Abstract：
:New clinical trials for diabetic macular oedema (DMO) are being designed to prove superiority over aflibercept when this agent is already very effective in improving visual acuity (VA) and DMO. The aim of this study was to determine the optimal inclusion-exclusion criteria for trials to aim for superiority in visual outcomes with newer agents. As Phase 1 studies are short duration, we aimed to evaluate the early response of aflibercept in a real-world cohort initiated on monthly aflibercept for 3 consecutive injections and observed the effects at 4 months. The sub-optimal responders were pre-defined based on different cut-offs for VA and central sub-field thickness (CST). 200 patients with treatment naïve DMO treated with 3 loading doses of aflibercept were included in the study. We found that those presenting with baseline VA of 35-54 ETDRS letters (n = 43) had higher proportion of sub-optimal responders compared to other categories (p < 0.001). Patients with baseline CST of less than 400 µm (n = 96) responded less well functionally and anatomically to loading dose than eyes with baseline CST of 400 µm or more (n = 104, p = 0.02), indicating that eyes with CST ≥ 400 µm is another inclusion criteria. There was minimal correlation between change in CST and change in VA at 4 months (r = - 0.27), suggesting that both these inclusion criteria are non-exclusive. However, for maximal efficacy, patients that meet both these inclusion criteria are more likely to show benefit from an alternative intervention. New trials should aim to include patients with treatment naïve DMO with VA between 35-54 letters and CST of 400 µm or more when aflibercept is used as the comparator.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Halim S,Gurudas S,Chandra S,Greenwood J,Sivaprasad Sdoi
10.1038/s41598-020-73571-6subject
Has Abstractpub_date
2020-10-05 00:00:00pages
16499issue
1issn
2045-2322pii
10.1038/s41598-020-73571-6journal_volume
10pub_type
杂志文章abstract：:Vaginal microbiota is an important early source of bacterial colonization for newborns. However, only a few small studies have investigated the composition of vaginal microbiota during labor. In this work, we analyzed vaginal swabs collected at 36 weeks gestation and at the onset of labor from 256 women participating ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17972-0
更新日期：2017-12-14 00:00:00
abstract：:The prognostic relevance of strokes in different locations is debated. For example, insular strokes have been associated with increased mortality, but this association could reflect their greater severity. In two independent cohorts of patients with supratentorial ischemic stroke (n = 90 and 105), we studied the progn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27883-3
更新日期：2018-06-22 00:00:00
abstract：:Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, and personality characteristics with alcohol use disorder (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve a clear understanding of the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06057-7
更新日期：2017-07-18 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-18707-x
更新日期：2018-01-15 00:00:00
abstract：:Next generation sequencing (NGS) together with protein expression analysis is back bone of molecularly targeted therapy in precision medicine. Our retrospective study shows our experience with NGS of 324 genes in combination with protein expression in patients with advanced breast cancer (aBC). The primary purpose was...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67393-9
更新日期：2020-06-26 00:00:00
abstract：:Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21282-4
更新日期：2018-02-16 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-69093-w
更新日期：2020-07-16 00:00:00
abstract：:Epilepsy is a chronic neurological disease with a variable therapeutic response. To design effective treatment strategies for epilepsy, it is important to understand treatment responses and predictive factors. However, limited data are available in Africa, including Ethiopia. The aim of this study was therefore to ass...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52574-y
更新日期：2019-11-07 00:00:00
abstract：:Diabetes is a globally prevalent disease that can cause visible microvascular complications such as diabetic retinopathy and macular edema in the human eye retina, the images of which are today used for manual disease screening and diagnosis. This labor-intensive task could greatly benefit from automatic detection usi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47181-w
更新日期：2019-07-24 00:00:00
abstract：:All real networks are different, but many have some structural properties in common. There seems to be no consensus on what the most common properties are, but scale-free degree distributions, strong clustering, and community structure are frequently mentioned without question. Surprisingly, there exists no simple gen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09421
更新日期：2015-04-29 00:00:00
abstract：:Despite numerous advances in genomics and bioinformatics, technological hurdles remain to examine host-microbe transcriptomics. Sometimes the transcriptome of either or both can be ascertained merely by generating more sequencing reads. However, many cases exist where bacterial mRNA needs to be enriched further to ena...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34850
更新日期：2016-10-07 00:00:00
abstract：:Genetic circuit-based biosensors have emerged as an effective analytical tool in synthetic biology; these biosensors can be applied to high-throughput screening of new biocatalysts and metabolic pathways. Sigma 54 (σ54)-dependent transcription factor (TF) can be a valuable component of these biosensors owing to its in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62892-1
更新日期：2020-04-08 00:00:00
abstract：:To construct a machine learning algorithm model of lymph node metastasis (LNM) in patients with poorly differentiated-type intramucosal gastric cancer. 1169 patients with postoperative gastric cancer were divided into a training group and a test group at a ratio of 7:3. The model for lymph node metastasis was establis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80582-w
更新日期：2021-01-14 00:00:00
abstract：:The static synchronous series compensator (SSSC) can add a series reactance to the transmission line, and when it is fed using auxiliary signals, it can participate in damping inter-area oscillations by changing the series reactance. In this paper, the effect of the SSSC on small-signal stability is investigated. The ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69123-7
