Pre-yield non-affine fluctuations and a hidden critical point in strained crystals.

abstract：:Functional reactivation of p53 pathway, although arduous, can potentially provide a broad-based strategy for cancer therapy owing to frequent p53 inactivation in human cancer. Using a phosphoprotein-screening array, we found that Benzyl Isothiocynate, (BITC) increases p53 phosphorylation in breast cancer cells and rev...

journal_title：Scientific reports

authors： Xie B,Nagalingam A,Kuppusamy P,Muniraj N,Langford P,Győrffy B,Saxena NK,Sharma D

更新日期：2017-01-10 00:00:00

abstract：:Magnetite (Fe3O4) is an iron ore mineral that is globally mined especially for steel production. It is denser (5.15 g/cm3) than Earth's crust (~2.7 g/cm3) and is expected to accumulate at the bottom of melt-rich magma reservoirs. However, recent studies revealed heterogeneous fluid bubble nucleation on oxide minerals ...

journal_title：Scientific reports

authors： Knipping JL,Webster JD,Simon AC,Holtz F

更新日期：2019-03-07 00:00:00

abstract：:The purpose of the present study was to assess the differential intraocular pressure response (IOP) to dexamethasone (DEX) treatment at two dose levels (100 or 500 nM) in perfusion cultured Indian cadaveric eyes to investigate glucocorticoid (GC) responsiveness. In a human organ-cultured anterior segment (HOCAS) set-u...

journal_title：Scientific reports

authors： Haribalaganesh R,Gowri Priya C,Sharmila R,Krishnadas S,Muthukkaruppan V,Willoughby CE,Senthilkumari S

更新日期：2021-01-12 00:00:00

abstract：:Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the failure of normal glucose-stimulated insulin secretion (GSIS) from p...

journal_title：Scientific reports

authors： Davey JS,Carmichael RE,Craig TJ

更新日期：2019-02-27 00:00:00

abstract：:In recent pioneer experiment, a strong spin-orbit coupling, with equal Rashba and Dresselhaus strengths, has been created in a trapped Bose-Einstein condensate. Moreover, many exotic superfluid phenomena induced by this strong spin-orbit coupling have been predicted. In this report, we show that this novel spin-orbit ...

journal_title：Scientific reports

authors： Lian J,Yu L,Liang JQ,Chen G,Jia S

更新日期：2013-11-07 00:00:00

abstract：:Soybean cyst nematode (SCN) Heterodera glycines is an obligate parasite that relies on the secretion of effector proteins to manipulate host cellular processes that favor the formation of a feeding site within host roots to ensure its survival. The sequence complexity and co-evolutionary forces acting upon these effec...

journal_title：Scientific reports

authors： Gardner M,Dhroso A,Johnson N,Davis EL,Baum TJ,Korkin D,Mitchum MG

更新日期：2018-02-06 00:00:00

abstract：:An ultrasensitive DNA biosensor has been developed through in-situ labeling of electroactive melamine-Cu(2+) complex (Mel-Cu(2+)) on the end of hairpin-like probe using gold nanoparticles (AuNPs) as the signal amplification platform. The 3'-thiolated hairpin-like probe was first immobilized to the gold electrode surfa...

journal_title：Scientific reports

authors： Wang Q,Gao F,Ni J,Liao X,Zhang X,Lin Z

更新日期：2016-03-02 00:00:00

abstract：:Site variation in fixation, staining, and scanning can confound automated tissue based image classifiers for disease characterization. In this study we incorporated stability into four feature selection methods for identifying the most robust and discriminating features for two prostate histopathology classification t...

journal_title：Scientific reports

authors： Leo P,Elliott R,Shih NNC,Gupta S,Feldman M,Madabhushi A

更新日期：2018-10-08 00:00:00

abstract：:The aim of this study was to identify the synergistic effect of microRNA expression with classical risk factors of coronary heart disease (CHD) and to explore their diagnostic value for coronary stenotic lesions in subjects with CHD. Plasma samples were obtained from 66 subjects with CHD and from 58 control individual...

journal_title：Scientific reports

authors： Ding XQ,Ge PC,Liu Z,Jia H,Chen X,An FH,Li LH,Chen ZH,Mao HW,Li ZY,Gu Y,Zhu TB,Li CJ,Wang LS,Ma WZ,Yang ZJ,Jia EZ

更新日期：2015-10-08 00:00:00

abstract：:Extracellular vesicles (EVs) are an important class of membrane-bound structures that have been widely investigated for their roles in intercellular communication in the contexts of tumor progression, vascular function, immunity and regenerative medicine. Much of the current knowledge on the functions of EVs pertains ...

