Phenotypic diversity identified by cardiac magnetic resonance in a large hypertrophic cardiomyopathy family with a single MYH7 mutation.

abstract：:A new approach for achieving two - dimensional (2D) atom localization microscopy based on the projection of three - dimensional (3D) localization in the plane of the detector is described in the present work. Spatial variation of the position-dependent 2D-localization pattern in the xy-plane is obtained with the shift...

journal_title：Scientific reports

authors： Dutta BK,Panchadhyayee P,Bayal I,Das N,Mahapatra PK

更新日期：2020-01-17 00:00:00

abstract：:An isolated black yeast-like strain was obtained from radiation-polluted soil collected from Xinjiang province in northwest China. On the basis of ITS and LSU rDNA sequence analysis, in combination with the colony morphology and phenotypic properties, the isolated strain was revealed to represent a novel variety of Au...

journal_title：Scientific reports

authors： Liu T,Zhu L,Zhang Z,Huang H,Zhang Z,Jiang L

更新日期：2017-12-14 00:00:00

abstract：:A challenging problem in network science is to control complex networks. In existing frameworks of structural or exact controllability, the ability to steer a complex network toward any desired state is measured by the minimum number of required driver nodes. However, if we implement actual control by imposing input s...

journal_title：Scientific reports

authors： Wang LZ,Chen YZ,Wang WX,Lai YC

更新日期：2017-01-11 00:00:00

abstract：:Interleukin-6 (IL-6) overproduction has been involved in the pathogenesis of several chronic inflammatory diseases and the administration of an anti-IL-6 receptor monoclonal antibody has been proven clinically efficient to treat them. However, the drawbacks of monoclonal antibodies have led our group to develop an inn...

journal_title：Scientific reports

authors： Desallais L,Bouchez C,Mouhsine H,Moreau G,Ratsimandresy R,Montes M,Do H,Quintin-Colonna F,Zagury JF

更新日期：2016-01-19 00:00:00

abstract：:Abiotic emergence of ordered information stored in the form of RNA is an important unresolved problem concerning the origin of life. A polymer longer than 40-100 nucleotides is necessary to expect a self-replicating activity, but the formation of such a long polymer having a correct nucleotide sequence by random react...

journal_title：Scientific reports

authors： Totani T

更新日期：2020-02-03 00:00:00

abstract：:The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles ...

journal_title：Scientific reports

authors： Koblischke M,Mackroth MS,Schwaiger J,Fae I,Fischer G,Stiasny K,Heinz FX,Aberle JH

更新日期：2017-08-21 00:00:00

abstract：:Eucalyptus globulus is an aromatic medicinal plant which known for its 1,8-cineole main pharmacological constituent exhibits as natural analgesic agent. Eucalyptus globulus-loaded micellar nanoparticle was developed via spontaneous emulsification technique and further evaluation for its analgesic efficacy study, in vi...

journal_title：Scientific reports

authors： Aziz ZAA,Nasir HM,Ahmad A,Setapar SHM,Ahmad H,Noor MHM,Rafatullah M,Khatoon A,Kausar MA,Ahmad I,Khan S,Al-Shaeri M,Ashraf GM

更新日期：2019-09-23 00:00:00

abstract：:In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have onl...

journal_title：Scientific reports

authors： Loley C,Alver M,Assimes TL,Bjonnes A,Goel A,Gustafsson S,Hernesniemi J,Hopewell JC,Kanoni S,Kleber ME,Lau KW,Lu Y,Lyytikäinen LP,Nelson CP,Nikpay M,Qu L,Salfati E,Scholz M,Tukiainen T,Willenborg C,Won HH,Zeng L

更新日期：2016-10-12 00:00:00

abstract：:The empirical research on the public goods game (PGG) indicates that both institutional rewards and institutional punishment can curb free-riding and that the punishment effect is stronger than the reward effect. Self-regarding models that are based on Nash equilibrium (NE) strategies or evolutionary game dynamics cor...

journal_title：Scientific reports

authors： Dong Y,Zhang B,Tao Y

更新日期：2016-06-24 00:00:00

abstract：:This research investigates the applicability of an ANN and genetic algorithms for modeling and multiobjective optimization of the thermal conductivity and viscosity of water-based spinel-type MnFe2O4 nanofluid. Levenberg-Marquardt, quasi-Newton, and resilient backpropagation methods are employed to train the ANN. The ...