更新日期：2020-07-22 00:00:00
abstract：:Traditional Protein-Protein Interaction (PPI) networks, which use a node and edge representation, lack some valuable information about the mechanistic details of biological processes. Mapping protein structures to these PPI networks not only provides structural details of each interaction but also helps us to find the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07351-0
更新日期：2017-08-03 00:00:00
abstract：:The use of micro- and nanodevices as multifunctional systems for biomedical applications has experienced an exponential growth during the past decades. Although a large number of studies have focused on the design and fabrication of new micro- and nanosystems capable of developing multiple functions, a deeper understa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11371
更新日期：2015-06-12 00:00:00
abstract：:We present the first complete, closed genome sequences of Streptococcus pyogenes strains NCTC 8198T and CCUG 4207T, the type strain of the type species of the genus Streptococcus and an important human pathogen that causes a wide range of infectious diseases. S. pyogenes NCTC 8198T and CCUG 4207T are derived from depo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68249-y
更新日期：2020-07-15 00:00:00
abstract：:Although geological and modelling evidence indicate that the last glacial inception in North America was in NE Canada, little is known about the glacial response of the nearby western Greenland Ice Sheet (GIS) during the glacial advance of marine oxygen isotope stage 4 (MIS4). Our multi-proxy study of a marine sedimen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51983-3
更新日期：2019-10-30 00:00:00
abstract：:The increasing ease and accuracy of protein-protein interaction detection has resulted in the ability to map the interactomes of multiple species. We now have an opportunity to compare species to better understand how interactomes evolve. As DNA and protein sequence alignment algorithms were required for comparative g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12074
更新日期：2015-07-13 00:00:00
abstract：:Cardiac output during cardiac catheterization is often estimated using the modified Fick method (COFick). In this proof-of-concept, prospective non-randomized study carried out in a single academic healthcare centre, we examined whether replacing COFick in the Gorlin formula with Cheetah-NICOM monitor cardiac output (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64753-3
更新日期：2020-05-12 00:00:00
abstract：:It was previously demonstrated that microRNA-199a (miR-199a) was down-regulated in testicular germ cell tumor (TGCT) partially caused by hypermethylation of its promoter. miR-199a is encoded by two loci in the human genome, miR-199a-1 on chromosome (Chr) 19 and miR-199a-2 on Chr 1. Both loci encode the same miR-199a. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06413
更新日期：2014-09-18 00:00:00
abstract：:We adopted a vision-based tracking system for augmented reality (AR), and evaluated whether it helped surgeons to localize the recurrent laryngeal nerve (RLN) during robotic thyroid surgery. We constructed an AR image of the trachea, common carotid artery, and RLN using CT images. During surgery, an AR image of the tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65439-6
更新日期：2020-05-21 00:00:00
abstract：:Estrogens protect against diet-induced obesity in women and female rodents. For example, a lack of estrogens in postmenopausal women is associated with an increased risk of weight gain, cardiovascular diseases, low-grade inflammation, and cancer. Estrogens act with leptin to regulate energy homeostasis in females. Lep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56723-1
更新日期：2019-12-27 00:00:00
abstract：:Nitrogen (N) deposition is a key factor that affects terrestrial biogeochemical cycles with a growing trend, especially in the southeast region of China, where shortage of available phosphorus (P) is particularly acute and P has become a major factor limiting plant growth and productivity. Arbuscular mycorrhizal fungi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69213-6
更新日期：2020-07-23 00:00:00
abstract：:Alexithymia is a psychological construct characterized by deficits in processing emotional stimuli. However, little is known about the processing of odours in alexithymia, even though there is extensive proof that emotion and olfaction are closely linked. The present study is aimed at investigating how alexithymic ind...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14404-x
更新日期：2017-10-26 00:00:00
abstract：:The performance of most error-correction (EC) algorithms that operate on genomics reads is dependent on the proper choice of its configuration parameters, such as the value of k in k-mer based techniques. In this work, we target the problem of finding the best values of these configuration parameters to optimize error...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52196-4
更新日期：2019-11-06 00:00:00
abstract：:Olfactory receptors are believed to play a central role in insects host-seeking, mating, and ovipositing. On the basis of male and female antennal transcriptome of adult Apolygus lucorum, a total of 110 candidate A. lucorum odorant receptors (AlucOR) were identified in this study including five previously annotated Al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37870
更新日期：2016-11-28 00:00:00
abstract：:The association of visual impairment and depression has been investigated in several studies based on a cross-sectional design, which cannot delineate temporal relationships. In the present study, we evaluated the influence of visual impairment on depression in all age groups using a longitudinal database of a nationa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20374-5
更新日期：2018-02-01 00:00:00
abstract：:Carbapenem resistant Enterobacteriaceae (CRE) pose an urgent risk to global human health. CRE that are non-susceptible to all commercially available antibiotics threaten to return us to the pre-antibiotic era. Using Single Molecule Real Time (SMRT) sequencing we determined the complete genome of a pandrug-resistant Kl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15082
更新日期：2015-10-19 00:00:00
abstract：:The increasing availability of electronic health care records has provided remarkable progress in the field of population health. In particular the identification of disease risk factors has flourished under the surge of available data. Researchers can now access patient data across a broad range of demographics and g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30465
更新日期：2016-07-27 00:00:00
