Abstract:
:The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental pathophysiology of diabetic retinopathy. The aim of this study was to investigate the effects of DPP4-inhibitors on vascular permeability and diabetic retinopathy. DPP4-inhibitor (diprotin A or sitagliptin) increased the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupted endothelial cell-to-cell junctions, which were attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor. Disruption of endothelial cell-to-cell junctions in the immuno-fluorescence images correlated with the actual leakage of the endothelial monolayer in the transwell endothelial permeability assay. In the Miles assay, vascular leakage was observed in the ears into which SDF-1α was injected, and this effect was aggravated by DPP4-inhibitor. In the model of retinopathy of prematurity, DPP4-inhibitor increased not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, DPP4-inhibitor increased the phosphorylation of Src and VE-cadherin and aggravated vascular leakage in the retinas. Collectively, DPP4-inhibitor induced vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway. These data highlight safety issues associated with the use of DPP4-inhibitors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee CS,Kim YG,Cho HJ,Park J,Jeong H,Lee SE,Lee SP,Kang HJ,Kim HSdoi
10.1038/srep29393subject
Has Abstractpub_date
2016-07-06 00:00:00pages
29393issn
2045-2322pii
srep29393journal_volume
6pub_type
杂志文章abstract::Inorganic elements are important components of medicinal herbs, and provide valuable experimental evidence for the quality evaluation and control of traditional Chinese medicine (TCM). In this study, to investigate the relationship between the inorganic elemental fingerprint and geographical origin identification of c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12933-z
更新日期:2017-10-03 00:00:00
abstract::Plant litter represents a major basal resource in streams, where its decomposition is partly regulated by litter traits. Litter-trait variation may determine the latitudinal gradient in decomposition in streams, which is mainly microbial in the tropics and detritivore-mediated at high latitudes. However, this hypothes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10640-3
更新日期:2017-09-05 00:00:00
abstract::In optical experiments one-sided reflectionless (ORL) and coherent perfect absorption (CPA) are unusual scattering properties yet fascinating for their fundamental aspects and for their practical interest. Although these two concepts have so far remained separated from each other, we prove that the two phenomena are i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35356
更新日期:2016-10-19 00:00:00
abstract::Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA. This is the rate-limiting step in the biosynthesis of the catecholamines - dopamine (DA), norepinephrine (NE), and epinephrine (EP). Catecholamines (CA) play a key role as neurotransmitters and hormones. Aberrant levels of CA are associated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54461-y
更新日期:2019-12-09 00:00:00
abstract::The high failure strain of thermoplastic elastomers (TPEs) is a very desirable feature for rechargeable Li-ion batteries by improving the lifetime of high specific capacity anode materials that undergo mechanical fractures induced by large volume variations. In this work, poly(styrene-b-2-hydroxyethyl acrylate) called...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40835-9
更新日期:2019-03-13 00:00:00
abstract::Herein, we examined the association between cytomegalovirus (CMV) coinfection and the progression of liver fibrosis in hepatitis C virus (HCV) infection, and investigated the effect of CMV coinfection on JAK-STAT pathway. CMV DNAemia was detected by PCR in DNA from controls (n = 120), and HCV patients with early (F0-F...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10604-7
更新日期:2017-09-04 00:00:00
abstract::The characterization of fully-defined in vitro hepatic culture systems requires testing of functional and morphological variables to obtain the optimal trophic support, particularly for cell therapeutics including bioartificial liver systems (BALs). Using serum-free fully-defined culture medium formulations, we measur...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02735
更新日期:2013-01-01 00:00:00
abstract::Geographically diverse samples from strawberry exhibiting symptoms of Strawberry Green Petal (SbGP), periwinkle plants with virescence, and blackberry, blueberry, and raspberry plants displaying yellowing and inedible fruits, were assayed for the presence of phytoplasma DNA. PCR targeting the 16S rRNA-encoding gene an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00895-1
更新日期:2017-04-19 00:00:00
abstract::Interferon (IFN)-γ release assays (IGRAs) are used to diagnose latent tuberculosis (TB) infection (LTBI). To improve the accuracy of these tests, different approaches, such as alternative cytokine detection and using different antigens, are considered. Following this purpose, this study aims to evaluate the addition o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70204-w
更新日期:2020-08-06 00:00:00
abstract::With land privatization and fencing of thousands of hectares of communal grazing areas, East Africa is struggling with one of the most radical cultural and environmental changes in its history. The 668,500-hectare Greater Mara is of crucial importance for the great migrations of large mammals and for Maasai pastoralis...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41450
更新日期:2017-01-25 00:00:00
abstract::Older patients, especially those with malignancy, may have an increased risk of pulmonary embolism (PE). However, few studies have evaluated the clinical characteristics and prognosis of older patients. We evaluated the clinical characteristics, prognosis, and risk factors in older patients with lung cancer complicate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58345-4
更新日期:2020-01-27 00:00:00
abstract::The helicene is constructed by twisted benzene or other aromatic rings, exhibiting a helical structure. Using first-principles calculations, we investigate the electronic transport of helicenes under stretching or compressing. Interestingly, a U-shaped curve of the current against d (the pitch of a helicene) is observ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16731
更新日期:2015-11-19 00:00:00
