Abstract：
:Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have recently been extensively researched as potential therapeutic agents against various cancers. EgKI-1 is a potent Kunitz type protease inhibitor identified from the canine tapeworm Echinococcus granulosus that has shown anti-cancer activities in vivo. In this study we show that EgKI-1 significantly reduced the growth of melanoma in the B16-F0 mouse model and was not toxic to normal surrounding tissue. Moreover, EgKI-1 treatment significantly reduced survivin expression levels and increased the CD8+ T cell population in draining axillary lymph nodes. Therefore, EgKI-1 potentially reduces tumor growth by inducing apoptosis and modulating the tumor microenvironment, and has potential for development as an intra-lesional treatment for melanoma.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ranasinghe SL,Rivera V,Boyle GM,McManus DPdoi
10.1038/s41598-019-52609-4subject
Has Abstractpub_date
2019-11-07 00:00:00pages
16207issue
1issn
2045-2322pii
10.1038/s41598-019-52609-4journal_volume
9pub_type
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