Investigation of biomarkers alterations after an acute tissue trauma in human trapezius muscle, using microdialysis.

abstract：:Cell and animal studies have demonstrated that circadian rhythm is governed by autonomous rhythmicity of clock genes. Although disturbances in circadian rhythm have been implicated in metabolic disease development, it remains unknown whether muscle circadian rhythm is altered in human models of type 2 diabetes. Here w...

journal_title：Scientific reports

authors： Hansen J,Timmers S,Moonen-Kornips E,Duez H,Staels B,Hesselink MK,Schrauwen P

更新日期：2016-10-19 00:00:00

abstract：:Sphingobium sp. strain TCM1 can degrade tris(2-chloroethyl) phosphate (TCEP) to inorganic phosphate and 2-chloroethanol. A phosphotriesterase (PTE), phosphodiesterase (PDE) and phosphomonoesterase (PME) are believed to be involved in the degradation of TCEP. The PTE and PME that respectively catalyze the first and thi...

journal_title：Scientific reports

authors： Abe K,Mukai N,Morooka Y,Makino T,Oshima K,Takahashi S,Kera Y

更新日期：2017-06-06 00:00:00

abstract：:The LiBH4/CaH2 composite are firstly studied as Concentrating Solar Power Thermal Storage Material. The LiBH4/CaH2 composite according to the stoichiometric ratio are synthesized by high-energy ball milling method. The kinetics, thermodynamics and cycling stability of LiBH4/CaH2 composite are investigated by XRD (X-ra...

journal_title：Scientific reports

authors： Li Y,Li P,Qu X

更新日期：2017-01-31 00:00:00

abstract：:Phosphopantetheinyl transferases (PPTases) play essential roles in both primary metabolisms and secondary metabolisms via post-translational modification of acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs). In this study, an industrial FK506 producing strain Streptomyces tsukubaensis L19, together wit...

journal_title：Scientific reports

authors： Wang YY,Zhang XS,Luo HD,Ren NN,Jiang XH,Jiang H,Li YQ

更新日期：2016-04-07 00:00:00

abstract：:The genome of influenza A virus (IAV) comprises eight RNA segments (vRNA) which are transcribed and replicated by the heterotrimeric IAV RNA-dependent RNA-polymerase (RdRp). RdRp consists of three subunits (PA, PB1 and PB2) and binds both the highly conserved 3'- and 5'-ends of the vRNA segment. The IAV RdRp is an imp...

journal_title：Scientific reports

authors： Swale C,Monod A,Tengo L,Labaronne A,Garzoni F,Bourhis JM,Cusack S,Schoehn G,Berger I,Ruigrok RW,Crépin T

更新日期：2016-04-20 00:00:00

abstract：:Perception can often be described as a statistically optimal inference process whereby noisy and incomplete sensory evidence is combined with prior knowledge about natural scene statistics. Previous evidence has shown that humans tend to underestimate the speed of unreliable moving visual stimuli. This finding has bee...

journal_title：Scientific reports

authors： Senna I,Parise CV,Ernst MO

更新日期：2015-09-15 00:00:00

abstract：:One quarter of individuals with Preserved Ratio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established methods to identify these individuals. We examined the utility of FVC/TLC in identifying features of obstructive lung disease. The ratio of post-bronchodilator FVC and TLCCT from c...

journal_title：Scientific reports

authors： Fortis S,Comellas A,Kim V,Casaburi R,Hokanson JE,Crapo JD,Silverman EK,Wan ES

更新日期：2020-03-20 00:00:00

abstract：:Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is used as a first-line treatment for advanced non-small cell lung cancer (NSCLC). However, most NSCLC patients inevitably develop gefitinib resistance, and the mechanisms underlying this resistance are not fully understood. In this study...

journal_title：Scientific reports

authors： Cao X,Lai S,Hu F,Li G,Wang G,Luo X,Fu X,Hu J

更新日期：2017-06-07 00:00:00

abstract：:In yeast, the pol3-01,L612M double mutant allele, which causes defects in DNA polymerase delta (Pol δ) proofreading (pol3-01) and nucleotide selectivity (pol3-L612M), confers an "ultramutator" phenotype that rapidly drives extinction of haploid and diploid MMR-proficient cells. Here, we investigate antimutator mutatio...

journal_title：Scientific reports

authors： Dennis DG,McKay-Fleisch J,Eitzen K,Dowsett I,Kennedy SR,Herr AJ

更新日期：2017-04-18 00:00:00

abstract：:Fluorescence microscopy is rapidly turning into nanoscopy. Among the various nanoscopy methods, the STED/RESOLFT super-resolution family has recently been expanded to image even large fields of view within a few seconds. This advance relies on using light patterns featuring substantial arrays of intensity minima for d...

