Long-term Effect of Radiotherapy in Rectal Cancer Patients with Mucinous Tumor: A Large Population Based Study.

abstract：:Wave retarders having spatially varying optical axes orientations, called q-plates are extremely efficient devices for converting spin to orbital angular momentum of light and for the generation of optical vortices. Most often, these plates are designed for a specific wavelength and have a homogeneous constant retarda...

journal_title：Scientific reports

authors： B R,Kadiri G,Raghavan G

更新日期：2019-08-15 00:00:00

abstract：:Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it als...

journal_title：Scientific reports

authors： Law BY,Chan WK,Xu SW,Wang JR,Bai LP,Liu L,Wong VK

更新日期：2014-07-01 00:00:00

abstract：:Subcutaneous white adipose tissue (scWAT) is the major fat depot in humans and is a central player in regulating whole body metabolism. Skin exposure to UV wavelengths from sunlight is required for Vitamin D synthesis and pigmentation, although it is plausible that longer visible wavelengths that penetrate the skin ma...

journal_title：Scientific reports

authors： Ondrusova K,Fatehi M,Barr A,Czarnecka Z,Long W,Suzuki K,Campbell S,Philippaert K,Hubert M,Tredget E,Kwan P,Touret N,Wabitsch M,Lee KY,Light PE

更新日期：2017-11-27 00:00:00

abstract：:Multigene expression signatures provide a molecular subdivision of early breast cancer associated with patient outcome. A gap remains in the validation of such signatures in clinical treatment groups of patients within population-based cohorts of unselected primary breast cancer representing contemporary disease stage...

journal_title：Scientific reports

authors： Vallon-Christersson J,Häkkinen J,Hegardt C,Saal LH,Larsson C,Ehinger A,Lindman H,Olofsson H,Sjöblom T,Wärnberg F,Ryden L,Loman N,Malmberg M,Borg Å,Staaf J

更新日期：2019-08-21 00:00:00

abstract：:Lack of effective anti-metastatic drugs creates a major hurdle for metastatic lung cancer therapy. For successful lung cancer treatment, there is a strong need of newer therapeutics with metastasis-inhibitory potential. In the present study, we determined the anti-metastatic and anti-angiogenic potential of a natural ...

journal_title：Scientific reports

authors： Shukla S,Sinha S,Khan S,Kumar S,Singh K,Mitra K,Maurya R,Meeran SM

更新日期：2016-02-24 00:00:00

abstract：:Adipocytes play a central role in maintaining metabolic homeostasis in the body. Differentiation of adipocyte precursor cells requires the transcriptional activity of peroxisome proliferator-activated receptor-γ (Pparγ) and CCAAT/enhancer binding proteins (C/Ebps). Transcriptional activity is regulated by signaling mo...

journal_title：Scientific reports

authors： Cai K,El-Merahbi R,Loeffler M,Mayer AE,Sumara G

更新日期：2017-08-03 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a chronic disease, and dietary modification is a crucial part of disease management. Okara is a sustainable source of fibre-rich food. Most of the valorization research on okara focused more on the physical attributes instead of the possible health attributes. The fermentation of oka...

journal_title：Scientific reports

authors： Chan LY,Takahashi M,Lim PJ,Aoyama S,Makino S,Ferdinandus F,Ng SYC,Arai S,Fujita H,Tan HC,Shibata S,Lee CK

更新日期：2019-11-26 00:00:00

abstract：:We characterized an anti-cancer fusion protein consisting of anthrax lethal factor (LF) and the catalytic domain of Pseudomonas exotoxin A by (i) mutating the N-terminal amino acids and by (ii) reductive methylation to dimethylate all lysines. Dimethylation of lysines was achieved quantitatively and specifically witho...

journal_title：Scientific reports

authors： Bachran C,Gupta PK,Bachran S,Leysath CE,Hoover B,Fattah RJ,Leppla SH

更新日期：2014-04-23 00:00:00

abstract：:Organic nanofibers have found various applications in optoelectronic devices. In such devices, exciton diffusion is a major aspect concerning their efficiency. In the case of singlet excitons, Förster transfer is the mechanism responsible for this process. Temperature and morphology are factors known to influence exci...

journal_title：Scientific reports

authors： de Sousa LE,da Silva Filho DA,de Sousa RT Jr,de Oliveira Neto PH

更新日期：2018-09-19 00:00:00

abstract：:Honeybee pupae morphology can be affected by a number of stressor, but in vivo investigation is difficult. A computed tomography (CT) technique was applied to visualize a comb's inner structure without damaging the brood. The CT scan was performed on a brood comb containing pupae developed from eggs laid by the queen ...

