当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Association of PPM1G methylation with risk-taking in alcohol use disorder.

Association of PPM1G methylation with risk-taking in alcohol use disorder.

Abstract：

:Alcohol use disorder (AUD) is a chronic and relapsing disease with a substantial genetic influence. Given the recent discovery of the association of PPM1G methylation with alcohol use disorder (AUD) from a genome-wide methylation study, we sought to verify and extend the previous work of AUD-related impulsivity in a Korean population with AUD. A total of 244 men with AUD were assessed for psychological characteristics and behavioral impulsivity using stop signal task (response inhibition) and Balloon Analog Risk Task (risk-taking). Leukocyte DNA methylation at PPM1G was quantified using pyrosequencing. The effects of PPM1G methylation on severity of problematic drinking measured by Alcohol Use Disorder Identification Test (AUDIT) and multidimensional impulsivity were tested using linear regression analyses. Hypermethylation of PPM1G was significantly associated with risk-taking propensity among men with AUD. No significant association of PPM1G methylation was found to be associated with AUDIT scores and response inhibition. Our findings indicate that altered methylation of PPM1G may influence the impulsive choice of risk-taking in AUD. Further research is required in order to determine the role of PPM1G in the pathophysiology of AUD and multidimensional impulsivity.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Park CI,Kim HW,Hwang SS,Kang JI,Kim SJ

doi

10.1038/s41598-020-62504-y

subject

Has Abstract

pub_date

2020-03-26 00:00:00

pages

5490

issue

1

issn

2045-2322

pii

10.1038/s41598-020-62504-y

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • A functionally conserved Polycomb response element from mouse HoxD complex responds to heterochromatin factors.

    abstract：:Anterior-posterior body axis in all bilaterians is determined by the Hox gene clusters that are activated in a spatio-temporal order. This expression pattern of Hox genes is established and maintained by regulatory mechanisms that involve higher order chromatin structure and Polycomb group (PcG) and trithorax group (t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03011

    authors： Vasanthi D,Nagabhushan A,Matharu NK,Mishra RK

    更新日期：2013-10-22 00:00:00

  • Inclusion of Population-specific Reference Panel from India to the 1000 Genomes Phase 3 Panel Improves Imputation Accuracy.

    abstract：:Imputation is a computational method based on the principle of haplotype sharing allowing enrichment of genome-wide association study datasets. It depends on the haplotype structure of the population and density of the genotype data. The 1000 Genomes Project led to the generation of imputation reference panels which h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06905-6

    authors： Ahmad M,Sinha A,Ghosh S,Kumar V,Davila S,Yajnik CS,Chandak GR

    更新日期：2017-07-27 00:00:00

  • Modelling Dunes from Lençóis Maranhenses National Park (Brazil): Largest dune field in South America.

    abstract：:This paper presents a digital elevation model (DEM) of the dunes found in the Lençóis Maranhenses National Park, an environmental protection area located in the Maranhão state (Brazil). The DEM supports the modeling studies of sand-dune evolution using multi-temporal satellite images and ground truth data, obtained th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43735-0

    authors： Dos Santos ALS,Borges HP,Silva Junior CHL,Piedade Junior RN,da Silva Bezerra D

    更新日期：2019-05-15 00:00:00

  • Effect of green tea consumption on blood pressure: a meta-analysis of 13 randomized controlled trials.

    abstract：:The studies investigating the effects of green tea on blood pressure (BP) have generated inconsistent results. The aim of this study is to quantitatively evaluate the effects of green tea on BP control. PubMed, Embase, and the Cochrane Library (updated to March 2014) were searched for randomized controlled trials eval...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/srep06251

    authors： Peng X,Zhou R,Wang B,Yu X,Yang X,Liu K,Mi M

    更新日期：2014-09-01 00:00:00

  • Author Correction: Bone Anabolic Response in the Calvaria Following Mild Traumatic Brain Injury is Mediated by the Cannabinoid-1 Receptor.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-73944-x

    authors： Eger M,Bader M,Bree D,Hadar R,Nemirovski A,Tam J,Levy D,Pick CG,Gabet Y

    更新日期：2020-10-09 00:00:00

  • Collagen morphology and texture analysis: from statistics to classification.

