Surface modification of microparticles causes differential uptake responses in normal and tumoral human breast epithelial cells.

abstract：:Signaling by members of the transforming growth factor-β (TGF-β) superfamily, such as TGF-β3 and BMP7, and oxygen tension play a pivotal role in chondrocyte biology. The objective of this research was to investigate the endogenous BMP7 expression in human osteoarthritis (OA) cartilage and the effect of oxygen tension ...

journal_title：Scientific reports

authors： Huang X,Zhong L,Post JN,Karperien M

更新日期：2018-07-06 00:00:00

abstract：:The manuscript highlights the efficacy of silver ions to act as a unique probe for the detection of bacterial contamination in water samples. The bacterial cell membrane adherence property of the silver ions was employed to develop two different bacterial detection assays employing colorimetric and electrochemical tec...

journal_title：Scientific reports

authors： Kumar V,Chopra A,Bisht B,Bhalla V

更新日期：2020-07-20 00:00:00

abstract：:Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm r...

journal_title：Scientific reports

authors： van Hengstum PJ,Donnelly JP,Fall PL,Toomey MR,Albury NA,Kakuk B

更新日期：2016-02-24 00:00:00

abstract：:Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our res...

journal_title：Scientific reports

authors： Barcellos HH,Kalichak F,da Rosa JG,Oliveira TA,Koakoski G,Idalencio R,de Abreu MS,Giacomini AC,Fagundes M,Variani C,Rossini M,Piato AL,Barcellos LJ

更新日期：2016-11-22 00:00:00

abstract：:High-density living is often associated with high disease risk due to density-dependent epidemic spread. Despite being paragons of high-density living, the social insects have largely decoupled the association with density-dependent epidemics. It is hypothesized that this is accomplished through prophylactic and induc...

journal_title：Scientific reports

authors： Quevillon LE,Hanks EM,Bansal S,Hughes DP

更新日期：2015-08-24 00:00:00

abstract：:Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein and/or -ligand interactions as well as GPCR oligomerisation. However the utility of BRET is limited by the requirement that the fusion protei...

journal_title：Scientific reports

authors： White CW,Vanyai HK,See HB,Johnstone EKM,Pfleger KDG

更新日期：2017-06-09 00:00:00

abstract：:Prosthesis embodiment, the perception of a prosthesis as part of one's body, may be an important component of functional recovery for individuals with upper limb absence. This work determined whether embodiment differs between body-powered and myoelectric prosthesis users. In a sample of nine individuals with transrad...

journal_title：Scientific reports

authors： Engdahl SM,Meehan SK,Gates DH

更新日期：2020-09-22 00:00:00

abstract：:Niemann-Pick type C1 (NPC1) disease is a rare autosomal recessive, neurodegenerative lysosomal storage disorder, which presents with a range of clinical phenotypes and hence diagnosis remains a challenge. In view of these difficulties, the search for a novel, NPC1-specific biomarker (or set of biomarkers) is a topic o...

journal_title：Scientific reports

authors： Probert F,Ruiz-Rodado V,Vruchte DT,Nicoli ER,Claridge TDW,Wassif CA,Farhat N,Porter FD,Platt FM,Grootveld M

更新日期：2017-07-24 00:00:00

abstract：:Astragalus membranaceus (HUANG QI, HQ) is a kind of traditional Chinese medicine. Researchers have widely concerned its antitumor effect. At present, there is still a lack of research on the treatment of laryngeal cancer with HQ. In this study, we integrated data from the weighted gene co-expression network of larynge...

journal_title：Scientific reports

authors： Dong KF,Huo MQ,Sun HY,Li TK,Li D

更新日期：2020-07-07 00:00:00

abstract：:β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the opening of the β-lactam ring and in t...

journal_title：Scientific reports

authors： Edoo Z,Arthur M,Hugonnet JE

更新日期：2017-08-22 00:00:00

abstract：:Severely injured patients frequently suffer compromised fracture healing because of systemic post-traumatic inflammation. An important trigger of the posttraumatic immune response is the complement anaphylatoxin C5a, which acts via two receptors, C5aR1 and C5aR2, expressed on immune and bone cells. The blockade of C5a...

journal_title：Scientific reports

authors： Kovtun A,Bergdolt S,Hägele Y,Matthes R,Lambris JD,Huber-Lang M,Ignatius A

