Abstract：
:New insect pest control agents are needed to meet the demands to feed an expanding global population, to address the desire for more environmentally-friendly insecticide tools, and to fill the loss of control options in some crop-pest complexes due to development of insecticide resistance. The spinosyns are a highly effective class of naturally occurring, fermentation derived insecticides, possessing a very favorable environmental profile. Chemically, the spinosyns are composed of a large complex macrolide tetracycle coupled to two sugars. As a means to further exploit this novel class of natural product-based insecticides, molecular modeling studies coupled with bioactivity-directed chemical modifications were used to define a less complex, synthetically accessible replacement for the spinosyn tetracycle. These studies lead to the discovery of highly insecticidal analogs, possessing a simple tri-aryl ring system as a replacement for the complex macrolide tetracycle.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Crouse GD,Demeter DA,Samaritoni G,McLeod CL,Sparks TCdoi
10.1038/s41598-018-22894-6subject
Has Abstractpub_date
2018-03-20 00:00:00pages
4861issue
1issn
2045-2322pii
10.1038/s41598-018-22894-6journal_volume
8pub_type
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