    abstract：:In this study we present an image analysis methodology capable of quantifying morphological changes in tissue collagen fibril organization caused by pathological conditions. Texture analysis based on first-order statistics (FOS) and second-order statistics such as gray level co-occurrence matrix (GLCM) was explored to...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02190

    authors： Mostaço-Guidolin LB,Ko AC,Wang F,Xiang B,Hewko M,Tian G,Major A,Shiomi M,Sowa MG

    更新日期：2013-01-01 00:00:00

  • Risk factors and pathological characteristics for intraductal tumor spread of submucosal gland in early esophageal squamous cell neoplasia.

    abstract：:The esophageal gland duct may serve as a pathway for the spread of early esophageal squamous cell neoplasia (ESCN) to a deeper layer. Deep intraductal tumor spreading cannot be completely eradicated by ablation therapy. However, the risk factors of ductal involvement (DI) in patients with ESCNs have yet to be investig...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-020-62668-7

    authors： Wang WL,Chang IW,Hsu MH,Chen TH,Tseng CM,Tseng CH,Tai CM,Wang HP,Lee CT

    更新日期：2020-04-22 00:00:00

  • Genome-wide discovery of DNA polymorphisms among chickpea cultivars with contrasting seed size/weight and their functional relevance.

    abstract：:Seed size/weight is a major agronomic trait which determine crop productivity in legumes. To understand the genetic basis of seed size determination, we sought to identify DNA polymorphisms between two small (Himchana 1 and Pusa 362) and two large-seeded (JGK 3 and PG 0515) chickpea cultivars via whole genome resequen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35140-w

    authors： Rajkumar MS,Garg R,Jain M

    更新日期：2018-11-14 00:00:00

  • Simultaneous bilateral total knee arthroplasty in patients with end-stage hemophilic arthropathy: a mean follow-up of 6 years.

    abstract：:To investigate the safety, cost-effectiveness, and clinical outcomes of simultaneous bilateral total knee arthroplasty (TKA) in hemophilic arthropathy (HA), the requirements for transfusions, complications, costs, hospital stays, Hospital for Special Surgery (HSS) knee scores, knee range of motion (ROM) and revision r...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19852-7

    authors： Jiang C,Zhao Y,Feng B,Zhai J,Bian Y,Qiu G,Weng X

    更新日期：2018-01-25 00:00:00

  • The RNA-binding protein CsrA plays a central role in positively regulating virulence factors in Erwinia amylovora.

    abstract：:The GacS/GacA two-component system (also called GrrS/GrrA) is a global regulatory system which is highly conserved among gamma-proteobacteria. This system positively regulates non-coding small regulatory RNA csrB, which in turn binds to the RNA-binding protein CsrA. However, how GacS/GacA-Csr system regulates virulenc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37195

    authors： Ancona V,Lee JH,Zhao Y

    更新日期：2016-11-15 00:00:00

  • Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy.

    abstract：:Brain hypometabolism is a common epilepsy-related finding in both patients and animal models. Fluorodeoxyglucose positron emission tomography studies have shown that recurrent seizures lead to reduced glucose metabolism in certain brain regions, but no studies have definitively determined whether this induces epilepto...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05038-0

    authors： Zhang H,Gao G,Zhang Y,Sun Y,Li H,Dong S,Ma W,Liu B,Wang W,Wu H,Zhang H

    更新日期：2017-07-19 00:00:00

  • Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars.

    abstract：:The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18944-0

    authors： Ezzat SM,Shouman SA,Elkhoely A,Attia YM,Elsesy MS,El Senousy AS,Choucry MA,El Gayed SH,El Sayed AA,Sattar EA,El Tanbouly N

    更新日期：2018-01-11 00:00:00

  • Lipid yield from the diatom Porosira glacialis is determined by solvent choice and number of extractions, independent of cell disruption.

    abstract：:Cell wall disruption is necessary to maximize lipid extraction yields in conventional species of mass-cultivated microalgae. This study investigated the effect of sonication, solvent choice and number of extractions on the lipid yield, lipid class composition and fatty acid composition of the diatom Porosira glacialis...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79269-z

    authors： Svenning JB,Dalheim L,Vasskog T,Matricon L,Vang B,Olsen RL

    更新日期：2020-12-17 00:00:00

  • Development and performance of a targeted whole exome sequencing enrichment kit for the dog (Canis Familiaris Build 3.1).