更新日期：2017-10-25 00:00:00

abstract：:Work stress is a risk factor for cardio-metabolic diseases, but few large-scale studies have examined the clinical profile of individuals with work stress. To address this limitation, we conducted a cross-sectional study including 43,593 working adults from a French population-based sample aged 18-72 years (the CONSTA...

journal_title：Scientific reports

authors： Magnusson Hanson LL,Westerlund H,Goldberg M,Zins M,Vahtera J,Hulvej Rod N,Stenholm S,Steptoe A,Kivimäki M

更新日期：2017-08-24 00:00:00

abstract：:The aim of the present study was to compare the clinical, radiological and histomorphometrical outcome of simultaneous implant placement following augmentation of atrophic maxillary sinuses using allograft (block or particles). Consecutive patients with maxillary residual alveolar ridge height ≤3 mm, scheduled for sin...

journal_title：Scientific reports

authors： Chaushu L,Chaushu G,Kolerman R,Vered M,Naishols S,Nissan J

更新日期：2020-06-03 00:00:00

abstract：:Highly Tm(3+) doped optical fibers are urgently desirable for 2.0 μm compact single-frequency fiber laser and high-repetition-rate mode-locked fiber laser. Here, we systematically investigated the optical parameters, energy transfer processes and thermal properties of Tm(3+) doped barium gallo-germanate (BGG) glasses....

journal_title：Scientific reports

authors： Wen X,Tang G,Yang Q,Chen X,Qian Q,Zhang Q,Yang Z

更新日期：2016-02-01 00:00:00

abstract：:A larger amount of sequence data in private and public databases produced by next-generation sequencing put new challenges due to limitation associated with the alignment-based method for sequence comparison. So, there is a high need for faster sequence analysis algorithms. In this study, we developed an alignment-fre...

journal_title：Scientific reports

authors： Saw AK,Raj G,Das M,Talukdar NC,Tripathy BC,Nandi S

更新日期：2019-03-06 00:00:00

abstract：:DNA-directed RNA polymerase II (pol II) is composed of ten core and two dissociable subunits. The dissociable subcomplex is a heterodimer of Rpb4/Polr2d and Rpb7/Polr2g, which are encoded by RPB4/polr2d and RPB7/polr2g genes, respectively. Functional studies of Rpb4/Polr2d in yeast have revealed that Rpb4 plays a role...

journal_title：Scientific reports

authors： Maeta M,Kataoka M,Nishiya Y,Ogino K,Kashima M,Hirata H

更新日期：2020-08-06 00:00:00

abstract：:Chronic HIV infection results in impairment of gut-associated lymphoid tissue leading to systemic immune activation. We previously showed that in early SIV-infected rhesus macaques intestinal dysfunction is initiated with the induction of the IL-1β pathway in the small intestine and reversed by treatment with an exoge...

journal_title：Scientific reports

authors： Golomb BL,Hirao LA,Dandekar S,Marco ML

更新日期：2016-04-22 00:00:00

abstract：:Obstructive sleep apnea (OSA) is associated with increasing risk of recurrent stroke and mortality. Nasogastric tubes used by dysphagic stroke patients may interfere with nasal continuous positive airway pressure (CPAP) due to air leakage. This study was evaluated the effects and short-term tolerability of high-flow n...

journal_title：Scientific reports

authors： Ho CH,Chen CL,Yu CC,Yang YH,Chen CY

更新日期：2020-05-22 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are unlikely to respond to hormonal therapies and anti-HER2-targeted therapies. TNBCs overexpress EGFR and exhibit constitutive activation of the PI3K/AKT/mTOR signalling pathway. We hypothesized that simultaneously blocking EGFR and mTOR could be a potential therapeutic strategy ...

journal_title：Scientific reports

authors： El Guerrab A,Bamdad M,Bignon YJ,Penault-Llorca F,Aubel C

更新日期：2020-04-14 00:00:00

abstract：:We herein describe a simple, sensitive and specific method for analysis of circulating microRNAs (miRNA), termed S-Poly(T) Plus real-time PCR assay. This new method is based on our previously developed S-Poly(T) method, in which a unique S-Poly(T) primer is used during reverse-transcription to increase sensitivity and...

journal_title：Scientific reports

authors： Niu Y,Zhang L,Qiu H,Wu Y,Wang Z,Zai Y,Liu L,Qu J,Kang K,Gou D

更新日期：2015-10-13 00:00:00

abstract：:Exosomes contain cell-specific collections of bioactive materials including proteins, lipids, and RNAs that are transported to recipient cells to exert their impacts. MicroRNAs (miRNAs) can function as tumor suppressor or oncogenic genes and miR-21 is one of the most frequently up-regulated miRNAs in solid tumors incl...