journal_title：Scientific reports

authors： Amani M,Amani P,Kasaeian A,Mahian O,Pop I,Wongwises S

更新日期：2017-12-12 00:00:00

abstract：:Here we present a set of measurements using Differential Scanning Fluorimetry (DSF) as an inexpensive, high throughput screening method to investigate the folding of silk protein molecules as they abandon their first native melt conformation, dehydrate and denature into their final solid filament conformation. Our fir...

journal_title：Scientific reports

authors： Vollrath F,Hawkins N,Porter D,Holland C,Boulet-Audet M

更新日期：2014-07-09 00:00:00

abstract：:We developed a spongy-like porous polymer (spongy monolith) consisting of poly(ethylene-co-glycidyl methacrylate) with continuous macropores that allowed efficient in situ reaction between the epoxy groups and proteins of interest. Immobilization of protein A on the spongy monolith enabled high-yield collection of imm...

journal_title：Scientific reports

authors： Kubota K,Kubo T,Tanigawa T,Naito T,Otsuka K

更新日期：2017-03-14 00:00:00

abstract：:Understanding virulence is vital for the development of novel therapeutics to target infections with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA), which cause an ongoing epidemic in the United States and are on a global rise. However, what defines virulence particularly of global CA-MRSA ...

journal_title：Scientific reports

authors： Li M,Dai Y,Zhu Y,Fu CL,Tan VY,Wang Y,Wang X,Hong X,Liu Q,Li T,Qin J,Ma X,Fang J,Otto M

更新日期：2016-06-14 00:00:00

abstract：:Melatonin has antioxidant and scavenger effects in the cellular antioxidant system. This research investigated the protective effects and underlying mechanisms of melatonin action in porcine somatic cell nuclear transfer (SCNT) embryos. The results suggested that the developmental competence of porcine SCNT embryos wa...

journal_title：Scientific reports

authors： Liang S,Jin YX,Yuan B,Zhang JB,Kim NH

更新日期：2017-09-11 00:00:00

abstract：:CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. CVB3 capsid protein VP1 is an immunodominant structural protein, containing several B- and T-cell epitopes. However, immunization of mice wit...

journal_title：Scientific reports

authors： Qi X,Xiong S

更新日期：2017-02-02 00:00:00

abstract：:Understanding ethanol-induced stresses and responses in biofuel-producing bacteria at systems level has significant implications in engineering more efficient biofuel producers. We present a computational study of transcriptomic and genomic data of both ethanol-stressed and ethanol-adapted E. coli cells with computati...

journal_title：Scientific reports

authors： Cao H,Wei D,Yang Y,Shang Y,Li G,Zhou Y,Ma Q,Xu Y

更新日期：2017-03-16 00:00:00

abstract：:To determine factors associated with delayed discharge of hospitalized patients with coronavirus disease (COVID-19). This retrospective cohort study included 47 patients with COVID-19 admitted to three hospitals in Quanzhou City, Fujian Province, China, between January 21, 2020 and March 6, 2020. Univariate and multiv...

journal_title：Scientific reports

authors： Lin P,Chen W,Huang H,Lin Y,Cai M,Lin D,Cai H,Su Z,Zhuang X,Yu X

更新日期：2021-01-13 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep30212. ...

journal_title：Scientific reports

authors： Xu H,Chen X,Xu X,Shi R,Suo S,Cheng K,Zheng Z,Wang M,Wang L,Zhao Y,Tian B,Hua Y

更新日期：2017-05-26 00:00:00

abstract：:Noisy galvanic vestibular stimulation (nGVS) delivered at imperceptible intensities can improve vestibular function in health and disease. Here we evaluated whether nGVS effects on vestibular function are only present during active stimulation or may exhibit relevant post-stimulation after-effects. Initially, nGVS amp...

journal_title：Scientific reports

authors： Keywan A,Badarna H,Jahn K,Wuehr M

更新日期：2020-02-13 00:00:00

abstract：:Zooplankton provide the key link between primary production and higher levels of the marine food web and they play an important role in mediating carbon sequestration in the ocean. All commercially harvested fish species depend on zooplankton populations. However, spatio-temporal distributions of zooplankton are notor...

journal_title：Scientific reports

authors： Basedow SL,McKee D,Lefering I,Gislason A,Daase M,Trudnowska E,Egeland ES,Choquet M,Falk-Petersen S

更新日期：2019-01-24 00:00:00

abstract：:In a previous study, we proposed that age-related mitochondrial respiration defects observed in elderly subjects are partially due to age-associated downregulation of nuclear-encoded genes, including serine hydroxymethyltransferase 2 (SHMT2), which is involved in mitochondrial one-carbon (1C) metabolism. This assertio...

