Abstract：
:In photodynamic therapy (PDT), cells are impregnated with a photosensitizing agent that is activated by light irradiation, thereby photochemically generating reactive oxygen species (ROS). The amounts of ROS produced depends on the PDT dose and the nature of the photosensitizer. Although high levels of ROS are cytotoxic, at physiological levels they play a key role as second messengers in cellular signaling pathways, pluripotency, and differentiation of stem cells. To investigate further the use of photochemically triggered manipulation of such pathways, we exposed mouse osteoblast precursor cells and rat primary mesenchymal stromal cells to low-dose PDT. Our results demonstrate that low-dose PDT can promote osteoblast differentiation via the activation of activator protein-1 (AP-1). Although PDT has been used primarily as an anti-cancer therapy, the use of light as a photochemical "molecular switch" to promote differentiation should expand the utility of this method in basic research and clinical applications.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kushibiki T,Tu Y,Abu-Yousif AO,Hasan Tdoi
10.1038/srep13114subject
Has Abstractpub_date
2015-08-17 00:00:00pages
13114issn
2045-2322pii
srep13114journal_volume
5pub_type
杂志文章abstract：:Hand, foot and mouth disease (HFMD) is a substantial burden throughout Asia, but the effects of temperature pattern on HFMD risk are inconsistent. To quantify the effect of temperature on HFMD incidence, Wuhan was chosen as the study site because of its high temperature variability and high HFMD incidence. Daily serie...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20318-z
更新日期：2018-01-31 00:00:00
abstract：:The present study investigated the effect of acute stress on attentional bias to threat using behavioral and ERP methods. Sixty-two male participants were randomly assigned to a stress condition (Trier Social Stress Test) or a control condition. To examine the impact of stress-induced cortisol on attentional bias to t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14138-w
更新日期：2017-11-06 00:00:00
abstract：:The human foot and ankle system is equipped with structures that can produce mechanical work through elastic (e.g., Achilles tendon, plantar fascia) or viscoelastic (e.g., heel pad) mechanisms, or by active muscle contractions. Yet, quantifying the work distribution among various subsections of the foot and ankle can ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15218-7
更新日期：2017-11-13 00:00:00
abstract：:Intracellular pathogens belonging to the genus Leishmania have developed effective strategies that enable them to survive within host immune cells. Immunostimulatory compounds that counteract such immunological escape mechanisms represent promising treatment options for diseases. Here, we demonstrate that a lipopeptid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09894-8
更新日期：2017-08-25 00:00:00
abstract：:Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and ana...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78832-y
更新日期：2020-12-17 00:00:00
abstract：:Exosomes are nano-sized endosome-derived small intraluminal vesicles, which are important facilitators of intercellular communication by transporting contents, such as protein, mRNA, and microRNAs, between neighboring cells, such as in the tumor microenvironment. The purpose of this study was to understand the mechani...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30110
更新日期：2016-07-22 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60629-8
更新日期：2020-02-25 00:00:00
abstract：:The poor bonding strength between biopolymer and bioceramic has remained an unsolved issue. In this study, graphene oxide (GO) was introduced as an interface phase to improve the interfacial bonding between polyetheretherketone (PEEK) and hydroxyapatite (HAP) for tissue engineering scaffolds. On the one hand, the conj...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46604
更新日期：2017-04-20 00:00:00
abstract：:The toxicological mechanisms of liver injury caused by most traditional Chinese medicine (TCM) remain largely unknown. Due to the unique features, exosomal microRNAs (miRNAs) are currently attracting major interests to provide further insights into toxicological mechanisms. Thus, taking Fructus Meliae Toosendan as an ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21113-6
更新日期：2018-02-12 00:00:00
abstract：:Tyrosine hydroxylase (TH), the initial enzyme in the melanin pathway, catalyzes tyrosine conversion into Dopa. Although expression and regulation of TH have been shown to affect cuticle pigmentation in insects, no direct functional studies to date have focused on the specific physiological processes involving the enzy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29835
更新日期：2016-07-15 00:00:00
abstract：:The spectral properties of Fano resonance generated in multilayer dielectric gratings (MDGs) are reported and numerically investigated in this paper. We examine the MDG consisting of numerous identically alternative chalcogenide glass (As2S3) and silica (SiO2) multilayers with several grating widths inscribed through ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34787-9
更新日期：2018-11-06 00:00:00
abstract：:There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. In this study, we subje...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32935
更新日期：2016-09-09 00:00:00
abstract：:Huanglongbing (HLB) (citrus greening disease) is one of the most serious bacterial diseases of citrus. It is caused by (1) Candidatus Liberibacter africanus, transmitted by Trioza erytreae and (2) C.L. asiaticus and C.L. americanus, transmitted by Diaphorina citri. As part of a multidisciplinary project on D. citri (w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64132-y
更新日期：2020-04-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20589
更新日期：2016-02-05 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-29328-3
更新日期：2018-07-23 00:00:00
