Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment.

abstract：:Thermal perception is essential for the survival and daily activities of people. Thus, it is desirable to realize thermal feedback stimulation for improving the sense of realism in virtual reality (VR) for users. For thermal stimulus, conventional systems utilize liquid circulation with bulky external sources or therm...

journal_title：Scientific reports

authors： Kim SW,Kim SH,Kim CS,Yi K,Kim JS,Cho BJ,Cha Y

更新日期：2020-07-09 00:00:00

abstract：:There is a growing interest concerning the relevance of salivary cortisone levels in stress-related research. However, studies investigating morning patterns and day-to-day variability of cortisone versus cortisol levels are lacking. Cortisol and cortisone analysis by liquid chromatography-tandem mass spectroscopy (LC...

journal_title：Scientific reports

authors： Bakusic J,De Nys S,Creta M,Godderis L,Duca RC

更新日期：2019-12-17 00:00:00

abstract：:Enterovirus 71 (EV71) is the predominant causative pathogen of hand-foot-and-mouth disease (HFMD). Contrary to other HFMD-causing enterovirus, EV71 can lead to severe neurological complications, even death. MicroRNAs (miRNAs) are small non-coding RNAs that constitute the largest family of gene regulators participating...

journal_title：Scientific reports

authors： Zheng C,Zheng Z,Sun J,Zhang Y,Wei C,Ke X,Liu Y,Deng L,Wang H

更新日期：2017-11-27 00:00:00

abstract：:Transgenic expression of I-E molecules prevents diabetes in NOD mice. So far, the precise role of these non-classical MHC II molecules remains elusive. Here, we showed that transgenic expression of I-E(k) alpha 16 molecule in NOD mice selectively reduced Th17 cells in the thymus and pancreatic draining lymph nodes. Th...

journal_title：Scientific reports

authors： Yang C,Guo N,Liu J,Yang J,Zhu K,Xiao H,Leng Q

更新日期：2015-08-07 00:00:00

abstract：:Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and industrial application. Here, we introduce a novel promoter switching method based on the DDI2 promoter (PDDI2) that...

journal_title：Scientific reports

authors： Wang Y,Zhang K,Li H,Xu X,Xue H,Wang P,Fu YV

更新日期：2019-08-29 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly. Zinc (Zn) ion interacts with the pathogenic hallmark, amyloid-β (Aβ), and is enriched in senile plaques in brain of AD patients. To understand Zn-chelated Aβ (ZnAβ) species, here we systematically characterized ZnAβ aggregates by ...

journal_title：Scientific reports

authors： Lee MC,Yu WC,Shih YH,Chen CY,Guo ZH,Huang SJ,Chan JCC,Chen YR

更新日期：2018-03-19 00:00:00

abstract：:We present a new collusion attack to a kind of quantum secret sharing schemes with entangled states. Using this attack, an unauthorized set of agents can gain access to the shared secret without the others' cooperation. Furthermore, we establish a general model for this kind of quantum secret sharing schemes and then ...

journal_title：Scientific reports

authors： Wang TY,Liu YZ,Wei CY,Cai XQ,Ma JF

更新日期：2017-05-30 00:00:00

abstract：:Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and expense of animal testing often makes it unfeasible to examine this large number of nanoparticles in vivo. This often leads to the investigation...

journal_title：Scientific reports

authors： Elias A,Crayton SH,Warden-Rothman R,Tsourkas A

更新日期：2014-07-28 00:00:00

abstract：:Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) of aluminium oxyhydroxide and aluminium hydroxyphosphate adjuvants was elucidated in attempt to correlate these properties with the biological responses observed post v...

journal_title：Scientific reports

authors： Mold M,Shardlow E,Exley C

更新日期：2016-08-12 00:00:00

abstract：:Engineering of efflux pumps is a promising way to improve host's tolerance to biofuels such as medium-chain alcohols (CmOHs); however, this strategy is restricted by poor understanding of the efflux pumps engaged in extrusion of solvents. In this study, several Escherichia coli mutants of multidrug transporters were e...

journal_title：Scientific reports

authors： Wang C,Yang L,Shah AA,Choi ES,Kim SW

更新日期：2015-11-13 00:00:00

abstract：:FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML. A frequent, clinical limitation is FLT3 selectivity, as concomitant inhibition of FLT3 and c-KIT ...

journal_title：Scientific reports

authors： Bharate JB,McConnell N,Naresh G,Zhang L,Lakkaniga NR,Ding L,Shah NP,Frett B,Li HY

