Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS.

abstract：:The arbitrary control of the polarization states of light has attracted the interest of the scientific community because of the wide range of modern optical applications that such control can afford. However, conventional polarization control setups are bulky and very often operate only within a narrow wavelength rang...

journal_title：Scientific reports

authors： Li Z,Liu W,Cheng H,Chen S,Tian J

更新日期：2015-12-15 00:00:00

abstract：:We present experimental evidence for scale invariant behaviour of the excitation spectrum in phase-fluctuating quasi-1d Bose gases after a rapid change of the external trapping potential. Probing density correlations in free expansion, we find that the temperature of an initial thermal state scales with the spatial ex...

journal_title：Scientific reports

authors： Rohringer W,Fischer D,Steiner F,Mazets IE,Schmiedmayer J,Trupke M

更新日期：2015-04-13 00:00:00

abstract：:Treatment of both-column fractures with posterior wall involvement is still a controversial topic. This type of posterior wall fracture is different from isolated acetabular posterior wall fracture (AO/OTA62-A1). The aim of this study is to compare the morphology of the posterior wall fragments of these two fracture p...

journal_title：Scientific reports

authors： Tian S,Chen Y,Yin Y,Zhang R,Hou Z,Zhang Y

更新日期：2019-12-27 00:00:00

abstract：:Currently, the arguments have existed in the strengthening mechanism and microstructural model of the nanocomposite film due to lack of the convincible experimental evidences. In this investigation, the quarternary TiSiCN nanocomposite films with the different C and Si contents are synthesized by the reactive-magnetro...

journal_title：Scientific reports

authors： Li W,Liu P,Xue Z,Ma F,Zhang K,Chen X,Feng R,Liaw PK

更新日期：2017-05-18 00:00:00

abstract：:The Brazilian Urban Mobility Policy integrates urban transport with traffic planning, establishing appropriate public policies that indicate the need for a safe and accessible public transport system. The major challenge is the inclusion of the elderly and people with disabilities. In this paper, we quantify the impac...

journal_title：Scientific reports

authors： Azevedo GA,Sampaio RR,Filho ASN,Moret MA,Murari TB

更新日期：2021-01-12 00:00:00

abstract：:Using the universal structure predictor algorithm, we proposed that two-dimensional MnB structures with p4mmm (α-MnB) and pmma (β-MnB) symmetries could be synthesized. This finding was verified by calculating the dynamical stability, molecular dynamics, and mechanical properties. The α-MnB had an in-plane stiffness Y ...

journal_title：Scientific reports

authors： Farooq MU,Hashmi A,Khan I,Hong J

更新日期：2017-12-06 00:00:00

abstract：:Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered. The primary purpose of this study was to determine the prognosis of AALA in critically ill patients and the second aim was to determine whether the survival was associated to the p...

journal_title：Scientific reports

authors： Yang CC,Chan KS,Tseng KL,Weng SF

更新日期：2016-10-17 00:00:00

abstract：:Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation. Here, we examine cross-regulation and combined functions of the tw...

journal_title：Scientific reports

authors： Staudacher JJ,Bauer J,Jana A,Tian J,Carroll T,Mancinelli G,Özden Ö,Krett N,Guzman G,Kerr D,Grippo P,Jung B

更新日期：2017-07-17 00:00:00

abstract：:Among atrial fibrillation (AF) patients, Danish nationwide registries (2011-2015) were used to examine temporal trends of initiation patterns of oral anticoagulation (OAC) treatment according to age. Overall, 43,299 AF patients initiating vitamin K antagonists (VKA) (42%), dabigatran (29%), rivaroxaban (13%), or apixa...

journal_title：Scientific reports

authors： Staerk L,Fosbøl EL,Gadsbøll K,Sindet-Pedersen C,Pallisgaard JL,Lamberts M,Lip GY,Torp-Pedersen C,Gislason GH,Olesen JB

更新日期：2016-08-11 00:00:00

abstract：:Geometric frustration, in which competing interactions give rise to degenerate ground states, potentially induces various exotic quantum phenomena in magnetic materials. Minimal models comprising triangular units, such as triangular and Kagome lattices, have been investigated for decades to realize novel quantum phase...

journal_title：Scientific reports

authors： Yamaguchi H,Okubo T,Kittaka S,Sakakibara T,Araki K,Iwase K,Amaya N,Ono T,Hosokoshi Y

更新日期：2015-10-15 00:00:00

abstract：:Spliced leader dependent trans-splicing (SLTS) has been described as an important RNA regulatory process that occurs in different organisms, including the trematode Schistosoma mansoni. We identified more than seven thousand putative SLTS sites in the parasite, comprising genes with a wide spectrum of functional class...