abstract：:Interactions of water with cellulose are of both fundamental and technological importance. Here, we characterize the properties of water associated with cellulose using deuterium labeling, neutron scattering and molecular dynamics simulation. Quasi-elastic neutron scattering provided quantitative details about the dyn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12035-w
更新日期：2017-09-19 00:00:00
abstract：:Cerebellar involvement in cognition, as well as in sensorimotor control, is increasingly recognized and is thought to depend on connections with the cerebral cortex. Anatomical investigations in animals and post-mortem humans have established that cerebro-cerebellar connections are contralateral to each other and incl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13079-8
更新日期：2017-10-09 00:00:00
abstract：:Anti-cytokine therapeutic antibodies have been demonstrated to be effective in the treatment of several auto-immune disorders. However, The problems in antibody manufacture and the immunogenicity caused by multiple doses of antibodies inspire people to use auto-cytokine as immunogen to induce anti-cytokine antibodies....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14150
更新日期：2015-09-28 00:00:00
abstract：:Animal coloration is a poorly-understood aspect of phenotypic variability. Here I expand initial studies of the colour gamut of birds by providing the first quantitative description of the colour variation of an entire avifauna: Australian landbirds (555 species). The colour of Australian birds occupies a small fracti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18514
更新日期：2015-12-18 00:00:00
abstract：:Rising global temperatures are proving to be detrimental for the agriculture. Hence, strategies are needed to induce thermotolerance in food crops to sustain the food production. GABA (γ-aminobutyric acid), a non-protein amino acid, can partially protect plants from high-temperature stress. This study hypothesises tha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44163-w
更新日期：2019-05-24 00:00:00
abstract：:Impurities in superconductors and their induced bound states are important both for engineering novel states such as Majorana zero-energy modes and for probing bulk properties of the superconducting state. The high-temperature cuprates offer a clear advantage in a much larger superconducting order parameter, but the n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44107
更新日期：2017-03-10 00:00:00
abstract：:In this article, we report the first observation of nanosecond laser induced transient dual absorption bands, one in the bandgap (TA₁) and another in the sub-bandgap (TA₂) regions of a-Ge₅As₃₀Se₆₅ thin films. Strikingly, these bands are thermally tunable and exhibit a unique contrasting characteristic: the magnitude o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06573
更新日期：2014-10-10 00:00:00
abstract：:Colour polymorphism may be maintained within a population by disruptive-selection. One hypothesis proposes that different morphs are adapted to different ambient light conditions, with lighter morphs having a selective advantage in bright conditions and darker morphs having advantages in darker conditions. The mechani...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07829-x
更新日期：2017-08-22 00:00:00
abstract：:Phase transition is a natural phenomenon happened around our daily life, represented by the process from ice to water. While melting and solidifying at a certain temperature, a high heat of fusion is accompanied, classified as the latent heat. Phase change material (PCM) has been widely applied to store and release la...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08884
更新日期：2015-03-09 00:00:00
abstract：:The ability to observe chemical reactions at the molecular level convincingly demonstrates the physical and chemical phenomena occurring throughout a reaction mechanism. Videos obtained through in situ transmission electron microscopy (TEM) revealed the oxidation of catalytic soot under practical reaction conditions. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10161
更新日期：2015-07-08 00:00:00
abstract：:Species in the genus Suaeda have few diagnostic characters and substantial morphological plasticity. Hence, regional floras do not provide clear taxonomic information for Suaeda spp. in East Asia. In order to assess the taxonomy of four species in the genus Suaeda (S. australis, S. maritima, S. japonica, and S. hetero...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78041-7
更新日期：2020-12-01 00:00:00
abstract：:Dentin sialoprotein (DSP) is a dentin extracellular matrix protein. It is involved in dental mesenchymal cell lineages and dentin formation through regulation of its target gene expression. DSP mutations cause dentin genetic diseases. However, mechanisms of DSP in controlling dental mesenchymal cell differentiation ar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00339-w
更新日期：2017-03-22 00:00:00
abstract：:It has been well established that some Armillaria species are symbionts of Polyporus umbellatus, However, little is known about the evolutionary history of P. umbellatus-Armillaria associations. In this research, we used an analysis based on the strength of the phylogenetic signal to investigate P. umbellatus-Armillar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04578-9
更新日期：2017-06-26 00:00:00
abstract：:Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals. We have previously established a zebrafish model of diet-induced obesity (DIO zebrafish) by overfeeding Artemia. Here we created DIO zebrafish using a different method to induce T2DM. Zebrafish were overfed a commercially available fish food using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01432-w
更新日期：2017-05-03 00:00:00
abstract：:Deficits in GABAergic inhibitory neurotransmission are a reliable finding in schizophrenia (SCZ) patients. Previous studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate neurophysiological abnormalities that are intermediate between probands and healthy controls. In this study, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43629
更新日期：2017-02-27 00:00:00
