Non-classical MHC I-E negatively regulates macrophage activation and Th17 cell development in NOD mice.

abstract：:Hybridization between heterospecific individuals has been documented as playing a direct role in promoting paternal leakage and mitochondrial heteroplasmy in both natural populations and laboratory conditions, by relaxing the egg-sperm recognition mechanisms. Here, we tested the hypothesis that hybridization can lead ...

journal_title：Scientific reports

authors： Mastrantonio V,Urbanelli S,Porretta D

更新日期：2019-12-16 00:00:00

abstract：:N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D). This is the first study aiming to assess the contribution of NDRG1 to differentiation of macrophage lineage cells, which has important implications for bone remodelin...

journal_title：Scientific reports

authors： Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M

更新日期：2016-01-18 00:00:00

abstract：:Generation of multiple mRNAs by alternative splicing is well known in the group of cytokines and has recently been reported for the human erythropoietin (EPO) gene. Here, we focus on the alternatively spliced EPO transcript characterized by deletion of exon 3 (hEPOΔ3). We show co-regulation of EPO and hEPOΔ3 in human ...

journal_title：Scientific reports

authors： Bonnas C,Wüstefeld L,Winkler D,Kronstein-Wiedemann R,Dere E,Specht K,Boxberg M,Tonn T,Ehrenreich H,Stadler H,Sillaber I

更新日期：2017-06-16 00:00:00

abstract：:Carbonatites, usually occurring within intra-continental rift-related settings, have strong light rare earth element (LREE) enrichment; they rarely contain economic heavy REE (HREE). Here, we report the identification of Late Triassic HREE-Mo-rich carbonatites in the northernmost Qinling orogen. The rocks contain abun...

journal_title：Scientific reports

authors： Song W,Xu C,Smith MP,Kynicky J,Huang K,Wei C,Zhou L,Shu Q

更新日期：2016-11-18 00:00:00

abstract：:The biliary tree is an essential component of transplantable human liver tissue. Despite recent advances in liver tissue engineering, attempts at re-creating the intrahepatic biliary tree have not progressed significantly. The finer branches of the biliary tree are structurally and functionally complex and heterogeneo...

journal_title：Scientific reports

authors： Lewis PL,Su J,Yan M,Meng F,Glaser SS,Alpini GD,Green RM,Sosa-Pineda B,Shah RN

更新日期：2018-08-15 00:00:00

abstract：:Increasing evidence has confirmed that immunoglobulins (Igs) can be expressed in non-B cells. Our previous work demonstrated that mesangial cells and podocytes express IgA and IgG, respectively. The aim of this work was to reveal whether proximal tubular epithelial cells (PTECs) express Igs. High-throughput single-cel...

journal_title：Scientific reports

authors： Deng Z,Wang X,Liu Y,Tian X,Deng S,Sun Y,Wang S,Zheng D,Cui Z,Pan Y,A L,Yan H,Qiu X,Wang Y

更新日期：2020-11-12 00:00:00

abstract：:This study utilized a Förster resonance energy transfer (FRET)-based molecular tension sensor and live cell imaging to evaluate the effect of osteocytes, a mechanosensitive bone cell, on the migratory behavior of tumor cells. Two cell lines derived from MDA-MB-231 breast cancer cells were transfected with the vinculin...

journal_title：Scientific reports

authors： Li F,Chen A,Reeser A,Wang Y,Fan Y,Liu S,Zhao X,Prakash R,Kota D,Li BY,Yokota H,Liu J

更新日期：2019-04-04 00:00:00

abstract：:Early diagnosis of hepatocellular carcinoma (HCC) remains challenging to date. Characteristic metabolic deregulations of HCC may enable novel biomarkers discovery for early diagnosis. A capillary electrophoresis-time of flight mass spectrometry (CE-TOF/MS)-based metabolomics approach was performed to discover and vali...

journal_title：Scientific reports

authors： Zeng J,Huang X,Zhou L,Tan Y,Hu C,Wang X,Niu J,Wang H,Lin X,Yin P

更新日期：2015-11-03 00:00:00

abstract：:The Xanthomonadaceae family consists of species of non-pathogenic and pathogenic γ-proteobacteria that infect different hosts, including humans and plants. In this study, we performed a comparative analysis using 69 fully sequenced genomes belonging to this family, with a focus on identifying proteins enriched in phyt...

journal_title：Scientific reports

authors： Assis RAB,Polloni LC,Patané JSL,Thakur S,Felestrino ÉB,Diaz-Caballero J,Digiampietri LA,Goulart LR,Almeida NF,Nascimento R,Dandekar AM,Zaini PA,Setubal JC,Guttman DS,Moreira LM

更新日期：2017-11-23 00:00:00

abstract：:Hepatocellular carcinoma is a common type of malignancy with a poor prognosis. Identification and utilisation of markers for monitoring and diagnosis are urgently needed. Alpha-fetoprotein (AFP) and Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) have been proved to be efficient biomarkers for hepatit...

