Topological constraints of structural elements in regulation of catalytic activity in HDV-like self-cleaving ribozymes.

abstract：:Faithful DNA replication is a prerequisite for cell proliferation. Several cytological studies have shown that chromosome structures alter in the S-phase of the cell cycle. However, the molecular mechanisms behind the alteration of chromosome structures associated with DNA replication have not been elucidated. Here, w...

journal_title：Scientific reports

authors： Ruan K,Yamamoto TG,Asakawa H,Chikashige Y,Kimura H,Masukata H,Haraguchi T,Hiraoka Y

更新日期：2015-07-30 00:00:00

abstract：:Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC). Methods of identifying BE patients at high risk for progression to high-grade dysplasia (HGD) or EAC are needed to improve outcomes and identify who will benefit most from intensive surveillance or ablative therapy. Clinical predi...

journal_title：Scientific reports

authors： Kambhampati S,Tieu AH,Luber B,Wang H,Meltzer SJ

更新日期：2020-03-17 00:00:00

abstract：:Soluble microbial products (SMPs) are of significant concern in the natural environment and in engineered systems. In this work, poly-γ-glutamic acid (γ-PGA), which is predominantly produced by Bacillus sp., was investigated in terms of pH-induced conformational changes and molecular interactions in aqueous solutions;...

journal_title：Scientific reports

authors： Wang LL,Chen JT,Wang LF,Wu S,Zhang GZ,Yu HQ,Ye XD,Shi QS

更新日期：2017-10-06 00:00:00

abstract：:The psychrophilic (cold-loving) fungus Pseudogymnoascus destructans was discovered more than a decade ago to be the pathogen responsible for white-nose syndrome, an emerging disease of North American bats causing unprecedented population declines. The same species of fungus is found in Europe but without associated mo...

journal_title：Scientific reports

authors： Ren P,Rajkumar SS,Zhang T,Sui H,Masters PS,Martinkova N,Kubátová A,Pikula J,Chaturvedi S,Chaturvedi V

更新日期：2020-08-17 00:00:00

abstract：:Translesion synthesis (TLS) is the mechanism by which DNA polymerases replicate through unrepaired DNA lesions. TLS is activated by monoubiquitination of the homotrimeric proliferating cell nuclear antigen (PCNA) at lysine-164, followed by the switch from replicative to specialized polymerases at DNA damage sites. Pol...

journal_title：Scientific reports

authors： Lau WC,Li Y,Zhang Q,Huen MS

更新日期：2015-10-27 00:00:00

abstract：:Web search tools are widely used by the general public to obtain health-related information, and analysis of search data is often suggested for public health monitoring. We analyzed popularity of searches related to smell loss and taste loss, recently listed as symptoms of COVID-19. Searches on sight loss and hearing ...

journal_title：Scientific reports

authors： Asseo K,Fierro F,Slavutsky Y,Frasnelli J,Niv MY

更新日期：2020-11-25 00:00:00

abstract：:Alcohol consumption before or during pregnancy poses serious health risks to the fetus; however, the underlying mechanisms involved remain obscure. Here, we investigated whether ethanol consumption before pregnancy affects maternal or fetal health and whether pharmacological inhibition of CYP2E1, a major ethanol oxida...

journal_title：Scientific reports

authors： Lee YJ,Kim JY,Lee DY,Park KJ,Kim GH,Kim JE,Roh GS,Lim JY,Koo S,Lim NK,Park HY,Kim WH

更新日期：2020-06-22 00:00:00

abstract：:Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of lifestyle-related diseases (LSRDs), but the important associations between these factors and LSRDs remain unknown. We quantified PFAAs and UA amongst Japanese subjects...

journal_title：Scientific reports

authors： Mahbub MH,Yamaguchi N,Takahashi H,Hase R,Ishimaru Y,Sunagawa H,Amano H,Kobayashi-Miura M,Kanda H,Fujita Y,Yamamoto H,Yamamoto M,Kikuchi S,Ikeda A,Kageyama N,Nakamura M,Tanabe T

更新日期：2017-12-15 00:00:00

abstract：:Herein, we demonstrate a simple yet novel luminescence assay for visual chiral discrimination of cysteine. Thioglycolic acid (TGA)-capped cadmium-telluride (CdTe) quantum dots (QDs) exposing green emission were directly synthesized in aqueous solution. The interaction between cysteine molecules and CdTe QDs induced th...

