Quantitative comparison of tumor delivery for multiple targeted nanoparticles simultaneously by multiplex ICP-MS.

Abstract:

:Given the rapidly expanding library of disease biomarkers and targeting agents, the number of unique targeted nanoparticles is growing exponentially. The high variability and expense of animal testing often makes it unfeasible to examine this large number of nanoparticles in vivo. This often leads to the investigation of a single formulation that performed best in vitro. However, nanoparticle performance in vivo depends on many variables, many of which cannot be adequately assessed with cell-based assays. To address this issue, we developed a lanthanide-doped nanoparticle method that allows quantitative comparison of multiple targeted nanoparticles simultaneously. Specifically, superparamagnetic iron oxide (SPIO) nanoparticles with different targeting ligands were created, each with a unique lanthanide dopant. Following the simultaneous injection of the various SPIO compositions into tumor-bearing mice, inductively coupled plasma mass spectroscopy was used to quantitatively and orthogonally assess the concentration of each SPIO composition in serial blood and resected tumor samples.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Elias A,Crayton SH,Warden-Rothman R,Tsourkas A

doi

10.1038/srep05840

subject

Has Abstract

pub_date

2014-07-28 00:00:00

pages

5840

issn

2045-2322

pii

srep05840

journal_volume

4

pub_type

杂志文章
  • Realizing Broadband and Invertible Linear-to-circular Polarization Converter with Ultrathin Single-layer Metasurface.

    abstract::The arbitrary control of the polarization states of light has attracted the interest of the scientific community because of the wide range of modern optical applications that such control can afford. However, conventional polarization control setups are bulky and very often operate only within a narrow wavelength rang...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18106

    authors: Li Z,Liu W,Cheng H,Chen S,Tian J

    更新日期:2015-12-15 00:00:00

  • Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression.

    abstract::There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17700-8

    authors: Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

    更新日期:2017-12-11 00:00:00

  • Interference experiment with asymmetric double slit by using 1.2-MV field emission transmission electron microscope.

    abstract::Advanced electron microscopy technologies have made it possible to perform precise double-slit interference experiments. We used a 1.2-MV field emission electron microscope providing coherent electron waves and a direct detection camera system enabling single-electron detections at a sub-second exposure time. We devel...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-19380-4

    authors: Harada K,Akashi T,Niitsu K,Shimada K,Ono YA,Shindo D,Shinada H,Mori S

    更新日期:2018-01-17 00:00:00

  • Fencing bodes a rapid collapse of the unique Greater Mara ecosystem.

    abstract::With land privatization and fencing of thousands of hectares of communal grazing areas, East Africa is struggling with one of the most radical cultural and environmental changes in its history. The 668,500-hectare Greater Mara is of crucial importance for the great migrations of large mammals and for Maasai pastoralis...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep41450

    authors: Løvschal M,Bøcher PK,Pilgaard J,Amoke I,Odingo A,Thuo A,Svenning JC

    更新日期:2017-01-25 00:00:00

  • Biogenic synthesis of AgNPs employing Terminalia arjuna leaf extract and its efficacy towards catalytic degradation of organic dyes.

    abstract::In the present work, we demonstrated the biosynthesis of silver nanoparticles (AgNPs) by highly stable, economic and eco-friendly method using leaf extract of Terminalia arjuna (T. arjuna) and employing as a catalyst for the degradation of methyl orange (MO), methylene blue (MB), congo red (CR) and 4- nitrophenol (4-N...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66851-8

    authors: Raj S,Singh H,Trivedi R,Soni V

    更新日期:2020-06-15 00:00:00

  • Thermodynamic evidence of giant salt deposit formation by serpentinization: an alternative mechanism to solar evaporation.

    abstract::The evaporation of seawater in arid climates is currently the main accepted driving mechanism for the formation of ancient and recent salt deposits in shallow basins. However, the deposition of huge amounts of marine salts, including the formation of tens of metres of highly soluble types (tachyhydrite and bischofite)...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48138-9

    authors: Debure M,Lassin A,Marty NC,Claret F,Virgone A,Calassou S,Gaucher EC

    更新日期:2019-08-12 00:00:00

  • Ordered micro/macro porous K-OMS-2/SiO2 nanocatalysts: Facile synthesis, low cost and high catalytic activity for diesel soot combustion.