journal_title：Scientific reports

authors： Wang G,Lu X,Du Q,Zhang G,Wang D,Wang Q,Guo X

更新日期：2020-08-11 00:00:00

abstract：:Many behaviors of cancer, such as progression, metastasis and drug resistance etc., cannot be fully understood by genetic mutations or intracellular signaling alone. Instead, they are emergent properties of the cell community which forms a tumor. Studies of tumor heterogeneity reveal that many cancer behaviors critica...

journal_title：Scientific reports

authors： Zhou JX,Taramelli R,Pedrini E,Knijnenburg T,Huang S

更新日期：2017-08-18 00:00:00

abstract：:The effects of ocean acidification (OA) on the early recruitment of pteropods in the Scotia Sea, was investigated considering the process of spawning, quality of the spawned eggs and their capacity to develop. Maternal OA stress was induced on female pteropods (Limacina helicina antarctica) through exposure to present...

journal_title：Scientific reports

authors： Manno C,Peck VL,Tarling GA

更新日期：2016-05-16 00:00:00

abstract：:Previous etiologic studies have indicated that both environmental and genetic factors play important roles in the occurrence and development of chronic Achilles tendinopathy (AT). A recent study documented the results of the largest genome-wide association study for chronic AT to date, indicating that MPP7, TIMP2 and ...

journal_title：Scientific reports

authors： Kang X,Tian B,Zhang L,Ge Z,Zhao Y,Zhang Y

更新日期：2019-11-26 00:00:00

abstract：:Protocadherin 19 (Pcdh19) is an X-linked gene belonging to the protocadherin superfamily, whose members are predominantly expressed in the central nervous system and have been implicated in cell-cell adhesion, axon guidance and dendrite self-avoidance. Heterozygous loss-of-function mutations in humans result in the ch...

journal_title：Scientific reports

authors： Pederick DT,Homan CC,Jaehne EJ,Piltz SG,Haines BP,Baune BT,Jolly LA,Hughes JN,Gecz J,Thomas PQ

更新日期：2016-05-31 00:00:00

abstract：:To identify novel phenotypic associations related to Cytochrome P450 Family 2 Subfamily A Member 6 (CYP2A6), we investigated the human phenome in a total of 11,271 individuals. Initially, we conducted a phenome-wide association study in 3,401 nicotine-exposed elderly subjects considering 358 phenotypic traits. We iden...

journal_title：Scientific reports

authors： Polimanti R,Jensen KP,Gelernter J

更新日期：2017-04-21 00:00:00

abstract：:We study the impact of light on the mammalian circadian system using the theory of phase response curves. Using a recently developed ansatz we derive a low-dimensional macroscopic model for the core circadian clock in mammals. Significantly, the variables and parameters in our model have physiological interpretations ...

journal_title：Scientific reports

authors： Hannay KM,Forger DB,Booth V

更新日期：2020-11-11 00:00:00

abstract：:Research on argillite as a possible host rock for nuclear waste disposal is still an open subject since many issues need to be clarified. In the Underground Research Laboratories constructed for this purpose, a damaged zone around the excavation has been systematically observed and characterized by the appearance of m...

journal_title：Scientific reports

authors： Zaoui A,Sekkal W

更新日期：2015-03-06 00:00:00

abstract：:Here we show that electrical tuning of the sensitivity of chemitransistor sensors, namely field-effect-transistors (FETs) exploiting nano/mesostructured sensing materials, can be used to effectively address two chief problems of state-of-the-art gas sensors, specifically fabrication reliability and degradation by agin...

journal_title：Scientific reports

authors： Lazzerini GM,Strambini LM,Barillaro G

更新日期：2013-01-01 00:00:00

abstract：:Adulterant herbal materials are a threat to consumer safety. In this study, we used DNA barcoding to investigate the proportions and varieties of adulterant species in traditional Chinese medicine (TCM) markets. We used a DNA barcode database of TCM (TCMD) that was established by our group to investigate 1436 samples ...

journal_title：Scientific reports

authors： Han J,Pang X,Liao B,Yao H,Song J,Chen S

更新日期：2016-01-07 00:00:00

abstract：:Agriculture resulted in extensive population growths and human activities. However, whether major human expansions started after Neolithic Time still remained controversial. With the benefit of 1000 Genome Project, we were able to analyze a total of 910 samples from 11 populations in Africa, Europe and Americas. From ...

journal_title：Scientific reports

authors： Zheng HX,Yan S,Qin ZD,Jin L

更新日期：2012-01-01 00:00:00

abstract：:Multisensory integration provides continuous and stable perception from separate sensory inputs. Here, we investigated the functional role of temporal binding between the visual and the tactile senses. To this end we used the paradigm of compression that induces shifts in time when probe stimuli are degraded, e.g., by...