journal_title：Scientific reports

authors： Facchini E,Nalon L,Andreis ME,Di Giancamillo M,Rizzi R,Mortarino M

更新日期：2019-07-23 00:00:00

abstract：:Parasites exhibiting a high degree of host specificity are expected to be intimately associated with their hosts. Therefore, the evolution of host-specific parasites is at least partially shaped by the evolutionary history and distribution of such hosts. Gill ectoparasites of Dactylogyrus (Monogenea) are specific to c...

journal_title：Scientific reports

authors： Benovics M,Desdevises Y,Vukić J,Šanda R,Šimková A

更新日期：2018-08-29 00:00:00

abstract：:Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...

journal_title：Scientific reports

authors： Alsaran H,Elkhadragy L,Shakya A,Long W

更新日期：2017-11-03 00:00:00

abstract：:Angulin-2/ILDR1 is a member of the angulin protein family, which is exclusively expressed at tricellular tight junctions in epithelia. Tricellular tight junctions are found where three cells meet and where three bicellular tight junction strands converge. Tricellular tight junctions are thought to be important for par...

journal_title：Scientific reports

authors： Hempstock W,Sugioka S,Ishizuka N,Sugawara T,Furuse M,Hayashi H

更新日期：2020-06-25 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that controls the cellular response to oxidative stress and possesses DNA-repair functions. It has important roles in the progression and outcomes of various diseases; however, its function and therapeutic prospects with respect to kidney injury ...

journal_title：Scientific reports

authors： Maruyama K,Nakagawa N,Aonuma T,Saito Y,Hayasaka T,Kano K,Horiuchi K,Takehara N,Kawabe JI,Hasebe N

更新日期：2019-05-24 00:00:00

abstract：:Functional interplays of microbial activity, genetic diversity and contaminant transformation are poorly understood in reactors for mineralizing halogenated aromatics anaerobically. Here, we investigated abundance and distribution of potential microbes and functional genes associated with pentachlorophenol (PCP) anaer...

journal_title：Scientific reports

authors： Li ZL,Nan J,Huang C,Liang B,Liu WZ,Cheng HY,Zhang C,Zhang D,Kong D,Kanamaru K,Kobayashi T,Wang AJ,Katayama A

更新日期：2016-01-11 00:00:00

abstract：:Cervical oesophageal cancer (CEC) is a relatively uncommon malignancy. The biological behaviour and treatment have not been well studied. This retrospective study reviewed the clinicopathological features of 28 patients with CEC who underwent surgical resection to investigate the biological behaviour, treatment and pr...

journal_title：Scientific reports

authors： Chen SB,Yang XH,Weng HR,Liu DT,Li H,Chen YP

更新日期：2017-06-12 00:00:00

abstract：:De novo protein sequencing is essential for understanding cellular processes that govern the function of living organisms and all sequence modifications that occur after a protein has been constructed from its corresponding DNA code. By obtaining the order of the amino acids that compose a given protein one can then d...

journal_title：Scientific reports

authors： Boynton P,Di Ventra M

更新日期：2016-05-03 00:00:00

abstract：:A variety of pathogenic bacteria infect host eukaryotic cells using protein toxins, which enter the cytosol and exert their cytotoxic effects. Anthrax lethal toxin, for example, utilizes the membrane-spanning translocase, protective antigen (PA) pore, to deliver the protein toxin lethal factor (LF) from the endosome i...

journal_title：Scientific reports

authors： Rabideau AE,Liao X,Akçay G,Pentelute BL

更新日期：2015-07-16 00:00:00

abstract：:Unmanned Aerial Systems (UAS) are increasingly being used recreationally, commercially and for wildlife research, but very few studies have quantified terrestrial mammalian reactions to UAS approaches. We used two Vertical Take-off and Landing (VTOL) UAS to approach seven herbivore species in the Moremi Game Reserve, ...

journal_title：Scientific reports

authors： Bennitt E,Bartlam-Brooks HLA,Hubel TY,Wilson AM

更新日期：2019-02-14 00:00:00

abstract：:Active methane seepage occurs congruent with a high density of up to 1 km-wide and 35 m deep seafloor craters (>100 craters within 700 km2 area) within lithified sedimentary rocks in the northern Barents Sea. The crater origin has been hypothesized to be related to rapid gas hydrate dissociation and methane release ar...

