Controlling Indomethacin Release through Vapor-Phase Deposited Hydrogel Films by Adjusting the Cross-linker Density.

Abstract:

:Vapor-phase deposited polymer coatings are applied on thin indomethacin films to modify the drug release. Hydrogel-forming co-polymers of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate were prepared directly on top of solution cast indomethacin thin films by initiated Chemical Vapor Deposition (iCVD). This technique allows for solvent-free processing under mild conditions, thus minimizing a potential impact on the pharmaceutical. The drug release behavior, among other properties, was evaluated for polymers of different compositions and at different temperatures. The data show that the release kinetics can be tuned by several orders of magnitude as the cross-linker fraction is varied in the polymer coating. While uncoated indomethacin films were fully released within an hour, polymer coatings showed gradual liberation over several hours to days. Additional insight is gained from evaluating the experimental dissolution data in the framework of diffusive transport. The results of this study show that the iCVD technique has some promises for pharmaceutical technology, potentially allowing for tailored release behavior also for other drug systems.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Christian P,Tumphart S,Ehmann HMA,Riegler H,Coclite AM,Werzer O

doi

10.1038/s41598-018-24238-w

subject

Has Abstract

pub_date

2018-05-08 00:00:00

pages

7134

issue

1

issn

2045-2322

pii

10.1038/s41598-018-24238-w

journal_volume

8

pub_type

杂志文章
  • Sequencing proteins with transverse ionic transport in nanochannels.

    abstract::De novo protein sequencing is essential for understanding cellular processes that govern the function of living organisms and all sequence modifications that occur after a protein has been constructed from its corresponding DNA code. By obtaining the order of the amino acids that compose a given protein one can then d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25232

    authors: Boynton P,Di Ventra M

    更新日期:2016-05-03 00:00:00

  • Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study.

    abstract::There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalenc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75267-3

    authors: Tamura T,Kuriyama N,Koyama T,Ozaki E,Matsui D,Kadomatsu Y,Tsukamoto M,Kubo Y,Okada R,Hishida A,Sasakabe T,Kawai S,Naito M,Takashima N,Kadota A,Tanaka K,Hara M,Suzuki S,Nakagawa-Senda H,Takezaki T,Shimoshikiryo I,

    更新日期:2020-10-28 00:00:00

  • Perinatal depression and anxiety of primipara is higher than that of multipara in Japanese women.

    abstract::The proportion of women who experience a depressive state after delivery differs between primiparas and multiparas, so it is important to clarify the different factors related to depression between the two groups. In this study, we confirmed the differences in depressive states, the perinatal period, and social suppor...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74088-8

    authors: Nakamura Y,Okada T,Morikawa M,Yamauchi A,Sato M,Ando M,Ozaki N

    更新日期:2020-10-13 00:00:00

  • Early outcomes after small incision lenticule extraction and photorefractive keratectomy for correction of high myopia.

    abstract::We prospectively compared visual and refractive outcomes in patients with high myopia and myopic astigmatism after small-incision lenticule extraction (SMILE) and photorefractive keratetctomy (PRK) with mitomycin C. Sixty-six eyes of 33 patients (mean age, 29.7 ± 5.6 years) were included (SMILE: 34 eyes, PRK 32 eyes)....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep32820

    authors: Chan TC,Yu MC,Ng A,Wang Z,Cheng GP,Jhanji V

    更新日期:2016-09-07 00:00:00

  • Off-axis rotor in Enterococcus hirae V-ATPase visualized by Zernike phase plate single-particle cryo-electron microscopy.

    abstract::EhV-ATPase is an ATP-driven Na+ pump in the eubacteria Enterococcus hirae (Eh). Here, we present the first entire structure of detergent-solubilized EhV-ATPase by single-particle cryo-electron microscopy (cryo-EM) using Zernike phase plate. The cryo-EM map dominantly showed one of three catalytic conformations in this...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-33977-9

    authors: Tsunoda J,Song C,Imai FL,Takagi J,Ueno H,Murata T,Iino R,Murata K

    更新日期:2018-10-23 00:00:00

  • An ultraviolet responsive hybrid solar cell based on titania/poly(3-hexylthiophene).