journal_title：Scientific reports

authors： Ghasemi F,Hormozi-Nezhad MR,Mahmoudi M

更新日期：2017-04-18 00:00:00

abstract：:We present a model on the simulation of the measurement-device independent quantum key distribution (MDI-QKD) with phase randomized general sources. It can be used to predict experimental observations of a MDI-QKD with linear channel loss, simulating corresponding values for the gains, the error rates in different bas...

journal_title：Scientific reports

authors： Wang Q,Wang XB

更新日期：2014-04-14 00:00:00

abstract：:Pseudomonas aeruginosa is a major threat for immune-compromised patients. Bacterial pneumonia can induce uncontrolled and massive neutrophil recruitment ultimately leading to acute respiratory distress syndrome and epithelium damage. Interleukin-22 plays a central role in the protection of the epithelium. In this stud...

journal_title：Scientific reports

authors： Broquet A,Jacqueline C,Davieau M,Besbes A,Roquilly A,Martin J,Caillon J,Dumoutier L,Renauld JC,Heslan M,Josien R,Asehnoune K

更新日期：2017-09-08 00:00:00

abstract：:The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we investigated the role...

journal_title：Scientific reports

authors： Shi Y,Lai X,Ye L,Chen K,Cao Z,Gong W,Jin L,Wang C,Liu M,Liao Y,Wang JM,Zhou N

更新日期：2017-02-10 00:00:00

abstract：:Measurements of volcanic tephra fallout deposits provide useful information about the magnitude and intensity of explosive volcanic eruptions and potential for remobilization of deposits as dangerous volcanic flows. However, gathering information in the vicinity of erupting craters is extremely dangerous, and moreover...

journal_title：Scientific reports

authors： Tanaka HKM

更新日期：2020-09-09 00:00:00

abstract：:In this study, to fabricate stable floating photocatalytic spheres, facile alcohol solvothermal reduction was first employed to modify commercial TiO2 (P25) photocatalysts to harvest visible light and improve their performances for photodegrading phenol in seawater exciting by visible light. Floating photocatalytic sp...

journal_title：Scientific reports

authors： Wang T,Li Y,Pan JH,Zhang YL,Wu LG,Dong CY,Li CJ

更新日期：2019-09-25 00:00:00

abstract：:Understanding the neural basis of poor impulse control in Internet addiction (IA) is important for understanding the neurobiological mechanisms of this syndrome. The current study investigated how neuronal pathways implicated in response inhibition were affected in IA using a Go-Stop paradigm and functional magnetic r...

journal_title：Scientific reports

authors： Li B,Friston KJ,Liu J,Liu Y,Zhang G,Cao F,Su L,Yao S,Lu H,Hu D

更新日期：2014-05-22 00:00:00

abstract：:Hibernation in mammals is a remarkable state of heterothermy wherein metabolic rates are reduced, core body temperatures reach ambient levels, and key physiological functions are suspended. Typically, hibernation is observed in cold-adapted mammals, though it has also been documented in tropical species and even prima...

journal_title：Scientific reports

authors： Blanco MB,Dausmann KH,Ranaivoarisoa JF,Yoder AD

更新日期：2013-01-01 00:00:00

abstract：:Recent evidence points at the role that human endogenous retroviruses (HERVs) may play through the activation of genes integrated across the human genome. Although a variety of genetic/epigenetic mechanisms maintain most HERVs silenced, independent environmental stimuli including infections may transactivate endogenou...

journal_title：Scientific reports

authors： Niegowska M,Wajda-Cuszlag M,Stępień-Ptak G,Trojanek J,Michałkiewicz J,Szalecki M,Sechi LA

更新日期：2019-04-18 00:00:00

abstract：:1β-hydroxy alantolactone, a sesquiterpene lactone, exhibits potent anti-inflammatory and anticancer activities. Recently, it has been found to target UbcH5s by covalently bonding with Cys85 specifically, but the exact molecular basis remains unclear. Here, we analyzed the structural specificity of the catalytic site o...

journal_title：Scientific reports

authors： Xu Y,Meng X

更新日期：2020-01-10 00:00:00

abstract：:Power induced wave collapse is one of the most fascinating phenomena in optics as it provides extremely high intensities, thus stimulating a range of nonlinear processes. For low power levels, propagation of beams in bulk media is dominated by diffraction, while above a certain threshold self-focusing is steadily enha...

journal_title：Scientific reports

authors： Muniz ALM,Wimmer M,Bisianov A,Morandotti R,Peschel U

更新日期：2019-07-02 00:00:00

abstract：:The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endangered list of threat...