    abstract::A series of novel oxide catalysts, which contain three-dimensionally ordered macroporous (3DOM) and microporous structure, were firstly designed and successfully synthesized by simple method. In the as-prepared catalysts, 3DOM SiO2 is used as support and microporous K-OMS-2 oxide nanoparticles are supported on the wal...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43894

    authors: Yu X,Zhao Z,Wei Y,Liu J

    更新日期:2017-04-26 00:00:00

  • Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport.

    abstract::Dysregulation of dopaminergic system induced by HIV-1 Tat protein-mediated direct inhibition of the dopamine transporter (DAT) has been implicated as a mediating factor of HIV-1 associated neurocognitive disorders. We have reported that single point mutations on human DAT (hDAT) at tyrosine88 (Y88F), lysine92 (K92M), ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39872-1

    authors: Sun WL,Quizon PM,Yuan Y,Strauss MJ,McCain R Jr,Zhan CG,Zhu J

    更新日期:2019-03-07 00:00:00

  • Wild specimens of sand fly phlebotomine Lutzomyia evansi, vector of leishmaniasis, show high abundance of Methylobacterium and natural carriage of Wolbachia and Cardinium types in the midgut microbiome.

    abstract::Phlebotomine sand flies are remarkable vectors of several etiologic agents (virus, bacterial, trypanosomatid Leishmania), posing a heavy health burden for human populations mainly located at developing countries. Their intestinal microbiota is involved in a wide range of biological and physiological processes, and cou...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53769-z

    authors: Vivero RJ,Villegas-Plazas M,Cadavid-Restrepo GE,Herrera CXM,Uribe SI,Junca H

    更新日期:2019-11-28 00:00:00

  • Exosomal miR-10a derived from amniotic fluid stem cells preserves ovarian follicles after chemotherapy.

    abstract::Chemotherapy (CTx)-induced premature ovarian failure (POF) in woman remains clinically irreversible. Amniotic fluid stem cells (AFSCs) have shown the potential to treat CTx-induced POF; however, the underlying mechanism is unclear. Here we demonstrate that AFSC-derived exosomes recapitulate the anti-apoptotic effect o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23120

    authors: Xiao GY,Cheng CC,Chiang YS,Cheng WT,Liu IH,Wu SC

    更新日期:2016-03-16 00:00:00

  • Relationship between frequency of hypoglycemic episodes and changes in carotid atherosclerosis in insulin-treated patients with type 2 diabetes mellitus.

    abstract::The effect of hypoglycemia on the progression of atherosclerosis in patients with type 2 diabetes mellitus (T2DM) remains largely unknown. This is a post hoc analysis of a randomized trial to investigate the relationship between hypoglycemic episodes and changes in carotid intima-media thickness (IMT). Among 274 study...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39965

    authors: Mita T,Katakami N,Shiraiwa T,Yoshii H,Kuribayashi N,Osonoi T,Kaneto H,Kosugi K,Umayahara Y,Gosho M,Shimomura I,Watada H

    更新日期:2017-01-09 00:00:00

  • Decreased temperature variance associated with biotic composition enhances coastal shrub encroachment.

    abstract::Regime shift from grasslands to shrub-dominated landscapes occur worldwide driven by altered land-use and climate change, affecting landscape function, biodiversity, and productivity. Warming winter temperatures are a main driver of expansion of the native, evergreen shrub, Morella cerifera, in coastal landscapes. Shr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-65161-3

    authors: Wood LK,Hays S,Zinnert JC

    更新日期:2020-05-19 00:00:00

  • The time course of auditory recognition measured with rapid sequences of short natural sounds.

    abstract::Human listeners are able to recognize accurately an impressive range of complex sounds, such as musical instruments or voices. The underlying mechanisms are still poorly understood. Here, we aimed to characterize the processing time needed to recognize a natural sound. To do so, by analogy with the "rapid visual seque...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43126-5

    authors: Isnard V,Chastres V,Viaud-Delmon I,Suied C

    更新日期:2019-05-29 00:00:00

  • Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps.

    abstract::We previously reported that chronic rhinosinusitis with nasal polyps (CRSwNP) was subdivided into four chronic rhinosinusitis (CRS) subtypes using the JESREC scoring system. We sought to identify the gene expression profile and biomarkers related with CRSwNP by RNA-sequence. RNA-sequencing was performed to identify di...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-29612-2

    authors: Ninomiya T,Noguchi E,Haruna T,Hasegawa M,Yoshida T,Yamashita Y,Okano M,Yoshida N,Haruna S,Sakuma Y,Ohta S,Ono J,Izuhara K,Okada M,Kidoguchi M,Tokunaga T,Okamoto M,Kanno M,Sakashita M,Takabayashi T,Narita N,Fujie

