Shear force modulates the activity of acid-sensing ion channels at low pH or in the presence of non-proton ligands.

abstract：:Microbial secondary metabolites are valuable resources for novel drug discovery. In particular, actinomycetes expressed a range of antibiotics against a spectrum of bacteria. In genus level, strain Allosalinactinospora lopnorensis CA15-2(T) is the first new actinomycete isolated from the Lop Nor region, China. Antimic...

journal_title：Scientific reports

authors： Huang C,Leung RK,Guo M,Tuo L,Guo L,Yew WW,Lou I,Lee SMY,Sun C

更新日期：2016-02-11 00:00:00

abstract：:We report a water decomposition mode called 'Aquaionic Splitting (AiS)' by means of iron corrosion in aqueous solution. In this paper, we investigated the phenomenon by controlling the reaction between iron and water. A pseudo-sacrificial protection method with oil paint was employed to select the anode and cathode fo...

journal_title：Scientific reports

authors： Murakami S,Zhang L,Watanabe S

更新日期：2020-02-03 00:00:00

abstract：:The accurate prediction of the impact of an amino acid substitution on the thermal stability of a protein is a central issue in protein science, and is of key relevance for the rational optimization of various bioprocesses that use enzymes in unusual conditions. Here we present one of the first computational tools to ...

journal_title：Scientific reports

authors： Pucci F,Bourgeas R,Rooman M

更新日期：2016-03-18 00:00:00

abstract：:Psychopathy is a personality disorder characterised by atypical moral behaviour likely rooted in atypical affective/motivational processing, as opposed to an inability to judge the wrongness of an action. Guilt is a moral emotion believed to play a crucial role in adherence to moral and social norms, but the mechanism...

journal_title：Scientific reports

authors： Seara-Cardoso A,Sebastian CL,McCrory E,Foulkes L,Buon M,Roiser JP,Viding E

更新日期：2016-11-03 00:00:00

abstract：:Chromosomal microarray (CMA) is now recommended as first tier for the evaluation in individuals with unexplained neurodevelopmental disorders (ND). However, in developing countries such as Brazil, classical cytogenetic tests are still the most used in clinical practice, as reflected by the scarcity of publications of ...

journal_title：Scientific reports

authors： Chaves TF,Baretto N,Oliveira LF,Ocampos M,Barbato IT,Anselmi M,De Luca GR,Barbato Filho JH,Pinto LLC,Bernardi P,Maris AF

更新日期：2019-11-28 00:00:00

abstract：:Determining oil migration distances from source rocks to reservoirs can greatly help in the search for new petroleum accumulations. Concentrations and ratios of polar organic compounds are known to change due to preferential sorption of these compounds in migrating oils onto immobile mineral surfaces. However, these c...

journal_title：Scientific reports

authors： Zhang L,Li M,Wang Y,Yin QZ,Zhang W

更新日期：2013-01-01 00:00:00

abstract：:The G protein-coupled receptor opsin is a phospholipid scramblase that facilitates rapid transbilayer phospholipid exchange in liposomes. The mechanism by which opsin scrambles lipids is unknown. It has been proposed that lipid translocation may occur at protein-protein interfaces of opsin dimers. To test this possibi...

journal_title：Scientific reports

authors： Pandey K,Ploier B,Goren MA,Levitz J,Khelashvili G,Menon AK

更新日期：2017-12-01 00:00:00

abstract：:Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential as...

journal_title：Scientific reports

authors： Jiang W,Sun H,Zhang J,Zhou Q,Wu Q,Li T,Zhang C,Li W,Zhang M,Xia X

更新日期：2015-10-16 00:00:00

abstract：:The activation and growth of tumour-initiating cells with stem-like properties in distant organs characterize colorectal cancer (CRC) growth and metastasis. Thus, inhibition of colon cancer stem cell (CCSC) growth holds promise for CRC growth and metastasis prevention. We and others have shown that farnesyl dimethyl c...

journal_title：Scientific reports

authors： Husain K,Coppola D,Yang CS,Malafa MP

更新日期：2021-01-26 00:00:00

abstract：:Willow (Salix spp.) seeds are able to tolerate desiccation, but differ from typical orthodox seeds in that they lose viability in a few days at room temperature, and in that the chloroplasts in embryo tissues do not dedifferentiate during maturation drying, thus retaining chlorophyll and maintaining intact their thyla...

journal_title：Scientific reports

authors： López-Fernández MP,Moyano L,Correa MD,Vasile F,Burrieza HP,Maldonado S

更新日期：2018-11-21 00:00:00

abstract：:In order to screen out an effective bone loss protectant from natural plant polyphenol and to elucidate the mechanism of the plant polyphenols that alleviate bone loss under simulated microgravity, the proliferation activities of 9 total polyphenol extracts from natural product (TPENP) on osteoblasts were measured. Po...

