Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression.

abstract：:Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to searc...

journal_title：Scientific reports

authors： Nowak JK,Grzybowska-Chlebowczyk U,Landowski P,Szaflarska-Poplawska A,Klincewicz B,Adamczak D,Banasiewicz T,Plawski A,Walkowiak J

更新日期：2014-04-24 00:00:00

abstract：:Owing to the diversity of pulse-wave morphology, pulse-based diagnosis is difficult, especially pulse-wave-pattern classification (PWPC). A powerful method for PWPC is a convolutional neural network (CNN). It outperforms conventional methods in pattern classification due to extracting informative abstraction and featu...

journal_title：Scientific reports

authors： Li G,Watanabe K,Anzai H,Song X,Qiao A,Ohta M

更新日期：2019-10-17 00:00:00

abstract：:Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escheric...

journal_title：Scientific reports

authors： Denkovskienė E,Paškevičius Š,Misiūnas A,Stočkūnaitė B,Starkevič U,Vitkauskienė A,Hahn-Löbmann S,Schulz S,Giritch A,Gleba Y,Ražanskienė A

更新日期：2019-10-28 00:00:00

abstract：:Fairly poor data are available on the relationship between taste perception, food preferences and oral microbiota. In the present study, we investigated the hypothesis that subjects with higher responsiveness to 6-n-propylthiuracil (PROP) might be characterized by a different taste sensitivity and tongue microbiota co...

journal_title：Scientific reports

authors： Cattaneo C,Gargari G,Koirala R,Laureati M,Riso P,Guglielmetti S,Pagliarini E

更新日期：2019-03-05 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK)-mediated phosphorylation cascade is a vital component of plant cellular signalling. Despite this, MAPK signalling cascade is less characterized in crop legumes. To fill this void, we present here a comprehensive phylogeny of MAPK kinases (MKKs) and MAPKs identified from 16 l...

journal_title：Scientific reports

authors： Purayannur S,Kumar K,Kaladhar VC,Verma PK

更新日期：2017-07-10 00:00:00

abstract：:Embryonic cryopreservation has a relatively low survival rate because of cytoskeletal damage. However, molecular anti-freezing mechanisms have been largely unexplored. This study investigated the significance of RhoA, involved in embryonic development, and the Rho/RhoA-associated kinase (ROCK) signalling pathway in cr...

journal_title：Scientific reports

authors： Gu M,Ni H,Sheng X,Pauciullo A,Liu Y,Guo Y

更新日期：2017-07-27 00:00:00

abstract：:Carbon coated TiO2 (TiO2@C) is fabricated by a convenient and green one-pot solvothermal method, in which ethylene glycol serve as both the reaction medium and carbon source without the addition of any other carbon additives. During the solvothermal process, ethylene glycol polymerize and coordinate with Ti4+ to form ...

journal_title：Scientific reports

authors： Tao H,Zhou M,Wang K,Cheng S,Jiang K

更新日期：2017-03-03 00:00:00

abstract：:Symbiodinium is a dinoflagellate that plays an important role in the physiology of the symbiotic relationships of Cnidarians such as corals and sea anemones. However, it is very difficult to cultivate free-living dinoflagellates after being isolated from the host, as they are very sensitive to environmental changes. H...

journal_title：Scientific reports

authors： Pasaribu B,Weng LC,Lin IP,Camargo E,Tzen JT,Tsai CH,Ho SL,Lin MR,Wang LH,Chen CS,Jiang PL

更新日期：2015-10-20 00:00:00

abstract：:Fear of predation can induce profound changes in the behaviour and physiology of prey species even if predator encounters are infrequent. For echolocating toothed whales, the use of sound to forage exposes them to detection by eavesdropping predators, but while some species exploit social defences or produce cryptic a...

journal_title：Scientific reports

authors： Aguilar de Soto N,Visser F,Tyack PL,Alcazar J,Ruxton G,Arranz P,Madsen PT,Johnson M

更新日期：2020-02-06 00:00:00

abstract：:Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...

journal_title：Scientific reports

authors： Tokuda H,Ito M,Sueyasu T,Sasaki H,Morita S,Kaneda Y,Rogi T,Kondo S,Kouzaki M,Tsukiura T,Shibata H

更新日期：2020-07-31 00:00:00

abstract：:Developmental changes in salamander skulls, before and after metamorphosis, affect the feeding capabilities of these animals. How changes in cranial morphology and tissue properties affect the function of the skull are key to decipher the early evolutionary history of the crown-group of salamanders. Here, 3D cranial b...

