An improved method for detecting circulating microRNAs with S-Poly(T) Plus real-time PCR.

abstract：:Studies have proven that IL-2 and IL-15 showed contrasting roles during CIK cells preparation. By employing microarray, we analyzed miRNA expression profiles of PBMC, CIKIL-2 and CIKIL-15. Advanced bioinformatic analyses were performed to explore the key miRNAs which may regulate cell proliferation and anti-tumor acti...

journal_title：Scientific reports

authors： Wang W,Li R,Meng M,Wei C,Xie Y,Zhang Y,Jiang L,Dong R,Wang C,Zhong Y,Yang F,Tang W,Jin X,Liu B,Hou Z

更新日期：2015-03-31 00:00:00

abstract：:Rab27 is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Recent studies reported that Rab27 expression is also associated with cancer prognosis. Therefore, we performed a meta-analysis to reveal the prognostic signi...

journal_title：Scientific reports

authors： Koh HM,Jang BG,Kim DC

更新日期：2020-08-24 00:00:00

abstract：:In the jejunum, PepT1 is particularly enriched in the well-differentiated absorptive epithelial cells in the villi. Studies of expression and function of PepT1 along the crypt-villus axis demonstrated that this protein is crucial to the process of di/tripeptide absorption. We recently exhibited that PepT1 plays an imp...

journal_title：Scientific reports

authors： Zhang Y,Viennois E,Zhang M,Xiao B,Han MK,Walter L,Garg P,Merlin D

更新日期：2016-06-01 00:00:00

abstract：:As it is altered by ionizing radiation, the vascular network is considered as a prime target in limiting normal tissue damage and improving tumor control in radiation therapy. Irradiation activates endothelial cells which then participate in the recruitment of circulating cells, especially by overexpressing cell adhes...

journal_title：Scientific reports

authors： Jaillet C,Morelle W,Slomianny MC,Paget V,Tarlet G,Buard V,Selbonne S,Caffin F,Rannou E,Martinez P,François A,Foulquier F,Allain F,Milliat F,Guipaud O

更新日期：2017-07-13 00:00:00

abstract：:Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair. Recent studies suggested the key role of CD8+T lymphocytes for mediating immune response in vitiligo through melanocyte differentiation antigens, including tyrosinase, gp100 and Mela...

journal_title：Scientific reports

authors： Cui T,Yi X,Guo S,Zhou F,Liu L,Li C,Li K,Gao T

更新日期：2016-11-08 00:00:00

abstract：:The widely used mood stabilizer valproate (VPA) causes perturbation of energy metabolism, which is implicated in both the therapeutic mechanism of action of the drug as well as drug toxicity. To gain insight into these mechanisms, we determined the effects of VPA on energy metabolism in yeast. VPA treatment increased ...

journal_title：Scientific reports

authors： Salsaa M,Pereira B,Liu J,Yu W,Jadhav S,Hüttemann M,Greenberg ML

更新日期：2020-07-16 00:00:00

abstract：:Vitiligo is characterized by death or functional defects of epidermal melanocytes through still controversial pathogenic process. Previously, we showed that mitochondria-driven pre-senescent phenotype diminishes the capability of vitiligo melanocytes to cope with stressful stimuli. In the current study, we investigate...

journal_title：Scientific reports

authors： Dell'Anna ML,Ottaviani M,Kovacs D,Mirabilii S,Brown DA,Cota C,Migliano E,Bastonini E,Bellei B,Cardinali G,Ricciardi MR,Tafuri A,Picardo M

更新日期：2017-10-20 00:00:00

abstract：:Inflammatory and cardiovascular biomarkers have been associated with obesity, but little is known about how they change upon dietary intervention and concomitant weight loss. Further, protein biomarkers might be useful for predicting weight loss in overweight and obese individuals. We performed secondary analyses in t...

journal_title：Scientific reports

authors： Figarska SM,Rigdon J,Ganna A,Elmståhl S,Lind L,Gardner CD,Ingelsson E

更新日期：2020-05-13 00:00:00

abstract：:This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC mediated IL-13 responses at the lung mucosae, unlike IL-13Rα1. Under lo...

journal_title：Scientific reports

authors： Roy S,Liu HY,Jaeson MI,Deimel LP,Ranasinghe C

更新日期：2020-01-23 00:00:00

abstract：:Inhaled corticosteroids (ICSs) are widely prescribed in chronic obstructive pulmonary disease (COPD). However, little is known about predictors of ICSs therapeutic response. To investigate whether the variation in glucocorticoid-induced transcript 1 (GLCCI1) rs37973 is associated with ICS efficacy. A total of 204 clin...