journal_title：Scientific reports

authors： Waage M,Serov P,Andreassen K,Waghorn KA,Bünz S

更新日期：2020-05-21 00:00:00

abstract：:Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinations against methicillin-resi...

journal_title：Scientific reports

authors： Xu X,Xu L,Yuan G,Wang Y,Qu Y,Zhou M

更新日期：2018-05-08 00:00:00

abstract：:Crotoxin B (CB) is a catalytically active group IIA sPLA2 from Crotalus durissus terrificus snake venom. In contrast to most GIIA sPLA2s, CB exhibits anti-inflammatory effects, including the ability to inhibit leukocyte functions. Lipid droplets (LDs) are lipid-rich organelles associated with inflammation and recogniz...

journal_title：Scientific reports

authors： Giannotti KC,Leiguez E,Carvalho AEZ,Nascimento NG,Matsubara MH,Fortes-Dias CL,Moreira V,Teixeira C

更新日期：2017-06-22 00:00:00

abstract：:Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-course changes of the c-miRNAs profiles in young males. The subjects (n = 45) were randomly divided into three...

journal_title：Scientific reports

authors： Cui S,Sun B,Yin X,Guo X,Chao D,Zhang C,Zhang CY,Chen X,Ma J

更新日期：2017-05-19 00:00:00

abstract：:Silver (Ag) is one of the seven metals of antiquity and an important engineering material in the electronic, medical, and chemical industries because of its unique noble and catalytic properties. Ag thin films are extensively used in modern electronics primarily because of their oxidation-resistance. Here we report a ...

journal_title：Scientific reports

authors： Lin SK,Nagao S,Yokoi E,Oh C,Zhang H,Liu YC,Lin SG,Suganuma K

更新日期：2016-10-05 00:00:00

abstract：:Manipulating the polarization states of electromagnetic (EM) waves, a fundamental issue in optics, attracted intensive attention recently. However, most of the devices realized so far are either too bulky in size, and/or are passive with only specific functionalities. Here we combine theory and experiment to demonstra...

journal_title：Scientific reports

authors： Xu HX,Sun S,Tang S,Ma S,He Q,Wang GM,Cai T,Li HP,Zhou L

更新日期：2016-06-08 00:00:00

abstract：:We introduce QuEST, the Quantum Exact Simulation Toolkit, and compare it to ProjectQ, qHipster and a recent distributed implementation of Quantum++. QuEST is the first open source, hybrid multithreaded and distributed, GPU accelerated simulator of universal quantum circuits. Embodied as a C library, it is designed so ...

journal_title：Scientific reports

authors： Jones T,Brown A,Bush I,Benjamin SC

更新日期：2019-07-24 00:00:00

abstract：:Whether the stress-loading of faults to failure in earthquakes appears to be random or to an extent explainable, given constraints on fault/shear-zone interaction and the build-up and release of stress over many earthquake cycles, is a key question for seismic hazard assessment. Here we investigate earthquake recurren...

journal_title：Scientific reports

authors： Sgambato C,Faure Walker JP,Mildon ZK,Roberts GP

更新日期：2020-07-29 00:00:00

abstract：:Anatase TiO2 is a typical photocatalyst, and its excellent performance is limited in ultraviolet light range due to its wide band gap of 3.2 eV. A series of Se-doped TiO2 nanoparticles in anatase structure with various Se concentrations up to 17.1 at.% were prepared using sol-gel method. The doped Se ions are confirme...

journal_title：Scientific reports

authors： Xie W,Li R,Xu Q

更新日期：2018-06-08 00:00:00

abstract：:Endogenous stress represents a major source of genome instability, but is in essence difficult to apprehend. Incorporation of labeled radionuclides into DNA constitutes a tractable model to analyze cellular responses to endogenous attacks. Here we show that incorporation of [(3)H]thymidine into CHO cells generates oxi...

journal_title：Scientific reports

authors： Saintigny Y,Chevalier F,Bravard A,Dardillac E,Laurent D,Hem S,Dépagne J,Radicella JP,Lopez BS

更新日期：2016-07-11 00:00:00

abstract：:The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to reconstruct the scenario of an uprising invasion of the famous water frogs (Pelophylax) in southern France, through a fine-s...

journal_title：Scientific reports

authors： Dufresnes C,Denoël M,di Santo L,Dubey S

更新日期：2017-07-26 00:00:00