Abstract:
:Medication-related osteonecrosis of the jaw (MRONJ) represents a complication of bisphosphonate treatment that responds poorly to standard treatment. In a retrospective cohort study we investigated a possible role of Actinomyces spp. in the pathogenesis of MRONJ. Deep biopsies of necrotic bone were collected during surgical treatment of MRONJ and evaluated by histology and microbiology for the presence of Actinomyces spp. Microbiological, demographic and clinicpathological data were analyzed for risk of Actinomyces-associated MRONJ. Between 2005 and 2014, 111 patients suffering from histologically-confirmed MRONJ were identified. Actinomyces spp. were detected in 99 cases (89%) by histology and in six further patients by microbiological culture. A diverse microbial flora was found in all specimens without association with Actinomyces spp. Demographic and clinicopathological characteristics did not separate significantly Actinomyces-positive from Actinomyces-negative cases. Our observations confirm previous reports of a high prevalence of Actinomyces spp. in MRONJ in the single largest cohort available up to now. The high prevalence of Actinomyces spp. and the lack of clinicopathological risk factors underline the prominent role of Actinomyces spp. in MRONJ and may change the current understanding of MRONJ. Established prolonged antimicrobial treatment regimens against Actinomyces spp. infection could therefore be a mainstay of future MRONJ management.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Russmueller G,Seemann R,Weiss K,Stadler V,Speiss M,Perisanidis C,Fuereder T,Willinger B,Sulzbacher I,Steininger Cdoi
10.1038/srep31604subject
Has Abstractpub_date
2016-08-17 00:00:00pages
31604issn
2045-2322pii
srep31604journal_volume
6pub_type
杂志文章abstract::Bronchospasm compresses the bronchial epithelium, and this compressive stress has been implicated in asthma pathogenesis. However, the molecular mechanisms by which this compressive stress alters pathways relevant to disease are not well understood. Using air-liquid interface cultures of primary human bronchial epithe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57755-8
更新日期:2020-01-22 00:00:00
abstract::It is our contention that for multiscale modelling of infectious disease systems to evolve and expand in scope, it needs to be founded on a theory. Such a theory would improve our ability to describe infectious disease systems in terms of their scales and levels of organization, and their inter-relationships. In this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52820-3
更新日期:2019-11-08 00:00:00
abstract::A robust method is presented for the segmentation of the full cerebral vasculature in 4-dimensional (4D) computed tomography (CT). The method consists of candidate vessel selection, feature extraction, random forest classification and postprocessing. Image features include among others the weighted temporal variance i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15617-w
更新日期:2017-11-15 00:00:00
abstract::Improving surface sensitivities of nanostructure-based plasmonic sensors is an important issue to be addressed. Among the SPR measurements, the wavelength interrogation is commonly utilized. We proposed using blue-shifted surface plasmon mode and Fano resonance, caused by the coupling of a cavity mode (angle-independe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28122-5
更新日期:2018-06-27 00:00:00
abstract::The preparation of mesoporous iron oxides with controllable physiochemical properties for effective therapeutic drug delivery remains a formidable challenge. Herein, iron oxide mesoporous magnetic microparticles (IO-MMMs) were prepared by a modified reverse hard-templating approach using, for the first time, acid-prep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46007-z
更新日期:2019-07-01 00:00:00
abstract::Sleep problems are considered a core symptom of depression. However, there is little information about the comorbidity of sleep problems and depression in low- and middle-income countries (LMICs), and whether sleep problems with depression confer additional risk for decrements in health compared to sleep problems alon...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48334-7
更新日期:2019-08-19 00:00:00
abstract::Coexisting bacteria form various microbial communities in human body parts. In these ecosystems they interact in various ways and the properties of the interaction network can be related to the stability and functional diversity of the local bacterial community. In this study, we analyze the interaction network among ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15920
更新日期:2015-10-30 00:00:00
abstract::Caspase-3-related DEVDase activity is initiated upon apoptosis in unfertilized starfish eggs. In this study, we cloned a starfish procaspase-3 corresponding to mammalian effector caspase containing a CARD that is similar to the amino terminal CARD of mammalian capsase-9, and we named it procaspase-3/9. Recombinant pro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19845-6
更新日期:2018-01-25 00:00:00
abstract::It is critical to understand how variations in chemical composition in surface seawater (SSW) affect the chemistry of marine atmospheric aerosols. We investigated the sea-to-air transfer of dissolved organic carbon (DOC) via cruise measurements of both ambient aerosols and SSW in the Oyashio and its coastal regions, t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32864-7
更新日期:2018-10-05 00:00:00
abstract::The intensification of marine aquaculture raises multiple sustainability issues, namely the handling of nutrient-rich effluents that can adversely impact ecosystems. As integrated multi-trophic aquaculture (IMTA) gains momentum, the use of halophyte plants to phytoremediate aquaculture effluents has received growing a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66093-8
更新日期:2020-06-22 00:00:00
abstract::Riboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35103
更新日期:2016-10-12 00:00:00
abstract::Living organisms have to adjust to their surrounding in order to survive in stressful conditions. We study this mechanism in one of most primitive creatures - photosynthetic green sulfur bacteria. These bacteria absorb photons very efficiently using the chlorosome antenna complexes and perform photosynthesis in extrem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05057
更新日期:2014-05-27 00:00:00
abstract::A plasmonic Ag/TiO2 photocatalytic composite was designed by selecting Ag quantum dots (Ag QDs) to act as a surface plasmon resonance (SPR) photosensitizer for driving the visible-light driven photoelectrocatalytic hydrogen evolution. Vertically oriented hierarchical TiO2 nanotube arrays (H-TiO2-NTAs) with macroporous...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10461