journal_title：Scientific reports

authors： Lei Y,Gao Y,Chen J,Li M,Wu X,Ning Q,Zhao J,Xiong W,Xu Y,Xie J

更新日期：2017-02-10 00:00:00

abstract：:Alcohol use disorder (AUD) is a chronic and relapsing disease with a substantial genetic influence. Given the recent discovery of the association of PPM1G methylation with alcohol use disorder (AUD) from a genome-wide methylation study, we sought to verify and extend the previous work of AUD-related impulsivity in a K...

journal_title：Scientific reports

authors： Park CI,Kim HW,Hwang SS,Kang JI,Kim SJ

更新日期：2020-03-26 00:00:00

abstract：:Microbial rhodopsin is a photoreceptor protein found in various bacteria and archaea, and it is considered to be a light-utilization device unique to heterotrophs. Recent studies have shown that several cyanobacterial genomes also include genes that encode rhodopsins, indicating that these auxiliary light-utilizing pr...

journal_title：Scientific reports

authors： Hasegawa M,Hosaka T,Kojima K,Nishimura Y,Nakajima Y,Kimura-Someya T,Shirouzu M,Sudo Y,Yoshizawa S

更新日期：2020-10-07 00:00:00

abstract：:Seed germination behavior is an important factor in the distribution of species. Many studies have shown that germination is controlled by phylogenetic constraints, however, it is not clear whether phylogenetic constraints or environmental cues explain seed germination of a genus from a common ancestor. In this study,...

journal_title：Scientific reports

authors： Fang XW,Zhang JJ,Xu DH,Pang J,Gao TP,Zhang CH,Li FM,Turner NC

更新日期：2017-09-12 00:00:00

abstract：:Nettles are commonly consumed in South Africa, Europe and Asia and are used in traditional medicine to treat a variety of ailments. In this study, the nutritional value of the leaves of nettles (Laportea alatipes and Obetia tenax) was evaluated and compared, when cooked and uncooked. The results showed a decrease in t...

journal_title：Scientific reports

authors： Mahlangeni NT,Moodley R,Jonnalagadda SB

更新日期：2020-06-17 00:00:00

abstract：:Although carbon nanotubes (CNTs) have shown great potential for enhancing the performance of polymer matrices, their reinforcement role still needs to be further improved. Here we implement a structural modification of multi-walled CNTs (MWCNTs) to fully utilize their fascinating mechanical and electrical properties v...

journal_title：Scientific reports

authors： Yang M,Weng L,Zhu H,Zhang F,Fan T,Zhang D

更新日期：2017-12-07 00:00:00

abstract：:Guidelines endorse targeted temperature management to reduce neurological sequelae and mortality after cardiac arrest (CA). Additional therapeutic approaches are lacking. Inhaled nitric oxide (iNO) given post systemic ischemia/reperfusion injury improves outcomes. Attenuated inflammation by iNO might be crucial in bra...

journal_title：Scientific reports

authors： Brücken A,Bleilevens C,Berger P,Nolte K,Gaisa NT,Rossaint R,Marx G,Derwall M,Fries M

更新日期：2018-04-30 00:00:00

abstract：:Most male lepidopterans produce fertile eupyrene sperm and non-fertile apyrene sperm, both of which are transferred to the female in a spermatophore during mating. Apyrene sperm outnumbers eupyrene sperm and both sperm types migrate from the bursa copulatrix to the spermatheca after mating. While eupyrene sperm are ma...

journal_title：Scientific reports

authors： Konagaya T,Idogawa N,Watanabe M

更新日期：2020-12-01 00:00:00

abstract：:Horizontal gene transfer (HGT) drives the evolution of recipient organism particularly if it provides a novel function which enhances the fitness or its adaption to the environment. Virus-host co-evolution is attractive for studying co-evolutionary processes, since viruses strictly replicate inside of the host cells a...

journal_title：Scientific reports

authors： Chen DS,Wu YQ,Zhang W,Jiang SJ,Chen SZ

更新日期：2016-06-07 00:00:00

abstract：:In southeastern China (SEC), the precipitation amount produced by the East Asian summer monsoon (EASM) is almost equivalent to that during the non-summer monsoon (NSM) period, both of them significantly affecting agriculture and socioeconomy. Here, we present a seasonally-resolved stalagmite δ18O record (δ18Os) for th...

journal_title：Scientific reports

authors： Zhang H,Cheng H,Spötl C,Cai Y,Sinha A,Tan L,Yi L,Yan H,Kathayat G,Ning Y,Li X,Zhang F,Zhao J,Edwards RL

