Abstract:
:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Röttgerding F,Wagemakers A,Koetsveld J,Fingerle V,Kirschfink M,Hovius JW,Zipfel PF,Wallich R,Kraiczy Pdoi
10.1038/s41598-019-42948-7subject
Has Abstractpub_date
2019-05-02 00:00:00pages
7056issue
1issn
2045-2322pii
10.1038/s41598-019-42948-7journal_volume
9pub_type
已发布勘误abstract::Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neuro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32616-7
更新日期:2018-09-21 00:00:00
abstract::In recent years methicillin-resistant Staphylococcus aureus has posed a challenge in treating skin and soft tissue infections. Finding new antimicrobial agents has therefore become imperative. We evaluated the in vitro antimicrobial activity of a synthetic peptide, P6, against multidrug resistant clinical strains of S...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53926-4
更新日期:2019-11-20 00:00:00
abstract::Determining oil migration distances from source rocks to reservoirs can greatly help in the search for new petroleum accumulations. Concentrations and ratios of polar organic compounds are known to change due to preferential sorption of these compounds in migrating oils onto immobile mineral surfaces. However, these c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02487
更新日期:2013-01-01 00:00:00
abstract::Radiation exposure during muscle development induces long-term decrements to skeletal muscle health, which contribute to reduced quality of life in childhood cancer survivors. Whether the effects of radiation on skeletal muscle are influenced by relevant physiological factors, such as obesity and exercise training rem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43204-8
更新日期:2019-04-30 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-36016-9
更新日期:2018-11-23 00:00:00
abstract::Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fusion is specific to FLC...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44653
更新日期:2017-03-17 00:00:00
abstract::Fabric-based personal heating patches have small geometric profiles and can be attached to selected areas of garments for personal thermal management to enable significant energy savings in built environments. Scalable fabrication of such patches with high thermal performance at low applied voltage, high durability an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35650-7
更新日期:2018-11-21 00:00:00
abstract::During capillary transit, red blood cells (RBCs) must exchange large quantities of CO2 and O2 in typically less than one second, but the degree to which this is rate-limited by diffusion through cytoplasm is not known. Gas diffusivity is intuitively assumed to be fast and this would imply that the intracellular path-l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36018
更新日期:2016-10-25 00:00:00
abstract::Organotypic, three-dimensional (3D) cancer models have enabled investigations of complex microtissues in increasingly realistic conditions. However, a drawback of these advanced models remains the poor biological relevance of cancer cell lines, while higher clinical significance would be obtainable with patient-derive...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06544-x
更新日期:2017-07-26 00:00:00
abstract::A relevant part of embolic strokes of undetermined source (ESUS) is assumed to be cardiogenic. As shown previously, certain biomarkers of endothelial pathology are related to atrial fibrillation (AF). In this long-term follow-up study, we aimed to investigate whether these biomarkers are associated with subsequently d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55943-9
更新日期:2019-12-19 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-34062-x
更新日期:2018-10-29 00:00:00
abstract::Bacterial global post-transcriptional regulators execute hundreds of interactions with targets that display varying molecular features while retaining specificity. Herein, we develop, validate, and apply a biophysical, statistical thermodynamic model of canonical target mRNA interactions with the CsrA global post-tran...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27474-2
更新日期:2018-07-02 00:00:00
abstract::For translocated animals, behavioral competence may be key to post-release survival. However, monitoring behavior is typically limited to tracking movements or inferring behavior at a gross scale via collar-mounted sensors. Animal-bourne acoustic monitoring may provide a unique opportunity to monitor behavior at a fin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41455-z
更新日期:2019-03-26 00:00:00
abstract::The ability to respond appropriately to challenges is an important contributor to fitness. Variation in the regulation of glucocorticoid hormones, which mediate the phenotypic response to challenges, can therefore influence the ability to persist in a given environment. We compared stress responsiveness in four popula...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70161-4
更新日期:2020-08-13 00:00:00
abstract::Glioblastoma (GBM) is the most aggressive type of brain tumors in adults with survival period <1.5 years of patients. The role of mTOR pathway is documented in invasion and migration, the features associated with aggressive phenotype in human GBM. However, most of the preclinical and clinical studies with mTOR inhibit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22455
更新日期:2016-03-04 00:00:00
abstract::Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-69560-4
