Abstract：
:The lack of a precisely-dated, unequivocal climate proxy from northern China, where precipitation variability is traditionally considered as an East Asian summer monsoon (EASM) indicator, impedes our understanding of the behaviour and dynamics of the EASM. Here we present a well-dated, pollen-based, ~20-yr-resolution quantitative precipitation reconstruction (derived using a transfer function) from an alpine lake in North China, which provides for the first time a direct record of EASM evolution since 14.7 ka (ka = thousands of years before present, where the "present" is defined as the year AD 1950). Our record reveals a gradually intensifying monsoon from 14.7-7.0 ka, a maximum monsoon (30% higher precipitation than present) from ~7.8-5.3 ka, and a rapid decline since ~3.3 ka. These insolation-driven EASM trends were punctuated by two millennial-scale weakening events which occurred synchronously to the cold Younger Dryas and at ~9.5-8.5 ka, and by two centennial-scale intervals of enhanced (weakened) monsoon during the Medieval Warm Period (Little Ice Age). Our precipitation reconstruction, consistent with temperature changes but quite different from the prevailing view of EASM evolution, points to strong internal feedback processes driving the EASM, and may aid our understanding of future monsoon behaviour under ongoing anthropogenic climate change.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen F,Xu Q,Chen J,Birks HJ,Liu J,Zhang S,Jin L,An C,Telford RJ,Cao X,Wang Z,Zhang X,Selvaraj K,Lu H,Li Y,Zheng Z,Wang H,Zhou A,Dong G,Zhang J,Huang X,Bloemendal J,Rao Zdoi
10.1038/srep11186subject
Has Abstractpub_date
2015-06-18 00:00:00pages
11186issn
2045-2322pii
srep11186journal_volume
5pub_type
杂志文章abstract：:The metal-free nitrogen-doped graphitic-carbon@graphene (Ng-C@G) is prepared from a composite of polyaniline and graphene by a facile polymerization following by pyrolysis for electrochemical oxygen reduction reaction (ORR). Pyrolysis creates a sponge-like with ant-cave-architecture in the polyaniline derived nitrogen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68260-3
更新日期：2020-07-24 00:00:00
abstract：:Tumor aggressiveness is usually associated with metastasis. MDA-MB 231, a triple-negative breast cancer (TNBC), is an aggressive type of breast cancer and associated with early metastasis. The Rho/ROCK pathway is a key regulator of cell motility involving cytoskeleton regulation through stabilization of actin filament...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14216-z
更新日期：2017-10-20 00:00:00
abstract：:Neurovascular unit (NVU) is a basic unit in the brain, including neurons, glial cells, blood vessels and extracellular matrix. This concept implies the importance of a three-dimensional (3D) culture model including these cell types for investigating brain functions. However, little is known about the construction of a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17411-0
更新日期：2017-12-11 00:00:00
abstract：:Although prolactin (PRL) and its receptor (PRLR) have been detected in glioblastoma multiforme (GBM), their role in its pathogenesis remains unclear. Our aim was to explore their contribution in GBM pathogenesis. We detected PRL and PRLR in all GBM cell lines tested. PRLR activation or overexpression using plasmid tra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55860-x
更新日期：2019-12-20 00:00:00
abstract：:Lack of standardization and unblinding threaten the research of mechanisms involved in expectancy effects on pain. We evaluated a computer-controlled virtual experimenter (VEx) to avoid these issues. Fifty-four subjects underwent a baseline-retest heat pain protocol. Between sessions, they received an expectancy manip...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77453-9
更新日期：2020-11-23 00:00:00
abstract：:Combining endurance training with resistance training (RT) may attenuate skeletal muscle hypertrophic adaptation versus RT alone; however, the underlying mechanisms are unclear. We investigated changes in markers of ribosome biogenesis, a process linked with skeletal muscle hypertrophy, following concurrent training v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18887-6
更新日期：2018-01-12 00:00:00
abstract：:The artificial earthquake of mb 6.1 related to the North Korea's sixth nuclear test occured at Mt. Mantap, North Korea on September 3, 2017. It was reported that a large and complex surface deformation was caused by the event. The surface deformation was composed of expansion of explosions, collapse, compaction and la...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74957-2