更新日期：2018-08-17 00:00:00

abstract：:The abundance and sinking of particulate black carbon (PBC) were examined for the first time in the western Arctic and Subarctic Oceans. In the central Arctic Ocean, high PBC concentrations with a mean of 0.021 ± 0.016 μmol L(-1) were observed in the marginal ice zone (MIZ). A number of parameters, including temperatu...

journal_title：Scientific reports

authors： Fang Z,Yang W,Chen M,Zheng M,Hu W

更新日期：2016-07-15 00:00:00

abstract：:In the rodent auditory system, the primary cortex is subdivided into two regions, both receiving direct inputs from the auditory thalamus: the primary auditory cortex (A1) and the anterior auditory field (AAF). Although neurons in the two regions display different response properties, like response latency, firing thr...

journal_title：Scientific reports

authors： Sołyga M,Barkat TR

更新日期：2019-07-03 00:00:00

abstract：:From 2010 to 2012, large outbreaks of EV-A71-related- hand foot and mouth disease (HFMD) occurred annually in China. Some cases had neurological complications and were closely associated with fatal cardiopulmonary collapse, but not all children with central nervous system (CNS) involvement demonstrated a poor prognosi...

journal_title：Scientific reports

authors： Long L,Xu L,Xiao Z,Hu S,Luo R,Wang H,Lu X,Xu Z,Yao X,Zhou L,Long H,Gong J,Song Y,Zhao L,Luo K,Zhang M,Feng L,Yang L,Sheng X,Fan X,Xiao B

更新日期：2016-03-22 00:00:00

abstract：:Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...

journal_title：Scientific reports

authors： Iwahori K,Shintani Y,Funaki S,Yamamoto Y,Matsumoto M,Yoshida T,Morimoto-Okazawa A,Kawashima A,Sato E,Gottschalk S,Okumura M,Kumanogoh A,Wada H

更新日期：2019-02-22 00:00:00

abstract：:Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of developing mild cognitive impairment (MCI) and dementia. The initial symptoms are very insidious at onset. We investigated the alterations in spontaneous brain activity and network connectivity through regional homogeneity (ReHo) and grap...

journal_title：Scientific reports

authors： Xiong Y,Chen X,Zhao X,Fan Y,Zhang Q,Zhu W

更新日期：2020-12-04 00:00:00

abstract：:Secreted Protein Acidic and Rich in Cysteine (SPARC)-related modular calcium-binding protein-2 (SMOC2), a secreted matricellular protein, is reported to be involved in various processes related to cancer progression such as regulating the cell cycle, angiogenesis, and invasion. However, its expression and prognostic s...

journal_title：Scientific reports

authors： Kim HS,Choi JH,Lee JY,Kang J,Myung JK,Kim WH,Jang BG

更新日期：2020-03-17 00:00:00

abstract：:We evaluated the performance of CSF biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients with cognitive symptoms. CSF samples from patients in two multicentre longitudinal studies (ADNI, n = 619; BioFINDER, n = 431) were analysed. Aβ(1-42), tTau and pTau CSF concentrat...

journal_title：Scientific reports

authors： Blennow K,Shaw LM,Stomrud E,Mattsson N,Toledo JB,Buck K,Wahl S,Eichenlaub U,Lifke V,Simon M,Trojanowski JQ,Hansson O

更新日期：2019-12-13 00:00:00

abstract：:To compare the soil water balance, yield and water use efficiency (WUE) of spring maize under different mulching types in the Loess Plateau, a 7-year field experiment was conducted in the Changwu region of the Loess Plateau. Three treatments were used in this experiment: straw mulch (SM), plastic film mulch (PM) and c...

journal_title：Scientific reports

authors： Lin W,Liu W,Xue Q

更新日期：2016-12-15 00:00:00

abstract：:The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective an...

journal_title：Scientific reports

authors： Chen B,Zhao Y,Li S,Yang L,Wang H,Wang T,Bin Shi,Gai Z,Heng X,Zhang C,Yang J,Zhang L

更新日期：2018-11-20 00:00:00

abstract：:The maternal environment can influence the intensity of seed dormancy and thus seasonal germination timing and post-germination life history traits. We tested the hypotheses that germination season influences phenotypic expression of post-germination life history traits in the cold desert annual Isatis violascens and ...

journal_title：Scientific reports

authors： Lu JJ,Tan DY,Baskin CC,Baskin JM

更新日期：2016-04-27 00:00:00

abstract：:Plasmonic metamaterials have overcome fundamental limitations in conventional optics by their capability to engineer material resonances and dispersions at will, holding great promise for sensing applications. Recent demonstrations of metamaterial sensors, however, have mainly relied on their resonant nature for stron...

journal_title：Scientific reports

authors： Ishikawa A,Hara S,Tanaka T,Hayashi Y,Tsuruta K

更新日期：2017-06-09 00:00:00