Prevalence and correlates of vitamin K deficiency in children with inflammatory bowel disease.

Abstract:

:Although vitamin K deficiency has been implicated in adult inflammatory bowel disease (IBD), its prevalence in pediatric IBD remains unknown. We carried out a cross-sectional study in 63 children with Crohn's disease (CD) and 48 with ulcerative colitis (UC) to assess the prevalence of vitamin K deficiency and to search for potential correlation between vitamin K status and pediatric IBD activity. Vitamin K status was assessed using protein induced by vitamin K absence-II (PIVKA-II; ELISA). Prevalence of vitamin K deficiency was 54.0% in CD and 43.7% in UC. Vitamin K deficiency was more common in patients with higher CD activity, in CD patients with higher mass Z-scores, and less common among children with CD treated with infliximab. Relation of vitamin K deficiency to pediatric IBD clinical course and treatment demand further research.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Nowak JK,Grzybowska-Chlebowczyk U,Landowski P,Szaflarska-Poplawska A,Klincewicz B,Adamczak D,Banasiewicz T,Plawski A,Walkowiak J

doi

10.1038/srep04768

subject

Has Abstract

pub_date

2014-04-24 00:00:00

pages

4768

issn

2045-2322

pii

srep04768

journal_volume

4

pub_type

杂志文章
  • Mapping livestock movements in Sahelian Africa.

    abstract::In the dominant livestock systems of Sahelian countries herds have to move across territories. Their mobility is often a source of conflict with farmers in the areas crossed, and helps spread diseases such as Rift Valley Fever. Knowledge of the routes followed by herds is therefore core to guiding the implementation o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65132-8

    authors: Jahel C,Lenormand M,Seck I,Apolloni A,Toure I,Faye C,Sall B,Lo M,Diaw CS,Lancelot R,Coste C

    更新日期:2020-05-20 00:00:00

  • Determinants of Quantitative Optical Coherence Tomography Angiography Metrics in Patients with Diabetes.

    abstract::Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed and quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there is a paucity of data examining whether OCT-A metrics are ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02767-0

    authors: Tang FY,Ng DS,Lam A,Luk F,Wong R,Chan C,Mohamed S,Fong A,Lok J,Tso T,Lai F,Brelen M,Wong TY,Tham CC,Cheung CY

    更新日期:2017-05-31 00:00:00

  • Multiparty Quantum Key Agreement Based on Quantum Search Algorithm.

    abstract::Quantum key agreement is an important topic that the shared key must be negotiated equally by all participants, and any nontrivial subset of participants cannot fully determine the shared key. To date, the embed modes of subkey in all the previously proposed quantum key agreement protocols are based on either BB84 or ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45046

    authors: Cao H,Ma W

    更新日期:2017-03-23 00:00:00

  • Neuroadaptive modelling for generating images matching perceptual categories.

    abstract::Brain-computer interfaces enable active communication and execution of a pre-defined set of commands, such as typing a letter or moving a cursor. However, they have thus far not been able to infer more complex intentions or adapt more complex output based on brain signals. Here, we present neuroadaptive generative mod...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-71287-1

    authors: Kangassalo L,Spapé M,Ruotsalo T

    更新日期:2020-09-07 00:00:00

  • Active Terahertz Chiral Metamaterials Based on Phase Transition of Vanadium Dioxide (VO2).

    abstract::Compared with natural materials, chiral metamaterials have been demonstrated with orders of magnitude stronger chiroptical response, which provides the basis for applications such as ultracompact polarization components and plasmonic-enhanced biosensing. Terahertz chiral metamaterials that allow dynamic polarization c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18472-x

    authors: Wang S,Kang L,Werner DH

    更新日期:2018-01-09 00:00:00

  • Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress.