    abstract：:Whole exome sequencing is a technique that aims to selectively sequence all exons of protein-coding genes. A canine whole exome sequencing enrichment kit was designed based on the latest canine reference genome (build 3.1.72). Its performance was tested by sequencing 2 exome captures, each consisting of 4 pre-capture ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05597

    authors： Broeckx BJ,Coopman F,Verhoeven GE,Bavegems V,De Keulenaer S,De Meester E,Van Niewerburgh F,Deforce D

    更新日期：2014-07-07 00:00:00

  • Large-scale semi-arid afforestation can enhance precipitation and carbon sequestration potential.

    abstract：:Afforestation is an important approach to mitigate global warming. Its complex interactions with the climate system, however, makes it controversial. Afforestation is expected to be effective in the tropics where biogeochemical and biogeophysical effects act in concert; however, its potential in the large semi-arid re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19265-6

    authors： Yosef G,Walko R,Avisar R,Tatarinov F,Rotenberg E,Yakir D

    更新日期：2018-01-17 00:00:00

  • Satellite radar observation of large surface collapses induced by the 2017 North Korea nuclear test.

    abstract：:The artificial earthquake of mb 6.1 related to the North Korea's sixth nuclear test occured at Mt. Mantap, North Korea on September 3, 2017. It was reported that a large and complex surface deformation was caused by the event. The surface deformation was composed of expansion of explosions, collapse, compaction and la...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74957-2

    authors： Baek WK,Jung HS,Kim TS

    更新日期：2020-10-20 00:00:00

  • Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells.

    abstract：:Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it als...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05510

    authors： Law BY,Chan WK,Xu SW,Wang JR,Bai LP,Liu L,Wong VK

    更新日期：2014-07-01 00:00:00

  • A Chinese Pane-Like 2D Metal-Organic Framework Showing Magnetic Relaxation and Luminescence Dual-Functions.

    abstract：:The discovery of graphene kicked off the curtain of atom-type two-dimensional (2D) materials. Layered metal-organic frameworks (MOFs) as parallel molecule-based 2D materials are more designable and more diverse, and magnetism may be induced by their metal ion nodes. However, the multifunctional 2D plane-like MOFs are ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11006-5

    authors： Liu CM,Zhang DQ,Hao X,Zhu DB

    更新日期：2017-09-11 00:00:00

  • Anthropogenic pressures drive population genetic structuring across a Critically Endangered lemur species range.

    abstract：:In recent decades Madagascar has experienced significant habitat loss and modification, with minimal understanding of how human land use practices have impacted the evolution of its flora and fauna. In light of ongoing and intensifying anthropogenic pressures, we seek new insight into mechanisms driving genetic variab...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52689-2

    authors： Baden AL,Mancini AN,Federman S,Holmes SM,Johnson SE,Kamilar J,Louis EE Jr,Bradley BJ

    更新日期：2019-11-07 00:00:00

  • Membrane capacitance recordings resolve dynamics and complexity of receptor-mediated endocytosis in Wnt signalling.

    abstract：:Receptor-mediated endocytosis is an essential process in signalling pathways for activation of intracellular signalling cascades. One example is the Wnt signalling pathway that seems to depend on endocytosis of the ligand-receptor complex for initiation of Wnt signal transduction. To date, the roles of different endoc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49082-4

    authors： Bandmann V,Mirsanaye AS,Schäfer J,Thiel G,Holstein T,Mikosch-Wersching M

    更新日期：2019-09-10 00:00:00

  • Discordancy Partitioning for Validating Potentially Inconsistent Pharmacogenomic Studies.

    abstract：:The Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE) are two major studies that can be used to mine for therapeutic biomarkers for cancers of a large variety. Model validation using the two datasets however has proved challenging. Both predictions and signatures do not consistentl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15590-4

    authors： Rao JS,Liu H

    更新日期：2017-11-09 00:00:00

  • Additive manufacturing of laminar flow cells for single-molecule experiments.

    abstract：:A microfluidic laminar flow cell (LFC) forms an indispensable component in single-molecule experiments, enabling different substances to be delivered directly to the point under observation and thereby tightly controlling the biochemical environment immediately surrounding single molecules. Despite substantial progres...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53151-z

    authors： Ahmadi A,Till K,Hafting Y,Schüttpelz M,Bjørås M,Glette K,Tørresen J,Rowe AD,Dalhus B

    更新日期：2019-11-14 00:00:00

  • Synergistic adsorption-photocatalytic degradation effect and norfloxacin mechanism of ZnO/ZnS@BC under UV-light irradiation.

