Abstract：
:Recent evidence points at the role that human endogenous retroviruses (HERVs) may play through the activation of genes integrated across the human genome. Although a variety of genetic/epigenetic mechanisms maintain most HERVs silenced, independent environmental stimuli including infections may transactivate endogenous elements favoring pathogenic conditions. Several studies associated exposures to Mycobacterium avium subsp. paratuberculosis (MAP) with increased anti-MAP seroreactivity in T1D patients. Here, we assessed humoral responses against HERV envelope antigens (HERV-KEnv and HERV-WEnv) and four MAP-derived peptides with human homologs in distinct populations: Sardinian children at T1D risk (rT1D) (n = 14), rT1D from mainland Italy (n = 54) and Polish youths with T1D (n = 74) or obesity unrelated to autoimmunity (OB) (n = 26). Unlike Sardinian rT1D, youths displayed increased anti-HERV-WEnv Abs prevalence compared to age-matched OB or healthy controls (24.32 vs. 11.54%, p = 0.02 for Polish T1D/OB and 31.48 vs. 11.90%, p = 0.0025 for Italian rT1D). Anti-HERV-KEnv responses showed variable trends across groups. A strong correlation between Abs levels against HERV-WEnv and homologous peptides was mirrored by time-related Abs patterns. Elevated values registered for HERV-WEnv overlaped with or preceded the detection of T1D diagnostic autoantibodies. These results support the hypothesis of MAP infection leading to HERV-W antigen expression and enhancing the production of autoantibodies in T1D.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Niegowska M,Wajda-Cuszlag M,Stępień-Ptak G,Trojanek J,Michałkiewicz J,Szalecki M,Sechi LAdoi
10.1038/s41598-019-42788-5subject
Has Abstractpub_date
2019-04-18 00:00:00pages
6282issue
1issn
2045-2322pii
10.1038/s41598-019-42788-5journal_volume
9pub_type
杂志文章abstract：:AKT is an important signal transduction protein that plays a crucial role in cancer development. Therefore, we evaluated associations between single nucleotide polymorphisms (SNPs) in the AKT promoter region and gastric cancer (GCa) risk in a case-control study of 1,110 GCa patients and 1,114 matched cancer-free contr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20008
更新日期：2016-01-28 00:00:00
abstract：:This study investigates physicochemical impact of ultrasonic irradiations on surface topography of woven fabrics. In a simultaneous in-situ sonochemical method, the synthesis and coating of zinc oxide nanoparticles (ZnO NPs) on woven textiles were successfully achieved. Different instruments i.e. Alambeta, moisture ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78305-2
更新日期：2020-12-03 00:00:00
abstract：:Age and sleep both affect emotional functioning. Since sleep patterns change over the lifespan, we investigated the effects of short sleep and age on empathic responses. In a randomized cross-over experimental design, healthy young and older volunteers (n = 47 aged 20-30 years and n = 39 aged 65-75 years) underwent fu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12098-9
更新日期：2017-09-25 00:00:00
abstract：:Despite the increasing number of studies conducted recently to evaluate the association between HPV infections and the risk of prostate cancer, the results remain inconclusive. Furthermore, the prevalence and distribution of overall and individual HPV types worldwide in prostate cancer has not been reported until now....
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep14667
更新日期：2015-10-06 00:00:00
abstract：:Quantum walks often provide telling insights about the structure of the system on which they are performed. In [Formula: see text]-symmetric and lossy dimer lattices, the topological properties of the band structure manifest themselves in the quantization of the mean displacement of such a walker. We investigate the f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30344-6
更新日期：2018-08-13 00:00:00
abstract：:Establishing the architecture of gene regulatory networks (GRNs) relies on chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-Seq) methods that provide genome-wide transcription factor binding sites (TFBSs). ChIP-Seq furnishes millions of short reads that, after alignment, describe the genom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08635
更新日期：2015-03-02 00:00:00
abstract：:Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7- tetramethyljulolidyl-9-en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08625-3
更新日期：2017-08-21 00:00:00
abstract：:The existing molecular cloning methods are often limited by the availability of suitable restriction sites. It is still a challenge for simultaneous cloning of multiple fragments into different sites of a single vector. Here we developed a novel method named improved overlap extension PCR (IOEP) for restriction enzyme...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52122-8
更新日期：2019-10-30 00:00:00
abstract：:We isolated a novel bacterial strain from a prokaryotic consortium associated to the psychrophilic marine ciliate Euplotes focardii, endemic of the Antarctic coastal seawater. The 16S rDNA sequencing and the phylogenetic analysis revealed the close evolutionary relationship to the Antarctic marine bacterium Marinomona...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66878-x
更新日期：2020-06-23 00:00:00
abstract：:ADC is a potential post treatment imaging biomarker in colorectal liver metastasis however measurements are affected by respiratory motion. This is compounded by increased statistical uncertainty in ADC measurement with decreasing tumour volume. In this prospective study we applied a retrospective motion correction me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40565-y
更新日期：2019-03-07 00:00:00
abstract：:Cooperative behaviors are common in humans, and they are the fundamental basis of our society. Theoretical and experimental studies have modeled environments where the behaviors of humans, or agents, have been restricted to analyze their social behavior. However, it is important that such studies can be generalized to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12481
更新日期：2015-07-28 00:00:00
abstract：:Animals living at high altitudes have evolved distinct phenotypic and genotypic adaptations against stressful environments. We studied the adaptive patterns of altitudinal stresses on transcriptome turnover in subterranean plateau zokors (Myospalax baileyi) in the high-altitude Qinghai-Tibetan Plateau. Transcriptomes ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22483-7
更新日期：2018-03-16 00:00:00