journal_title：Scientific reports

authors： Baxter AA,Phan TK,Hanssen E,Liem M,Hulett MD,Mathivanan S,Poon IKH

更新日期：2019-05-17 00:00:00

abstract：:Thomas Kent was an Irish rebel who was executed by British forces in the aftermath of the Easter Rising armed insurrection of 1916 and buried in a shallow grave on Cork prison's grounds. In 2015, ninety-nine years after his death, a state funeral was offered to his living family to honor his role in the struggle for I...

journal_title：Scientific reports

authors： Fernandes D,Sirak K,Novak M,Finarelli JA,Byrne J,Connolly E,Carlsson JE,Ferretti E,Pinhasi R,Carlsson J

更新日期：2017-01-30 00:00:00

abstract：:Cardiovascular diseases are directly linked to smoking habits, which has both physiological and anatomical effects on the systemic and retinal circulations, and these changes can be detected with fundus photographs. Here, we aimed to 1- design a Convolutional Neural Network (CNN), using retinal photographs, to differe...

journal_title：Scientific reports

authors： Vaghefi E,Yang S,Hill S,Humphrey G,Walker N,Squirrell D

更新日期：2019-05-09 00:00:00

abstract：:Insecticides and other agrochemicals have become indispensable components of the agricultural system to ensure a notable increase in crop yield and food production. As a natural consequence, chemical residues result in significantly increased contamination of both terrestrial and aquatic ecosystems. The present study ...

journal_title：Scientific reports

authors： Basal WT,Ahmed ART,Mahmoud AA,Omar AR

更新日期：2020-11-11 00:00:00

abstract：:Results from live cell imaging of fluorescently tagged Cellulose Synthase (CESA) proteins in Cellulose Synthesis Complexes (CSCs) have enhanced our understanding of cellulose biosynthesis, including the mechanisms of action of cellulose synthesis inhibitors. However, this method has been applied only in Arabidopsis th...

journal_title：Scientific reports

authors： Tran ML,McCarthy TW,Sun H,Wu SZ,Norris JH,Bezanilla M,Vidali L,Anderson CT,Roberts AW

更新日期：2018-01-15 00:00:00

abstract：:In 2010, a new rabbit hemorrhagic disease virus (RHDV) variant, designated RHDV2, was identified for the first time in Italy. Studies have shown that RHDV2 differs from RHDV1 (traditional RHDV) in terms of its antigenic profile and genetic characteristics. The VP60 protein of RHDV is a structural protein that plays im...

journal_title：Scientific reports

authors： Kong D,Liu J,Jiang Q,Yu Z,Hu X,Guo D,Huang Q,Jiao M,Qu L

更新日期：2016-02-16 00:00:00

abstract：:We investigated molecular dissociation induced by 10-keV X-ray irradiation in dense ice at pressures up to 40 GPa at 300 K. The dissociation yield estimated from the oxygen K-edge X-ray Raman spectra, showed that the molecular dissociation was enhanced up to 14 GPa and gradually suppressed on further compression to 40...

journal_title：Scientific reports

authors： Fukui H,Hiraoka N,Hirao N,Aoki K,Akahama Y

更新日期：2016-05-25 00:00:00

abstract：:Changes in climate and atmospheric CO2 and nitrogen (N) over the last several decades have induced significant effects on forest carbon (C) cycling. However, contributions of individual factors are largely unknown because of the lack of long observational data and the undifferentiating between intrinsic factors and ex...

journal_title：Scientific reports

authors： Wu C,Hember RA,Chen JM,Kurz WA,Price DT,Boisvenue C,Gonsamo A,Ju W

更新日期：2014-03-25 00:00:00

abstract：:Patients with Idiopathic Parkinson's Disease (PD) have an increased risk for fractures. Currently, many studies have reported inferior outcomes in PD patients after orthopedic procedures. However, there are very few studies assessing the outcome of upper extremity fractures (UEF) in PD patients. In this study, we revi...

journal_title：Scientific reports

authors： Chou TA,Chang CY,Wang JP,Huang YC,Chen WM,Huang TF

更新日期：2020-12-03 00:00:00

abstract：:Despite our increasing understanding of zebrafish heart development and regeneration, there is limited information about the distribution of endothelial cells (ECs) in the adult zebrafish heart. Here, we investigate and compare the distribution of cardiac ECs (cECs) in adult mouse and zebrafish ventricles. Surprisingl...

journal_title：Scientific reports

authors： Patra C,Kontarakis Z,Kaur H,Rayrikar A,Mukherjee D,Stainier DYR

更新日期：2017-06-02 00:00:00

abstract：:Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study inves...

journal_title：Scientific reports

authors： Chukwueke CC,Kowalczyk WJ,Di Ciano P,Gendy M,Taylor R,Heishman SJ,Le Foll B

更新日期：2020-03-05 00:00:00

abstract：:Fire blight, caused by the enterobacterium Erwinia amylovora, is a destructive disease, which can affect most members of the Rosaceae family. Since no significant genomic differences have been found by others to explain differences in virulence, we used here a gel-based proteomic approach to elucidate mechanisms and k...