journal_title：Scientific reports

authors： Smedley CJ,Stanley PA,Qazzaz ME,Prota AE,Olieric N,Collins H,Eastman H,Barrow AS,Lim KH,Kam TS,Smith BJ,Duivenvoorden HM,Parker BS,Bradshaw TD,Steinmetz MO,Moses JE

更新日期：2018-07-13 00:00:00

abstract：:Patients who undergo total hip arthroplasty (THA) may experience a large amount of blood loss. The objective of our study is to include randomized controlled trials (RCTs) and compare the clinical outcomes of fibrin sealant (FS) versus placebo after a THA. In October 2015, we searched the following databases: Medline,...

journal_title：Scientific reports

authors： Zhao Z,Ma X,Ma J,Sun X,Li F,Lv J

更新日期：2018-01-08 00:00:00

abstract：:At the species level, plants can respond to climate changes by changing their leaf traits; however, there is scant information regarding the responses of morphological, physiological and anatomical traits of plant functional types (PFTs) to aridity. Herein, the leaf traits of five PFTs representing 17 plant species in...

journal_title：Scientific reports

authors： Guo C,Ma L,Yuan S,Wang R

更新日期：2017-01-20 00:00:00

abstract：:The early detection of cognitive impairment or dementia is in the focus of current research as the amount of cognitively impaired individuals will rise intensely in the next decades due to aging population worldwide. Currently available diagnostic tools to detect mild cognitive impairment (MCI) or dementia are time-co...

journal_title：Scientific reports

authors： Müller S,Herde L,Preische O,Zeller A,Heymann P,Robens S,Elbing U,Laske C

更新日期：2019-03-05 00:00:00

abstract：:Solving the crystal structure of Cbl(TKB) in complex with a pentapeptide, pYTPEP, revealed that the PEP region adopted a poly-L-proline type II (PPII) helix. An unnatural amino acid termed a proline-templated glutamic acid (ptE) that constrained both the backbone and sidechain to the bound conformation was synthesized...

journal_title：Scientific reports

authors： Kumar EA,Chen Q,Kizhake S,Kolar C,Kang M,Chang CE,Borgstahl GE,Natarajan A

更新日期：2013-01-01 00:00:00

abstract：:We developed an optimized Dipheylthiocarbazone or Dithizone (DTZ) with improved physical and chemical properties to characterize human islets and insulin-producing cells differentiated from embryonic stem cells. Application of the newly formulated iDTZ (i stands for islet) over a range of temperatures, time intervals ...

journal_title：Scientific reports

authors： Khiatah B,Qi M,Wu Y,Chen KT,Perez R,Valiente L,Omori K,Isenberg JS,Kandeel F,Yee JK,Al-Abdullah IH

更新日期：2019-06-26 00:00:00

abstract：:We show that the space in which scientific, technological and economic activities interplay with each other can be mathematically shaped using techniques from statistical physics of networks. We build a holistic view of the innovation system as the tri-layered network of interactions among these many activities (scien...

journal_title：Scientific reports

authors： Pugliese E,Cimini G,Patelli A,Zaccaria A,Pietronero L,Gabrielli A

更新日期：2019-11-11 00:00:00

abstract：:Lasing behavior of optically active planar topological Weyl semimetal (TWS) is investigated in view of the Kerr and Faraday rotations. Robust topological character of TWS is revealed by the presence of Weyl nodes and relevant surface conductivities. We focus our attention on the surfaces where no Fermi arcs are formed...

journal_title：Scientific reports

authors： Oktay G,Sarısaman M,Tas M

更新日期：2020-02-20 00:00:00

abstract：:Visual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the eff...

journal_title：Scientific reports

authors： Arima M,Tsukamoto S,Fujiwara K,Murayama M,Fujikawa K,Sonoda KH

更新日期：2017-06-20 00:00:00

abstract：:Acid-sensing ion channels (ASICs) belong to the degenerin/epithelial sodium channel protein family that form mechanosensitive ion channels. Evidence as to whether or not ASICs activity is directly modulated by mechanical force is lacking. Human ASICs (hASIC1V3, hASIC2a and hASIC3a) were heterologously expressed as hom...

journal_title：Scientific reports

authors： Barth D,Fronius M

更新日期：2019-05-01 00:00:00

abstract：:In this study, we evaluated the sink and source of the surface water along the PRE using a mixing model method with salinity as tracer. The observational data showed that the decreasing of dissolved inorganic nitrogen (DIN) did not closely follow the physical mixing lines of freshwater and modified seawater. In the we...

journal_title：Scientific reports

authors： Wu ML,Hong YG,Yin JP,Dong JD,Wang YS

更新日期：2016-11-11 00:00:00