Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders.

abstract：:Powdery mildew, a common cereal disease caused by the fungus Blumeria graminis, is a major limiting factor of barley production and genetic resistance is the most appropriate protection against it. To aid the breeding of new cultivars and their marketing, resistance genes can be postulated in homogeneous accessions. A...

journal_title：Scientific reports

authors： Dreiseitl A

更新日期：2020-11-03 00:00:00

abstract：:Urate transporter 1 (URAT1/SLC22A12), a urate transporter gene, is a causative gene for renal hypouricemia type 1. Among several reported nonsynonymous URAT1 variants, R90H (rs121907896) and W258X (rs121907892) are frequent causative mutations for renal hypouricemia. However, no case-control study has evaluated the re...

journal_title：Scientific reports

authors： Sakiyama M,Matsuo H,Shimizu S,Nakashima H,Nakamura T,Nakayama A,Higashino T,Naito M,Suma S,Hishida A,Satoh T,Sakurai Y,Takada T,Ichida K,Ooyama H,Shimizu T,Shinomiya N

更新日期：2016-01-29 00:00:00

abstract：:Although recovery following a stroke is limited, undamaged neurons under the right conditions can establish new connections and take on-board lost functions. Sonic hedgehog (Shh) signaling is integral for developmental axon growth, but its role after injury has not been fully examined. To investigate the effects of Sh...

journal_title：Scientific reports

authors： Berretta A,Gowing EK,Jasoni CL,Clarkson AN

更新日期：2016-02-23 00:00:00

abstract：:Bacterial periplasmic-binding proteins have been acclaimed as general biosensing platform, but their range of natural ligands is too limited for optimal development of chemical compound detection. Computational redesign of the ligand-binding pocket of periplasmic-binding proteins may yield variants with new properties...

journal_title：Scientific reports

authors： Tavares D,Reimer A,Roy S,Joublin A,Sentchilo V,van der Meer JR

更新日期：2019-11-15 00:00:00

abstract：:Bats are an important reservoir for zoonotic viruses. To date, only three RVA strains have been reported in bats in Kenya and China. In the current study we investigated the genetic diversity of RVAs in fecal samples from 87 straw-colored fruit bats living in close contact with humans in Cameroon using viral metagenom...

journal_title：Scientific reports

authors： Yinda CK,Zeller M,Conceição-Neto N,Maes P,Deboutte W,Beller L,Heylen E,Ghogomu SM,Van Ranst M,Matthijnssens J

更新日期：2016-09-26 00:00:00

abstract：:Microbiota-derived short-chain fatty acids (SCFAs) and organic acids produced by the fermentation of non-digestible fibre can communicate from the microbiome to host tissues and modulate homeostasis in mammals. The microbiome has circadian rhythmicity and helps the host circadian clock function. We investigated the ef...

journal_title：Scientific reports

authors： Tahara Y,Yamazaki M,Sukigara H,Motohashi H,Sasaki H,Miyakawa H,Haraguchi A,Ikeda Y,Fukuda S,Shibata S

更新日期：2018-01-23 00:00:00

abstract：:Upper lip scars are at risk of hypertrophy. Our center therefore uses microporous tape and silicone sheeting for postoperative scar care following cleft lip repair. However, some babies have previously ingested their silicone sheeting, which has the potential for respiratory compromise or gastrointestinal obstruction....

journal_title：Scientific reports

authors： Chang CS,Wallace CG,Hsiao YC,Huang JJ,Chen ZC,Chang CJ,Lo LJ,Chen PK,Chen JP,Chen YR

更新日期：2018-05-09 00:00:00

abstract：:It is well known that collective migrations of oxygen vacancies in oxide is the key principle of resistance change in oxide-based resistive memory (OxRAM). The practical usefulness of OxRAM mainly arises from the fact that these oxygen vacancy migrations take place at relatively low operating voltages. The activation ...

journal_title：Scientific reports

authors： Hur JH

更新日期：2019-11-19 00:00:00

abstract：:Mequindox (MEQ) is a synthetic antimicrobial agent of quinoxaline-1,4-dioxide group (QdNOs). The liver is regarded as the toxicity target of QdNOs, and the role of N → O group-associated various toxicities mediated by QdNOs is well recognized. However, the mechanism underlying the in vivo effects of MEQ on the liver, ...

journal_title：Scientific reports

authors： Liu Q,Lei Z,Huang A,Wu Q,Xie S,Awais I,Dai M,Wang X,Yuan Z

更新日期：2017-02-03 00:00:00

abstract：:An orb web's prey capture thread relies on its glue droplets to retain insects until a spider can subdue them. Each droplet's viscoelastic glycoprotein adhesive core extends to dissipate the forces of prey struggle as it transfers force to stiffer, support line flagelliform fibers. In large orb webs, switchback captur...

