Desmoteplase for Acute Ischemic Stroke within 3 to 9 Hours after Symptom Onset: Evidence from Randomized Controlled Trials.

abstract：:Early growth response 1 (EGR1) is a multifunctional transcription factor; Positive and negative functions of EGR1 in various tumors rely on the integrated functions of various genes it regulates. In this study, we observed the role of EGR1 in non-small-cell lung carcinoma (NSCLC) and identified genes that influence ce...

journal_title：Scientific reports

authors： Zhang H,Chen X,Wang J,Guang W,Han W,Zhang H,Tan X,Gu Y

更新日期：2014-07-03 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that act as ligand-activated transcription factors. PPAR agonists have well-documented anti-inflammatory and neuroprotective roles in the central nervous system. Recent evidence suggests that PPAR agonists are attractive therapeutic agen...

journal_title：Scientific reports

authors： Warden A,Truitt J,Merriman M,Ponomareva O,Jameson K,Ferguson LB,Mayfield RD,Harris RA

更新日期：2016-06-10 00:00:00

abstract：:Controlled quantum teleportation involves a third party as a controller for the teleportation of state. Here, we present the novel protocols for controlling teleportation of the arbitrary two-qubit and three-qubit states through five-qubit and seven-qubit cluster states respectively. In these schemes, Alice sends the ...

journal_title：Scientific reports

authors： Kumar A,Haddadi S,Pourkarimi MR,Behera BK,Panigrahi PK

更新日期：2020-08-12 00:00:00

abstract：:The centrosome is the microtubule organizing center of human cells and facilitates a myriad of cellular functions including organization of the mitotic spindle to ensure faithful chromosome segregation during mitosis, cell polarization and migration, and primary cilia formation. A numerical increase in centrosomes, or...

journal_title：Scientific reports

authors： Denu RA,Burkard ME

更新日期：2020-07-17 00:00:00

abstract：:Near-critical plasmas irradiated at ultra-high laser intensities (I > 1018W/cm2) allow to improve the performances of laser-driven particle and radiation sources and to explore scenarios of great astrophysical interest. Near-critical plasmas with controlled properties can be obtained with nanostructured low-density ma...

journal_title：Scientific reports

authors： Fedeli L,Formenti A,Cialfi L,Pazzaglia A,Passoni M

更新日期：2018-03-01 00:00:00

abstract：:Event-free survival (EFS) is considered the most reliable surrogate endpoint for overall survival (OS) in randomised controlled trials (RCTs) of adjuvant therapies for malignant tumours. However, the surrogacy of intermediate endpoints such as EFS for OS in trials of patients with osteosarcoma has not been investigate...

journal_title：Scientific reports

authors： Tanaka K,Kawano M,Iwasaki T,Matsuda S,Itonaga I,Tsumura H

更新日期：2020-05-22 00:00:00

abstract：:Colorectal cancer (CRC) is the most common type cancers in the world. CRC occurs sporadically in the majority of cases, indicating the predominant cause of the disease are environmental factors. Diet-induced changes in gut-microbiome are recently supposed to contribute on epidemics of CRC. This study was aimed to inve...

journal_title：Scientific reports

authors： Kim DJ,Yang J,Seo H,Lee WH,Ho Lee D,Kym S,Park YS,Kim JG,Jang IJ,Kim YK,Cho JY

更新日期：2020-02-18 00:00:00

abstract：:In unpredictable environments in which reliable cues for predicting environmental variation are lacking, a diversifying bet-hedging strategy for diapause exit is expected to evolve, whereby only a portion of diapausing forms will resume development at the first occurrence of suitable conditions. This study focused on ...

journal_title：Scientific reports

authors： Tarazona E,Lucas-Lledó JI,Carmona MJ,García-Roger EM

更新日期：2020-12-07 00:00:00

abstract：:In order to ensure successful development, cells of the early mammalian embryo must differentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or primitive endoderm (PE) specification within the ICM. Here, we deciphered the mechanism that assures the correct order of these sequenti...

journal_title：Scientific reports

authors： Wigger M,Kisielewska K,Filimonow K,Plusa B,Maleszewski M,Suwińska A

更新日期：2017-11-09 00:00:00

abstract：:Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of DG and venlafaxine (VLX) in a chronic social defeat stress model...

journal_title：Scientific reports

authors： Bai S,Zhang X,Chen Z,Wang W,Hu Q,Liang Z,Shen P,Gui S,Zeng L,Liu Z,Chen J,Xie X,Huang H,Han Y,Wang H,Xie P