journal_title：Scientific reports

authors： Zhou Z,Fortuny J,Marcé-Nogué J,Skutschas PP

更新日期：2017-08-31 00:00:00

abstract：:Due to distinct biological behavior of mucinous adenocarcinoma (MAC) and signet ring cell cancer (SRC), the efficacy of radiotherapy on long-term outcome for rectal cancer (RC) patients with mucinous tumors is still unclear. Here, we identified 1808 RC patients with MAC/SRC from Surveillance, Epidemiology, and End-Res...

journal_title：Scientific reports

authors： Guan X,Jia S,Chen W,Jiang Z,Liu Z,Chen Y,Wang G,Wang X

更新日期：2017-03-08 00:00:00

abstract：:Transcriptome diversity in adult neurons is partly mediated by RNA binding proteins (RBPs), including the RBFOX factors. RBFOX3/NeuN, a neuronal maturity marker, is strangely depleted in suprachiasmatic nucleus (SCN) neurons, and may be compensated by a change in Rbfox2 expression. In this study, we found no superfici...

journal_title：Scientific reports

authors： Partridge LMM,Carter DA

更新日期：2017-08-30 00:00:00

abstract：ABTRACT:Establishing a cure for HIV is hindered by the persistence of latently infected cells which constitute the viral reservoir. Real-time qPCR, used for quantification of this reservoir by measuring HIV DNA, requires external calibration; a common choice of calibrator is the 8E5 cell line, which is assumed to be st...

journal_title：Scientific reports

authors： Busby E,Whale AS,Ferns RB,Grant PR,Morley G,Campbell J,Foy CA,Nastouli E,Huggett JF,Garson JA

更新日期：2017-04-26 00:00:00

abstract：:Photoluminescence (PL) was used to estimate the concentration of carbon in GaN grown by hydride vapor phase epitaxy (HVPE). The PL data were compared with profiles of the impurities obtained from secondary ion mass spectrometry (SIMS) measurements. Comparison of PL and SIMS data has revealed that apparently high conce...

journal_title：Scientific reports

authors： Reshchikov MA,Vorobiov M,Andrieiev O,Ding K,Izyumskaya N,Avrutin V,Usikov A,Helava H,Makarov Y

更新日期：2020-02-10 00:00:00

abstract：:Network alignment (NA) compares networks with the goal of finding a node mapping that uncovers highly similar (conserved) network regions. Existing NA methods are homogeneous, i.e., they can deal only with networks containing nodes and edges of one type. Due to increasing amounts of heterogeneous network data with nod...

journal_title：Scientific reports

authors： Gu S,Johnson J,Faisal FE,Milenković T

更新日期：2018-08-21 00:00:00

abstract：:It is frequently assumed that in the limit of vanishing cooling rate, the glass transition phenomenon becomes a thermodynamic transition at a temperature TK. However, with any finite cooling rate, the system falls out of equilibrium at temperatures near Tg(>TK), implying that the very existence of the putative thermod...

journal_title：Scientific reports

authors： Chakrabarty S,Karmakar S,Dasgupta C

更新日期：2015-07-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Delplancke TDJ,de Seymour JV,Tong C,Sulek K,Xia Y,Zhang H,Han TL,Baker PN

更新日期：2020-02-21 00:00:00

abstract：:We previously developed red lettuce (Lactuca sativa L.) cultivars with high flavonoid and phenolic acid content and demonstrated their anti-diabetic effect. Here we report on developing three fertile and true-breeding lettuce lines enriched with flavonoids with reported beneficial health effects. These lines were iden...

journal_title：Scientific reports

authors： Gurdon C,Poulev A,Armas I,Satorov S,Tsai M,Raskin I

更新日期：2019-03-01 00:00:00

abstract：:Dysfunction of cortical GABAergic interneurons are involved in numerous neurological disorders including epilepsy, schizophrenia and autism; and replenishment of these cells by transplantation strategy has proven to be a feasible and effective method to help revert the symptoms in several animal models. To develop met...

journal_title：Scientific reports

authors： Wang Q,Hong P,Gao H,Chen Y,Yang Q,Jiang M,Li H

更新日期：2016-01-11 00:00:00

abstract：:Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, the multiple potential pharmacological actions o...

journal_title：Scientific reports

authors： Makino T,Izumi K,Hiratsuka K,Kano H,Shimada T,Nakano T,Kadomoto S,Naito R,Iwamoto H,Yaegashi H,Shigehara K,Kadono Y,Nakata H,Saito Y,Nakagawa-Goto K,Sakai N,Iwata Y,Wada T,Mizokami A