更新日期:2020-07-31 00:00:00
abstract::In this study, a rational combination of 200 pre-selected Carbohydrate-Active enzymes (CAZymes) and sulfatases were tested, individually or combined, according to their ability to degrade Chlorella vulgaris cell wall to access its valuable nutritional compounds. The disruption of microalgae cell walls by a four-enzyme...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41775-0
更新日期:2019-03-29 00:00:00
abstract::Limited data is available on phenotypic variations with the same genotype in hypertrophic cardiomyopathy (HCM). The present study aims to explore the relationship between genotype and phenotype characterized by cardiovascular magnetic resonance (CMR) in a large Chinese family. A proband diagnosed with HCM from a multi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19372-4
更新日期:2018-01-17 00:00:00
abstract::Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1∆/∆ mice are deaf, Tmc2∆/∆ mice have normal hearing, and double homozygous Tmc1∆/∆; Tmc2∆/∆ mice have deafness and profound vestibular dysfunction. These phenotypes are consistent with their different spatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29709-8
更新日期:2018-08-14 00:00:00
abstract::A hybrid optoplasmonic amplifier, injection-seeded by an internally-generated Raman signal and operating in the visible (563-675 nm), is proposed and evidence for amplification is presented. Comprising a gain medium tethered to a whispering gallery mode (WGM) resonator with a protein, and a plasmonic surface, the opti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06168
更新日期:2014-08-26 00:00:00
abstract::Horizontal gene transfer (HGT) drives the evolution of recipient organism particularly if it provides a novel function which enhances the fitness or its adaption to the environment. Virus-host co-evolution is attractive for studying co-evolutionary processes, since viruses strictly replicate inside of the host cells a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26934
更新日期:2016-06-07 00:00:00
abstract::A combination of a solution process and the control of the electric potential for magnetism represents a new approach to operating spintronic devices with a highly controlled efficiency and lower power consumption with reduced production cost. As a paradigmatic example, we investigated Co/Pt(111) in the Bloch-wall reg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43700
更新日期:2017-03-03 00:00:00
abstract::Inhibitors of PD-1 signaling have revolutionized cancer therapy. PD-1 and PD-L1 antibodies have been approved for the treatment of cancer. To date, therapeutic PD-1 inhibitors have not been compared in a functional assay. We used an efficient T cell reporter platform to evaluate the efficacy of five clinically used PD...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47910-1
更新日期:2019-08-07 00:00:00
abstract::Millions of individuals worldwide suffer from impaired vision, a condition with multiple origins that often impinge upon the light sensing cells of the retina, the photoreceptors, affecting their integrity. The molecular components contributing to this integrity are however not yet fully understood. Here we have asked...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61970-8
更新日期:2020-03-20 00:00:00
abstract::Deforestation and forest degradation around the world endanger the functioning of ecosystems, climate stability, and conservation of biodiversity. We assessed the spatial and temporal dynamics of forest cover in Myanmar's Hkakabo Razi Landscape (HRL) to determine its integrity based on forest change and fragmentation ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70917-y
更新日期:2020-08-19 00:00:00
abstract::Poor oral health is not only associated with diabetes and cardiovascular disease but adverse pregnancy outcomes. However the influence of dental caries on pregnancy is unknown. The aim of this study was to evaluate the association between dental caries and adverse pregnancy outcomes and the effect of treatment for den...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62306-2
更新日期:2020-03-24 00:00:00
abstract::Adaptation of visual responses enhances visual information processing mainly by preserving the full dynamic range of neuronal responses during changing light conditions and is found throughout the whole visual system. Although adaptation in the primate superior colliculus neurons has received much attention little is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27331-2
更新日期:2018-06-12 00:00:00
abstract::Understanding the excited-state dynamics in perovskite photovoltaics is necessary for progress in these materials, but changes in dynamics depending on the fabrication processes used for perovskite photoactive layers remain poorly characterised. Here we report a comparative study on femtosecond transient absorption (T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16654-1
更新日期:2017-11-28 00:00:00
abstract::Autophagy is a crucial and physiological process for cell survival from yeast to mammals, including protozoan parasites. Toxoplasma gondii, an intracellular parasite, typically exploits autophagic machinery of host cell; however host cell upregulates autophagy to combat the infection. Herein we tested the efficacy of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01525-6
更新日期:2017-04-28 00:00:00
abstract::Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69438-5
更新日期:2020-07-28 00:00:00