    abstract::Here we present an ultraviolet responsive inorganic-organic hybrid solar cell based on titania/poly(3-hexylthiophene) (TiO(2)/P3HT) heterojuction. In this solar cell, TiO(2) is an ultraviolet light absorber and electronic conductor, P3HT is a hole conductor, the light-to-electrical conversion is realized by the cooper...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01283

    authors: Wu J,Yue G,Xiao Y,Lin J,Huang M,Lan Z,Tang Q,Huang Y,Fan L,Yin S,Sato T

    更新日期:2013-01-01 00:00:00

  • Electronic Excitation Dynamics in Liquid Water under Proton Irradiation.

    abstract::Molecular behaviour of liquid water under proton irradiation is of great importance to a number of technological and medical applications. The highly energetic proton generates a time-varying field that is highly localized and heterogeneous at the molecular scale, and massive electronic excitations are produced as a r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40379

    authors: Reeves KG,Kanai Y

    更新日期:2017-01-13 00:00:00

  • Noise Reduction in Complex Biological Switches.

    abstract::Cells operate in noisy molecular environments via complex regulatory networks. It is possible to understand how molecular counts are related to noise in specific networks, but it is not generally clear how noise relates to network complexity, because different levels of complexity also imply different overall number o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20214

    authors: Cardelli L,Csikász-Nagy A,Dalchau N,Tribastone M,Tschaikowski M

    更新日期:2016-02-08 00:00:00

  • Transient effects of chemotherapy for testicular cancer on mouse behaviour.

    abstract::The treatment of testicular cancer includes unilateral orchiectomy and chemotherapy and is curative for most patients. However, observational studies revealed an association with depression, anxiety and cognitive impairment. It is unclear whether these side effects are caused by chemotherapy, hemicastration or the dis...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67081-8

    authors: Borbélyová V,Renczés E,Chovanec M,Mego M,Celec P

    更新日期:2020-06-23 00:00:00

  • Background free imaging of single mRNAs in live cells using split fluorescent proteins.

    abstract::We describe a technique for imaging single mRNAs in living cells based on fluorescent protein (FP) complementation. We employ the high affinity interaction between the bacterial phage MS2/PP7 coat proteins and their respective RNA binding motifs as an RNA scaffold to bring two halves of a split-FP together to image si...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03615

    authors: Wu B,Chen J,Singer RH

    更新日期:2014-01-09 00:00:00

  • Microbial oil-degradation under mild hydrostatic pressure (10 MPa): which pathways are impacted in piezosensitive hydrocarbonoclastic bacteria?

    abstract::Oil spills represent an overwhelming carbon input to the marine environment that immediately impacts the sea surface ecosystem. Microbial communities degrading the oil fraction that eventually sinks to the seafloor must also deal with hydrostatic pressure, which linearly increases with depth. Piezosensitive hydrocarbo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23526

    authors: Scoma A,Barbato M,Hernandez-Sanabria E,Mapelli F,Daffonchio D,Borin S,Boon N

    更新日期:2016-03-29 00:00:00

  • Multiscale architectured materials with composition and grain size gradients manufactured using high-pressure torsion.

    abstract::The concept of multiscale architectured materials is established using composition and grain size gradients. Composition-gradient nanostructured materials are produced from coarse grained interstitial free steels via carburization and high-pressure torsion. Quantitative analyses of the dislocation density using X-ray ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26590

    authors: Kang JY,Kim JG,Park HW,Kim HS

    更新日期:2016-05-27 00:00:00

  • The corticosteroid compounds prednisolone and vamorolone do not alter the nociception phenotype and exacerbate liver injury in sickle cell mice.

    abstract::Clinicians often hesitate prescribing corticosteroids to treat corticosteroid-responsive conditions in sickle cell disease (SCD) patients because their use can be associated with complications (increased hospital readmission, rebound pain, strokes, avascular necrosis, acute chest syndrome). Consequently, SCD patients ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24274-6

    authors: Almeida LEF,Damsker JM,Albani S,Afsar N,Kamimura S,Pratt D,Kleiner DE,Quezado M,Gordish-Dressman H,Quezado ZMN

    更新日期:2018-04-17 00:00:00

  • Camera-based optical palpation.

    abstract::Optical elastography is undergoing extensive development as an imaging tool to map mechanical contrast in tissue. Here, we present a new platform for optical elastography by generating sub-millimetre-scale mechanical contrast from a simple digital camera. This cost-effective, compact and easy-to-implement approach ope...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72603-5

    authors: Sanderson RW,Fang Q,Curatolo A,Adams W,Lakhiani DD,Ismail HM,Foo KY,Dessauvagie BF,Latham B,Yeomans C,Saunders CM,Kennedy BF