journal_title：Scientific reports

authors： Chmyrov A,Leutenegger M,Grotjohann T,Schönle A,Keller-Findeisen J,Kastrup L,Jakobs S,Donnert G,Sahl SJ,Hell SW

更新日期：2017-03-20 00:00:00

abstract：:Humans have an innate set of emotions recognised universally. However, emotion recognition also depends on socio-cultural rules. Although adults recognise vocal emotions universally, they identify emotions more accurately in their native language. We examined developmental trajectories of universal vocal emotion recog...

journal_title：Scientific reports

authors： Chronaki G,Wigelsworth M,Pell MD,Kotz SA

更新日期：2018-06-14 00:00:00

abstract：:This study investigates the relationship between objective cognitive impairment (OCI), subjective cognitive complaints and depressive symptoms in men and women with classical and non-classical Fabry disease (FD). Cognitive functioning was assessed using a neuropsychological test battery, subjective cognitive complaint...

journal_title：Scientific reports

authors： Körver S,Geurtsen GJ,Hollak CEM,van Schaik IN,Longo MGF,Lima MR,Vedolin L,Dijkgraaf MGW,Langeveld M

更新日期：2019-01-17 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) elicit antitumour effects by activating the host immunity and cause immune-related adverse events (irAEs). ICI-related interstitial lung disease (ICI-ILD) is a fatal irAE that is difficult to treat; moreover, its incidence is relatively higher in patients with lung cancer. Therefore...

journal_title：Scientific reports

authors： Okada N,Matsuoka R,Sakurada T,Goda M,Chuma M,Yagi K,Zamami Y,Nishioka Y,Ishizawa K

更新日期：2020-08-13 00:00:00

abstract：:The intrauterine environment is particularly vulnerable to environmental exposures. We previously established a mouse model that provided evidence for pregnancy complications and placental anti-angiogenesis in response to Aroclor 1254 (A-1254), a mixture of polychlorinated biphenyls (PCBs). Importantly, these effects ...

journal_title：Scientific reports

authors： Kalkunte S,Huang Z,Lippe E,Kumar S,Robertson LW,Sharma S

更新日期：2017-01-10 00:00:00

abstract：:Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, ca...

journal_title：Scientific reports

authors： Boulding T,McCuaig RD,Tan A,Hardy K,Wu F,Dunn J,Kalimutho M,Sutton CR,Forwood JK,Bert AG,Goodall GJ,Malik L,Yip D,Dahlstrom JE,Zafar A,Khanna KK,Rao S

更新日期：2018-01-08 00:00:00

abstract：:Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions ...

journal_title：Scientific reports

authors： Tu S,Yuan GC,Shao Z

更新日期：2017-01-31 00:00:00

abstract：:The architecture of the genome influences the functions of DNA from bacteria to eukaryotes. Intrinsically disordered regions (IDR) of eukaryotic histones have pivotal roles in various processes of gene expression. IDR is rare in bacteria, but interestingly, mycobacteria produce a unique histone-like protein, MDP1 that...

journal_title：Scientific reports

authors： Savitskaya A,Nishiyama A,Yamaguchi T,Tateishi Y,Ozeki Y,Nameta M,Kon T,Kaboso SA,Ohara N,Peryanova OV,Matsumoto S

更新日期：2018-05-29 00:00:00

abstract：:Cyclamen persicum (cyclamen) is a commercially valuable, winter-blooming perennial plant. We cloned two cyclamen orthologues of AGAMOUS (AG), CpAG1 and CpAG2, which are mainly expressed in the stamen and carpel, respectively. Cyclamen flowers have 5 petals, but expression of a chimeric repressor of CpAG1 (CpAG1-SRDX) ...

journal_title：Scientific reports

authors： Tanaka Y,Oshima Y,Yamamura T,Sugiyama M,Mitsuda N,Ohtsubo N,Ohme-Takagi M,Terakawa T

更新日期：2013-01-01 00:00:00

abstract：:Recent studies have shown inconsistent results regarding the value of desmoteplase for treating acute ischemic stroke (AIS) when administered within an extended time window. We performed a meta-analysis to explore the value of desmoteplase in AIS treatment. The MEDLINE, EMBASE, and Cochrane Library databases were sear...

journal_title：Scientific reports

authors： Shi L,Liang F,Li Y,Shao A,Zhou K,Yu J,Zhang J

更新日期：2016-09-27 00:00:00

abstract：:Recent studies have indicated that different post-translational modifications (PTMs) synergistically orchestrate specific biological processes by crosstalks. However, the preference of the crosstalk among different PTMs and the evolutionary constraint on the PTM crosstalk need further dissections. In this study, the i...