更新日期：2020-10-20 00:00:00
abstract：:To increase the yield potential while limiting the environmental impact of N management practices is an important issue in rice cultivation. The large-grain rice cultivar Akita 63 showed higher N-use efficiency for grain production. To elucidate this, we analyzed yield characteristics of Akita 63 in comparison with th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69289-0
更新日期：2020-07-22 00:00:00
abstract：:The human β-defensin-1 (HBD1) is an antimicrobial peptide constitutively expressed by epithelial cells at mucosal surfaces. In addition to its microbicidal properties, the loss of HBD1 expression in several cancers suggests that it may also have an anti-tumor activity. Here, we investigated the link between HBD1 expre...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36387-z
更新日期：2018-12-21 00:00:00
abstract：:The pristine lignin molecules contain multiple reactive hydroxyl [OH] groups, some of which undergo limited polymerization depending on their configuration (aromatic or aliphatic) or conformation. The key issue in lignin-polymerization is to quantify the number of hydroxyl groups in the pristine molecules for subseque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43296-2
更新日期：2019-05-07 00:00:00
abstract：:We investigated a recovery pattern in subjective and objective measures among 52 patients with cubital tunnel syndrome after anterior subcutaneous transposition of the ulnar nerve. Disabilities of the Arm, Shoulder and Hand (DASH) score (primary outcome), numbness score, grip and pinch strength, Semmes-Weinstein (SW) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27497
更新日期：2016-06-06 00:00:00
abstract：:The opening of connexin (Cx) hemichannels in the membrane is tightly regulated by calcium (Ca2+) and membrane voltage. Electrophysiological and atomic force microscopy experiments indicate that Ca2+ stabilizes the hemichannel closed state. However, structural data show that Ca2+ binding induces an electrostatic seal p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15975-5
更新日期：2017-11-20 00:00:00
abstract：:While Brassica oleracea vegetables have been linked to cancer prevention, the exact mechanism remains unknown. Regulation of gene expression by cross-species microRNAs has been previously reported; however, its link to cancer suppression remains unexplored. In this study we address both issues. We confirm plant microR...
journal_title：Scientific reports
pub_type： 杂志文章,收录出版
doi：10.1038/srep32773
更新日期：2016-09-08 00:00:00
abstract：:Treatment as Prevention (TasP) using directly-acting antivirals has been advocated for Hepatitis C Virus (HCV) in people who inject drugs (PWID), but treatment is expensive and TasP's effectiveness is uncertain. Previous modelling has assumed a homogeneously-mixed population or a static network lacking turnover in the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01862-6
更新日期：2017-05-12 00:00:00
abstract：:Identification of nodal metastasis and tumor extranodal extension (ENE) is crucial for head and neck cancer management, but currently only can be diagnosed via postoperative pathology. Pretreatment, radiographic identification of ENE, in particular, has proven extremely difficult for clinicians, but would be greatly i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32441-y
更新日期：2018-09-19 00:00:00
abstract：:The Przewalski's gazelle (Procapra przewalskii) is one of the most endangered ungulates in the world, with fewer than 2,000 individuals surviving in nine habitat fragments on the Qinghai-Tibet Plateau and isolated by human settlements and infrastructure. In particular, the Qinghai-Tibet railway, which crosses the larg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18163-7
更新日期：2017-12-21 00:00:00
abstract：:Within the framework of precision agriculture, the determination of various soil properties is moving into focus, especially the demand for sensors suitable for in-situ measurements. Energy-dispersive X-ray fluorescence (EDXRF) can be a powerful tool for this purpose. In this study a huge diverse soil set (n = 598) fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53426-5
更新日期：2019-11-26 00:00:00
abstract：:The abrasion resistance of coated glass surfaces is an important parameter for judging lifetime performance, but practical testing procedures remain overly simplistic and do often not allow for direct conclusions on real-world degradation. Here, we combine quantitative two-dimensional image analysis and mechanical abr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17708
更新日期：2015-12-10 00:00:00
