Abstract：
:We propose a deep learning model - Probabilistic Prognostic Estimates of Survival in Metastatic Cancer Patients (PPES-Met) for estimating short-term life expectancy (>3 months) of the patients by analyzing free-text clinical notes in the electronic medical record, while maintaining the temporal visit sequence. In a single framework, we integrated semantic data mapping and neural embedding technique to produce a text processing method that extracts relevant information from heterogeneous types of clinical notes in an unsupervised manner, and we designed a recurrent neural network to model the temporal dependency of the patient visits. The model was trained on a large dataset (10,293 patients) and validated on a separated dataset (1818 patients). Our method achieved an area under the ROC curve (AUC) of 0.89. To provide explain-ability, we developed an interactive graphical tool that may improve physician understanding of the basis for the model's predictions. The high accuracy and explain-ability of the PPES-Met model may enable our model to be used as a decision support tool to personalize metastatic cancer treatment and provide valuable assistance to the physicians.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Banerjee I,Gensheimer MF,Wood DJ,Henry S,Aggarwal S,Chang DT,Rubin DLdoi
10.1038/s41598-018-27946-5subject
Has Abstractpub_date
2018-07-03 00:00:00pages
10037issue
1issn
2045-2322pii
10.1038/s41598-018-27946-5journal_volume
8pub_type
杂志文章abstract：:Ankle arthrodesis with the Ilizarov method is an accepted form of treatment of advanced degenerative changes of the ankle joint. Incorrect balance and load distribution on the lower limbs may result in pain and dysfunction. The aim of the study was to assess the change of balance and load distribution in lower extremi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34016-3
更新日期：2018-10-24 00:00:00
abstract：:Epitope characterization is critical for elucidating the mechanism of action of drug candidates. However, traditional high-resolution epitope mapping techniques are not well suited for screening numerous drug candidates recognizing a similar target. Here, we use Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41179-0
更新日期：2019-03-18 00:00:00
abstract：:Application of acute kidney injury (AKI) biomarkers with consideration of nonrenal conditions and systemic severity has not been sufficiently determined. Herein, urinary neutrophil gelatinase-associated lipocalin (NGAL), L-type fatty acid-binding protein (L-FABP) and nonrenal disorders, including inflammation, hypoper...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33077
更新日期：2016-09-08 00:00:00
abstract：:Materials' mechanical properties highly depend on their internal structures. Designing novel structure is an effective route to improve materials' performance. One-dimensional disordered (ODD) structure is a kind of particular structure in silicon carbide (SiC), which highly affects its mechanical properties. Herein, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67652-9
更新日期：2020-07-09 00:00:00
abstract：:The estrogen receptor (ER) regulates the survival and growth of breast cancer cells, but it is less clear how components of the tissue microenvironment affect ER-mediated responses. We set out to test how human mammary fibroblasts (HMFs) modulate ER signaling and downstream cellular responses. We exposed an organotypi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25461-1
更新日期：2018-05-08 00:00:00
abstract：:Dirt and microorganisms are the major problems in textiles which can generate unpleasant odor during their growth. Here, zinc oxide (ZnO) nanoparticles prepared by sol-gel method were loaded on the cotton fabrics using spin coating technique to enhance their antimicrobial properties and water repellency. The effects o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22324-7
更新日期：2018-03-02 00:00:00
abstract：:Toll-like receptors (TLRs) play a key role in innate and adaptive immunity, protecting the host from viral pathogens. We studied the effect of TLR7 polymorphisms on disease susceptibility and progression of chronic hepatitis B (CHB) infection in Chinese adults. Blood samples were taken from 612 patients with confirmed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12698-5
更新日期：2017-09-29 00:00:00
abstract：:Gut microbiota dysbiosis features progressive HIV infection and is a potential target for intervention. Herein, we explored the microbiome of 16 elite controllers (EC), 32 antiretroviral therapy naive progressors and 16 HIV negative controls. We found that the number of observed genera and richness indices in fecal mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06675-1
更新日期：2017-07-24 00:00:00
abstract：:A previous randomized, controlled trial had demonstrated that complete intraureteral stent placement (CIU-SP) was superior to conventional stent placement (C-SP) in terms of improvement of stent-related urinary symptoms. However, it is unclear as to which subdomain symptom and cohort could benefit the most from CIU-SP...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-72937-0
更新日期：2020-09-28 00:00:00
abstract：:The freshwater crustacean Daphnia is known for its ability to develop inducible morphological defences that thwart predators. These defences are developed only in the presence of predators and are realized as morphological shape alterations e.g. 'neckteeth' in D. pulex and 'crests' in D. longicephala. Both are discuss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09649-5
更新日期：2017-08-29 00:00:00
abstract：:A paper-based upconversion fluorescence resonance energy transfer assay device is proposed for sensitive detection of CEA. The device is fabricated on a normal filter paper with simple nano-printing method. Upconversion nanoparticles tagged with specific antibodies are printed to the test zones on the test paper, foll...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23406
更新日期：2016-03-22 00:00:00
abstract：:Bumblebees are exposed to pesticides applied for crop protection while foraging on treated plants, with increasing evidence suggesting that this sublethal exposure has implications for pollinator declines. The challenges of navigating and learning to manipulate many different flowers underline the critical role learni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16508
更新日期：2015-11-16 00:00:00
abstract：:The synthesis of ordered monolayers of gold nano-urchin (Au-NU) nanostructures with controlled size, directly on thin films using a simple electrochemical method is reported in this study. In order to demonstrate one of the vast potential applications, the developed Au-NUs were formed on the electrodes of transducers ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24625