更新日期：2017-08-29 00:00:00

abstract：:Competing time scales involved in rapid rising micro-droplets in comparison to substantially slower biodegradation processes at oil-water interfaces highlights a perplexing question: how do biotic processes occur and alter the fates of oil micro-droplets (<500 μm) in the 400 m thick Deepwater Horizon deep-sea plume? F...

journal_title：Scientific reports

authors： White AR,Jalali M,Boufadel MC,Sheng J

更新日期：2020-03-09 00:00:00

abstract：:Constrained layer dampers (CLD) are in widespread use for passive vibration damping, in applications including aerospace structures. However, the introducing of the damping layer can reduce the stiffness of the sandwich structures. A viscoelastic material filling (VMF) is chosen to balance structural and vibrational p...

journal_title：Scientific reports

authors： Wang R,Shang J,Li X,Luo Z,Wu W

更新日期：2018-06-25 00:00:00

abstract：:The fatty acid (FA) profile has a considerable impact on the nutritional and technological quality of milk and dairy products. The molecular mechanism underlying the regulation of fat metabolism in bovine mammary gland have been not completely elucidated. We conducted genome-wide association studies (GWAS) across 65 m...

journal_title：Scientific reports

authors： Pegolo S,Dadousis C,Mach N,Ramayo-Caldas Y,Mele M,Conte G,Schiavon S,Bittante G,Cecchinato A

更新日期：2017-12-11 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most prevalent cancers worldwide and Alpha B-crystallin (CRYAB) protein has been identified as a prognostic biomarker for CRC. We evaluated CRYAB C-802G (rs14133)polymorphism in association with CRC risk and survival in Chinese population. We genotyped for CRYAB C-802G (rs14133), ...

journal_title：Scientific reports

authors： Wu X,Zheng YZ,Han B,Wang K

更新日期：2018-08-06 00:00:00

abstract：:We present a prototype for conducting rapid, inexpensive and point-of-care-compatible nucleic acid amplification tests (NAATs) for tuberculosis (TB). The fluorescent isothermal paper-and-plastic NAAT (FLIPP-NAAT) uses paper-based loop mediated isothermal amplification (LAMP) for DNA detection. The cost of materials re...

journal_title：Scientific reports

authors： Kaur N,Michael JS,Toley BJ

更新日期：2019-10-25 00:00:00

abstract：:The early replication of some orally-acquired prion strains upon stromal-derived follicular dendritic cells (FDC) within the small intestinal Peyer's patches is essential to establish host infection, and for the disease to efficiently spread to the brain. Factors that influence the early accumulation of prions in Peye...

journal_title：Scientific reports

authors： Sánchez-Quintero A,Bradford BM,Maizels R,Donaldson DS,Mabbott NA

更新日期：2019-04-30 00:00:00

abstract：:Aldosterone antagonists slow the progression of chronic kidney disease (CKD), but their use is limited by hyperkalemia, especially when associated with RAS inhibitors. We examined the renoprotective effects of Ly, a novel non-steroidal mineralocorticoid receptor (MR) blocker, through two experimental protocols: In Pro...

journal_title：Scientific reports

authors： Fujihara CK,Kowala MC,Breyer MD,Sena CR,Rodrigues MV,Arias SCA,Fanelli C,Malheiros DM,Jadhav PK,Montrose-Rafizadeh C,Krieger JE,Zatz R

更新日期：2017-08-11 00:00:00

abstract：:This retrospective study was designed to compare prognostic relevance of magnetic resonance imaging (MRI) findings before and after neoadjuvant chemoradiotherapy (CRT). From 2002 to 2010, 399 patients who underwent surgery after CRT for rectal cancer (≥T3) and had adequate pre-CRT (mr) and post-CRT (ymr) MRI findings ...

journal_title：Scientific reports

authors： Song KS,Lee DW,Kim B,Hur BY,Kim MJ,Kim MJ,Hong CW,Park SC,Park HC,Sohn DK,Kim BC,Han KS,Oh JH

更新日期：2019-07-11 00:00:00

abstract：:Aerobic organisms evolved conserved mechanisms controlling the generation of reactive oxygen species (ROS) to maintain redox homeostasis signaling and modulate signal transduction, gene expression and cellular functional responses under physiological conditions. The production of ROS by mitochondria is essential in th...

