was associated with skin aging, but no direct link between indoor air pollutants and skin aging manifestations has ever been shown. Here we directly measured the indoor PM2.5 exposur...

journal_title：Scientific reports

authors： Ding A,Yang Y,Zhao Z,Hüls A,Vierkötter A,Yuan Z,Cai J,Zhang J,Gao W,Li J,Zhang M,Matsui M,Krutmann J,Kan H,Schikowski T,Jin L,Wang S

更新日期：2017-11-10 00:00:00

abstract：:Angiogenesis plays a key role in several diseases including cancer, ischemic vascular disease, and Alzheimer's disease. Chemical genetic screening of endothelial tube formation provides a robust approach for identifying signalling components that impact microvascular network morphology as well as endothelial cell biol...

journal_title：Scientific reports

authors： Sailem HZ,Al Haj Zen A

更新日期：2020-08-14 00:00:00

abstract：:Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the world's poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes of controlling leis...

journal_title：Scientific reports

authors： Norcliffe JL,Mina JG,Alvarez E,Cantizani J,de Dios-Anton F,Colmenarejo G,Valle SG,Marco M,Fiandor JM,Martin JJ,Steel PG,Denny PW

更新日期：2018-03-02 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ravaioli M,De Pace V,Angeletti A,Comai G,Vasuri F,Baldassarre M,Maroni L,Odaldi F,Fallani G,Caraceni P,Germinario G,Donadei C,Malvi D,Del Gaudio M,Bertuzzo VR,Siniscalchi A,Ranieri VM,D'Errico A,Pasquinelli G,Morell

更新日期：2020-09-01 00:00:00

abstract：:We propose a scheme for generating an entangled state for two atoms trapped in two separate cavities coupled to each other. The scheme is based on the competition between the unitary dynamics induced by the classical fields and the collective decays induced by the dissipation of two non-local bosonic modes. In this sc...

journal_title：Scientific reports

authors： Jin Z,Su SL,Zhu AD,Wang HF,Shen LT,Zhang S

更新日期：2017-12-15 00:00:00

abstract：:The spontaneous activity of sinoatrial node (SAN) pacemaker cells is generated by a functional interplay between the activity of ionic currents of the plasma membrane and intracellular Ca2+ dynamics. The molecular correlate of a dihydropyridine (DHP)-sensitive sustained inward Na+ current (I st), a key player in SAN a...

journal_title：Scientific reports

authors： Toyoda F,Mesirca P,Dubel S,Ding WG,Striessnig J,Mangoni ME,Matsuura H

更新日期：2017-08-11 00:00:00

abstract：:Several reviews have analyzed the factors that affect the change in soil organic C (SOC) when forest is converted to agricultural land; however, the effects of forest type and cultivation stage on these changes have generally been overlooked. We collated observations from 453 paired or chronosequential sites where for...

journal_title：Scientific reports

authors： Wei X,Shao M,Gale W,Li L

更新日期：2014-02-11 00:00:00

abstract：:VCF2CNA is a tool (Linux commandline or web-interface) for copy-number alteration (CNA) analysis and tumor purity estimation of paired tumor-normal VCF variant file formats. It operates on whole genome and whole exome datasets. To benchmark its performance, we applied it to 46 adult glioblastoma and 146 pediatric neur...

journal_title：Scientific reports

authors： Putnam DK,Ma X,Rice SV,Liu Y,Newman S,Zhang J,Chen X

更新日期：2019-07-17 00:00:00

abstract：:The identification of the modes of action of bioactive compounds is a major challenge in chemical systems biology of diseases. Genome-wide expression profiling of transcriptional responses to compound treatment for human cell lines is a promising unbiased approach for the mode-of-action analysis. Here we developed a n...

journal_title：Scientific reports

authors： Iwata M,Sawada R,Iwata H,Kotera M,Yamanishi Y

更新日期：2017-01-10 00:00:00

abstract：:Alpha synuclein (α-syn) is a central player in neurodegeneration, but the mechanisms triggering its pathology are not fully understood. Here we found that α-syn is a highly efficient substrate for arginyltransferase ATE1 and is arginylated in vivo by a novel mid-chain mechanism that targets the acidic side chains of E...

journal_title：Scientific reports

authors： Wang J,Han X,Leu NA,Sterling S,Kurosaka S,Fina M,Lee VM,Dong DW,Yates JR 3rd,Kashina A