更新日期：2018-02-27 00:00:00

abstract：:Cell-based assays are growing in importance for screening drugs and investigating their mechanisms of action. Most of the assays use so-called "normal" cell strain because it is difficult to produce cell lines in which the disease conditions are reproduced. In this study, we used a cell-resealing technique, which reve...

journal_title：Scientific reports

authors： Kano F,Noguchi Y,Murata M

更新日期：2017-11-09 00:00:00

abstract：:Human and animal infections of Enterocytozoon bieneusi (E. bieneusi) have consistently been reported worldwide, garnering public attention; however, the molecular epidemiology of E. bieneusi in the giant panda remains limited. We surveyed captive giant pandas in China for the presence of E. bieneusi by using PCR and s...

journal_title：Scientific reports

authors： Li W,Zhong Z,Song Y,Gong C,Deng L,Cao Y,Zhou Z,Cao X,Tian Y,Li H,Feng F,Zhang Y,Wang C,Li C,Yang H,Huang X,Fu H,Geng Y,Ren Z,Wu K,Peng G

更新日期：2018-04-26 00:00:00

abstract：:In the recent years, new molecular methods have been proposed to discriminate multicentric hepatocellular carcinomas (HCC) from intrahepatic metastases. Some of these methods utilize sequencing data to assess similarities between cancer genomes, whilst other achieved the same results with transcriptome and methylome d...

journal_title：Scientific reports

authors： Lackner C,Quagliata L,Cross W,Ribi S,Heinimann K,Paradiso V,Quintavalle C,Kovacova M,Baumhoer D,Piscuoglio S,Terracciano L,Kovac M

更新日期：2019-03-14 00:00:00

abstract：:The combined regulation of a network of inhibitory and activating T cell receptors may be a critical step in the development of chronic HCV infection. Ex vivo HCV MHC class I + II tetramer staining and bead-enrichment was performed with baseline and longitudinal PBMC samples of a cohort of patients with acute, chronic...

journal_title：Scientific reports

authors： Ackermann C,Smits M,Woost R,Eberhard JM,Peine S,Kummer S,Marget M,Kuntzen T,Kwok WW,Lohse AW,Jacobs T,Boettler T,Schulze Zur Wiesch J

更新日期：2019-07-23 00:00:00

abstract：:Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hypothesised that dogs with congestive heart failure have quantifiable ...

journal_title：Scientific reports

authors： Seo J,Matthewman L,Xia D,Wilshaw J,Chang YM,Connolly DJ

更新日期：2020-08-13 00:00:00

abstract：:The bacterial stringent response is a key regulator of bacterial virulence, biofilm formation and antibiotic tolerance, and is a promising target for the development of new antibacterial compounds. The intracellular nucleotide (p)ppGpp acts as a messenger orchestrating the stringent response. A synthetic peptide 1018 ...

journal_title：Scientific reports

authors： Andresen L,Tenson T,Hauryliuk V

更新日期：2016-11-07 00:00:00

abstract：:A fundamental challenge for behavioral neuroscientists is to accurately quantify (dis)similarities in animal behavior without excluding inherent variability present between individuals. We explored two new applications of curve and shape alignment techniques to address this issue. As a proof-of-concept we applied thes...

journal_title：Scientific reports

authors： Stamps MT,Go S,Mathuru AS

更新日期：2019-11-12 00:00:00

abstract：:Due to chromatic aberration, blue images are defocused when the eye is focused to the middle of the visible spectrum, yet we normally are not aware of chromatic blur. The eye suffers from monochromatic aberrations which degrade the optical quality of all images projected on the retina. The combination of monochromatic...

journal_title：Scientific reports

authors： Benedi-Garcia C,Vinas M,Dorronsoro C,Burns SA,Peli E,Marcos S

更新日期：2021-01-11 00:00:00

abstract：:The physical mechanism of the anthropogenic triggering of large earthquakes on active faults is studied on the basis of experimental phenomenology, i.e., that earthquakes occur on active tectonic faults, that crustal stress values are those measured in situ and, on active faults, comply to the values of the stress dro...

journal_title：Scientific reports

authors： Mulargia F,Bizzarri A

更新日期：2014-08-26 00:00:00

abstract：:Plants exude a diverse cocktail of metabolites into the soil as response to exogenous and endogenous factors. So far, root exudates have mainly been studied under artificial conditions due to methodological difficulties. In this study, each five perennial grass and forb species were investigated for polar and semi-pol...