journal_title：Scientific reports

authors： Opell BD,Stellwagen SD

更新日期：2019-12-30 00:00:00

abstract：:Human listeners are able to recognize accurately an impressive range of complex sounds, such as musical instruments or voices. The underlying mechanisms are still poorly understood. Here, we aimed to characterize the processing time needed to recognize a natural sound. To do so, by analogy with the "rapid visual seque...

journal_title：Scientific reports

authors： Isnard V,Chastres V,Viaud-Delmon I,Suied C

更新日期：2019-05-29 00:00:00

abstract：:Weathered granite of ion-adsorption rare earth elements (REEs) ore collected at Jiangxi Province, China was investigated to identify the minerals abundant in REEs. The analyses of scanning electron microscopy (SEM)-energy dispersive spectrometry (EDS) and laser ablation inductively coupled plasma mass spectrometry (LA...

journal_title：Scientific reports

authors： Mukai H,Kon Y,Sanematsu K,Takahashi Y,Ito M

更新日期：2020-11-19 00:00:00

abstract：:We demonstrate the application of whole exome sequencing to discover the rare variants for congenital pouch colon, acronymed CPC. For 18 affected individuals in a total of 64 samples, we sequenced coding regions to a mean coverage of 100×. A sufficient depth of ca. 94% of targeted exomes was achieved. Filtering agains...

journal_title：Scientific reports

authors： Mathur P,Medicherla KM,Chaudhary S,Patel M,Bagali P,Suravajhala P

更新日期：2018-04-27 00:00:00

abstract：:Recently, sex steroid membrane receptors garnered world-wide attention because they may be related to sex hormone-mediated unknown rapid non-genomic action that cannot be currently explained by their genomic action via nuclear receptors. Progesterone affects cell proliferation and survival via non-genomic effects. In ...

journal_title：Scientific reports

authors： Kasubuchi M,Watanabe K,Hirano K,Inoue D,Li X,Terasawa K,Konishi M,Itoh N,Kimura I

更新日期：2017-07-12 00:00:00

abstract：:Recruitment is one of the dominant processes regulating fish population productivity. It is, however, notoriously difficult to predict, as it is the result of a complex multi-step process. Various fine-scale drivers might act on the pathway from adult population characteristics to spawning behaviour and egg production...

journal_title：Scientific reports

authors： Brosset P,Smith AD,Plourde S,Castonguay M,Lehoux C,Van Beveren E

更新日期：2020-09-30 00:00:00

abstract：:Little is known about the effect of long-term diet patterns on the composition and functional potential of the human salivary microbiota. In the present study, we sought to contribute to the ongoing elucidation of dietary effects on the oral microbial community by examining the diversity, composition and functional po...

journal_title：Scientific reports

authors： Hansen TH,Kern T,Bak EG,Kashani A,Allin KH,Nielsen T,Hansen T,Pedersen O

更新日期：2018-04-11 00:00:00

abstract：:A crystalline solid exhibits thermally induced localised non-affine droplets in the absence of external stress. Here we show that upon an imposed shear, the size of these droplets grow until they percolate at a critical strain, well below the value at which the solid begins to yield. This critical point does not manif...

journal_title：Scientific reports

authors： Das T,Ganguly S,Sengupta S,Rao M

更新日期：2015-06-03 00:00:00

abstract：:Monitoring marine top predators is fundamental for assessing the health and functioning of open ocean ecosystems. Although recently tracking observations have substantially increased, factors determining the horizontal exploration of the ocean by marine predators are still largely unknown, especially at the scale of b...

journal_title：Scientific reports

authors： Della Penna A,De Monte S,Kestenare E,Guinet C,d'Ovidio F

更新日期：2015-12-15 00:00:00

abstract：:Transport of tissue-derived lymphatic fluid and clearance by draining lymph nodes are pivotal for maintenance of fluid homeostasis in the body and for immune-surveillance of the self- and non-self-proteomes. Yet a quantitative analysis of nodal filtration of the tissue-derived proteome present in lymphatic fluid has n...

journal_title：Scientific reports

authors： Clement CC,Wang W,Dzieciatkowska M,Cortese M,Hansen KC,Becerra A,Thangaswamy S,Nizamutdinova I,Moon JY,Stern LJ,Gashev AA,Zawieja D,Santambrogio L

更新日期：2018-07-26 00:00:00

abstract：:Ice adhesion is mainly dictated by surface properties, and water wettability is frequently correlated with ice adhesion strength. However, these established correlations are limited to high ice adhesion and become invalid when the ice adhesion strength is low. Here we carried out an experimental study to explore the r...

journal_title：Scientific reports

authors： He Z,Vågenes ET,Delabahan C,He J,Zhang Z

更新日期：2017-02-07 00:00:00

abstract：:One of the key motivations in producing 3D structures has always been the realization of metamaterials with effective constituent properties that can be tuned in all propagation directions at various frequencies. Here, we report the investigation of spatially oriented "Nanograter" structures with orientation-dependent...