journal_title：Scientific reports

authors： Tani H,Mito T,Velagapudi V,Ishikawa K,Umehara M,Nakada K,Suomalainen A,Hayashi JI

更新日期：2019-11-05 00:00:00

abstract：:Fanconi Anemia is a rare genetic disease associated with DNA repair defects, congenital abnormalities and infertility. Most of FA pathway is evolutionary conserved, allowing dissection and mechanistic studies in simpler model systems such as Caenorhabditis elegans. In the present study, we employed C. elegans to bette...

journal_title：Scientific reports

authors： Germoglio M,Valenti A,Gallo I,Forenza C,Santonicola P,Silva N,Adamo A

更新日期：2020-01-09 00:00:00

abstract：:Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated...

journal_title：Scientific reports

authors： De Gennaro L,Gorgoni M,Reda F,Lauri G,Truglia I,Cordone S,Scarpelli S,Mangiaruga A,D'atri A,Lacidogna G,Ferrara M,Marra C,Rossini PM

更新日期：2017-01-03 00:00:00

abstract：:Exhaled nitric oxide (eNO) is a useful biomarker of various physiological conditions, including asthma and other pulmonary diseases. Herein a fast and sensitive analytical method has been developed for the quantitative detection of eNO based on extractive electrospray ionization mass spectrometry (EESI-MS). Exhaled NO...

journal_title：Scientific reports

authors： Pan S,Tian Y,Li M,Zhao J,Zhu L,Zhang W,Gu H,Wang H,Shi J,Fang X,Li P,Chen H

更新日期：2015-03-04 00:00:00

abstract：:Raman microspectroscopy provides the means to obtain local orientations on polycrystalline materials at the submicrometer level. The present work demonstrates how orientation-distribution maps composed of Raman intensity distributions can be acquired on large areas of several hundreds of square micrometers. A polycrys...

journal_title：Scientific reports

authors： Schmid T,Schäfer N,Levcenko S,Rissom T,Abou-Ras D

更新日期：2015-12-17 00:00:00

abstract：:4D flow MRI enables quantitative assessment of helical flow. Current methods are susceptible to noise. To evaluate helical flow patterns in healthy volunteers and patients with bicuspid aortic valves (BAV) at 1.5 T and 3 T using pressure-based helix-extraction in 4D flow MRI. Two intraindividual 4D flow MRI examinatio...

journal_title：Scientific reports

authors： Ebel S,Dufke J,Köhler B,Preim B,Behrendt B,Riekena B,Jung B,Stehning C,Kropf S,Grothoff M,Gutberlet M

更新日期：2020-02-19 00:00:00

abstract：:Previous reports on epigenetic mechanisms involved in alcohol abuse have focus on hepatic and neuronal regions, leaving the immune system and specifically monocyte-derived dendritic cells (MDDCs) understudied. Our lab has previously shown histone deacetylases are modulated in cells derived from alcohol users and after...

journal_title：Scientific reports

authors： Parira T,Figueroa G,Laverde A,Casteleiro G,Gomez Hernandez ME,Fernandez-Lima F,Agudelo M

更新日期：2017-09-11 00:00:00

abstract：:Many efforts have been made in the last 30 years to develop more relevant in vitro models to study genotoxic responses of drugs and environmental contaminants. While 2D HepaRG cells are one of the most promising models for liver toxicology, a switch to 3D cultures that integrate both in vivo architecture and cell-cell...

journal_title：Scientific reports

authors： Mandon M,Huet S,Dubreil E,Fessard V,Le Hégarat L

更新日期：2019-07-22 00:00:00

abstract：:Unlike their wolf ancestors, dogs have unique social skills for communicating and cooperating with humans. Previously, significant heritabilities for human-directed social behaviors have been found in laboratory beagles. Here, a Genome-Wide Association Study identified two genomic regions associated with dog's human-d...

journal_title：Scientific reports

authors： Persson ME,Wright D,Roth LS,Batakis P,Jensen P

更新日期：2016-09-29 00:00:00

abstract：:The epithelial-to-mesenchymal transition (EMT) is one of mechanisms that induce renal interstitial fibrosis. Understanding EMT in renal fibrosis has important therapeutic implications for patients with kidney disease. Alpha-lipoic acid (ALA) is a natural compound with antioxidant properties. Studies for ALA are perfor...

journal_title：Scientific reports

authors： Cho HS,Kim JH,Jang HN,Lee TW,Jung MH,Kim TH,Chang SH,Park DJ

更新日期：2017-04-05 00:00:00