Novel highly divergent reassortant bat rotaviruses in Cameroon, without evidence of zoonosis.

Abstract:

:Bats are an important reservoir for zoonotic viruses. To date, only three RVA strains have been reported in bats in Kenya and China. In the current study we investigated the genetic diversity of RVAs in fecal samples from 87 straw-colored fruit bats living in close contact with humans in Cameroon using viral metagenomics. Five (near) complete RVA genomes were obtained. A single RVA strain showed a partial relationship with the Kenyan bat RVA strain, whereas the other strains were completely novel. Only the VP7 and VP4 genes showed significant variability, indicating the occurrence of frequent reassortment events. Comparing these bat RVA strains with currently used human RVA screening primers indicated that most of the novel VP7 and VP4 segments would not be detected in routine epidemiological screening studies. Therefore, novel consensus screening primers were developed and used to screen samples from infants with gastroenteritis living in close proximity with the studied bat population. Although RVA infections were identified in 36% of the infants, there was no evidence of zoonosis. This study identified multiple novel bat RVA strains, but further epidemiological studies in humans will have to assess if these viruses have the potential to cause gastroenteritis in humans.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Yinda CK,Zeller M,Conceição-Neto N,Maes P,Deboutte W,Beller L,Heylen E,Ghogomu SM,Van Ranst M,Matthijnssens J

doi

10.1038/srep34209

subject

Has Abstract

pub_date

2016-09-26 00:00:00

pages

34209

issn

2045-2322

pii

srep34209

journal_volume

6

pub_type

杂志文章
  • Topological constraints of structural elements in regulation of catalytic activity in HDV-like self-cleaving ribozymes.

    abstract::Self-cleaving ribozymes fold into intricate structures, which orient active site groups into catalytically competent conformations. Most ribozyme families have distinct catalytic cores stabilized by tertiary interactions between domains peripheral to those cores. We show that large hepatitis delta virus (HDV)-like rib...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28179

    authors: Webb CH,Nguyen D,Myszka M,Lupták A

    更新日期:2016-06-15 00:00:00

  • A persistent memory advantage is specific to grapheme-colour synaesthesia.

    abstract::For people with synaesthesia ordinary stimuli such as digits or letters induce concurrent experiences such as colours. Synaesthesia is associated with a memory advantage and the aim of this study was to investigate whether this advantage persists across time. We tested recognition memory of four different types of syn...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60388-6

    authors: Lunke K,Meier B

    更新日期:2020-02-26 00:00:00

  • The Arabidopsis defensin gene, AtPDF1.1, mediates defence against Pectobacterium carotovorum subsp. carotovorum via an iron-withholding defence system.

    abstract::Plant defensins (PDFs) are cysteine-rich peptides that have a range of biological functions, including defence against fungal pathogens. However, little is known about their role in defence against bacteria. In this study, we showed that the protein encoded by ARABIDOPSIS THALIANA PLANT DEFENSIN TYPE 1.1 (AtPDF1.1) is...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08497-7

    authors: Hsiao PY,Cheng CP,Koh KW,Chan MT

    更新日期:2017-08-23 00:00:00

  • Spider foraging strategy affects trophic cascades under natural and drought conditions.

    abstract::Spiders can cause trophic cascades affecting litter decomposition rates. However, it remains unclear how spiders with different foraging strategies influence faunal communities, or present cascading effects on decomposition. Furthermore, increased dry periods predicted in future climates will likely have important con...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12396

    authors: Liu S,Chen J,Gan W,Schaefer D,Gan J,Yang X

    更新日期:2015-07-23 00:00:00

  • Early detection and late cognitive control of emotional distraction by the prefrontal cortex.

    abstract::Unpleasant emotional distraction can impair the retention of non-emotional information in working memory (WM). Research links the prefrontal cortex with the successful control of such biologically relevant distractors, although the temporal changes in this brain mechanism remain unexplored. We use magnetoencephalograp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10046

    authors: García-Pacios J,Garcés P,Del Río D,Maestú F

    更新日期:2015-06-12 00:00:00

  • Mitogenomics of historical type specimens of Australasian turtles: clarification of taxonomic confusion and old mitochondrial introgression.

