Abstract：
:The central dogma of molecular biology describes the translation of genetic information from mRNA to protein, but does not specify the quantitation or timing of this process across the genome. We have analyzed protein and gene expression in a diverse set of human tissues. To study concordance and discordance of gene and protein expression, we integrated mass spectrometry data from the Human Proteome Map project and RNA-Seq measurements from the Genotype-Tissue Expression project. We analyzed 16,561 genes and the corresponding proteins in 14 tissue types across nearly 200 samples. A comprehensive tissue- and gene-specific analysis revealed that across the 14 tissues, correlation between mRNA and protein expression was positive and ranged from 0.36 to 0.5. We also identified 1,012 genes whose RNA and protein expression was correlated across all the tissues and examined genes and proteins that were concordantly and discordantly expressed for each tissue of interest. We extended our analysis to look for genes and proteins that were differentially correlated in cancer compared to normal tissues, showing higher levels of correlation in normal tissues. Finally, we explored the implications of these findings in the context of biomarker and drug target discovery.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kosti I,Jain N,Aran D,Butte AJ,Sirota Mdoi
10.1038/srep24799subject
Has Abstractpub_date
2016-05-04 00:00:00pages
24799issn
2045-2322pii
srep24799journal_volume
6pub_type
杂志文章abstract：:Although nearly one fifth of all human cancers have an infectious aetiology, the causes for the majority of cancers remain unexplained. Despite the enormous data output from high-throughput shotgun sequencing, viral DNA in a clinical sample typically constitutes a proportion of host DNA that is too small to be detecte...
journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
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更新日期：2015-05-19 00:00:00
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pub_type： 已发布勘误
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Scientific reports
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更新日期：2015-01-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-02-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-02-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-10-24 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-02-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-02-25 00:00:00