abstract::In this article, we report the first observation of nanosecond laser induced transient dual absorption bands, one in the bandgap (TA₁) and another in the sub-bandgap (TA₂) regions of a-Ge₅As₃₀Se₆₅ thin films. Strikingly, these bands are thermally tunable and exhibit a unique contrasting characteristic: the magnitude o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06573
更新日期:2014-10-10 00:00:00
abstract::Burgeoning availability of genome-wide association study (GWAS) results and national biobank data has led to growing interest in performing multi-trait genetic analyses. Numerous multi-trait GWAS methods that exploit either summary statistics or individual-level data have been developed, but their relative performance...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38837
更新日期:2017-03-13 00:00:00
abstract::To evaluate the association of admission serum levels of 25(OH)D, parathormone and the related electrolytes with severity of illness and clinical outcomes in neurosurgical critically ill patients, serum levels of 25(OH)D, parathormone, calcium, magnesium, and phosphate, along with APACHE II score were measured for 210...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21177-4
更新日期:2018-02-14 00:00:00
abstract::Spreading broadly refers to the notion of an entity propagating throughout a networked system via its interacting components. Evidence of its ubiquity and severity can be seen in a range of phenomena, from disease epidemics to financial systemic risk. In order to understand the dynamics of these critical phenomena, co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22770-3
更新日期:2018-03-12 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-64153-7
更新日期:2020-04-29 00:00:00
abstract::Mid-infrared quantum cascade lasers operating under external optical feedback and external periodic bias forcing are shown to exhibit a deterministic chaotic pattern composed of frequencies which are linked to the one of the forcing. Results also show that both the amplitude and the frequency of the forcing play a key...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40861-7
更新日期:2019-03-14 00:00:00
abstract::The amphibian chytrid fungus Batrachochytrium dendrobatidis is an emerging infectious pathogen present on every continent except Antarctica. It causes the disease chytridiomycosis in a subset of species but does not always result in disease or death for every host. Ambient temperature influences both amphibian metabol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35874-7
更新日期:2019-01-14 00:00:00
abstract::Fluorescence visualization devices (FVs) are useful for detecting malignant lesions because of their simple and noninvasive application. However, their quantitative application has been challenging. This study aimed to quantitatively and statistically evaluate the change in fluorescence intensity (FI) during the progr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44287-z
更新日期:2019-05-24 00:00:00
abstract::Although semantic processing has traditionally been associated with brain responses maximal at 350-400 ms, recent studies reported that words of different semantic types elicit topographically distinct brain responses substantially earlier, at 100-200 ms. These earlier responses have, however, been achieved using insu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01928
更新日期:2013-01-01 00:00:00
abstract::Plastic degradation rates in the marine environment are essential to understand. This study demonstrates that in plastic-microbial interaction experiments, residual monomeric and oligomeric content of PA6 significantly influences the development of dissolved organic carbon. While it is well recognized that additives i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-38685-6
更新日期:2019-02-14 00:00:00
abstract::Zirconium compounds has been widely attention over the last decades due to its excellent physical and chemical properties. Zirconium nitride nanopowders were synthesized via a simple direct carbothermic nitridation process of internal gel derived zirconia in the presence of nano-sized carbon black. The effects of reac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55450-x
更新日期:2019-12-16 00:00:00
abstract::Salvia miltiorrhiza Bunge, which contains tanshinones and phenolic acids as major classes of bioactive components, is one of the most widely used herbs in traditional Chinese medicine. Production of tanshinones and phenolic acids is enhanced by methyl jasmonate (MeJA). Transcription factor MYC2 is the switch of jasmon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22852
更新日期:2016-03-07 00:00:00
abstract::High tumor vascular endothelial growth factor (VEGF) levels are associated with poor treatment outcomes in prostate cancer (PCa), and immune deficiency in the PCa microenvironment, especially suppression of dendritic cell (DC) proliferation, has been confirmed. In this study, we (1) investigated whether VEGF participa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06242-8
更新日期:2017-07-18 00:00:00
abstract::Clinicians often hesitate prescribing corticosteroids to treat corticosteroid-responsive conditions in sickle cell disease (SCD) patients because their use can be associated with complications (increased hospital readmission, rebound pain, strokes, avascular necrosis, acute chest syndrome). Consequently, SCD patients ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24274-6
更新日期:2018-04-17 00:00:00
abstract::Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is complex and has not been fully understood. C10orf99 was a recently identified human antimicrobial peptide whose mRNA expression is elevated in psoriatic human skin samples. In this study, we investigated the functional roles ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26996-z
更新日期:2018-06-05 00:00:00
abstract::Quantifying how close two datasets are to each other is a common and necessary undertaking in scientific research. The Pearson product-moment correlation coefficient r is a widely used measure of the degree of linear dependence between two data series, but it gives no indication of how similar the values of these seri...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19401
更新日期:2016-01-14 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-22649-3
更新日期:2018-03-12 00:00:00
abstract::We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42480
更新日期:2017-02-16 00:00:00