    abstract::Pterostilbene (PT), the natural dimethylated analog of resveratrol (RSV), is a potent anticarcinogen for non-small-cell lung cancer (NSCLC), but its anti-NSCLC mechanisms remain unclear. In this study, we show that PT treatment time- and dose-dependently enhanced the endoplasmic reticulum stress (ERS) signaling (i.e.,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08547-0

    authors: Ma Z,Yang Y,Di S,Feng X,Liu D,Jiang S,Hu W,Qin Z,Li Y,Lv J,Fan C,Yan X,Li X

    更新日期:2017-08-14 00:00:00

  • Long-term follow-up of therapeutic ERCP in 78 patients aged 90 years or older.

    abstract::This study aimed to determine the performance and long-term outcomes of therapeutic ERCP in very old patients. Patients aged or over 90 (Group A, n = 78) and consecutive sex-matched controls (Group B, n = 312) under 65 selected were compared. More patients in Group A had chronic concomitant diseases, but the success a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04918

    authors: Hu L,Sun X,Hao J,Xie T,Liu M,Xin L,Sun T,Liu M,Zou W,Ye B,Liu F,Wang D,Cao N,Liao Z,Li Z

    更新日期:2014-05-13 00:00:00

  • A negative covariation between toxoplasmosis and CoVID-19 with alternative interpretations.

    abstract::Coronaviruses may exert severely negative effects on the mortality and morbidity of birds and mammals including humans and domestic animals. Most recently CoVID-19 has killed about half million people (27th of June, 2020). Susceptibility to this disease appears to differ markedly across different societies but the fac...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69351-x

    authors: Jankowiak Ł,Rozsa L,Tryjanowski P,Møller AP

    更新日期:2020-07-27 00:00:00

  • Epidemiology Investigation of stroke among Mongolian and Han population aged over 45 in Inner Mongolia.

    abstract::To discuss the status of epidemiology of stroke in the Mongolian and Han population aged over 45 years and to understand the treatment and prevention of stroke. Data collected on stroke populations aged over 45 years in the six areas in Inner Mongolia were analyzed by using stratified multi-stage cluster sampling. The...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45710

    authors: Zhang C,Lan T,Zhe Y,Hu B,Zhang G,He J,Wang Z,Jiang M,Hu R

    更新日期:2017-04-04 00:00:00

  • Uncovering representations of sleep-associated hippocampal ensemble spike activity.

    abstract::Pyramidal neurons in the rodent hippocampus exhibit spatial tuning during spatial navigation, and they are reactivated in specific temporal order during sharp-wave ripples observed in quiet wakefulness or slow wave sleep. However, analyzing representations of sleep-associated hippocampal ensemble spike activity remain...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32193

    authors: Chen Z,Grosmark AD,Penagos H,Wilson MA

    更新日期:2016-08-30 00:00:00

  • Surface-plasmon-enhanced deep-UV light emitting diodes based on AlGaN multi-quantum wells.

    abstract::We report the development of complete structural AlGaN-based deep-ultraviolet light-emitting diodes with an aluminum thin layer for increasing light extraction efficiency. A 217% enhancement in peak photoluminescence intensity at 294 nm is observed. Cathodoluminescence measurement demonstrates that the internal quantu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00816

    authors: Gao N,Huang K,Li J,Li S,Yang X,Kang J

    更新日期:2012-01-01 00:00:00

  • Possible existence of optical communication channels in the brain.

    abstract::Given that many fundamental questions in neuroscience are still open, it seems pertinent to explore whether the brain might use other physical modalities than the ones that have been discovered so far. In particular it is well established that neurons can emit photons, which prompts the question whether these biophoto...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36508

    authors: Kumar S,Boone K,Tuszyński J,Barclay P,Simon C

    更新日期:2016-11-07 00:00:00

  • Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine.

    abstract::Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of DG and venlafaxine (VLX) in a chronic social defeat stress model...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10391-1

    authors: Bai S,Zhang X,Chen Z,Wang W,Hu Q,Liang Z,Shen P,Gui S,Zeng L,Liu Z,Chen J,Xie X,Huang H,Han Y,Wang H,Xie P