journal_title：Scientific reports

authors： Sun LH,Tian D,Yang ZC,Li JL

更新日期：2020-05-19 00:00:00

abstract：:During capillary transit, red blood cells (RBCs) must exchange large quantities of CO2 and O2 in typically less than one second, but the degree to which this is rate-limited by diffusion through cytoplasm is not known. Gas diffusivity is intuitively assumed to be fast and this would imply that the intracellular path-l...

journal_title：Scientific reports

authors： Richardson SL,Swietach P

更新日期：2016-10-25 00:00:00

abstract：:Cervical carcinoma is the fourth most common cause of death in woman, caused by human papillomavirus (HPV) infections and arising from the cervix. Cytoskeleton-associated protein 2 (CKAP2), also known as tumor-associated microtubule-associated protein, has been linked to tumorigenic effects. In the present study, we s...

journal_title：Scientific reports

authors： Guo QS,Song Y,Hua KQ,Gao SJ

更新日期：2017-05-18 00:00:00

abstract：:Selective attention plays a prominent role in prioritizing information in working memory (WM), improving performance for attended representations. However, it remains unclear whether unattended WM representations suffer from information loss. Here we tested the hypothesis that within WM, selectively attending to an it...

journal_title：Scientific reports

authors： Günseli E,Fahrenfort JJ,van Moorselaar D,Daoultzis KC,Meeter M,Olivers CNL

更新日期：2019-09-18 00:00:00

abstract：:The Ebola filovirus causes severe hemorrhagic fever with a high fatality rate in humans. The primary structural matrix protein VP40 displays transformer-protein characteristics and exists in different conformational and oligomeric states. VP40 plays crucial roles in viral assembly and budding at the plasma membrane of...

journal_title：Scientific reports

authors： Pavadai E,Gerstman BS,Chapagain PP

更新日期：2018-06-27 00:00:00

abstract：:There is an urgent need to quantify anthropogenic influence on forest carbon stocks. Using satellite-based radar imagery for such purposes has been challenged by the apparent loss of signal sensitivity to changes in forest aboveground volume (AGV) above a certain 'saturation' point. The causes of saturation are debate...

journal_title：Scientific reports

authors： Joshi N,Mitchard ETA,Brolly M,Schumacher J,Fernández-Landa A,Johannsen VK,Marchamalo M,Fensholt R

更新日期：2017-06-14 00:00:00

abstract：:The yield of pepper plants (Capsicum spp.) is their most important trait and is affected by the flower number and flowering time. Capsicum annuum produces a single flower per node and has an early flowering habit. By contrast, Capsicum chinense yields multiple flowers per node and has a late flowering character. Howev...

journal_title：Scientific reports

authors： Zhu Z,Sun B,Wei J,Cai W,Huang Z,Chen C,Cao B,Chen G,Lei J

更新日期：2019-01-31 00:00:00

abstract：:Voice disorder such as vocal fatigue is a common and complex multifaceted clinical problem that presents a significant impact on quality of life. In this study, the functional near-infrared diffuse optical technique (fNIRS-DOT) was proposed as a novel approach for human vocal cords oxidative metabolism detection and a...

journal_title：Scientific reports

authors： Lin TC,Chen JC,Liu CH,Lee CY,Tsou YA,Chuang CC

更新日期：2017-12-05 00:00:00

abstract：:Coastal ecosystems play significant ecological and economic roles but are threatened and facing decline. Microbes drive various biogeochemical processes in coastal ecosystems. Tidal flats are critical components of coastal ecosystems; however, the structure and function of microbial communities in tidal flats are poor...

journal_title：Scientific reports

authors： Lv X,Ma B,Yu J,Chang SX,Xu J,Li Y,Wang G,Han G,Bo G,Chu X

更新日期：2016-11-08 00:00:00

abstract：:The temperate bamboos (tribe Arundinarieae, Poaceae) are strongly supported as monophyly in recent molecular studies, but taxonomic delineation and phylogenetic relationships within the tribe lack resolution. Here, we sampled 39 species (36 temperate bamboos and 3 outgroups) for restriction-site associated DNA sequenc...

journal_title：Scientific reports

authors： Wang X,Ye X,Zhao L,Li D,Guo Z,Zhuang H

更新日期：2017-09-14 00:00:00