    abstract：:Norfloxacin (NOF) is an environmentally harmful and ubiquitous aquatic pollutant with extensive production and application. In this study, a novel composition named carbon-based composite photocatalytic material of zinc oxide and zinc sulphide (ZnO/ZnS@BC) was successfully obtained by the impregnation-roasting method ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68517-x

    authors： Liu W,He T,Wang Y,Ning G,Xu Z,Chen X,Hu X,Wu Y,Zhao Y

    更新日期：2020-07-17 00:00:00

  • Predicting county-scale maize yields with publicly available data.

    abstract：:Maize (corn) is the dominant grain grown in the world. Total maize production in 2018 equaled 1.12 billion tons. Maize is used primarily as an animal feed in the production of eggs, dairy, pork and chicken. The US produces 32% of the world's maize followed by China at 22% and Brazil at 9% ( https://apps.fas.usda.gov/p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71898-8

    authors： Jiang Z,Liu C,Ganapathysubramanian B,Hayes DJ,Sarkar S

    更新日期：2020-09-11 00:00:00

  • Mapping the genetic diversity of HLA haplotypes in the Japanese populations.

    abstract：:Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17855

    authors： Saw WY,Liu X,Khor CC,Takeuchi F,Katsuya T,Kimura R,Nabika T,Ohkubo T,Tabara Y,Yamamoto K,Yokota M,Japanese Genome Variation Consortium.,Teo YY,Kato N

    更新日期：2015-12-09 00:00:00

  • The origin of rare alkali metals in geothermal fluids of southern Tibet, China: A silicon isotope perspective.

    abstract：:Geothermal waters from the Semi, Dagejia and Kawu hot springs in the Shiquanhe-Yarlung Zangbo geothermal field of southern Tibet (China) are highly enriched in rare alkali metals (RAM). However, the enrichment mechanism is still hotly debated. Here, we report the first silicon isotope data of these geothermal waters t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44249-5

    authors： Wang W,Wei HZ,Jiang SY,Tan HB,Eastoe CJ,Williams-Jones AE,Hohl SV,Wu HP

    更新日期：2019-05-27 00:00:00

  • Galectin-3 Enhances Migration of Minature Pig Bone Marrow Mesenchymal Stem Cells Through Inhibition of RhoA-GTP Activity.

    abstract：:Bone marrow mesenchymal stem cells (BM-MSCs) are used in tissue engineering because of their migration characters. However, BM-MSCs have limitations in terms of reaching injuries and self-renewal. Therefore, enhancement of BM-MSC migration is important for therapeutic applications. Here, we assessed whether galectin-3...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep26577

    authors： Gao Q,Xia Y,Liu L,Huang L,Liu Y,Zhang X,Xu K,Wei J,Hu Y,Mu Y,Li K

    更新日期：2016-05-24 00:00:00

  • Alexithymia and emotional reactions to odors.

    abstract：:Alexithymia is a psychological construct characterized by deficits in processing emotional stimuli. However, little is known about the processing of odours in alexithymia, even though there is extensive proof that emotion and olfaction are closely linked. The present study is aimed at investigating how alexithymic ind...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14404-x

    authors： Cecchetto C,Rumiati RI,Aiello M

    更新日期：2017-10-26 00:00:00

  • Impact of nutritional supplements on cognitive development of children in developing countries: A meta-analysis.

    abstract：:Nutritional supplements may be important on cognition but the evidence is heterogeneous. This meta-analysis aimed (1) to determine whether nutritional supplements provided to pregnant women or young children could improve cognitive development of children in developing countries, and (2) to explore how supplementation...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-017-11023-4

    authors： Ip P,Ho FKW,Rao N,Sun J,Young ME,Chow CB,Tso W,Hon KL

    更新日期：2017-09-06 00:00:00

  • Extraction of nano-silicon with activated carbons simultaneously from rice husk and their synergistic catalytic effect in counter electrodes of dye-sensitized solar cells.

    abstract：:The extraction of renewable energy resources particularly from earth abundant materials has always been a matter of significance in industrial products. Herein, we report a novel simultaneous extraction of nano-silicon with activated carbons (nano-Si@ACs) from rice husk (RH) by chemical activation method. As-extracted...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39314

    authors： Ahmad W,Bahrani MR,Yang Z,Khan J,Jing W,Jiang F,Chu L,Liu N,Li L,Gao Y

    更新日期：2016-12-21 00:00:00