    更新日期:2017-08-29 00:00:00

  • Effect of non-linearity of a predictor on the shape and magnitude of its receiver-operating-characteristic curve in predicting a binary outcome.

    abstract::Area under a receiver-operating-characteristic (AUROC) curve is widely used in medicine to summarize the ability of a continuous predictive marker to predict a binary outcome. This study illustrated how a U-shaped or inverted U-shaped continuous predictor would affect the shape and magnitude of its AUROC curve in pred...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10408-9

    authors: Ho KM

    更新日期:2017-08-31 00:00:00

  • Author Correction: Some coral diseases track climate oscillations in the Caribbean.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-23087-x

    authors: Randall CJ,van Woesik R

    更新日期:2018-03-19 00:00:00

  • Generation of femtosecond γ-ray bursts stimulated by laser-driven hosing evolution.

    abstract::The promising ability of a plasma wiggler based on laser wakefield acceleration to produce betatron X-rays with photon energies of a few keV to hundreds of keV and a peak brilliance of 10(22)-10(23) photons/s/mm(2)/mrad(2)/0.1%BW has been demonstrated, providing an alternative to large-scale synchrotron light sources....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30491

    authors: Ma Y,Chen L,Li D,Yan W,Huang K,Chen M,Sheng Z,Nakajima K,Tajima T,Zhang J

    更新日期:2016-07-26 00:00:00

  • Exploring simvastatin, an antihyperlipidemic drug, as a potential topical antibacterial agent.

    abstract::The rapid rise of bacterial resistance to traditional antibiotics combined with the decline in discovery of novel antibacterial agents has created a global public health crisis. Repurposing existing drugs presents an alternative strategy to potentially expedite the discovery of new antimicrobial drugs. The present stu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep16407

    authors: Thangamani S,Mohammad H,Abushahba MF,Hamed MI,Sobreira TJ,Hedrick VE,Paul LN,Seleem MN

    更新日期:2015-11-10 00:00:00

  • Isolation, Purification, and Characterization of Heparinase from Streptomyces variabilis MTCC 12266.

    abstract::Arterial/venous thrombosis is the major cardiovascular disorder accountable for substantial mortality; and the current demand for antithrombotic agents is extensive. Heparinases depolymerize unfractionated heparin (UFH) for the production of low molecular-weight heparins (LMWHs; used as anticoagulants against thrombos...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42740-7

    authors: Singh V,Haque S,Kumari V,El-Enshasy HA,Mishra BN,Somvanshi P,Tripathi CKM

    更新日期:2019-04-24 00:00:00

  • Automatic graphene transfer system for improved material quality and efficiency.

    abstract::In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible su...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep21676

    authors: Boscá A,Pedrós J,Martínez J,Palacios T,Calle F

    更新日期:2016-02-10 00:00:00

  • A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1.

    abstract::Ceramide, a bioactive lipid and signaling molecule associated with cardiovascular disease, is known to activate extracellular signal regulated kinases 1 and 2 (ERK1/2). Here, we determined that the effect of ceramide on ERK1/2 is mediated by ceramide signaling on an ERK scaffold protein, IQ motif containing GTPase act...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-09434-4

    authors: Vetterkind S,Lin QQ,Morgan KG

    更新日期:2017-08-24 00:00:00

  • The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair.

    abstract::Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell adhesion molecule (NCAM). Several studies have shown that it is important for correct formation of brain circuitries during development and for synaptic plasticity, learning and memory in the adult. PSA also plays a major rol...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26927

    authors: Saini V,Lutz D,Kataria H,Kaur G,Schachner M,Loers G

    更新日期:2016-06-21 00:00:00

  • Pathogenic lineage of Perkinsea associated with mass mortality of frogs across the United States.