journal_title：Scientific reports

authors： Pan Z,Liu Z,Cheng H,Wang Y,Gao T,Ullah S,Ren J,Xue Y

更新日期：2014-12-05 00:00:00

abstract：:The ancient harbour of Pisa, Portus Pisanus, was one of Italy's most influential seaports for many centuries. Nonetheless, very little is known about its oldest harbour and the relationships between environmental evolution and the main stages of harbour history. The port complex that ensured Pisa's position as an econ...

journal_title：Scientific reports

authors： Kaniewski D,Marriner N,Morhange C,Vacchi M,Sarti G,Rossi V,Bini M,Pasquinucci M,Allinne C,Otto T,Luce F,Van Campo E

更新日期：2018-08-23 00:00:00

abstract：:Particulate matter (PM) induces oxidative stress in vivo, leading to adverse health effects. Oxidative potential (OP) of PM is increasingly studied as a relevant metric for health impact (instead of PM mass concentration) as much of the ambient particle mass do not contribute to PM toxicity. Several assays have been d...

journal_title：Scientific reports

authors： Calas A,Uzu G,Martins JMF,Voisin D,Spadini L,Lacroix T,Jaffrezo JL

更新日期：2017-09-14 00:00:00

abstract：:Among patients with non-small cell lung cancer (NSCLC), best supportive care (BSC) is well-known to improve patient's quality of life and prolong survival. This study aimed to clarify (1) the decision-making factors of BSC alone and (2) the prognostic factors after selection of no further anticancer therapies. We retr...

journal_title：Scientific reports

authors： Kitazawa H,Takeda Y,Naka G,Sugiyama H

更新日期：2019-12-27 00:00:00

abstract：:Although physiological changes are the most evident indicators of skin aging by alteration of the skin's structure and function, we question whether skin aging is also affected by the structure and assembly process of the skin microbiome. We analysed the skin microbiomes of 73 healthy Chinese women in two age groups (...

journal_title：Scientific reports

authors： Kim HJ,Kim JJ,Myeong NR,Kim T,Kim D,An S,Kim H,Park T,Jang SI,Yeon JH,Kwack I,Sul WJ

更新日期：2019-11-14 00:00:00

abstract：:The lack of a precisely-dated, unequivocal climate proxy from northern China, where precipitation variability is traditionally considered as an East Asian summer monsoon (EASM) indicator, impedes our understanding of the behaviour and dynamics of the EASM. Here we present a well-dated, pollen-based, ~20-yr-resolution ...

journal_title：Scientific reports

authors： Chen F,Xu Q,Chen J,Birks HJ,Liu J,Zhang S,Jin L,An C,Telford RJ,Cao X,Wang Z,Zhang X,Selvaraj K,Lu H,Li Y,Zheng Z,Wang H,Zhou A,Dong G,Zhang J,Huang X,Bloemendal J,Rao Z

更新日期：2015-06-18 00:00:00

abstract：:Various neurophysiological and cognitive functions are based on transferring information between spiking neurons via a complex system of synaptic connections. In particular, the capacity of presynaptic inputs to influence the postsynaptic outputs-the efficacy of the synapses-plays a principal role in all aspects of hi...

journal_title：Scientific reports

authors： Dabaghian Y

更新日期：2019-01-24 00:00:00

abstract：:Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industr...

journal_title：Scientific reports

authors： Xu Y,Wang S,Chan HF,Lu H,Lin Z,He C,Chen M

更新日期：2017-04-24 00:00:00

abstract：:Recent studies have demonstrated functions of miR-145 in vascular smooth muscle cells (VSMCs) phenotypes and vascular diseases. In this study, we aim to determine whether CD40 is involved in miR-145 mediated switch of VSMC phenotypes. In cultured VSMCs, the effects of miR-145 and CD40 on TNF-α, TGF-β, and Homocysteine...

journal_title：Scientific reports

authors： Guo X,Li D,Chen M,Chen L,Zhang B,Wu T,Guo R

更新日期：2016-10-12 00:00:00

abstract：:Neuroinflammation is involved in the pathogenesis of Parkinson's disease (PD) and other neurodegenerative disorders. We show that lack of PINK1- a mitochondrial kinase linked to recessive familial PD - leads to glia type-specific abnormalities of innate immunity. PINK1 loss enhances LPS/IFN-γ stimulated pro-inflammato...

journal_title：Scientific reports

authors： Sun L,Shen R,Agnihotri SK,Chen Y,Huang Z,Büeler H

更新日期：2018-01-10 00:00:00

abstract：:Habitat fragmentation is considered as major threat to biodiversity worldwide. Biodiversity can be described as taxonomic, functional and phylogenetic diversity. However, the effect of forest fragmentation on taxonomic, phylogenetic and functional diversity is barely understood. We compare the response of taxonomic (s...

journal_title：Scientific reports

authors： Bełcik M,Lenda M,Amano T,Skórka P

更新日期：2020-11-23 00:00:00