Abstract：
:N-myc downstream regulated gene 1 (NDRG1) is a responsible gene for a hereditary motor and sensory neuropathy-Lom (Charcot-Marie-Tooth disease type 4D). This is the first study aiming to assess the contribution of NDRG1 to differentiation of macrophage lineage cells, which has important implications for bone remodeling and inflammatory angiogenesis. Ndrg1 knockout (KO) mice exhibited abnormal curvature of the spine, high trabecular bone mass, and reduced number of osteoclasts. We observed that serum levels of macrophage colony-stimulating factor (M-CSF) and macrophage-related cytokines were markedly decreased in KO mice. Differentiation of bone marrow (BM) cells into osteoclasts, M1/M2-type macrophages and dendritic cells was all impaired. Furthermore, KO mice also showed reduced tumor growth and angiogenesis by cancer cells, accompanied by decreased infiltration of tumor-associated macrophages. The transfer of BM-derived macrophages from KO mice into BM-eradicated wild type (WT) mice induced much less tumor angiogenesis than observed in WT mice. Angiogenesis in corneas in response to inflammatory stimuli was also suppressed with decreased infiltration of macrophages. Taken together, these results indicate that NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis. This study strongly suggests the crucial role of NDRG1 in differentiation process for macrophages.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono Mdoi
10.1038/srep19470subject
Has Abstractpub_date
2016-01-18 00:00:00pages
19470issn
2045-2322pii
srep19470journal_volume
6pub_type
杂志文章abstract：:The aperture stop of the iris is subject to refraction by the cornea, and thus an outside observer sees a virtual image: the "entrance pupil" of the eye. When viewed off-axis, the entrance pupil has an elliptical form. The precise appearance of the entrance pupil is a consequence of the anatomical and optical properti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45827-3
更新日期：2019-06-27 00:00:00
abstract：:We study the capillary retraction of a Newtonian semi-infinite liquid filament through analytical methods. We derive a long-time asymptotic-state expansion for the filament profile using a one-dimensional free-surface slender cylindrical flow model based on the three-dimensional axisymmetric Navier-Stokes equations. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51824-3
更新日期：2019-10-29 00:00:00
abstract：:Aryl nitriles are versatile compounds that can be synthesized via transition-metal-mediated cyanation of aryl halides. Most of the supported-heterogeneous catalysts are noble-metals based and there are very limited numbers of efficient non-noble metal based catalysts demonstrated for the cyanation of aryl halides. Her...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57483-z
更新日期：2020-01-20 00:00:00
abstract：:The interplay between spin states and metallization in compressed CoCl2 is investigated by combining diffraction, resistivity and spectroscopy techniques under high-pressure conditions and ab-initio calculations. A pressure-induced metallization along with a Co2+ high-spin (S = 3/2) to low-spin (S = 1/2) crossover tra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41337-4
更新日期：2019-04-01 00:00:00
abstract：:Discovery of novel biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Serum metabolite profiling of ST-elevation myocardial infarction (STEMI), unstable angina (UA) and healthy controls was performed using gas chromatography mass spectrometry (GC/MS), solid-phase microextraction coupled to ga...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36359
更新日期：2016-11-08 00:00:00
abstract：:Lithium (Li) is the cornerstone maintenance treatment for bipolar disorders (BD), but response rates are highly variable. To date, no clinical or biological marker is available to reliably define eligibility criteria for a maintenance treatment with Li. We examined whether the prophylactic response to Li (assessed ret...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69073-0
更新日期：2020-07-22 00:00:00
abstract：:Deoxynivalenol (DON) is one of the most abundant mycotoxins and exerts many adverse effects on humans and animals. To date, the transporting mechanism of DON in mammalian cells remains unclear. In this study, the parallel artificial membrane permeability assay (PAMPA), Transwell models and metabolic inhibitors were us...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06199-8
更新日期：2017-07-19 00:00:00
abstract：:The aggregation of gold nanoparticles (AuNPs) is known to induce an enhancement of localized surface plasmon resonance due to the coupling of plasmonic fields of adjacent nanoparticles. Here we show that AuNPs aggregation also causes a significant enhancement of chemiluminescence in the presence of luminophores. The p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14580-w
更新日期：2017-10-25 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep46130. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/srep46820
更新日期：2017-05-26 00:00:00
abstract：:Currently, a comprehensive assessment between mitochondrial DNA (mtDNA) content and cancer risk is lacking. We designed this meta-analysis to test the hypothesis that altered mtDNA copy number might influence genetic susceptibility to some specific types of cancer. The processes of literature search, eligibility appra...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep10039
更新日期：2015-05-08 00:00:00
abstract：:The rapid urbanization in China has been associated with a growing hunger for energy consumption and steadily-increasing CO2 emissions. In this paper, an integrated system dynamics model composed of four sub-models is developed to simulate the urbanization and energy consumption in China from 1998 to 2050. Three scena...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66125-3
更新日期：2020-06-19 00:00:00
abstract：:Spatiotemporal tracking of tracer particles or objects of interest can reveal localized behaviors in biological and physical systems. However, existing tracking algorithms are most effective for relatively low numbers of particles that undergo displacements smaller than their typical interparticle separation distance....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23488-y
更新日期：2018-04-03 00:00:00
abstract：:Glial fibrillary acidic protein expressing (GFAP+) glia modulate nociceptive neuronal activity in both the peripheral nervous system (PNS) and the central nervous system (CNS). Resident GFAP+ glia in dorsal root ganglia (DRG) known as satellite glial cells (SGCs) potentiate neuronal activity by releasing pro-inflammat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71073-z
更新日期：2020-08-25 00:00:00
