A DNA methylation signature discriminates between excellent and non-response to lithium in patients with bipolar disorder type 1.

abstract：:The malaria vaccine BK-SE36 is a recombinant protein (SE36) based on the Honduras 1 serine repeat antigen-5 of Plasmodium falciparum, adsorbed to aluminium hydroxide gel. The phase Ib trial in Uganda demonstrated the safety and immunogenicity of BK-SE36. Ancillary analysis in the follow-up study of 6-20 year-old volun...

journal_title：Scientific reports

authors： Yagi M,Palacpac NM,Ito K,Oishi Y,Itagaki S,Balikagala B,Ntege EH,Yeka A,Kanoi BN,Katuro O,Shirai H,Fukushima W,Hirota Y,Egwang TG,Horii T

更新日期：2016-10-05 00:00:00

abstract：:Hydrogen recovery through solar-driven biomass conversion by photo-fermentative bacteria (PFB) has been regarded as a promising way for sustainable energy production. However, a considerable fraction of organic substrate was consumed for the growth of PFB as biocatalysts, furthermore, these PFB were continuously washe...

journal_title：Scientific reports

authors： Xie GJ,Liu BF,Wang RQ,Ding J,Ren HY,Zhou X,Ren NQ

更新日期：2015-11-05 00:00:00

abstract：:Carbonaceous particulate matter (PM), comprising black carbon (BC), primary organic aerosol (POA) and secondary organic aerosol (SOA, from atmospheric aging of precursors), is a highly toxic vehicle exhaust component. Therefore, understanding vehicle pollution requires knowledge of both primary emissions, and how thes...

journal_title：Scientific reports

authors： Platt SM,El Haddad I,Pieber SM,Zardini AA,Suarez-Bertoa R,Clairotte M,Daellenbach KR,Huang RJ,Slowik JG,Hellebust S,Temime-Roussel B,Marchand N,de Gouw J,Jimenez JL,Hayes PL,Robinson AL,Baltensperger U,Astorga C,Prévô

更新日期：2017-07-13 00:00:00

abstract：:Patients with Idiopathic Parkinson's Disease (PD) have an increased risk for fractures. Currently, many studies have reported inferior outcomes in PD patients after orthopedic procedures. However, there are very few studies assessing the outcome of upper extremity fractures (UEF) in PD patients. In this study, we revi...

journal_title：Scientific reports

authors： Chou TA,Chang CY,Wang JP,Huang YC,Chen WM,Huang TF

更新日期：2020-12-03 00:00:00

abstract：:We show a hybrid structure consisting of Si film with photonic crystal surface and random triangular gold grooves reflector at the bottom, which is capable of realizing efficient, broad-band, wide-angle optical absorption. It is numerically demonstrated that the enhanced absorption in a broad wavelength range (0.3-9.9...

journal_title：Scientific reports

authors： Chen ZH,Qiao N,Yang Y,Ye H,Liu S,Wang W,Wang Y

更新日期：2015-08-04 00:00:00

abstract：:Many freshwater and coastal marine ecosystems across the world may have undergone an ecosystem regime change due to a combination of rising anthropogenic disturbances and regional climate change. Such a change in aquatic ecosystems is commonly seen as shifts in algal species. But considerably less detail is known abou...

journal_title：Scientific reports

authors： Yuan F,Depew R,Soltis-Muth C

更新日期：2014-12-01 00:00:00

abstract：:In January 2016, the Arctic experienced an extremely anomalous warming event after an extraordinary increase in air temperature at the end of 2015. During this event, a strong intrusion of warm and moist air and an increase in downward longwave radiation, as well as a loss of sea ice in the Barents and Kara seas, were...

journal_title：Scientific reports

authors： Kim BM,Hong JY,Jun SY,Zhang X,Kwon H,Kim SJ,Kim JH,Kim SW,Kim HK

更新日期：2017-01-04 00:00:00

abstract：:Antibody based bio-molecular drugs are an exciting, new avenue of drug development as an alternative to the more traditional small chemical compounds. However, the binding mechanism and the effect on the conformational ensembles of a therapeutic antibody to its peptide or protein antigen have not yet been well studied...

journal_title：Scientific reports

authors： Bekker GJ,Fukuda I,Higo J,Kamiya N

更新日期：2020-01-29 00:00:00

abstract：:Clinical benefit from trastuzumab and other anti-human epidermal growth factor receptor-2 (HER2) therapies in patients with HER2-positive gastric cancer (GC) remains limited by primary or acquired resistance. We aimed to investigate the impact of concomitant molecular alterations to HER2 amplification on the clinical ...

journal_title：Scientific reports

authors： Lee JY,Hong M,Kim ST,Park SH,Kang WK,Kim KM,Lee J

更新日期：2015-03-19 00:00:00

abstract：:Three main surveillance systems (laboratory-confirmed, influenza-like illness (ILI) and nationwide Notifiable Infectious Diseases Reporting Information System (NIDRIS)) have been used for influenza surveillance in China. However, it is unclear which surveillance system is more reliable in developing influenza early wa...