journal_title：Scientific reports

authors： Liu Z,Cui A,Gong Z,Li H,Xia X,Shen TH,Li J,Yang H,Li W,Gu C

更新日期：2016-06-30 00:00:00

abstract：:Cellular locomotion is a central hallmark of eukaryotic life. It is governed by cell-extrinsic molecular factors, which can either emerge in the soluble phase or as immobilized, often adhesive ligands. To encode for direction, every cue must be present as a spatial or temporal gradient. Here, we developed a microfluid...

journal_title：Scientific reports

authors： Schwarz J,Bierbaum V,Merrin J,Frank T,Hauschild R,Bollenbach T,Tay S,Sixt M,Mehling M

更新日期：2016-11-07 00:00:00

abstract：:An obstacle for precision improvement in quantum metrology is the information loss causing by the unavoidable interaction between probe system and environment. Quantum fluctuations are environment no system can be isolated from and it will make the precision of initial parameter estimation of the probe atom decrease w...

journal_title：Scientific reports

authors： Jin Y

更新日期：2017-03-24 00:00:00

abstract：:Some previous studies have indicated that valproate (VPA) might change the pharmacokinetics and enhance the effects of propofol. We evaluated whether clinical VPA therapy affected the propofol blood level, the protein-unbound free propofol level, and/or the anesthetic effects of propofol in the clinical setting. The s...

journal_title：Scientific reports

authors： Kodama M,Higuchi H,Ishii-Maruhama M,Nakano M,Honda-Wakasugi Y,Maeda S,Miyawaki T

更新日期：2020-01-31 00:00:00

abstract：:This study aimed to examine hemodynamic responses and the necessity of breaks under long working hours. Thirty-eight healthy males conducted PC-based work from 9:10 to 22:00. Nine 10-minute short breaks and two long breaks (a 1-hour break and a 50-minute break) were provided, and hemodynamic responses were measured re...

journal_title：Scientific reports

authors： Liu X,Ikeda H,Oyama F,Wakisaka K,Takahashi M

更新日期：2018-09-28 00:00:00

abstract：:Chronic kidney disease (CKD) progresses to end-stage renal failure via renal tubulointerstitial fibrosis. Malnutrition, inflammation, and arteriosclerosis interact to exacerbate the poor prognosis of CKD, and their effective management is thus essential. The traditional Japanese medicine Rikkunshito (RKT) exerts appet...

journal_title：Scientific reports

authors： Wakui H,Yamaji T,Azushima K,Uneda K,Haruhara K,Nakamura A,Ohki K,Kinguchi S,Kobayashi R,Urate S,Suzuki T,Kamimura D,Minegishi S,Ishigami T,Kanaoka T,Matsuo K,Miyazaki T,Fujikawa T,Yamashita A,Tamura K

更新日期：2020-02-05 00:00:00

abstract：:Adolescence is a critical stage of development and has an important influence on energy balance-related behaviours (EBRBs). When adolescents are associated with obesity it can lead to increased cardiometabolic risk. Here we assess if EBRBs adopted by adolescents included in a subsample are associated with markers of t...

journal_title：Scientific reports

authors： Forkert ECO,Moraes ACF,Carvalho HB,Manios Y,Widhalm K,González-Gross M,Gutierrez A,Kafatos A,Censi L,De Henauw S,Moreno LA

更新日期：2019-04-23 00:00:00

abstract：:An encapsulated formulation of Bacillus thuringiensis (Bt) was produced by the Pickering emulsion technique to improve its activity and stability under UV-A radiation. In this technique latex particles, GO nanosheets, olive oil, ethanol, and water were used to encapsulate Bt in colloidosomes. The protective efficacy o...

journal_title：Scientific reports

authors： Jalali E,Maghsoudi S,Noroozian E

更新日期：2020-11-26 00:00:00

abstract：:This work aimed to use artificial intelligence to predict subjective refraction from wavefront aberrometry data processed with a novel polynomial decomposition basis. Subjective refraction was converted to power vectors (M, J0, J45). Three gradient boosted trees (XGBoost) algorithms were trained to predict each power ...

journal_title：Scientific reports

authors： Rampat R,Debellemanière G,Malet J,Gatinel D

更新日期：2020-05-22 00:00:00

abstract：:A culture system that can recapitulate myelination in vitro will not only help us better understand the mechanism of myelination and demyelination, but also find out possible therapeutic interventions for treating demyelinating diseases. Here, we introduce a simple and reproducible myelination culture system using mou...

journal_title：Scientific reports

authors： Hyung S,Yoon Lee B,Park JC,Kim J,Hur EM,Francis Suh JK

更新日期：2015-10-12 00:00:00