abstract：:Nuclear proteins are primarily regulatory factors governing gene expression. Multiple factors determine the localization of a protein in the nucleus. An upright identification of nuclear proteins is way far from accuracy. We have attempted to combine information from subcellular prediction tools, experimental evidence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70713-8
更新日期：2020-09-15 00:00:00
abstract：:Immunopathology corresponds to self-damage of the inflammatory response, resulting from oxidizing molecules produced when the immune system is activated. Immunopathology often contributes to age-related diseases and is believed to accelerate ageing. Prevention of immunopathology relies on endogenous antioxidant enzyme...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12769-7
更新日期：2017-09-29 00:00:00
abstract：:Human lactoferrin (hLF) is a valuable protein for pharmaceutical products and functional foods, and worldwide demand for this protein has steadily increased. However, large-scale recombinant human lactoferrin (rhLF) production using current animal bioreactor techniques is limited by the low expression of foreign prote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11462-z
更新日期：2017-09-06 00:00:00
abstract：:The growth dynamics of Ga(In)N semiconductors by Plasma-Assisted Molecular Beam Epitaxy (PAMBE) at low temperatures (T = 450 °C) is here investigated. The presence of droplets at the growth surface strongly affects the adatom incorporation dynamics, making the growth rate a decreasing function of the metal flux imping...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28984-9
更新日期：2018-07-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-46782-9
更新日期：2019-07-24 00:00:00
abstract：:Empathetic verbal feedback from others has been shown to alleviate the intensity of experimental pain. To investigate the brain changes associated with this effect, we conducted 3T-fMRI measurements in 30 healthy subjects who received painful thermal stimuli on their left hand while overhearing empathetic, neutral or ...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-44879-9
更新日期：2019-06-10 00:00:00
abstract：:Second-harmonic generation (SHG) is the most specific label-free indicator of collagen accumulation in widespread pathologies such as fibrosis, and SHG-based measurements hold important potential for biomedical analyses. However, efficient collagen SHG scoring in histological slides is hampered by the limited depth-of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29863
更新日期：2016-07-20 00:00:00
abstract：:Streptococcus pneumoniae (pneumococcus) is a principal cause of bacterial middle ear infections, pneumonia, and meningitis. Capsule-targeted pneumococcal vaccines have likely contributed to increased carriage of nonencapsulated S. pneumoniae (NESp). Some NESp lineages are associated with highly efficient DNA uptake an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75988-5
更新日期：2020-11-03 00:00:00
abstract：:Anionic redox reactions attributed to oxygen have attracted much attention as a new approach to overcoming the energy-density limits of cathode materials. Several oxides have been suggested as new cathode materials with high capacities based on anionic (oxygen) redox reactions. Although most still have a large portion...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49806-6
更新日期：2019-09-12 00:00:00
abstract：:Respiratory Distress Syndrome (RDS) is the commonest diagnosis after premature birth. We aimed to audit clinical practices before and after introduction of a national guideline in Wales on RDS management. Anonymised, prospective data on all infants born at <34 weeks of gestation and cared for at one of the participati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60091-6
更新日期：2020-02-26 00:00:00
abstract：:The experimental approach for the study of cardiometabolic disorders requires the use of animal models fed with commercial diets whose composition differs notably, even between diets used for control groups. While chow diets are usually made of agricultural by-products, purified low-fat diets (LF) contain a higher per...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59674-0
更新日期：2020-02-19 00:00:00
abstract：:Adverse maternal environments, such as diabetes and obesity, impair placental mitochondrial function, which affects fetal development and offspring long-term health. The underlying mechanisms and effective interventions to abrogate such effect remain unclear. Our previous studies demonstrated impaired mitochondrial bi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65415-0
更新日期：2020-05-20 00:00:00
abstract：:Pre-shared non-local entanglement dramatically simplifies and improves the performance of quantum error correction via entanglement-assisted quantum error-correcting codes (EAQECCs). However, even considering the noise in quantum communication only, the non-local sharing of a perfectly entangled pair is technically im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07203
更新日期：2014-11-26 00:00:00
abstract：:Cues previously paired with rewarding stimuli induce a time-dependent increase in the motivational craving state (incubation of craving). Whether there is an increase in craving for high-fat (HF) food over time, which may contribute to overeating and obesity, has not been determined. We hypothesized that cues paired w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30900
更新日期：2016-08-03 00:00:00
abstract：:Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12511
更新日期：2015-07-27 00:00:00
abstract：:Galectin-3 is a biomarker of fibrosis, inflammation and oxidative stress, and its role in heart remodelling and exercise intolerance has not been conclusively proven in heart failure (HF) patients with reduced ejection fraction (rEF). We prospectively assessed 67 consecutive patients with symptomatic HF and left ventr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73634-8
更新日期：2020-10-07 00:00:00
abstract：:The starch granule is Nature's way to store energy in green plants over long periods. Irrespective of their origins, starches display distinct structural features that are the fingerprints of levels of organization over six orders of magnitude. We hypothesized that Nature retains hierarchical material structures at al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72218-w
更新日期：2020-11-18 00:00:00
abstract：:In chronic neurodegenerative syndromes, neurons progressively die through a generalized retraction pattern triggering retrograde axonal degeneration toward the cell bodies, which molecular mechanisms remain elusive. Recent observations suggest that direct activation of pro-apoptotic signaling in axons triggers local d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32777
更新日期：2016-09-08 00:00:00