    abstract::Diagnosability is central to taxonomy as are type specimens which define taxa. New advances in technologies and the discovery of new informative traits must be matched with previous taxonomic decisions based on name-bearing type specimens. Consequently, the challenge of sequencing highly degraded DNA from historical t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42310-x

    authors: Kehlmaier C,Zhang X,Georges A,Campbell PD,Thomson S,Fritz U

    更新日期:2019-04-09 00:00:00

  • Role of JAK-STAT signaling in maturation of phagosomes containing Staphylococcus aureus.

    abstract::Phagocytosis is a required mechanism for the defense against pathogens. Staphylococcus aureus, an important bacterial pathogen, can promptly escape from phagosomes and proliferate within the cytoplasm of host. However, the mechanism of phagocytosis against S. aureus has not been intensively investigated. In this study...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14854

    authors: Zhu F,Zhou Y,Jiang C,Zhang X

    更新日期:2015-10-07 00:00:00

  • Horizontally-acquired genetic elements in the mitochondrial genome of a centrohelid Marophrys sp. SRT127.

    abstract::Mitochondrial genomes exhibit diverse features among eukaryotes in the aspect of gene content, genome structure, and the mobile genetic elements such as introns and plasmids. Although the number of published mitochondrial genomes is increasing at tremendous speed, those of several lineages remain unexplored. Here, we ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-41238-6

    authors: Nishimura Y,Shiratori T,Ishida KI,Hashimoto T,Ohkuma M,Inagaki Y

    更新日期:2019-03-19 00:00:00

  • Anxiety and depression in diabetes care: longitudinal associations with health-related quality of life.

    abstract::Anxiety and depression are commonly found in patients with diabetes, but little is known about how the anxiety and depression symptoms of diabetes patients and the health-related quality of life (HRQoL) over time influence each other. Therefore, we conducted a survey among patients with diabetes (T1) and repeated the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57647-x

    authors: Liu X,Haagsma J,Sijbrands E,Buijks H,Boogaard L,Mackenbach JP,Erasmus V,Polinder S

    更新日期:2020-05-20 00:00:00

  • A nomogram model for screening the risk of diabetes in a large-scale Chinese population: an observational study from 345,718 participants.

    abstract::Our study is major to establish and validate a simple type||diabetes mellitus (T2DM) screening model for identifying high-risk individuals among Chinese adults. A total of 643,439 subjects who participated in the national health examination had been enrolled in this cross-sectional study. After excluding subjects with...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68383-7

    authors: Xue M,Su Y,Feng Z,Wang S,Zhang M,Wang K,Yao H

    更新日期:2020-07-14 00:00:00

  • Structural characterization of site-modified nanocapsid with monodispersed gold clusters.

    abstract::Hepatitis E Virus-like particles self-assemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions. Previously, the nanocapsid was engineered to specifically bind and enter breast cancer cells, where successful tumor targeting was demonstrated in animal models. In the p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17171-x

    authors: Stark MC,Baikoghli MA,Lahtinen T,Malola S,Xing L,Nguyen M,Nguyen M,Sikaroudi A,Marjomäki V,Häkkinen H,Cheng RH

    更新日期:2017-12-06 00:00:00

  • Subcellular localization of the sigma-1 receptor in retinal neurons - an electron microscopy study.

    abstract::The Sigma-1 receptor (S1R) is known to play a protective role in the central nervous system including the retina. A major barrier for understanding the underlying mechanism is an ambiguity of S1R subcellular localizations. We thus conducted the first electron microscopy (EM) study of S1R subcellular distribution in th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10689

    authors: Mavlyutov TA,Epstein M,Guo LW

    更新日期:2015-06-02 00:00:00

  • Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation.

    abstract::The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental pathophysiology of diabe...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29393

    authors: Lee CS,Kim YG,Cho HJ,Park J,Jeong H,Lee SE,Lee SP,Kang HJ,Kim HS

    更新日期:2016-07-06 00:00:00

  • Optimization of human mesenchymal stem cell manufacturing: the effects of animal/xeno-free media.

    abstract::Due to their immunosuppressive properties, mesenchymal stem cells (MSC) have been evaluated for the treatment of immunological diseases. However, the animal-derived growth supplements utilized for MSC manufacturing may lead to clinical complications. Characterization of alternative media formulations is imperative for...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16570

    authors: Oikonomopoulos A,van Deen WK,Manansala AR,Lacey PN,Tomakili TA,Ziman A,Hommes DW

