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Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.

Abstract：

:Potassium (K+) channels shape the response properties of neurons. Although enormous progress has been made to characterize K+ channels in the primary auditory neurons, the molecular identities of many of these channels and their contributions to hearing in vivo remain unknown. Using a combination of RNA sequencing and single molecule fluorescent in situ hybridization, we localized expression of transcripts encoding the sodium-activated potassium channels KNa1.1 (SLO2.2/Slack) and KNa1.2 (SLO2.1/Slick) to the primary auditory neurons (spiral ganglion neurons, SGNs). To examine the contribution of these channels to function of the SGNs in vivo, we measured auditory brainstem responses in KNa1.1/1.2 double knockout (DKO) mice. Although auditory brainstem response (wave I) thresholds were not altered, the amplitudes of suprathreshold responses were reduced in DKO mice. This reduction in amplitude occurred despite normal numbers and molecular architecture of the SGNs and their synapses with the inner hair cells. Patch clamp electrophysiology of SGNs isolated from DKO mice displayed altered membrane properties, including reduced action potential thresholds and amplitudes. These findings show that KNa1 channel activity is essential for normal cochlear function and suggest that early forms of hearing loss may result from physiological changes in the activity of the primary auditory neurons.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Reijntjes DOJ,Lee JH,Park S,Schubert NMA,van Tuinen M,Vijayakumar S,Jones TA,Jones SM,Gratton MA,Xia XM,Yamoah EN,Pyott SJ

doi

10.1038/s41598-019-39119-z

subject

Has Abstract

pub_date

2019-02-22 00:00:00

pages

2573

issue

1

issn

2045-2322

pii

10.1038/s41598-019-39119-z

journal_volume

9

pub_type

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