更新日期：2016-04-19 00:00:00
abstract：:Rett syndrome (RTT) is a neurodevelopmental disorder mainly caused by mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding protein 2 (MeCP2), located on the X chromosome. Many RTT patients have breathing abnormalities, such as apnea and breathing irregularity, and respiratory infection is th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12293-8
更新日期：2017-09-20 00:00:00
abstract：:Suffering from giant size of objective lenses and infeasible manipulations of distant targets, telescopes could not seek helps from present super-resolution imaging, such as scanning near-field optical microscopy, perfect lens and stimulated emission depletion microscopy. In this paper, local light diffraction shrinka...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18485
更新日期：2015-12-18 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is a common health problem during pregnancy and its prevalence is increasing globally, especially in China. The aim of this study was to investigate socioeconomic, environmental and lifestyle factors associated with GDM in Chinese women. A matched pair case-control study was conduct...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26412-6
更新日期：2018-05-25 00:00:00
abstract：:Parkinson's disease (PD) is an incapacitating neurodegenerative disease. Patients with PD and their caregivers may have interactive effects on each other's psychological well-being. This study aimed to assess the dyadic dynamics of resilience, fatigue, and suicidal ideation on the depression severity of PD patients an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79609-z
更新日期：2021-01-13 00:00:00
abstract：:New clinical trials for diabetic macular oedema (DMO) are being designed to prove superiority over aflibercept when this agent is already very effective in improving visual acuity (VA) and DMO. The aim of this study was to determine the optimal inclusion-exclusion criteria for trials to aim for superiority in visual o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73571-6
更新日期：2020-10-05 00:00:00
abstract：:A fundamental task in cancer research aims at the identification of new pharmacological therapies that can affect tumor growth. Differentiation therapy might exploit this function not only for hematological diseases, such as acute promyelocytic leukemia (APML) but also for epithelial tumors, including lung cancer. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05047-z
更新日期：2017-07-06 00:00:00
abstract：:An enormous amount of tumor sequencing data has been generated through large scale sequencing efforts. The functional consequences of the majority of mutations identified by such projects remain an open, unexplored question. This problem is particularly complicated in the case of rare mutations where frequency of occu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38968
更新日期：2016-12-16 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-21306-z
更新日期：2018-03-06 00:00:00
abstract：:Few studies focused on the residue of thiamethoxam and its metabolite clothianidin on strawberry where it is widely used, despite this is essential to assess the potential food risk of thiamethoxam and its main metabolite clothianidin. In this study, the dissipation of thiamethoxam and its metabolite clothianidin duri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33334-w
更新日期：2018-10-15 00:00:00
abstract：:Carotenoids are anti-oxidative agents. Human skin and eyes contain specific carotenoid species known to prevent various pathologies caused by oxidative stress. We quantified skin and eye carotenoid levels and investigated their potential correlation in a population including 985 Japanese patients and staff members of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45751-6
更新日期：2019-06-27 00:00:00
abstract：:Trophic variation in food web structure occurs among and within ecosystems. The magnitude of variation, however, differs from system to system. In ephemeral pond ecosystems, temporal dynamics are relatively more important than in many systems given that hydroperiod is the ultimate factor determining the presence of an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08026-6
更新日期：2017-08-08 00:00:00
abstract：:New Delhi metallo-β-lactamase (NDM) had been reported to be the predominant carbapenemase among Escherichia coli in Taiwan. However, studies focusing on the clonal background and epidemiology of plasmids carrying NDM genes were limited. Between 2016 and 2018, all clinical E. coli and Klebsiella pneumoniae isolates tha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82166-8
更新日期：2021-01-28 00:00:00
abstract：:InGaN light emitting diodes (LED) structure with an embedded 1/4λ-stack nanoporous-GaN/undoped-GaN distributed Bragg reflectors (DBR) structure have been demonstrated. Si-heavily doped GaN epitaxial layers (n(+)-GaN) in the 12-period n(+)-GaN/u-GaN stack structure are transformed into low refractive index nanoporous G...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29138
更新日期：2016-07-01 00:00:00
abstract：:Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have recently been extensively researched as potential therapeutic agents against var...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52609-4
更新日期：2019-11-07 00:00:00
abstract：:Higher and lower levels of alertness typically lead to a leftward and rightward bias in attention, respectively. This relationship between alertness and spatial attention potentially has major implications for health and safety. The current study examined alertness and spatial attention under simulated shiftworking co...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-71800-6
更新日期：2020-09-11 00:00:00
abstract：:In the last forty years therapy outcomes for depression have remained the same with approximately 50% of patients responding to treatments. Advances are urgently required. We hypothesised that a recent treatment, metacognitive therapy (MCT), might be more effective, by targeting mental control processes that directly ...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-64577-1
更新日期：2020-05-12 00:00:00
abstract：:Therizinosaurian theropods evolved many highly specialized osteological features in association with their bulky proportions, which were unusual in the context of the generally gracile Theropoda. Here we report a new therizinosaur, Lingyuanosaurus sihedangensis gen. et sp. nov., based on a specimen recovered from the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41560-z
更新日期：2019-03-22 00:00:00