journal_title：Scientific reports

authors： Zimmermann E,Derichs C,Fink GR

更新日期：2016-05-16 00:00:00

abstract：:The mammalian Major Histocompatibility Complex (MHC) region contains several gene families characterized by highly polymorphic loci with extensive nucleotide diversity, copy number variation of paralogous genes, and long repetitive sequences. This structural complexity has made it difficult to construct a reliable ref...

journal_title：Scientific reports

authors： Viļuma A,Mikko S,Hahn D,Skow L,Andersson G,Bergström TF

更新日期：2017-03-31 00:00:00

abstract：:We analysed the ligand-based activation mechanism of the prostate-specific G-protein coupled receptor (PSGR), which is an olfactory receptor that mediates cellular growth in prostate cancer cells. Furthermore, it is an olfactory receptor with a known chemically near identic antagonist/agonist pair, α- and β-ionone. Us...

journal_title：Scientific reports

authors： Wolf S,Jovancevic N,Gelis L,Pietsch S,Hatt H,Gerwert K

更新日期：2017-11-22 00:00:00

abstract：:Understanding drought-tolerance mechanisms and identifying genetic dominance are important for crop improvement. Setaria italica, which is extremely drought-tolerant, has been regarded as a model plant for studying stress biology. Moreover, different genotypes of S. italica have evolved various drought-tolerance/avoid...

journal_title：Scientific reports

authors： Tang S,Li L,Wang Y,Chen Q,Zhang W,Jia G,Zhi H,Zhao B,Diao X

更新日期：2017-08-30 00:00:00

abstract：:Organic photodetectors are interesting for low cost, large area optical sensing applications. Combining organic semiconductors with discrete absorption bands outside the visible wavelength range with transparent and conductive electrodes allows for the fabrication of visibly transparent photodetectors. Visibly transpa...

journal_title：Scientific reports

authors： Zhang H,Jenatsch S,De Jonghe J,Nüesch F,Steim R,Véron AC,Hany R

更新日期：2015-03-24 00:00:00

abstract：:Chronic consumption of excess ethanol increases the risk of colorectal cancer. The pathogenesis of ethanol-related colorectal cancer (ER-CRC) is thought to be partly mediated by gut microbes. Specifically, bacteria in the colon and rectum convert ethanol to acetaldehyde (AcH), which is carcinogenic. However, the effec...

journal_title：Scientific reports

authors： Tsuruya A,Kuwahara A,Saito Y,Yamaguchi H,Tsubo T,Suga S,Inai M,Aoki Y,Takahashi S,Tsutsumi E,Suwa Y,Morita H,Kinoshita K,Totsuka Y,Suda W,Oshima K,Hattori M,Mizukami T,Yokoyama A,Shimoyama T,Nakayama T

更新日期：2016-06-13 00:00:00

abstract：:Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB) treatment regimens. PZA-resistance in M. tuberculosis is increasing, especially among M/XDR cases. Noted issues with PZA Drug Susceptibility Testing (DST) have driven the search for alternative tests. This study provides a com...

journal_title：Scientific reports

authors： Ramirez-Busby SM,Rodwell TC,Fink L,Catanzaro D,Jackson RL,Pettigrove M,Catanzaro A,Valafar F

更新日期：2017-06-19 00:00:00

abstract：:Doping with the optimum concentration of carriers (electrons or holes) can modify the physical properties of materials. Therefore, improved ways to achieve carrier doping have been pursued extensively for more than 50 years. Metal-intercalation is one of the most important techniques for electron doping of organic / i...

journal_title：Scientific reports

authors： Takahei Y,Tomita K,Itoh Y,Ashida K,Lee JH,Nishimoto N,Kimura T,Kudo K,Nohara M,Kubozono Y,Kambe T

更新日期：2016-01-06 00:00:00

abstract：:The causes underlying sex differences in lifespan are strongly debated. While females commonly outlive males in humans, this is generally less pronounced in societies before the demographic transition to low mortality and fertility rates. Life-history theory suggests that reduced reproduction should benefit female lif...

journal_title：Scientific reports

authors： Bolund E,Lummaa V,Smith KR,Hanson HA,Maklakov AA

更新日期：2016-04-18 00:00:00

abstract：:De novo mutations (DNMs), including germinal and postzygotic mutations (PZMs), are a strong source of causality for Autism Spectrum Disorder (ASD). However, the biological processes involved behind them remain unexplored. Our aim was to detect DNMs (germinal and PZMs) in a Spanish ASD cohort (360 trios) and to explore...

journal_title：Scientific reports

authors： Alonso-Gonzalez A,Calaza M,Amigo J,González-Peñas J,Martínez-Regueiro R,Fernández-Prieto M,Parellada M,Arango C,Rodriguez-Fontenla C,Carracedo A

更新日期：2021-01-11 00:00:00