更新日期:2015-06-12 00:00:00
abstract::Humans walk and run, as well as change their gait speed, through the control of their complicated and redundant musculoskeletal system. These gaits exhibit different locomotor behaviors, such as a double-stance phase in walking and flight phase in running. The complex and redundant nature of the musculoskeletal system...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37460-3
更新日期:2019-01-23 00:00:00
abstract::The release of radon in active fault zones is a sustained radioactive pollution source of the atmospheric environment. The species, concentration and flux of radon emitted in soil gas in active fault zones in the Capital of China were investigated by in-situ field measurements. Two main species of radon discharging fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35262-1
更新日期:2018-11-13 00:00:00
abstract::The resistance-nodulation-cell division (RND)-type xenobiotic efflux system plays a major role in the multidrug resistance of gram-negative bacteria. The only constitutively expressed RND system of Escherichia coli consists of the inner membrane transporter AcrB, the membrane fusion protein AcrA, and the outer membran...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21909
更新日期:2016-02-26 00:00:00
abstract::Fluorescence microscopy is rapidly turning into nanoscopy. Among the various nanoscopy methods, the STED/RESOLFT super-resolution family has recently been expanded to image even large fields of view within a few seconds. This advance relies on using light patterns featuring substantial arrays of intensity minima for d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44619
更新日期:2017-03-20 00:00:00
abstract::Stream microbes that occur in the Mediterranean Basin have been shown to possess heightened sensitivity to intensified water stress attributed to climate change. Here, we investigate the effects of long-term drought (150 days), storms and rewetting (7 days) on the diversity and composition of archaea, bacteria and fun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49832-4
更新日期:2019-09-18 00:00:00
abstract::BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06915-4
更新日期:2017-07-27 00:00:00
abstract::This work aimed to prepare solvent-free or green Bi2O2CO3 for quantum dot nanostructures (QDNSs) based on cellulose as a stabilizer and green capping agent to sorafenib delivery for liver targeting. Because the walnut tree is one of the most abundant trees in Iran, it was tried to synthesize Bi2O2CO3 QDNSs using a wal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78266-6
更新日期:2020-12-04 00:00:00
abstract::Analytical equations are derived depicting four possible scenarios resulting from pulsed signaling of a system subject to Hill-type dynamics. Pulsed Hill-type dynamics involves the binding of multiple signal molecules to a receptor and occurs e.g., when transcription factor p53 orchestrates cancer prevention, during c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20466-2
更新日期:2018-02-01 00:00:00
abstract::Just as the topology of the Fermi surface defines the properties of the free electrons in metals and semiconductors, the geometry of the iso-frequency surface in the phase space of the propagating electromagnetic waves, determines the optical properties of the corresponding optical materials. Furthermore, in the direc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17824
更新日期:2015-12-16 00:00:00
abstract::The physical properties of polycrystalline materials depend on their microstructure, which is the nano- to centimeter scale arrangement of phases and defects in their interior. Such microstructure depends on the shape, crystallographic phase and orientation, and interfacing of the grains constituting the material. Thi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09717-w
更新日期:2017-08-25 00:00:00
abstract::Photodynamic therapy (PDT), wherein light sensitive non-toxic agents are locally and selectively activated using light, has emerged as an appealing alternative to traditional cancer chemotherapy. Yet to date, PDT efficacy has been mostly characterized using 2D cultures. Compared to 2D cultures, 3D sphere culture gener...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12175
更新日期:2015-07-08 00:00:00
abstract::P-type doping in high Al-content AlGaN alloys is a main challenge for realizing AlGaN-based deep ultraviolet optoelectronics devices. According to the first-principles calculations, Mg activation energy may be reduced so that a high hole concentration can be obtained by introducing nanoscale (AlN)5/(GaN)1 superlattice...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44223
更新日期:2017-03-14 00:00:00
abstract::In this study, a noninvasive quantitative measure was used to identify short and long term post-concussion syndrome (PCS) both from each other and from healthy control populations. We used Electrovestibulography (EVestG) for detecting neurophysiological PCS consequent to a mild traumatic brain injury (mTBI) in both sh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15487-2
更新日期:2017-11-27 00:00:00
abstract::In arthropods, retinoid X receptor (RXR) is a highly conserved nuclear hormone receptor. By forming a heterodimeric complex with the ecdysone receptor (EcR), RXR is known to be vital importance for various physiological processes. However, in comparison to EcR, the RXR signaling pathway and its roles in crustacean rep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23654
更新日期:2016-03-24 00:00:00
abstract::Sickle cell anaemia (SCA) is characterized by reduced red blood cell (RBC) deformability and nitric oxide (NO) bioavailability. The aim of the study was to investigate whether exercise might affect these parameters in SCA. SCA patients and healthy controls (AA) performed an acute submaximal exercise test until subject...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48364-1
更新日期:2019-08-14 00:00:00
abstract::Enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) with different physicochemical properties were developed to enhance activity against intracellular Salmonella. Their cellular uptake, intracellular elimination and antibacterial activity were studied in RAW 264.7 cells. During the experimental period...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41104
更新日期:2017-01-23 00:00:00
abstract::Integrin α11β1 is a collagen-binding integrin, which is receiving increasing attention in the context of wound healing and fibrosis. Although α11β1 integrin displays similar collagen specificity to α2β1 integrin, both integrins have distinct in vivo functions. In this context, the contribution of α11 subunit cytoplasm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51689-6
更新日期:2019-10-25 00:00:00