    更新日期:2020-09-29 00:00:00

  • The number of key carcinogenic events can be predicted from cancer incidence.

    abstract::The widely accepted multiple-hit hypothesis of carcinogenesis states that cancers arise after several successive events. However, no consensus has been reached on the quantity and nature of these events, although "driver" mutations or epimutations are considered the most probable candidates. By using the largest publi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12448-7

    authors: Belikov AV

    更新日期:2017-09-22 00:00:00

  • Creating the Functional Single-Ring GroEL-GroES Chaperonin Systems via Modulating GroEL-GroES Interaction.

    abstract::Chaperonin and cochaperonin, represented by E. coli GroEL and GroES, are essential molecular chaperones for protein folding. The double-ring assembly of GroEL is required to function with GroES, and a single-ring GroEL variant GroELSR forms a stable complex with GroES, arresting the chaperoning reaction cycle. GroES I...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10499-4

    authors: Illingworth M,Ellis H,Chen L

    更新日期:2017-08-29 00:00:00

  • Life cycle assessment of polyphenols extraction processes from waste biomass.

    abstract::Waste biomass from forestry and wood processing industries is a source to obtain fine chemicals, and its processing is a good example of circular economy, but it generates secondary environmental impacts. The main objective of this study was to analyse the environmental performances of laboratory scale processes for p...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70587-w

    authors: Barjoveanu G,Pătrăuțanu OA,Teodosiu C,Volf I

    更新日期:2020-08-12 00:00:00

  • Modeling how shark and dolphin skin patterns control transitional wall-turbulence vorticity patterns using spatiotemporal phase reset mechanisms.

    abstract::Many slow-moving biological systems like seashells and zebrafish that do not contend with wall turbulence have somewhat organized pigmentation patterns flush with their outer surfaces that are formed by underlying autonomous reaction-diffusion (RD) mechanisms. In contrast, sharks and dolphins contend with wall turbule...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06650

    authors: Bandyopadhyay PR,Hellum AM

    更新日期:2014-10-23 00:00:00

  • Fine-tuning the expression of target genes using a DDI2 promoter gene switch in budding yeast.

    abstract::Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and industrial application. Here, we introduce a novel promoter switching method based on the DDI2 promoter (PDDI2) that...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49000-8

    authors: Wang Y,Zhang K,Li H,Xu X,Xue H,Wang P,Fu YV

    更新日期:2019-08-29 00:00:00

  • Remarkably high mobility ultra-thin-film metal-oxide transistor with strongly overlapped orbitals.

    abstract::High mobility channel thin-film-transistor (TFT) is crucial for both display and future generation integrated circuit. We report a new metal-oxide TFT that has an ultra-thin 4.5 nm SnO2 thickness for both active channel and source-drain regions, very high 147 cm(2)/Vs field-effect mobility, high ION/IOFF of 2.3 × 10(7...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19023

    authors: Shih CW,Chin A,Lu CF,Su WF

    更新日期:2016-01-08 00:00:00

  • On chip shapeable optical tweezers.

    abstract::Particles manipulation with optical forces is known as optical tweezing. While tweezing in free space with laser beams was established in the 1980s, integrating the optical tweezers on a chip is a challenging task. Recent experiments with plasmonic nanoantennas, microring resonators, and photonic crystal nanocavities ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02290

    authors: Renaut C,Cluzel B,Dellinger J,Lalouat L,Picard E,Peyrade D,Hadji E,de Fornel F

    更新日期:2013-01-01 00:00:00

  • Combining short and long read sequencing to characterize antimicrobial resistance genes on plasmids applied to an unauthorized genetically modified Bacillus.

    abstract::Antimicrobial resistance (AMR) is a major public health threat. Plasmids are able to transfer AMR genes among bacterial isolates. Whole genome sequencing (WGS) is a powerful tool to monitor AMR determinants. However, plasmids are difficult to reconstruct from WGS data. This study aimed to improve the characterization,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61158-0

    authors: Berbers B,Saltykova A,Garcia-Graells C,Philipp P,Arella F,Marchal K,Winand R,Vanneste K,Roosens NHC,De Keersmaecker SCJ