journal_title：Scientific reports

authors： Diao Y,Chen B,Wei L,Wang Z

更新日期：2018-08-24 00:00:00

abstract：:To compare the soil water balance, yield and water use efficiency (WUE) of spring maize under different mulching types in the Loess Plateau, a 7-year field experiment was conducted in the Changwu region of the Loess Plateau. Three treatments were used in this experiment: straw mulch (SM), plastic film mulch (PM) and c...

journal_title：Scientific reports

authors： Lin W,Liu W,Xue Q

更新日期：2016-12-15 00:00:00

abstract：:The inhibitory behaviour of non-ionic sugar based N,N'-didodecyl-N,N'-digluconamideethylenediamine gemini surfactant, designated as Glu(12)-2-Glu(12) on mild steel (MS) corrosion in 3.5% NaCl at 30-60 °C was explored using weight loss, PDP, EIS and SEM/EDAX/AFM techniques. The compound inhibited the corrosion of mild ...

journal_title：Scientific reports

authors： Aslam R,Mobin M,Aslam J,Lgaz H

更新日期：2018-02-27 00:00:00

abstract：:We report on measurements of the switching current distributions on two-dimensional superconducting NbTiN strips that are 5 nm thick and 80 nm wide. We observe that the width of the switching current distributions has a non-monotonous temperature dependence, where it is constant at the lowest temperatures up to about ...

journal_title：Scientific reports

authors： Ejrnaes M,Salvoni D,Parlato L,Massarotti D,Caruso R,Tafuri F,Yang XY,You LX,Wang Z,Pepe GP,Cristiano R

更新日期：2019-05-29 00:00:00

abstract：:Subclinical hypothyroidism has been associated with dyslipidemia, hypertension, and increased risk of coronary artery disease. However, limited is known for its effect on renal function. Here we aimed to investigate whether subclinical hypothyroidism is associated with reduced estimated glomerular filtration rate (eGF...

journal_title：Scientific reports

authors： Chang YC,Chang CH,Yeh YC,Chuang LM,Tu YK

更新日期：2018-02-01 00:00:00

abstract：:Leukemia cells are superior to hematopoietic cells with a normal differentiation potential in buffering cellular stresses, but the underlying mechanisms for this leukemic advantage are not fully understood. Using CRISPR/Cas9 deletion of the canonical autophagy-essential gene Atg7, we found that erythroleukemia K562 ce...

journal_title：Scientific reports

authors： Wang J,Fang Y,Yan L,Yuan N,Zhang S,Xu L,Nie M,Zhang X,Wang J

更新日期：2016-04-19 00:00:00

abstract：:We propose a deep learning model - Probabilistic Prognostic Estimates of Survival in Metastatic Cancer Patients (PPES-Met) for estimating short-term life expectancy (>3 months) of the patients by analyzing free-text clinical notes in the electronic medical record, while maintaining the temporal visit sequence. In a si...

journal_title：Scientific reports

authors： Banerjee I,Gensheimer MF,Wood DJ,Henry S,Aggarwal S,Chang DT,Rubin DL

更新日期：2018-07-03 00:00:00

abstract：:The purpose of this study is to investigate whether implementing a myofascial release (MFR) protocol designed to restore the myofascial properties of the diaphragm has any effect on the symptoms, quality of life, and consumption of proton pump inhibitors (PPI) drugs by patients with non-erosive gastroesophageal reflux...

journal_title：Scientific reports

authors： Martínez-Hurtado I,Arguisuelas MD,Almela-Notari P,Cortés X,Barrasa-Shaw A,Campos-González JC,Lisón JF

更新日期：2019-05-13 00:00:00

abstract：:Three dimensional single particle trapping and manipulation is an outstanding challenge in various fields ranging from basic physics to life sciences. By monitoring the response of a trapped particle to a designed environment one can extract its characteristics. In addition, quantum dynamics of a spatially scanned wel...

journal_title：Scientific reports

authors： Kayci M,Radenovic A

更新日期：2015-11-12 00:00:00

abstract：:The extracellular matrix (ECM) is a highly dynamic network constantly remodeled by a fine-tuned protein formation and degradation balance. Matrix metalloproteinases (MMPs) constitute key orchestrators of ECM degradation. Their activity is controlled by tissue inhibitors of metalloproteinases (TIMPs) and glycosaminogly...

journal_title：Scientific reports

authors： Ruiz-Gómez G,Vogel S,Möller S,Pisabarro MT,Hempel U

更新日期：2019-03-20 00:00:00

abstract：:Routine antimicrobial susceptibility testing (AST) can prevent deaths due to bacteria and reduce the spread of multi-drug-resistance, but cannot be regularly performed in resource-limited-settings due to technological challenges, high-costs, and lack of trained professionals. We demonstrate an automated and cost-effec...

journal_title：Scientific reports

authors： Feng S,Tseng D,Di Carlo D,Garner OB,Ozcan A

更新日期：2016-12-15 00:00:00

abstract：:The Internet of Things is driving extensive efforts to develop intelligent everyday objects. This requires seamless integration of relatively simple electronics, for example through 'stick-on' electronics labels. We believe the future evolution of this technology will be governed by Wright's Law, which was first propo...