journal_title：Scientific reports

authors： Yang X,Liu D,Wei K,Liu X,Meng L,Yu D,Li H,Li B,He J,Hu W

更新日期：2018-02-12 00:00:00

abstract：:The opportunistic pathogen Staphylococcus aureus is responsible for causing infections related to indwelling medical devices, where this pathogen is able to attach and form biofilms. The intrinsic properties given by the self-produced extracellular biofilm matrix confer high resistance to antibiotics, triggering infec...

journal_title：Scientific reports

authors： Matilla-Cuenca L,Gil C,Cuesta S,Rapún-Araiz B,Žiemytė M,Mira A,Lasa I,Valle J

更新日期：2020-11-03 00:00:00

abstract：:In photodynamic therapy (PDT), cells are impregnated with a photosensitizing agent that is activated by light irradiation, thereby photochemically generating reactive oxygen species (ROS). The amounts of ROS produced depends on the PDT dose and the nature of the photosensitizer. Although high levels of ROS are cytotox...

journal_title：Scientific reports

authors： Kushibiki T,Tu Y,Abu-Yousif AO,Hasan T

更新日期：2015-08-17 00:00:00

abstract：:The Przewalski's gazelle (Procapra przewalskii) is one of the most endangered ungulates in the world, with fewer than 2,000 individuals surviving in nine habitat fragments on the Qinghai-Tibet Plateau and isolated by human settlements and infrastructure. In particular, the Qinghai-Tibet railway, which crosses the larg...

journal_title：Scientific reports

authors： Yu H,Song S,Liu J,Li S,Zhang L,Wang D,Luo SJ

更新日期：2017-12-21 00:00:00

abstract：:Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and...

journal_title：Scientific reports

authors： Ferrando B,Gomez-Cabrera MC,Salvador-Pascual A,Puchades C,Derbré F,Gratas-Delamarche A,Laparre L,Olaso-Gonzalez G,Cerda M,Viosca E,Alabajos A,Sebastiá V,Alberich-Bayarri A,García-Castro F,Viña J

更新日期：2018-02-23 00:00:00

abstract：:Organometallic trihalide perovskites are promising materials for photovoltaic applications, which have demonstrated a rapid rise in photovoltaic performance in a short period of time. We report a facile one-step method to fabricate planar heterojunction perovskite solar cells by chemical vapor deposition (CVD), with a...

journal_title：Scientific reports

authors： Tavakoli MM,Gu L,Gao Y,Reckmeier C,He J,Rogach AL,Yao Y,Fan Z

更新日期：2015-09-22 00:00:00

abstract：:Nitrogen-Vacancy (NV) centers in diamond are promising solid-state quantum emitters that can be utilized for photonic quantum applications. Various diamond nanophotonic devices have been fabricated for efficient extraction of single photons emitted from NV centers to a single guided mode. However, for constructing sca...

journal_title：Scientific reports

authors： Yonezu Y,Wakui K,Furusawa K,Takeoka M,Semba K,Aoki T

更新日期：2017-10-11 00:00:00

abstract：:Medication-related osteonecrosis of the jaw (MRONJ) represents a complication of bisphosphonate treatment that responds poorly to standard treatment. In a retrospective cohort study we investigated a possible role of Actinomyces spp. in the pathogenesis of MRONJ. Deep biopsies of necrotic bone were collected during su...

journal_title：Scientific reports

authors： Russmueller G,Seemann R,Weiss K,Stadler V,Speiss M,Perisanidis C,Fuereder T,Willinger B,Sulzbacher I,Steininger C

更新日期：2016-08-17 00:00:00

abstract：:Quantum key distribution involving decoy-states is a significant application of quantum information. By using three-intensity decoy-states of single-photon-added coherent sources, we propose a practically realizable scheme on quantum key distribution which approaches very closely the ideal asymptotic case of an infini...

journal_title：Scientific reports

authors： Wang D,Li M,Guo GC,Wang Q

更新日期：2015-10-14 00:00:00

abstract：:Hyperactivity of signal transducer and activity of transcription 3 (STAT3) plays a crucial role in melanoma invasion and metastasis. Gene therapy applying siRNA targeting STAT3 is a potential therapeutic strategy for melanoma. In this article, we first fabricated safe and novel dissolving microneedles (MNs) for topica...

journal_title：Scientific reports

authors： Pan J,Ruan W,Qin M,Long Y,Wan T,Yu K,Zhai Y,Wu C,Xu Y

更新日期：2018-01-18 00:00:00

abstract：:Traffic-related air pollution is known to be associated with skin aging manifestations. We previously found that the use of fossil fuels was associated with skin aging, but no direct link between indoor air pollutants and skin aging manifestations has ever been shown. Here we directly measured the indoor PM2.5 exposur...

journal_title：Scientific reports

authors： Ding A,Yang Y,Zhao Z,Hüls A,Vierkötter A,Yuan Z,Cai J,Zhang J,Gao W,Li J,Zhang M,Matsui M,Krutmann J,Kan H,Schikowski T,Jin L,Wang S