    更新日期:2020-03-09 00:00:00

  • Association between the ambient temperature and the occurrence of human Salmonella and Campylobacter infections.

    abstract::Salmonella spp. and thermotolerant Campylobacter spp. are the most important causes of human bacterial diarrheal infections worldwide. These bacterial species are influenced by several factors like behaviour of the host, shedding, environment incl. directly or indirectly through ambient temperature, and the infections...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28442

    authors: Yun J,Greiner M,Höller C,Messelhäusser U,Rampp A,Klein G

    更新日期:2016-06-21 00:00:00

  • Composite materials with enhanced dimensionless Young's modulus and desired Poisson's ratio.

    abstract::We have designed a new type of composite materials which not only has a Young's modulus much larger than the Voigt limit, but also is always nearly isotropic. Moreover, its Poisson's ratio can be designed at a desired value, e.g. positive, or negative, or zero. We have also demonstrated that structural hierarchy can h...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14103

    authors: Zhu HX,Fan TX,Zhang D

    更新日期:2015-09-11 00:00:00

  • Deposition of calcium in an in vitro model of human breast tumour calcification reveals functional role for ALP activity, altered expression of osteogenic genes and dysregulation of the TRPM7 ion channel.

    abstract::Microcalcifications are vital mammographic indicators contributing to the early detection of up to 50% of non-palpable tumours and may also be valuable as prognostic markers. However, the precise mechanism by which they form remains incompletely understood. Following development of an in vitro model using human breast...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-36496-9

    authors: O'Grady S,Morgan MP

    更新日期:2019-01-24 00:00:00

  • Chronic mercury exposure in Late Neolithic/Chalcolithic populations in Portugal from the cultural use of cinnabar.

    abstract::Cinnabar is a natural mercury sulfide (HgS) mineral of volcanic or hydrothermal origin that is found worldwide. It has been mined prehistorically and historically in China, Japan, Europe, and the Americas to extract metallic mercury (Hg(0)) for use in metallurgy, as a medicinal, a preservative, and as a red pigment fo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14679

    authors: Emslie SD,Brasso R,Patterson WP,Carlos Valera A,McKenzie A,Maria Silva A,Gleason JD,Blum JD

    更新日期:2015-10-01 00:00:00

  • Signatures of adaptation and symbiosis in genomes and transcriptomes of Symbiodinium.

    abstract::Symbiodinium is best-known as the photosynthetic symbiont of corals, but some clades are symbiotic in other organisms or include free-living forms. Identifying similarities and differences among these clades can help us understand their relationship with corals, and thereby inform on measures to manage coral reefs in ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15029-w

    authors: González-Pech RA,Ragan MA,Chan CX

    更新日期:2017-11-03 00:00:00

  • Fibrin clots are equilibrium polymers that can be remodeled without proteolytic digestion.

    abstract::Fibrin polymerization is a necessary part of hemostasis but clots can obstruct blood vessels and cause heart attacks and strokes. The polymerization reactions are specific and controlled, involving strong knob-into-hole interactions to convert soluble fibrinogen into insoluble fibrin. It has long been assumed that clo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00879

    authors: Chernysh IN,Nagaswami C,Purohit PK,Weisel JW

    更新日期:2012-01-01 00:00:00

  • Influence of a patient transfer network of US inpatient facilities on the incidence of nosocomial infections.

    abstract::Antibiotic-resistant bacterial infections are a substantial source of morbidity and mortality and have a common reservoir in inpatient settings. Transferring patients between facilities could be a mechanism for the spread of these infections. We wanted to assess whether a network of hospitals, linked by inpatient tran...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-02245-7

    authors: Fernández-Gracia J,Onnela JP,Barnett ML,Eguíluz VM,Christakis NA

    更新日期:2017-06-07 00:00:00

  • RTB Lectin: a novel receptor-independent delivery system for lysosomal enzyme replacement therapies.

    abstract::Enzyme replacement therapies have revolutionized patient treatment for multiple rare lysosomal storage diseases but show limited effectiveness for addressing pathologies in "hard-to-treat" organs and tissues including brain and bone. Here we investigate the plant lectin RTB as a novel carrier for human lysosomal enzym...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14144

    authors: Acosta W,Ayala J,Dolan MC,Cramer CL

    更新日期:2015-09-18 00:00:00