journal_title：Scientific reports

authors： Holtappels M,Noben JP,Van Dijck P,Valcke R

更新日期：2018-08-03 00:00:00

abstract：:Schizophrenia is one of the most prevalent psychiatric disorders with complex genetic etiology. Accumulating evidence suggests that energy metabolism and oxidative stress play important roles in the pathophysiology of schizophrenia. Dysfunction of mitochondrial respiratory chain and altered expression of complex I sub...

journal_title：Scientific reports

authors： Li X,Zhang W,Tang J,Tan L,Luo XJ,Chen X,Yao YG

更新日期：2015-06-08 00:00:00

abstract：:Suffering from giant size of objective lenses and infeasible manipulations of distant targets, telescopes could not seek helps from present super-resolution imaging, such as scanning near-field optical microscopy, perfect lens and stimulated emission depletion microscopy. In this paper, local light diffraction shrinka...

journal_title：Scientific reports

authors： Wang C,Tang D,Wang Y,Zhao Z,Wang J,Pu M,Zhang Y,Yan W,Gao P,Luo X

更新日期：2015-12-18 00:00:00

abstract：:Due to their unique properties, Weyl semimetals (WSMs) are promising materials for the future electronics. Currently, the two types (I and II) of WSMs are discovered experimentally. These types of WSMs differ from each other in their topological properties. In this paper we showed that a coexistence of types I and II ...

journal_title：Scientific reports

authors： Alisultanov ZZ

更新日期：2018-09-12 00:00:00

abstract：:That the human brain contains magnetite is well established; however, its spatial distribution in the brain has remained unknown. We present room temperature, remanent magnetization measurements on 822 specimens from seven dissected whole human brains in order to systematically map concentrations of magnetic remanence...

journal_title：Scientific reports

authors： Gilder SA,Wack M,Kaub L,Roud SC,Petersen N,Heinsen H,Hillenbrand P,Milz S,Schmitz C

更新日期：2018-07-27 00:00:00

abstract：:Emergence of polyphagous herbivorous insects entails significant adaptation to recognize, detoxify and digest a variety of host-plants. Despite of its biological and practical importance - since insects eat 20% of crops - no exhaustive analysis of gene repertoires required for adaptations in generalist insect herbivor...

journal_title：Scientific reports

authors： Gouin A,Bretaudeau A,Nam K,Gimenez S,Aury JM,Duvic B,Hilliou F,Durand N,Montagné N,Darboux I,Kuwar S,Chertemps T,Siaussat D,Bretschneider A,Moné Y,Ahn SJ,Hänniger S,Grenet AG,Neunemann D,Maumus F,Luyten I,Labadi

更新日期：2017-09-25 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are a potential therapy for many chronic inflammatory diseases due to their regenerative, immunologic and anti-inflammatory properties. The two-way dialogue between MSCs and macrophages is crucial to tissue regeneration and repair. Previous research demonstrated that murine adipose-der...

journal_title：Scientific reports

authors： Souza-Moreira L,Soares VC,Dias SDSG,Bozza PT

更新日期：2019-12-30 00:00:00

abstract：:Site-specific genome modification (SSM) is an important tool for mosquito functional genomics and comparative gene expression studies, which contribute to a better understanding of mosquito biology and are thus a key to finding new strategies to eliminate vector-borne diseases. Moreover, it allows for the creation of ...

journal_title：Scientific reports

authors： Häcker I,Harrell Ii RA,Eichner G,Pilitt KL,O'Brochta DA,Handler AM,Schetelig MF

更新日期：2017-03-07 00:00:00

abstract：:Bismuth has long been a prototypical system for investigating phase transformations and melting at high pressure. Despite decades of experimental study, however, the lattice-level response of Bi to rapid (shock) compression and the relationship between structures occurring dynamically and those observed during slow (s...

journal_title：Scientific reports

authors： Gorman MG,Coleman AL,Briggs R,McWilliams RS,McGonegle D,Bolme CA,Gleason AE,Galtier E,Lee HJ,Granados E,Śliwa M,Sanloup C,Rothman S,Fratanduono DE,Smith RF,Collins GW,Eggert JH,Wark JS,McMahon MI

更新日期：2018-11-16 00:00:00

abstract：:MRI of hyperpolarized media, such as (129)Xe and (3)He, shows great potential for clinical applications. The optimal use of the available spin polarization requires accurate flip angle calibrations and T1 measurements. Traditional flip angle calibration methods are time-consuming and suffer from polarization losses du...

journal_title：Scientific reports

authors： Zhong J,Ruan W,Han Y,Sun X,Ye C,Zhou X

更新日期：2016-05-12 00:00:00