更新日期：2017-09-12 00:00:00

abstract：:Bacillus thuringiensis insecticidal toxin (Bt) rice will be commercialized as a main food source. Traditional safety assessments on genetically modified products pay little attention on gastrointestinal (GI) health. More data about GI health of Bt rice must be provided to dispel public' doubts about the potential effe...

journal_title：Scientific reports

authors： Yuan Y,Xu W,He X,Liu H,Cao S,Qi X,Huang K,Luo Y

更新日期：2013-01-01 00:00:00

abstract：:Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make attractive targets for new drugs. Here, by genome-wide phenotypic profiling, we identify and cat...

journal_title：Scientific reports

authors： Dragset MS,Ioerger TR,Zhang YJ,Mærk M,Ginbot Z,Sacchettini JC,Flo TH,Rubin EJ,Steigedal M

更新日期：2019-08-06 00:00:00

abstract：:Alkaline sulfide-rich hot springs provide a unique environment for microbial community and arsenic (As) biogeochemistry. In this study, a representative alkaline sulfide-rich hot spring, Zimeiquan in the Tengchong geothermal area, was chosen to study arsenic geochemistry and microbial community using Illumina MiSeq se...

journal_title：Scientific reports

authors： Jiang Z,Li P,Van Nostrand JD,Zhang P,Zhou J,Wang Y,Dai X,Zhang R,Jiang D,Wang Y

更新日期：2016-04-29 00:00:00

abstract：:Deer are an iconic group of large mammals that originated in the Early Miocene of Eurasia (ca. 19 Ma). While there is some consensus on key relationships among their members, on the basis of molecular- or morphology-based analyses, or combined approaches, many questions remain, and the bony labyrinth has shown conside...

journal_title：Scientific reports

authors： Mennecart B,DeMiguel D,Bibi F,Rössner GE,Métais G,Neenan JM,Wang S,Schulz G,Müller B,Costeur L

更新日期：2017-10-13 00:00:00

abstract：:Deep venous thrombosis (DVT) is a common complication of orthopedic surgery. Genetic risk factors and high heritability carried a substantial risk of DVT. In this study, we aimed to investigate the potential association in the Han Chinese population between the polymorphisms of BDKRB2 and KNG1 and DVT after orthopedic...

journal_title：Scientific reports

authors： Wang Q,Cheng G,Wang X,Wang D,Yang Y,Chen K,Ye J,Qing Z

更新日期：2018-11-26 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Zhang Y,Launay H,Schramm A,Lebrun R,Gontero B

更新日期：2018-08-29 00:00:00

abstract：:SLC7A10 (Asc-1) is a sodium-independent amino acid transporter known to facilitate transport of a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomers. It has been described as a neuronal transporter with a primary role related to modulation of excitatory glutama...

journal_title：Scientific reports

authors： Ehmsen JT,Liu Y,Wang Y,Paladugu N,Johnson AE,Rothstein JD,du Lac S,Mattson MP,Höke A

更新日期：2016-10-19 00:00:00

abstract：:Colloidal crystals composed of micro- or nano- colloids have been investigated in various fields such as photonics due to their unique optical properties. Binary colloidal crystals have an outstanding potential for fine-tuning material properties by changing the components, concentration, or size of colloids. Because ...

journal_title：Scientific reports

authors： Nho HW,Yoon TH

更新日期：2017-09-29 00:00:00

abstract：:Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39(+) Treg were isolated from normal donors' peripheral blood and co-incubated with TEX or exosomes iso...

journal_title：Scientific reports

authors： Muller L,Mitsuhashi M,Simms P,Gooding WE,Whiteside TL

更新日期：2016-02-04 00:00:00

abstract：:The precision and accuracy of quantifying semi-volatile organic compounds (SVOCs) in solution by GC/MS, particularly when volume errors are unpredictable or difficult to control, are improved by utilizing internal standards (IS). Not obvious though is the extent to which timing IS addition affects measurement. To illu...

journal_title：Scientific reports

authors： Otim O,Rocha J Jr

更新日期：2020-10-19 00:00:00

abstract：:Hyperactivated mTOR signaling in the developing brain has been implicated in multiple forms of pathology including tuberous sclerosis complex (TSC). To date, various phenotypic defects such as cortical lamination irregularity, subependymal nodule formation, dysmorphic astrocyte differentiation and dendritic malformati...