journal_title：Scientific reports

authors： Dietz S,Herz K,Gorzolka K,Jandt U,Bruelheide H,Scheel D

更新日期：2020-07-01 00:00:00

abstract：:Oral submucous fibrosis (OSF), regarded as a precancerous condition, is characterized by juxta-epithelial inflammatory reaction followed by fibro-elastic change in the lamina properia and epithelial atrophy. The pathologic mechanisms of OSF still need to be further clarified. In the study, we investigated the function...

journal_title：Scientific reports

authors： Yu CC,Yu CH,Chang YC

更新日期：2016-11-15 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ezewudo M,Borens A,Chiner-Oms Á,Miotto P,Chindelevitch L,Starks AM,Hanna D,Liwski R,Zignol M,Gilpin C,Niemann S,Kohl TA,Warren RM,Crook D,Gagneux S,Hoffner S,Rodrigues C,Comas I,Engelthaler DM,Alland D,Rigouts L,

更新日期：2020-02-21 00:00:00

abstract：:We investigated whether maternal metabolic environment affects mesenchymal stromal/stem cells (MSCs) from umbilical cord's Wharton's Jelly (WJ) on a molecular level, and potentially render them unsuitable for clinical use in multiple recipients. In this pilot study on umbilical cords post partum from healthy non-obese...

journal_title：Scientific reports

authors： Badraiq H,Cvoro A,Galleu A,Simon M,Miere C,Hobbs C,Schulz R,Siow R,Dazzi F,Ilic D

更新日期：2017-12-14 00:00:00

abstract：:Neonates are more susceptible to infections than adults. This susceptibility is thought to reflect neonates' qualitative and quantitative defects in the adaptive and innate immune responses. Differential expression of cell surface receptors may result in altered thresholds of neonatal immune cell activation. We determ...

journal_title：Scientific reports

authors： Zenarruzabeitia O,Vitallé J,García-Obregón S,Astigarraga I,Eguizabal C,Santos S,Simhadri VR,Borrego F

更新日期：2016-09-06 00:00:00

abstract：:Schizophrenia is a common and severe mental disorder arising from complex gene-environment interactions affecting brain development and functioning. While a consensus on the neuroanatomical correlates of schizophrenia is emerging, much of its fundamental pathobiology remains unknown. In this study, we explore brain mo...

journal_title：Scientific reports

authors： Qvist P,Eskildsen SF,Hansen B,Baragji M,Ringgaard S,Roovers J,Paternoster V,Molgaard S,Corydon TJ,Stødkilde-Jørgensen H,Glerup S,Mors O,Wegener G,Nyengaard JR,Børglum AD,Christensen JH

更新日期：2018-11-07 00:00:00

abstract：:Dementia is a major public health issue worldwide and chronic use of benzodiazepine, which is very frequent in northern countries, was found to be a risk factor of dementia. This work aims at evaluating the impact of a reduction in chronic use of benzodiazepine on the future burden of dementia in France. Using estimat...

journal_title：Scientific reports

authors： Jacqmin-Gadda H,Guillet F,Mathieu C,Helmer C,Pariente A,Joly P

更新日期：2020-09-04 00:00:00

abstract：:In the field of neuroprosthetics, the current state-of-the-art method involves controlling the prosthesis with electromyography (EMG) or electrooculography/electroencephalography (EOG/EEG). However, these systems are both expensive and time consuming to calibrate, susceptible to interference, and require a lengthy lea...

journal_title：Scientific reports

authors： Hazubski S,Hoppe H,Otte A

更新日期：2020-10-01 00:00:00

abstract：:Bacteriophage capsids constitute icosahedral shells of exceptional stability that protect the viral genome. Many capsids display on their surface decoration proteins whose structure and function remain largely unknown. The decoration protein pb10 of phage T5 binds at the centre of the 120 hexamers formed by the major ...

journal_title：Scientific reports

authors： Vernhes E,Renouard M,Gilquin B,Cuniasse P,Durand D,England P,Hoos S,Huet A,Conway JF,Glukhov A,Ksenzenko V,Jacquet E,Nhiri N,Zinn-Justin S,Boulanger P

更新日期：2017-02-06 00:00:00

abstract：:Despite recent advances in drug delivery, the targeted treatment of unhealthy cells or tissues continues to remain a priority. In cancer (much like other pathologies), delivery vectors are designed to exploit physical and biological features of unhealthy tissues that are not always homogenous across the disease. In so...

journal_title：Scientific reports

authors： Evangelopoulos M,Yazdi IK,Acciardo S,Palomba R,Giordano F,Pasto A,Sushnitha M,Martinez JO,Basu N,Torres A,Hmaidan S,Parodi A,Tasciotti E

更新日期：2020-01-13 00:00:00