更新日期：2021-01-12 00:00:00

abstract：:Endoplasmic reticulum (ER) stress preconditioning protects cells against methylmercury (MeHg) cytotoxicity by inducing integrated stress responses such as eIF2α phosphorylation, ATF4 accumulation, and nonsense-mediated mRNA decay (NMD) suppression. Here we demonstrated that ER stress preconditioning results in the upr...

journal_title：Scientific reports

authors： Usuki F,Fujimura M,Yamashita A

更新日期：2017-09-28 00:00:00

abstract：:Amorphous thin films from Ge-As-Te system were prepared by pulsed laser deposition to study their intrinsic photostability, morphology, chemical composition, structure and optical properties. Photostability of fabricated layers was studied by spectroscopic ellipsometry within as-deposited as well as relaxed (annealed)...

journal_title：Scientific reports

authors： Hawlová P,Verger F,Nazabal V,Boidin R,Němec P

更新日期：2015-03-23 00:00:00

abstract：:Dendritic Cells (DCs) recognize infectious non-self molecules and engage the adaptive immune system thereby initiating long lasting, antigen-specific responses. As such, the ability to activate DCs is considered a key tool to enhance the efficacy and quality of vaccination. Here we report a novel immunomodulatory sulf...

journal_title：Scientific reports

authors： Manzo E,Cutignano A,Pagano D,Gallo C,Barra G,Nuzzo G,Sansone C,Ianora A,Urbanek K,Fenoglio D,Ferrera F,Bernardi C,Parodi A,Pasquale G,Leonardi A,Filaci G,De Palma R,Fontana A

更新日期：2017-07-24 00:00:00

abstract：:The formation of proper sensory afferent connections during development is essential for brain function. Activity-based competition is believed to drive ocular dominance columns (ODC) in mammals and in experimentally-generated three-eyed frogs. ODC formation is thus a compromise of activity differences between two eye...

journal_title：Scientific reports

authors： Elliott KL,Houston DW,Fritzsch B

更新日期：2015-02-09 00:00:00

abstract：:Glial fibrillary acidic protein expressing (GFAP+) glia modulate nociceptive neuronal activity in both the peripheral nervous system (PNS) and the central nervous system (CNS). Resident GFAP+ glia in dorsal root ganglia (DRG) known as satellite glial cells (SGCs) potentiate neuronal activity by releasing pro-inflammat...

journal_title：Scientific reports

authors： Xie AX,Madayag A,Minton SK,McCarthy KD,Malykhina AP

更新日期：2020-08-25 00:00:00

abstract：:Concurrent generation and mixing phenomenon of thermoacoustic (TA) and magnetoacoustic (MA) waves in water are predicted and observed. A theory unifying TA and MA is further put forward to analyze it. By scaling down the radio frequency in thermoacoustics to the low mega Hertz range and by incorporating appropriately ...

journal_title：Scientific reports

authors： Feng X,Gao F,Kishor R,Zheng Y

更新日期：2015-06-26 00:00:00

abstract：:Edible insects are often considered a nutritious, protein-rich, environmentally sustainable alternative to traditional livestock with growing popularity among North American consumers. While the nutrient composition of several insects is characterized, all potential health impacts have not been evaluated. In addition ...

journal_title：Scientific reports

authors： Stull VJ,Finer E,Bergmans RS,Febvre HP,Longhurst C,Manter DK,Patz JA,Weir TL

更新日期：2018-07-17 00:00:00

abstract：:Urban climate is determined by a variety of factors, whose knowledge can help to attenuate heat stress in the context of ongoing urbanization and climate change. We study the influence of city size and urban form on the Urban Heat Island (UHI) phenomenon in Europe and find a complex interplay between UHI intensity and...

journal_title：Scientific reports

authors： Zhou B,Rybski D,Kropp JP

更新日期：2017-07-06 00:00:00

abstract：:Multiple epidermal growth factor-like-domains 10 (MEGF10), a critical member of the apoptotic engulfment pathway, mediates axon pruning and synapse elimination during brain development. Previous studies indicated that synaptic pruning deficit was associated with autism-related phenotypes. However, the relationship bet...

journal_title：Scientific reports

authors： Wu Z,Qin J,You Y,Ma Y,Jia M,Wang L,Lu T,Yue W,Ruan Y,Zhang D,Li J,Wang L

更新日期：2017-05-23 00:00:00