journal_title：Scientific reports

authors： Shin J,Kim M,Jung HJ,Cha HL,Suh-Kim H,Ahn S,Jung J,Kim Y,Jun Y,Lee S,Hwang D,Kim J

更新日期：2017-06-06 00:00:00

abstract：:The high neutron detection efficiency, good gamma-ray discrimination and non-toxicity of 3He made of proportional counters filled with this gas the obvious choice for neutron detection, particularly in radiation portal monitors (RPM), used to control the illicit transport of nuclear material, of which neutron detector...

journal_title：Scientific reports

authors： Amaro FD,Monteiro CM,Dos Santos JM,Antognini A

更新日期：2017-02-09 00:00:00

abstract：:One-year time series of current velocities and hydrographic parameters based on four deep moorings deployed east of the Luzon Strait are employed to study the deep current at the western boundary (DCWB) of the northern Philippine Basin. While the mean current is relatively weak, the DCWB is highly variable on an intra...

journal_title：Scientific reports

authors： Zhou C,Zhao W,Tian J,Yang Q,Huang X,Zhang Z,Qu T

更新日期：2018-09-25 00:00:00

abstract：:Compact silicon integrated lasers are of significant interest for various applications. We present a detailed investigation for realizing sub-mm long on-chip laser structures operating at λ = 1.533 µm on the silicon-on-insulator photonic platform by combining a multi-segment silicon waveguide structure and a recently ...

journal_title：Scientific reports

authors： Tu Z,Zhang J,Rönn J,Alonso-Ramos C,Leroux X,Vivien L,Sun Z,Cassan É

更新日期：2020-07-02 00:00:00

abstract：:The coal fires, a global catastrophe for hundreds of years, have been proved extremely difficult to control, and hit almost every coal-bearing area globally. Meanwhile, underground coal fires contain tremendous reservoir of geothermal energy. Approximately one billion tons of coal burns underground annually in the wor...

journal_title：Scientific reports

authors： Shi B,Su H,Li J,Qi H,Zhou F,Torero JL,Chen Z

更新日期：2017-07-13 00:00:00

abstract：:Tumor growth and metastasis are responsible for most cancer patients' deaths. Here, we report that eupolyphaga sinensis walker has an essential role in resisting hepatocellular carcinoma growth and metastasis. Compared with proliferation, colony formation, transwell assay and transplantable tumor in nude mouse in vitr...

journal_title：Scientific reports

authors： Zhang Y,Zhan Y,Zhang D,Dai B,Ma W,Qi J,Liu R,He L

更新日期：2014-07-01 00:00:00

abstract：:Soluble starch synthase I (SSI) is a key enzyme in the biosynthesis of plant amylopectin. In this study, the gene named IbSSI, was cloned from sweet potato, an important starch crop. A high expression level of IbSSI was detected in the leaves and storage roots of the sweet potato. Its overexpression significantly incr...

journal_title：Scientific reports

authors： Wang Y,Li Y,Zhang H,Zhai H,Liu Q,He S

更新日期：2017-05-24 00:00:00

abstract：:Network structure has often proven to be important in understanding the decision behavior of individuals or agents in different interdependent situations. Computational studies predict that network structure has a crucial influence on behavior in iterated 2 by 2 asymmetric 'battle of the sexes' games. We test such beh...

journal_title：Scientific reports

authors： Broere J,Buskens V,Stoof H,Sánchez A

更新日期：2019-05-02 00:00:00

abstract：:The roles of multifunctional CD4 T cells in human tuberculosis are not well defined. In this study, we found that patients with tuberculosis had decreased PMA/ionomycin stimulated multifunctional CD4 T cells, and increased Mycobacterium tuberculosis antigen-specific multifunctional CD4 T cells, when compared to indivi...

journal_title：Scientific reports

authors： Qiu Z,Zhang M,Zhu Y,Zheng F,Lu P,Liu H,Graner MW,Zhou B,Chen X

更新日期：2012-01-01 00:00:00

abstract：:Successful realization of spin-orbit coupling in atomic gases by the NIST scheme opens the prospect of studying the effects of spin-orbit coupling on many-body physics in an unprecedentedly controllable way. Here we derive the linearized hydrodynamic equations for the normal atomic gases of the spin-orbit coupling by ...

journal_title：Scientific reports

authors： Hou YH,Yu Z

更新日期：2015-10-20 00:00:00