abstract：:We report the phonon and magnetic properties of various well-stabilized Co3O4 nanoparticles. The net valence in cobalt (II)/(III) cation can be obtained by subtracting the Co2+ ions in tetrahedral interstices and Co3+ ions in the octahedral interstices, respectively, which will possess spatial inhomogeneity of its mag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18563-9
更新日期：2018-01-10 00:00:00
abstract：:Transforming growth factor-β/Smad3 signaling plays a critical role in the process of chronic kidney disease (CKD), but targeting Smad3 systematically may cause autoimmune disease by impairing immunity. In this study, we used whole-transcriptome RNA-sequencing to identify the differential gene expression profile, gene ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17901
更新日期：2015-12-09 00:00:00
abstract：:Circadian clocks are endogenous oscillators driving daily rhythms in physiology. The cell-autonomous clock is governed by an interlocked network of transcriptional feedback loops. Hundreds of clock-controlled genes (CCGs) regulate tissue specific functions. Transcriptome studies reveal that different organs (e.g. live...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05782
更新日期：2014-07-22 00:00:00
abstract：:Manganese has long been employed as a T1-shortening agent in magnetic resonance imaging (MRI) applications, but these techniques are limited by the biotoxicity of bulk-manganese. Positron emission tomography (PET) offers superior contrast sensitivity compared with MRI, and recent preclinical PET studies employing 52gM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03202-0
更新日期：2017-06-08 00:00:00
abstract：:Atlantic bluefin tuna (Thunnus thynnus) from the two main spawning populations in the Mediterranean and Gulf of Mexico occur together in the western, central and eastern Atlantic. Stock composition of catches from mixing areas is uncertain, presenting a major challenge to the sustainable management of the fisheries. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71355-6
更新日期：2020-09-07 00:00:00
abstract：:Molecular level understanding of permeation of nanoparticles through human skin establishes the basis for development of novel transdermal drug delivery systems and design and formulation of cosmetics. Recent experiments suggest that surface coated nano-sized gold nanoparticles (AuNPs) can penetrate the rat and human ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45292
更新日期：2017-03-28 00:00:00
abstract：:We previously demonstrated that ABCD4 does not localize to peroxisomes but rather, the endoplasmic reticulum (ER), because it lacks the NH2-terminal hydrophilic region required for peroxisomal targeting. It was recently reported that mutations in ABCD4 result in a failure to release vitamin B12 from lysosomes. A simil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30183
更新日期：2016-07-26 00:00:00
abstract：:In experiments that test plant diversity-productivity relationships, the common practice of weeding unsown species and disallowing species colonization may have the unintended consequence of favoring priority effects that maintain niche complementarity in determining productivity. However, in naturally assembled commu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70402-6
更新日期：2020-08-07 00:00:00
abstract：:The mechanistic target of rapamycin (mTOR) is a central mediator of protein synthesis in skeletal muscle. We utilized immunofluorescence approaches to study mTOR cellular distribution and protein-protein co-localisation in human skeletal muscle in the basal state as well as immediately, 1 and 3 h after an acute bout o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05483-x
更新日期：2017-07-10 00:00:00
abstract：:Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (NHD), a rare genetic disease characterized by early-onset dementia with leukoencephalopathy and bone cysts. An NHD-associated mutation, c.482 + 2 T > C, disrupts the splice donor site of intron 3 and causes aberrant skipping of exon 3, resulting in the los...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25204-2
更新日期：2018-05-02 00:00:00
abstract：:Results on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify more eligible studies that calculated pooled OR and WMD with 95% CI to assess their associations. Ov...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/s41598-017-18670-7
更新日期：2018-01-17 00:00:00
abstract：:Development of cost-effective counter electrode (CE) materials is a key issue for practical applications of photoelectrochemical solar energy conversion. Kesterite Cu2ZnSnS4 (CZTS) has been recognized as a potential CE material, but its electrocatalytic activity is still insufficient for the recovery of I-/I3- electro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26770-1
更新日期：2018-06-07 00:00:00
abstract：:Auxetic foams continue to interest researchers owing to their unique and enhanced properties. Existing studies attest to the importance of fabrication mechanisms and parameters. However, disparity in thermo-mechanical parameters has left much debate as to which factors dominate fabrication output quality. This paper p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75298-w
更新日期：2020-10-27 00:00:00
abstract：:Small amphipods (Halice sp. MT-2017) with body length <1 cm were collected from the Challenger Deep (~10,920 m below sea level). The divergence time of their lineage was approximately 109 Mya, making this group ancient compared to others under study. The mitochondrial genome of Halice sp. shared the usual gene compone...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38735-z
更新日期：2019-02-22 00:00:00
abstract：:Tree leaves are commonly composed of thin mesophyll, carrying out photosynthesis under sunlight, and thick veins. Although the role of leaf veins in water transportation has been known for a long time, their role in providing structural support and guaranteeing large sunlighted area was rarely studied and remains elus...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31763-1
更新日期：2018-09-14 00:00:00
abstract：:The complex architecture of the cortical part of the bovine-femur was examined to develop potential tissue engineering (TE) scaffolds. Weight-change and X-ray diffraction (XRD) results show that significant phase transformation and morphology conversion of the bone occur at 500-750°C and 750-900°C, respectively. Anoth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05843
更新日期：2014-07-28 00:00:00
abstract：:Autonomic modulation and cardiorespiratory variables are influenced by numerous factors, including anthropometric variables. We investigated autonomic recovery following aerobic exercise in healthy men with different waist-stature ratio (WSR) values. The study was conducted with 52 healthy men aged 18 to 30 years, div...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-34246-5
更新日期：2018-10-31 00:00:00