journal_title：Scientific reports

authors： Boroni M,Sammeth M,Gava SG,Jorge NAN,Macedo AM,Machado CR,Mourão MM,Franco GR

更新日期：2018-03-01 00:00:00

abstract：:Atomic force microscopy is used to conduct single-asperity friction measurements at a water-graphite interface. Local mapping of the frictional force, which is based on the degree of the cantilever twisting, shows nearly friction-free when a tip scans over a nanobubble. Surprisingly, apart from being gapless, the asso...

journal_title：Scientific reports

authors： Yang CW,Leung KT,Ding RF,Ko HC,Lu YH,Fang CK,Hwang IS

更新日期：2018-02-15 00:00:00

abstract：:Future climate change has the potential to alter the distribution and prevalence of plant pathogens, which may have significant implications for both agricultural crops and natural plant communities. However, there are few long-term datasets against which modelled predictions of pathogen responses to climate change ca...

journal_title：Scientific reports

authors： Wood JR,Díaz FP,Latorre C,Wilmshurst JM,Burge OR,Gutiérrez RA

更新日期：2018-11-21 00:00:00

abstract：:Tacrolimus has a narrow therapeutic window and considerable variability in clinical use. Our goal was to compare the performance of multiple linear regression (MLR) and eight machine learning techniques in pharmacogenetic algorithm-based prediction of tacrolimus stable dose (TSD) in a large Chinese cohort. A total of ...

journal_title：Scientific reports

authors： Tang J,Liu R,Zhang YL,Liu MZ,Hu YF,Shao MJ,Zhu LJ,Xin HW,Feng GW,Shang WJ,Meng XG,Zhang LR,Ming YZ,Zhang W

更新日期：2017-02-08 00:00:00

abstract：:BEST1 is a Ca2+-activated Cl- channel predominantly expressed in retinal pigment epithelium (RPE), and over 250 genetic mutations in the BEST1 gene have been identified to cause retinal degenerative disorders generally known as bestrophinopathies. As most BEST1 mutations are autosomal dominant, it is of great biomedic...

journal_title：Scientific reports

authors： Ji C,Li Y,Kittredge A,Hopiavuori A,Ward N,Yao P,Fukuda Y,Zhang Y,Tsang SH,Yang T

更新日期：2019-12-13 00:00:00

abstract：:We present a table-top beamline providing a soft X-ray supercontinuum extending up to 370 eV from high-order harmonic generation with sub-13 fs 1300 nm driving pulses and simultaneous production of sub-5 fs pulses centered at 800 nm. Optimization of high harmonic generation in a long and dense gas medium yields a phot...

journal_title：Scientific reports

authors： Barreau L,Ross AD,Garg S,Kraus PM,Neumark DM,Leone SR

更新日期：2020-04-01 00:00:00

abstract：:As an important online information retaining and processing function, working memory plays critical roles in many other cognitive functions. Several long-term factors, such as age, addiction and diseases, have been affirmed to impair working memory, but whether or how the short-term factors, like painful stimuli or em...

journal_title：Scientific reports

authors： Chen M,Wang YZ,Ma CC,Li QZ,Zhou H,Fu J,Yang QQ,Zhang YM,Liu Y,Cao JL

更新日期：2017-07-03 00:00:00

abstract：:Heterotrimeric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPCRs. However, some non-receptor proteins are also GEFs. GIV (a.k.a Girdin) was the first non-receptor protein for which the GEF activity was ascribed to a well-defined protein sequence that directly binds Gαi....

journal_title：Scientific reports

authors： DiGiacomo V,de Opakua AI,Papakonstantinou MP,Nguyen LT,Merino N,Blanco-Canosa JB,Blanco FJ,Garcia-Marcos M

更新日期：2017-08-17 00:00:00

abstract：:Quantum cryptography is set to become a key technology for future secure communications. However, to get maximum benefit in communication networks, transmission links will need to be shared among several quantum keys for several independent users. Such links will enable switching in quantum network nodes of the quantu...

journal_title：Scientific reports

authors： Bacco D,Ding Y,Dalgaard K,Rottwitt K,Oxenløwe LK

更新日期：2017-09-29 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) is a regulatory and cytoprotective neuropeptide, its deficiency implies accelerated aging in mice. It is present in the auditory system having antiapoptotic effects. Expression of Ca2+-binding proteins and its PAC1 receptor differs in the inner ear of PACAP-de...

journal_title：Scientific reports

authors： Fulop DB,Humli V,Szepesy J,Ott V,Reglodi D,Gaszner B,Nemeth A,Szirmai A,Tamas L,Hashimoto H,Zelles T,Tamas A