更新日期：2017-11-10 00:00:00

abstract：:Silver nanoparticles (AgNPs) demonstrating good antimicrobial activity are widely used in many fields. However, the impact of AgNPs on the community structures of marine biofilms that drive biogeochemical cycling processes and the recruitment of marine invertebrate larvae remains unknown. Here, we employed MiSeq seque...

journal_title：Scientific reports

authors： Yang JL,Li YF,Liang X,Guo XP,Ding DW,Zhang D,Zhou S,Bao WY,Bellou N,Dobretsov S

更新日期：2016-11-21 00:00:00

abstract：:Nano-scale investigations of bainitic structures formed at temperatures below 350 °C have shown that the bainitic ferrite lattice is super-saturated in carbon. A high density of intrinsic defects would be playing a part in the carbon-supersaturation levels detected. In this work, the role of C-vacancy complexes on car...

journal_title：Scientific reports

authors： Rementeria R,Domínguez-Reyes R,Capdevila C,Garcia-Mateo C,Caballero FG

更新日期：2020-01-16 00:00:00

abstract：:Although it has been reported that uterine signal transducer and activator of transcription 3 (STAT3) is essential for embryo implantation, the exact roles of uterine epithelial and stromal STAT3 on embryo implantation have not been elucidated. To address this issue, we generated Stat3-floxed/Ltf-iCre (Stat3-eKO), Sta...

journal_title：Scientific reports

authors： Hiraoka T,Hirota Y,Fukui Y,Gebril M,Kaku T,Aikawa S,Hirata T,Akaeda S,Matsuo M,Haraguchi H,Saito-Kanatani M,Shimizu-Hirota R,Takeda N,Yoshino O,Fujii T,Osuga Y

更新日期：2020-09-23 00:00:00

abstract：:The simplest and most commonly used acoustic levitator is comprised of a transmitter and an opposing reflecting surface. This type of device, however, is only able to levitate objects along one direction, at distances multiple of half of a wavelength. In this work, we show how a customised reflective acoustic metamate...

journal_title：Scientific reports

authors： Polychronopoulos S,Memoli G

更新日期：2020-03-06 00:00:00

abstract：:Increasing structural complexity at nanoscale can permit superior control over photophysical properties in the precursor-derived semiconductors. We demonstrate here the synthesis of silicon carbonitride (SiCN)/boron nitride (BN) nanocomposites via a polymer precursor route wherein the cobalt polyamine complexes used a...

journal_title：Scientific reports

authors： Zhang Q,Jia D,Yang Z,Cai D,Laine RM,Li Q,Zhou Y

更新日期：2017-01-13 00:00:00

abstract：:Mechanical factors play a key role in regulating the development of cartilage degradation in osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and chondrocytes. To explore the effects of mechanical stress on cartilage morphology, we observed cartilages in different regions by...

journal_title：Scientific reports

authors： Liu Q,Hu X,Zhang X,Duan X,Yang P,Zhao F,Ao Y

更新日期：2016-11-17 00:00:00

abstract：:We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular level. To this end, we have used mice subjected to transverse aortic constriction and imaged adjacent cardiac tissue sections by microfocus X-ray diff...

journal_title：Scientific reports

authors： Nicolas JD,Khan A,Markus A,Mohamed BA,Toischer K,Alves F,Salditt T

更新日期：2020-11-09 00:00:00

abstract：:PCTAIRE kinase 3 (PCTK3) is a member of the cyclin dependent kinase family, but its physiological function remains unknown. We previously reported that PCTK3-knockdown HEK293T cells showed actin accumulation at the leading edge, suggesting that PCTK3 is involved in the regulation of actin reorganization. In this study...

journal_title：Scientific reports

authors： Matsuda S,Kawamoto K,Miyamoto K,Tsuji A,Yuasa K

更新日期：2017-03-31 00:00:00

abstract：:Potassium (K+) channels shape the response properties of neurons. Although enormous progress has been made to characterize K+ channels in the primary auditory neurons, the molecular identities of many of these channels and their contributions to hearing in vivo remain unknown. Using a combination of RNA sequencing and...

journal_title：Scientific reports

authors： Reijntjes DOJ,Lee JH,Park S,Schubert NMA,van Tuinen M,Vijayakumar S,Jones TA,Jones SM,Gratton MA,Xia XM,Yamoah EN,Pyott SJ

更新日期：2019-02-22 00:00:00

abstract：:Platelets of α-zirconium phosphate (α-ZrP) obtained from the reflux method in H3PO4 are successfully exfoliated into water via the intercalation of alkanol amines. With volume fractions greater than 0.02 they are stacked into tactoids of few layers with a repeat distance in the order of 10 nm. The tactoids align into ...

journal_title：Scientific reports

authors： Lin X,Schmelter D,Imanian S,Hintze-Bruening H

更新日期：2019-11-08 00:00:00