abstract：:Microbial survival in dynamic environments requires the ability to successfully respond to abrupt changes in osmolarity. The mechanosensitive channel of large conductance (MscL) is a ubiquitous channel that facilitates the survival of bacteria and archaea under severe osmotic downshock conditions by relieving excess t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32536-6
更新日期：2018-10-01 00:00:00
abstract：:Disease associated genetic variations often cause intracellular enzyme inactivation, dysregulation and instability. However, allosteric communication of mutational effects to distant functional sites leading to loss-of-function remains poorly understood. We characterize here interdomain site-to-site communication by w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44532
更新日期：2017-03-14 00:00:00
abstract：:Protein phosphorylation enables a rapid adjustment of cellular activities to diverse intracellular and environmental stimuli. Many phosphoproteins are targeted on more than one site, which allows the integration of multiple signals and the implementation of complex responses. However, the hierarchy and interplay betwe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80357-3
更新日期：2021-01-13 00:00:00
abstract：:Memory function deficits induced by Alzheimer's disease (AD) are believed to be one of the causes of an increased risk of tripping in patients. Working memory contributes to accurate stepping over obstacles during locomotion, and AD-induced deficits of this memory function may lead to an increased risk of contact with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07220
更新日期：2014-11-27 00:00:00
abstract：:The incidence of cancer in the United Kingdom has increased significantly over the last four decades. The aim of this study was to examine trends in UK cancer incidence and mortality by cancer site and assess the potential for overdiagnosis. Using Cancer Research UK incidence and mortality data for the period (1971-20...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32844-x
更新日期：2018-10-02 00:00:00
abstract：:Intracontinental biotic divisions across the vast Palaearctic region are not well-characterized. Past research has revealed patterns ranging from a lack of population structure to deep divergences along varied lines of separation. Here we compared biogeographic patterns of two Palaearctic shorebirds with different hab...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54715-9
更新日期：2019-12-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-67554-w
更新日期：2020-06-25 00:00:00
abstract：:To study the influence of the position of the double bond and ring size on the stability of hydrogen bonded complexes, the 1:1 complexes formed between 2,2,2-trifluoroethanol (TFE) and three heterocyclic compounds including 2,3-dihydrofuran (2,3-DHF), 2,5-dihydrofuran (2,5-DHF) and 3,4-dihydropyran (3,4-DHP) were inve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11921-7
更新日期：2017-09-12 00:00:00
abstract：:Intergroup competition has an important impact on the survival and fitness of individuals in group-living species. However, factors influencing the probability of winning an encounter are not fully understood. We studied the influence of numerical advantage and location of the encounter on the chances of winning in ei...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28457
更新日期：2016-06-22 00:00:00
abstract：:Plant derived biogenic synthesis of nanoparticles (NP) has been the recent trend in material science as featured sustainable catalysts. A great deal of the current nanocatalytic research has been oriented on the bio-inspired green catalysts based on their wide applicability. In this context, CuO NPs are synthesized fo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81320-6
更新日期：2021-01-21 00:00:00
abstract：:Membrane proteins are distinguished from soluble proteins by their insertion into biological membranes. This insertion is achieved via a noticeable arrangement of hydrophobic amino acids that are exposed at the surface of the protein, and renders the interaction with the aliphatic tails of lipids more energetically fa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17216-1
更新日期：2017-12-05 00:00:00
abstract：:Comparison of kinetic and thermodynamic properties of IRP1 (iron regulatory protein1) binding to FRT (ferritin) and ACO2 (aconitase2) IRE-RNAs, with or without Mn2+, revealed differences specific to each IRE-RNA. Conserved among animal mRNAs, IRE-RNA structures are noncoding and bind Fe2+ to regulate biosynthesis rate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09093-5
更新日期：2017-08-17 00:00:00
