Abstract：
:Clinical benefit from trastuzumab and other anti-human epidermal growth factor receptor-2 (HER2) therapies in patients with HER2-positive gastric cancer (GC) remains limited by primary or acquired resistance. We aimed to investigate the impact of concomitant molecular alterations to HER2 amplification on the clinical outcome of trastuzumab-treated patients. Using immunohistochemistry (IHC), copy number variations (CNVs), and Ion Ampliseq Cancer Panel, we analyzed the status of concomitant alterations in 50 HER2-positive advanced GC patients treated with trastuzumab in combination with other chemotherapeutic agents. The percentage of tumor samples with at least one concomitant alteration was 40% as assessed by IHC, 16% by CNVs, and 64% by Ampliseq sequencing. Median progression-free survival (PFS) was 8.0 months (95% confidence interval, 4.8-11.3). Patients were divided into two subgroups according to PFS values with a cutoff point of 8 months; results show that concomitant genomic alterations do not correlate with trastuzumab response. However, CNVs of CCNE1 significantly correlated (p < 0.05) with a shorter survival time. Our findings indicate that additional alterations implemented for prediction of clinical benefit from HER2-targeting agents in GC remained unclear. Further studies will be needed to elucidate the role of each specific biomarker and to optimize therapeutic approaches.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee JY,Hong M,Kim ST,Park SH,Kang WK,Kim KM,Lee Jdoi
10.1038/srep09289subject
Has Abstractpub_date
2015-03-19 00:00:00pages
9289issn
2045-2322pii
srep09289journal_volume
5pub_type
杂志文章abstract：:The poor control of the adhesion of TiO2 nanotubes (TNTs) layers to a non-anodized titanium (Ti) substrate has limited their widespread application, because the stripping mechanism has not yet been revealed. Here, we report a novel method to control the detachment of TNTs by post-treatment of the as-fabricated samples...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07178
更新日期：2014-11-24 00:00:00
abstract：:This study aims to determine the prevalence of health personnel with normal weight central obesity and to investigate whether this group had higher cardiovascular disease (CVD) risk factors than those of the people with normal weight and without central obesity. A waist-to-height ratio was calculated as waist circumfe...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/srep37100
更新日期：2016-11-16 00:00:00
abstract：:We investigate temperature smearing effects on the electron-boson spectral density function (I(2)χ(ω)) obtained from optical data using a maximum entropy inversion method. We start with two simple model input I(2)χ(ω), calculate the optical scattering rates at selected temperatures using the model input spectral densi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23647
更新日期：2016-03-31 00:00:00
abstract：:The feedback between dyke and sill intrusions and the evolution of stresses within volcanic systems is poorly understood, despite its importance for magma transport and volcano instability. Long-lived ocean island volcanoes are crosscut by thousands of dykes, which must be accommodated through a combination of flank s...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-10-15 00:00:00
abstract：:In eusocial Hymenoptera (ants, bees and wasps), queen and worker adult castes typically arise via environmental influences. A fundamental challenge is to understand how a single genome can thereby produce alternative phenotypes. A powerful approach is to compare the molecular basis of caste determination and different...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-03-31 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-05-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-06-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41086
更新日期：2017-01-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10058-x
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
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更新日期：2016-02-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-07-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74120-x
更新日期：2020-10-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-04-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06216-w
更新日期：2017-07-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51652-5
更新日期：2019-10-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58130-3
更新日期：2020-01-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21030-8
更新日期：2018-02-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-11-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07699
更新日期：2015-01-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-07-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-11-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01018
更新日期：2012-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-05-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46568-z
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