    更新日期:2015-11-13 00:00:00

  • Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail.

    abstract::Aedes aegypti is the primary vector for transmission of Dengue, Zika and chikungunya viruses. Previously it was shown that Dengue virus infection of the mosquito led to an in increased expression of the odorant binding protein 22 (AeOBP22) within the mosquito salivary gland and that siRNA mediated knockdown of AeOBP22...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60242-9

    authors: Wang J,Murphy EJ,Nix JC,Jones DNM

    更新日期:2020-02-24 00:00:00

  • Rare structural variants in the DOCK8 gene identified in a cohort of 439 patients with neurodevelopmental disorders.

    abstract::Detection of copy number variations (CNVs) is a first-tier clinical diagnostic test for children with neurodevelopmental disorders (NDD), which reveals the genetic cause of the disorder in more than 20%. These are mostly known microdeletion/microduplication syndromes, but variants of unknown clinical significance (VOU...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27824-0

    authors: Krgovic D,Kokalj Vokac N,Zagorac A,Gregoric Kumperscak H

    更新日期:2018-06-21 00:00:00

  • A continuous evolution system for contracting the host range of bacteriophage T7.

    abstract::Bacteriophage T7 is an intracellular parasite that recognizes its host via its tail and tail fiber proteins, known as receptor-binding proteins (RBPs). The RBPs attach to specific lipopolysaccharide (LPS) features on the host. Various studies have shown expansion of the phage's host range via mutations in the genes en...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-57221-0

    authors: Holtzman T,Globus R,Molshanski-Mor S,Ben-Shem A,Yosef I,Qimron U

    更新日期:2020-01-15 00:00:00

  • Strain-induced phase transition and electron spin-polarization in graphene spirals.

    abstract::Spin-polarized triangular graphene nanoflakes (t-GNFs) serve as ideal building blocks for the long-desired ferromagnetic graphene superlattices, but they are always assembled to planar structures which reduce its mechanical properties. Here, by joining t-GNFs in a spiral way, we propose one-dimensional graphene spiral...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05699

    authors: Zhang X,Zhao M

    更新日期:2014-07-16 00:00:00

  • The Limits of Effective Degrees of Freedom in UCA based Orbital Angular Momentum Multiplexed Communications.

    abstract::Orbital angular momentum (OAM) multiplexing technique has recently emerged and generated widespread interests since the OAM was discovered as a property of electromagnetic wave and acoustic wave. It was widely acknowledged that OAM multiplexing can achieve very high effective degrees of freedom (EDOF) and improve the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61329-z

    authors: Li Z,Qu F,Wei Y,Yang G,Xu W,Xu J

    更新日期:2020-03-23 00:00:00

  • Implicit Theory of Mind under realistic social circumstances measured with mobile eye-tracking.

    abstract::Recently, there has been a debate whether implicit Theory of Mind can be reliably measured using anticipatory looking tasks. Previous anticipatory looking paradigms used video stimuli to measure implicit Theory of Mind; however, numerous replications of these paradigms were unsuccessful. This lack of replications may ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-80614-5

    authors: Kulke L,Hinrichs MAB

    更新日期:2021-01-13 00:00:00

  • Insecticide-induced leg loss does not eliminate biting and reproduction in Anopheles gambiae mosquitoes.

    abstract::Recent successes in malaria control have been largely attributable to the deployment of insecticide-based vector control tools such as bed nets and indoor residual spraying. Pyrethroid-treated bed nets are acutely neurotoxic to mosquitoes, inducing symptoms such as loss of coordination, paralysis, and violent spasms. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46674

    authors: Isaacs AT,Lynd A,Donnelly MJ

    更新日期:2017-04-25 00:00:00

  • Ambient Processed, Water-Stable, Aqueous-Gated sub 1 V n-type Carbon Nanotube Field Effect Transistor.

    abstract::In this paper we report for the first time an n-type carbon nanotube field effect transistor which is air- and water-stable, a necessary requirement for electrolyte gated CMOS circuit operation. The device is obtained through a simple process, where the native p-type transistor is converted to an n-type. This conversi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29882-w

    authors: Joshi S,Bhatt VD,Jaworska E,Michalska A,Maksymiuk K,Becherer M,Gagliardi A,Lugli P