更新日期：2019-10-10 00:00:00

abstract：:Tobacco smoking is the major cause of many chronic diseases, especially lung cancer. Knowledge about population-wide tobacco use and exposure is essential to characterise its burden on public health and evaluate policy efficacy. Obtaining such knowledge remains challenging with current methods (e.g., surveys, biomonit...

journal_title：Scientific reports

authors： Lai FY,Lympousi K,Been F,Benaglia L,Udrisard R,Delémont O,Esseiva P,Thomaidis NS,Covaci A,van Nuijs ALN

更新日期：2018-09-05 00:00:00

abstract：:The incidence of resistant Candida isolates, especially Candida albicans, has increased continuously. To overcome the resistance, research on antifungal agent sensitizers has attracted considerable attention. Omeprazole and lansoprazole were found to inhibit the growth of sensitive C. albicans and hyphae formation in ...

journal_title：Scientific reports

authors： Lu M,Yan H,Yu C,Yuan L,Sun S

更新日期：2020-01-16 00:00:00

abstract：:An important safety concern on cell-based gene therapy is that few methods have been available to control the proliferation and functioning of therapeutic protein-expressing cells after transplantation. We previously reported that the proliferation and functioning of the cells transfected with herpes simplex virus thy...

journal_title：Scientific reports

authors： Tsujimura M,Kusamori K,Katsumi H,Sakane T,Yamamoto A,Nishikawa M

更新日期：2019-12-11 00:00:00

abstract：:Tyrosylprotein sulfotransferases (TPSTs) are enzymes that catalyze post-translational tyrosine sulfation of proteins. In humans, there are only two TPST isoforms, designated TPST1 and TPST2. In a previous study, we reported the crystal structure of TPST2, which revealed the catalytic mechanism of the tyrosine sulfatio...

journal_title：Scientific reports

authors： Tanaka S,Nishiyori T,Kojo H,Otsubo R,Tsuruta M,Kurogi K,Liu MC,Suiko M,Sakakibara Y,Kakuta Y

更新日期：2017-08-18 00:00:00

abstract：:Limited reference values exist for visceral adipose tissue (VAT) mass measured by DXA. The objectives of this study were to provide reference values for DXA-derived VAT mass and compare the association with anthropometry measures. The study cohort comprised 677 men and 738 women aged 18-65 years from Western Australia...

journal_title：Scientific reports

authors： Staynor JMD,Smith MK,Donnelly CJ,Sallam AE,Ackland TR

更新日期：2020-10-30 00:00:00

abstract：:Beneficial effects of CO2 on photosynthetic organisms will be a key driver of ecosystem change under ocean acidification. Predicting the responses of macroalgal species to ocean acidification is complex, but we demonstrate that the response of assemblages to elevated CO2 are correlated with inorganic carbon physiology...

journal_title：Scientific reports

authors： Cornwall CE,Revill AT,Hall-Spencer JM,Milazzo M,Raven JA,Hurd CL

更新日期：2017-04-18 00:00:00

abstract：:We show a coding method of suspension array based on the laser induced breakdown spectroscopy (LIBS), which promotes the barcodes from analog to digital. As the foundation of digital optical barcodes, nanocrystals encoded microspheres are prepared with self-assembly encapsulation method. We confirm that digital multip...

journal_title：Scientific reports

authors： He Q,Liu Y,He Y,Zhu L,Zhang Y,Shen Z

更新日期：2016-11-03 00:00:00

abstract：:There is emerging evidence that microRNAs (miRNAs) dysregulation is involved in the genesis and the progression of Prostate Cancer (PCa), thus potentially increasing their use in urological clinical practice. This is the first pilot study which utilizes Illumina Deep Sequencing to examine the entire miRNAs spectrum ex...

journal_title：Scientific reports

authors： Guelfi G,Cochetti G,Stefanetti V,Zampini D,Diverio S,Boni A,Mearini E

更新日期：2018-05-08 00:00:00

abstract：:Biological N2 fixation (BNF) in the rhizosphere of Podocarpaceae is currently attributed to unspecific diazotrophs with negligible impact on N acquisition. Here, we report specific and high associative BNF in dead cells of root nodules of Lepidothamnus fonkii distributed in ombrotrophic peatlands of Patagonia. BNF of ...

journal_title：Scientific reports

authors： Borken W,Horn MA,Geimer S,Aguilar NA,Knorr KH

更新日期：2016-12-15 00:00:00

abstract：:Because of the lack of cell wall, Micoplasma species require a fine control of membrane fluidity and integrity. mg517 is an essential gene of Mycoplasma genitalium responsible for the biosynthesis of membrane glycoglycerolipids. It encodes for a unique glycosyltransferase (MG517) with processive activity, transferring...

journal_title：Scientific reports

authors： Romero-García J,Biarnés X,Planas A

更新日期：2019-05-08 00:00:00