    更新日期:2018-07-30 00:00:00

  • Potassium fertilisation reduces radiocesium uptake by Japanese cypress seedlings grown in a stand contaminated by the Fukushima Daiichi nuclear accident.

    abstract::We analysed suppressive effects of potassium (K) fertilisation on radiocesium (137Cs) uptake by hinoki cypress (Chamaecyparis obtusa) seedlings from soils contaminated after the Fukushima Daiichi Nuclear Power Plant accident. Three-year-old seedlings were planted in a clear-cut forest (ca. 4 ha) during June-July 2014,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15401-w

    authors: Komatsu M,Hirai K,Nagakura J,Noguchi K

    更新日期:2017-11-15 00:00:00

  • Optimizing rice plant photosynthate allocation reduces N2O emissions from paddy fields.

    abstract::Rice paddies are a major source of anthropogenic nitrous oxide (N2O) emissions, especially under alternate wetting-drying irrigation and high N input. Increasing photosynthate allocation to the grain in rice (Oryza sativa L.) has been identified as an effective strategy of genetic and agronomic innovation for yield en...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29333

    authors: Jiang Y,Huang X,Zhang X,Zhang X,Zhang Y,Zheng C,Deng A,Zhang J,Wu L,Hu S,Zhang W

    更新日期:2016-07-05 00:00:00

  • Polarization and Thickness Dependent Absorption Properties of Black Phosphorus: New Saturable Absorber for Ultrafast Pulse Generation.

    abstract::Black phosphorus (BP) has recently been rediscovered as a new and interesting two-dimensional material due to its unique electronic and optical properties. Here, we study the linear and nonlinear optical properties of BP flakes. We observe that both the linear and nonlinear optical properties are anisotropic and can b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15899

    authors: Li D,Jussila H,Karvonen L,Ye G,Lipsanen H,Chen X,Sun Z

    更新日期:2015-10-30 00:00:00

  • Genetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: a new clue for the contribution of chromatin remodeling in carcinogenesis.

    abstract::Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inactivating mutations in SWI/SNF subunits involved in the molecular basis of hepatocarcinogenesis. To test the hyp...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04147

    authors: Zhong R,Liu L,Tian Y,Wang Y,Tian J,Zhu BB,Chen W,Qian JM,Zou L,Xiao M,Shen N,Yang H,Lou J,Qiu Q,Ke JT,Lu XH,Wang ZL,Song W,Zhang T,Li H,Wang L,Miao XP

    更新日期:2014-02-21 00:00:00

  • Oxytocin improves synchronisation in leader-follower interaction.

    abstract::The neuropeptide oxytocin has been shown to affect social interaction. Meanwhile, the underlying mechanism remains highly debated. Using an interpersonal finger-tapping paradigm, we investigated whether oxytocin affects the ability to synchronise with and adapt to the behaviour of others. Dyads received either oxytoci...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep38416

    authors: Gebauer L,Witek MAG,Hansen NC,Thomas J,Konvalinka I,Vuust P

    更新日期:2016-12-08 00:00:00

  • Classification models for Invasive Ductal Carcinoma Progression, based on gene expression data-trained supervised machine learning.

    abstract::Early detection of breast cancer and its correct stage determination are important for prognosis and rendering appropriate personalized clinical treatment to breast cancer patients. However, despite considerable efforts and progress, there is a need to identify the specific genomic factors responsible for, or accompan...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60740-w

    authors: Roy S,Kumar R,Mittal V,Gupta D

    更新日期:2020-03-05 00:00:00

  • d-PET-controlled "off-on" Polarity-sensitive Probes for Reporting Local Hydrophilicity within Lysosomes.

    abstract::Polarity-sensitive fluorescent probes are powerful chemical tools for studying biomolecular structures and activities both in vitro and in vivo. However, the lack of "off-on" polarity-sensing probes has limited the accurate monitoring of biological processes that involve an increase in local hydrophilicity. Here, we d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep35627

    authors: Zhu H,Fan J,Mu H,Zhu T,Zhang Z,Du J,Peng X

    更新日期:2016-10-21 00:00:00

  • The Enzymatic Activity of APOBE3G Multimers.