    更新日期:2018-07-30 00:00:00

  • MALDI-Imaging Mass Spectrometry: a step forward in the anatomopathological characterization of stenotic aortic valve tissue.

    abstract::Aortic stenosis (AS) is the most common form of valve disease. Once symptoms develop, there is an inexorable deterioration with a poor prognosis; currently there are no therapies capable of modifying disease progression, and aortic valve replacement is the only available treatment. Our goal is to study the progression...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27106

    authors: Mourino-Alvarez L,Iloro I,de la Cuesta F,Azkargorta M,Sastre-Oliva T,Escobes I,Lopez-Almodovar LF,Sanchez PL,Urreta H,Fernandez-Aviles F,Pinto A,Padial LR,Akerström F,Elortza F,Barderas MG

    更新日期:2016-06-03 00:00:00

  • Spectrochemical differentiation in gestational diabetes mellitus based on attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy and multivariate analysis.

    abstract::Gestational diabetes mellitus (GDM) is a hyperglycaemic imbalance first recognized during pregnancy, and affects up to 22% of pregnancies worldwide, bringing negative maternal-fetal consequences in the short- and long-term. In order to better characterize GDM in pregnant women, 100 blood plasma samples (50 GDM and 50 ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75539-y

    authors: Bernardes-Oliveira E,de Freitas DLD,de Morais CLM,Cornetta MDCM,Camargo JDAS,de Lima KMG,Crispim JCO

    更新日期:2020-11-06 00:00:00

  • Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations.

    abstract::Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) of aluminium oxyhydroxide and aluminium hydroxyphosphate adjuvants was elucidated in attempt to correlate these properties with the biological responses observed post v...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep31578

    authors: Mold M,Shardlow E,Exley C

    更新日期:2016-08-12 00:00:00

  • Gender differences measured by the MATRICS consensus cognitive battery in chronic schizophrenia patients.

    abstract::Using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), previous study showed significant gender differences for cognitive deficits in immediate and delayed memory in schizophrenia patients. However, RBANS does not include reasoning and problem solving, and social cognition. These cognitive f...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-017-12027-w

    authors: Zhang B,Han M,Tan S,De Yang F,Tan Y,Jiang S,Zhang X,Huang XF

    更新日期:2017-09-19 00:00:00

  • Fine-tuning the expression of target genes using a DDI2 promoter gene switch in budding yeast.

    abstract::Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and industrial application. Here, we introduce a novel promoter switching method based on the DDI2 promoter (PDDI2) that...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49000-8

    authors: Wang Y,Zhang K,Li H,Xu X,Xue H,Wang P,Fu YV

    更新日期:2019-08-29 00:00:00

  • Toxicity of fluralaner, a companion animal insecticide, relative to industry-leading agricultural insecticides against resistant and susceptible strains of filth flies.

    abstract::Filth flies cause billions of dollars of losses annually to the animal production industry. Fluralaner is a relatively new pesticide currently sold for control of fleas, ticks, and mites on companion animals and poultry. We examined the efficacy of fluralaner against three species of filth flies. Insecticide-susceptib...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68121-z

    authors: Burgess ER,Geden CJ,Lohmeyer KH,King BH,Machtinger ET,Scott JG

    更新日期:2020-07-07 00:00:00

  • Emotion perception improvement following high frequency transcranial random noise stimulation of the inferior frontal cortex.

    abstract::Facial emotion perception plays a key role in interpersonal communication and is a precursor for a variety of socio-cognitive abilities. One brain region thought to support emotion perception is the inferior frontal cortex (IFC). The current study aimed to examine whether modulating neural activity in the IFC using hi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11578-2

    authors: Penton T,Dixon L,Evans LJ,Banissy MJ

    更新日期:2017-09-12 00:00:00

  • Neuroprotective effects of a Coeloglossum viride var. Bracteatum extract in vitro and in vivo.

    abstract::The excessive release and accumulation of glutamate in the brain is known to be associated with excitotoxicity. CE, an extract derived from the plant Coeloglossum viride var. Bracteatum, exerted neuroprotective effects against amyloid toxicity and oxidative stress in cortical neurons. The aims of this study are to exa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08957-0

    authors: Pan RY,Ma J,Wu HT,Liu QS,Qin XY,Cheng Y

    更新日期:2017-08-23 00:00:00