journal_title：Scientific reports

authors： Myny K,Smout S,Rockelé M,Bhoolokam A,Ke TH,Steudel S,Cobb B,Gulati A,Gonzalez Rodriguez F,Obata K,Marinkovic M,Pham DV,Hoppe A,Gelinck GH,Genoe J,Dehaene W,Heremans P

更新日期：2014-12-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： de Oliveira GL,Marques AH,da Fonseca VF,Pozzolo BA,Panacioni F,Santos TC,Guedes AA,Mocelin AG,Bertin RL,Ulbrich AZ

更新日期：2020-10-28 00:00:00

abstract：:This paper reports a facile and green method for conversion of graphene oxide (GO) into graphene by low-temperature heating (80 °C) in the presence of a glass wafer. Compared to conventional GO chemical reduction methods, the presented approach is easy-scalable, operationally simple, and based on the use of a non-toxi...

journal_title：Scientific reports

authors： Rabchinskii MK,Dideikin AT,Kirilenko DA,Baidakova MV,Shnitov VV,Roth F,Konyakhin SV,Besedina NA,Pavlov SI,Kuricyn RA,Lebedeva NM,Brunkov PN,Vul' AY

更新日期：2018-09-20 00:00:00

abstract：:Leukemia is the most commonly diagnosed childhood cancer, although its etiology is still largely unknown. Growing evidence supports a role for infection in the etiology of acute lymphocytic leukemia (ALL), and the involvement of the immune system suggests that vaccination may also play a role. However, the findings pr...

journal_title：Scientific reports

authors： Morra ME,Kien ND,Elmaraezy A,Abdelaziz OAM,Elsayed AL,Halhouli O,Montasr AM,Vu TL,Ho C,Foly AS,Phi AP,Abdullah WM,Mikhail M,Milne E,Hirayama K,Huy NT

更新日期：2017-11-22 00:00:00

abstract：:Mutations in the SNX14 gene cause spinocerebellar ataxia, autosomal recessive 20 (SCAR20) in both humans and dogs. Studies implicating the phenotypic consequences of SNX14 mutations to be consequences of subcellular disruption to autophagy and lipid metabolism have been limited to in vitro investigation of patient-der...

journal_title：Scientific reports

authors： Bryant D,Seda M,Peskett E,Maurer C,Pomeranz G,Ghosh M,Hawkins TA,Cleak J,Datta S,Hariri H,Eckert KM,Jafree DJ,Walsh C,Demetriou C,Ishida M,Alemán-Charlet C,Vestito L,Seselgyte R,McDonald JG,Bitner-Glindzicz M,Hemb

更新日期：2020-08-13 00:00:00

abstract：:Cinnabar is a natural mercury sulfide (HgS) mineral of volcanic or hydrothermal origin that is found worldwide. It has been mined prehistorically and historically in China, Japan, Europe, and the Americas to extract metallic mercury (Hg(0)) for use in metallurgy, as a medicinal, a preservative, and as a red pigment fo...

journal_title：Scientific reports

authors： Emslie SD,Brasso R,Patterson WP,Carlos Valera A,McKenzie A,Maria Silva A,Gleason JD,Blum JD

更新日期：2015-10-01 00:00:00

abstract：:Solute segregating to grain boundary can stabilize the microstructure of nanocrystalline materials, but a lot of solutes also cause embrittlement effect on interfacial strength. Therefore, uncovering the solute effect on grain boundary strength is very important for nanocrystalline alloys design. In this work, we have...

journal_title：Scientific reports

authors： Huang Z,Wang P,Chen F,Shen Q,Zhang L

更新日期：2020-10-08 00:00:00

abstract：:Toll-like receptor 9 (TLR9) is crucial to the host immune response against fungi, such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, but its importance in Cryptococcus gattii infection is unknown. Our study aimed to understand the role of TLR9 during the course of experimental C. gattii infec...

journal_title：Scientific reports

authors： da Silva-Junior EB,Firmino-Cruz L,Guimarães-de-Oliveira JC,De-Medeiros JVR,de Oliveira Nascimento D,Freire-de-Lima M,de Brito-Gitirana L,Morrot A,Previato JO,Mendonça-Previato L,Decote-Ricardo D,de Matos Guedes HL,Freire-de-Lima

更新日期：2021-01-14 00:00:00

abstract：:Temporal baselines are needed for biodiversity, in order for the change in biodiversity to be measured over time, the targets for biodiversity conservation to be defined and conservation progress to be evaluated. Limited biodiversity information is widely recognized as a major barrier for identifying temporal baseline...

journal_title：Scientific reports

authors： Mihoub JB,Henle K,Titeux N,Brotons L,Brummitt NA,Schmeller DS

更新日期：2017-01-30 00:00:00