    abstract::Emerging infectious diseases such as chytridiomycosis and ranavirus infections are important contributors to the worldwide decline of amphibian populations. We reviewed data on 247 anuran mortality events in 43 States of the United States from 1999-2015. Our findings suggest that a severe infectious disease of tadpole...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10456-1

    authors: Isidoro-Ayza M,Lorch JM,Grear DA,Winzeler M,Calhoun DL,Barichivich WJ

    更新日期:2017-08-31 00:00:00

  • Morphological landscape of endothelial cell networks reveals a functional role of glutamate receptors in angiogenesis.

    abstract::Angiogenesis plays a key role in several diseases including cancer, ischemic vascular disease, and Alzheimer's disease. Chemical genetic screening of endothelial tube formation provides a robust approach for identifying signalling components that impact microvascular network morphology as well as endothelial cell biol...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70440-0

    authors: Sailem HZ,Al Haj Zen A

    更新日期:2020-08-14 00:00:00

  • Real-time Kinematic Positioning of INS Tightly Aided Multi-GNSS Ionospheric Constrained PPP.

    abstract::Real-time Precise Point Positioning (PPP) technique is being widely applied for providing precise positioning services with the significant improvement on satellite precise products accuracy. With the rapid development of the multi-constellation Global Navigation Satellite Systems (multi-GNSS), currently, about 80 nav...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30488

    authors: Gao Z,Shen W,Zhang H,Niu X,Ge M

    更新日期:2016-07-29 00:00:00

  • Magma transport in sheet intrusions of the Alnö carbonatite complex, central Sweden.

    abstract::Magma transport through the Earth's crust occurs dominantly via sheet intrusions, such as dykes and cone-sheets, and is fundamental to crustal evolution, volcanic eruptions and geochemical element cycling. However, reliable methods to reconstruct flow direction in solidified sheet intrusions have proved elusive. Aniso...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27635

    authors: Andersson M,Almqvist BS,Burchardt S,Troll VR,Malehmir A,Snowball I,Kübler L

    更新日期:2016-06-10 00:00:00

  • KvN mechanics approach to the time-dependent frequency harmonic oscillator.

    abstract::Using the Ermakov-Lewis invariants appearing in KvN mechanics, the time-dependent frequency harmonic oscillator is studied. The analysis builds upon the operational dynamical model, from which it is possible to infer quantum or classical dynamics; thus, the mathematical structure governing the evolution will be the sa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26759-w

    authors: Ramos-Prieto I,Urzúa-Pineda AR,Soto-Eguibar F,Moya-Cessa HM

    更新日期:2018-05-30 00:00:00

  • Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines.

    abstract::Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines with different responses to NDV, Fayoumi and Leghorn, were challenged with LaSota N...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19754-8

    authors: Zhang J,Kaiser MG,Deist MS,Gallardo RA,Bunn DA,Kelly TR,Dekkers JCM,Zhou H,Lamont SJ

    更新日期:2018-01-19 00:00:00

  • Wild chimpanzees show group differences in selection of agricultural crops.

    abstract::The ability of wild animals to respond flexibly to anthropogenic environmental changes, including agriculture, is critical to survival in human-impacted habitats. Understanding use of human foods by wildlife can shed light on the acquisition of novel feeding habits and how animals respond to human-driven land-use chan...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05956

    authors: McLennan MR,Hockings KJ

    更新日期:2014-08-05 00:00:00

  • Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin.

    abstract::Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46060

    authors: Xu Y,Wang S,Chan HF,Lu H,Lin Z,He C,Chen M

    更新日期:2017-04-24 00:00:00

  • Neuro-inflammatory effects of photodegradative products of bilirubin.

    abstract::Phototherapy was introduced in the early 1950's, and is the primary treatment of severe neonatal jaundice or Crigler-Najjar syndrome. Nevertheless, the potential biological effects of the products generated from the photodegradation of bilirubin during phototherapy remain unknown. This is very relevant in light of rec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-25684-2

    authors: Jašprová J,Dal Ben M,Hurný D,Hwang S,Žížalová K,Kotek J,Wong RJ,Stevenson DK,Gazzin S,Tiribelli C,Vítek L

    更新日期:2018-05-10 00:00:00