    abstract::APOBEC3G (A3G) belongs to the family of cytosine deaminases that play an important role in the innate immune response. Similar to other, two-domain members of the APOBEC family, A3G is prone to concentration-dependent oligomerization, which is an integral for its function in the cell. It is shown that oligomerization ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36372-6

    authors: Pan Y,Zagorski K,Shlyakhtenko LS,Lyubchenko YL

    更新日期:2018-12-18 00:00:00

  • Computational geometric tools for quantitative comparison of locomotory behavior.

    abstract::A fundamental challenge for behavioral neuroscientists is to accurately quantify (dis)similarities in animal behavior without excluding inherent variability present between individuals. We explored two new applications of curve and shape alignment techniques to address this issue. As a proof-of-concept we applied thes...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52300-8

    authors: Stamps MT,Go S,Mathuru AS

    更新日期:2019-11-12 00:00:00

  • Author Correction: Visualization and quantification of the degenerative pattern of the talus in unilateral varus ankle osteoarthritis.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-60514-4

    authors: Seki H,Ogihara N,Kokubo T,Suda Y,Ishii K,Nagura T

    更新日期:2020-02-19 00:00:00

  • Publisher Correction: PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation.

    abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/s41598-017-14858-z

    authors: Hu C,Yu M,Ren Y,Li K,Maggio DM,Mei C,Ye L,Wei J,Jin J,Zhuang Z,Tong H

    更新日期:2017-11-07 00:00:00

  • Taxonomic and functional diversity increase the aesthetic value of coralligenous reefs.

    abstract::The aesthetic value of landscapes contributes to human well-being. However, studies which have investigated the link between biodiversity and ecosystem services have not taken aesthetic value into account. In this study we evaluated how the aesthetics of coralligenous reefs, a key marine ecosystem in the Mediterranean...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34229

    authors: Tribot AS,Mouquet N,Villéger S,Raymond M,Hoff F,Boissery P,Holon F,Deter J

    更新日期:2016-09-28 00:00:00

  • EGFP-EGF1-conjugated poly (lactic-co-glycolic acid) nanoparticles as a carrier for the delivery of CCR2- shRNA to atherosclerotic macrophage in vitro.

    abstract::Reducing macrophage recruitment by silencing chemokine (C-C motif) receptor 2 (CCR2) expression is a promising therapeutic approach against atherosclerosis. However the transfection of macrophages with siRNA is often technically challenging. EGFP-EGF1-conjugated poly (lactic-co-glycolic acid) (PLGA) nanoparticles (ENP...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76416-4

    authors: Wu Z,Chen C,Luo J,Davis JRJ,Zhang B,Tang L,Shi W,Liao D

    更新日期:2020-11-12 00:00:00

  • Structure- and conformation-activity studies of nociceptin/orphanin FQ receptor dimeric ligands.

    abstract::The peptide nociceptin/orphanin FQ (N/OFQ) and the N/OFQ receptor (NOP) constitute a neuropeptidergic system that modulates various biological functions and is currently targeted for the generation of innovative drugs. In the present study dimeric NOP receptor ligands with spacers of different lengths were generated u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45817

    authors: Pacifico S,Carotenuto A,Brancaccio D,Novellino E,Marzola E,Ferrari F,Cerlesi MC,Trapella C,Preti D,Salvadori S,Calò G,Guerrini R

    更新日期:2017-04-06 00:00:00

  • Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) is associated with features of and progression to obstructive lung disease.

    abstract::One quarter of individuals with Preserved Ratio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established methods to identify these individuals. We examined the utility of FVC/TLC in identifying features of obstructive lung disease. The ratio of post-bronchodilator FVC and TLCCT from c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61932-0

    authors: Fortis S,Comellas A,Kim V,Casaburi R,Hokanson JE,Crapo JD,Silverman EK,Wan ES

    更新日期:2020-03-20 00:00:00

  • A Reciprocal Interaction between β-Catenin and Osterix in Cementogenesis.

    abstract::Although accumulating evidence indicates that both β-catenin and osterix (Osx) are essential for bone and tooth development, few studies have investigated the interaction of these two key proteins in the context of cementogenesis. In this study, we used transgenic mice with constitutively active β-catenin and inactive...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08607-5

    authors: Choi H,Kim TH,Yang S,Lee JC,You HK,Cho ES

    更新日期:2017-08-15 00:00:00