Abstract：
:Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, the multiple potential pharmacological actions of both have yet to be fully understood. This study therefore investigated the effects of kahweol acetate and cafestol on human renal cancer ACHN and Caki-1 cells. Accordingly, the combination of kahweol acetate and cafestol administration synergistically inhibited cell proliferation and migration by inducing apoptosis and inhibiting epithelial-mesenchymal transition. Mechanistic dissection revealed that kahweol acetate and cafestol inhibited Akt and ERK phosphorylation. Moreover, kahweol acetate and cafestol downregulated the expression of not only C-C chemokine receptors 2, 5, and 6 but also programmed death-ligand 1, indicating their effects on the tumor microenvironment. Thus, kahweol acetate and cafestol may be novel therapeutic candidates for renal cancer considering that they exert multiple pharmacological effects.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Makino T,Izumi K,Hiratsuka K,Kano H,Shimada T,Nakano T,Kadomoto S,Naito R,Iwamoto H,Yaegashi H,Shigehara K,Kadono Y,Nakata H,Saito Y,Nakagawa-Goto K,Sakai N,Iwata Y,Wada T,Mizokami Adoi
10.1038/s41598-020-80302-4subject
Has Abstractpub_date
2021-01-12 00:00:00pages
675issue
1issn
2045-2322pii
10.1038/s41598-020-80302-4journal_volume
11pub_type
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