journal_title：Scientific reports

authors： Alberdi P,Cabezas-Cruz A,Prados PE,Rayo MV,Artigas-Jerónimo S,de la Fuente J

更新日期：2019-09-13 00:00:00

abstract：:Human mesenchymal stromal cells (MSCs) have served as a major cellular resource for cell-based immunomodulatory and regenerative therapies. However, genomic instability may accumulate during ex vivo expansion of MSCs, thereby increasing the potential of malignant transformation. Here, we performed whole genome sequenc...

journal_title：Scientific reports

authors： Kim M,Rhee JK,Choi H,Kwon A,Kim J,Lee GD,Jekarl DW,Lee S,Kim Y,Kim TM

更新日期：2017-11-06 00:00:00

abstract：:Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our res...

journal_title：Scientific reports

authors： Barcellos HH,Kalichak F,da Rosa JG,Oliveira TA,Koakoski G,Idalencio R,de Abreu MS,Giacomini AC,Fagundes M,Variani C,Rossini M,Piato AL,Barcellos LJ

更新日期：2016-11-22 00:00:00

abstract：:Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine and drug discovery. In this study, we performed comparative studies between deep neural networks (DNN) and othe...

journal_title：Scientific reports

authors： Tsou LK,Yeh SH,Ueng SH,Chang CP,Song JS,Wu MH,Chang HF,Chen SR,Shih C,Chen CT,Ke YY

更新日期：2020-10-08 00:00:00

abstract：:Humans walk and run, as well as change their gait speed, through the control of their complicated and redundant musculoskeletal system. These gaits exhibit different locomotor behaviors, such as a double-stance phase in walking and flight phase in running. The complex and redundant nature of the musculoskeletal system...

journal_title：Scientific reports

authors： Aoi S,Ohashi T,Bamba R,Fujiki S,Tamura D,Funato T,Senda K,Ivanenko Y,Tsuchiya K

更新日期：2019-01-23 00:00:00

abstract：:We evaluated regression of iris neovascularization (INV) using en-face anterior-segment optical coherence tomography angiography (AS-OCTA) after anti-vascular endothelial growth factor (VEGF) therapy. Seven consecutive eyes with INV were examined before and after anti-VEGF therapy, and all AS-OCTA scans were obtained ...

journal_title：Scientific reports

authors： Shiozaki D,Sakimoto S,Shiraki A,Wakabayashi T,Fukushima Y,Oie Y,Usui S,Sato S,Sakaguchi H,Nishida K

更新日期：2019-07-16 00:00:00

abstract：:A cerebral aneurysm occurs as a result of a weakened blood vessel, which allows blood to flow into a sac or a ballooned section. Recent advancement shows that a new device, 'flow-diverter', can divert blood flow away from the aneurysm sac. People found that a flow-diverter based on thin film nitinol (TFN), works very ...

journal_title：Scientific reports

authors： Chen Y,Howe C,Lee Y,Cheon S,Yeo WH,Chun Y

更新日期：2016-03-24 00:00:00

abstract：:Zr-based metallic glasses are prepared by quenching supercooled liquid under pressure. These glasses are stable in ambient conditions after decompression. The High Pressure Quenched glasses have a distinct structure and properties. The pair distribution function shows redistribution of the Zr-Zr interatomic distances ...

journal_title：Scientific reports

authors： Dmowski W,Yoo GH,Gierlotka S,Wang H,Yokoyama Y,Park ES,Stelmakh S,Egami T

更新日期：2020-06-11 00:00:00

abstract：:The formation of OD (order-disorder) phases of the LPSO (long-period stacking ordered)-type in Mg-Al-RE (RE (rare earth) = Y, La, Ce, Nd, Sm, Dy, Ho, Er and Yb) ternary systems has been investigated for both as-solidified and annealed conditions. The OD phase is found to form in those systems with RE = Y, Nd, Sm, Dy, ...

journal_title：Scientific reports

authors： Kishida K,Yokobayashi H,Inui H

更新日期：2017-09-25 00:00:00

abstract：:Organic gases undergoing conversion to form secondary organic aerosol (SOA) during atmospheric aging are largely unidentified, particularly in regions influenced by anthropogenic emissions. SOA dominates the atmospheric organic aerosol burden and this knowledge gap contributes to uncertainties in aerosol effects on cl...

journal_title：Scientific reports

authors： Bruns EA,El Haddad I,Slowik JG,Kilic D,Klein F,Baltensperger U,Prévôt AS

更新日期：2016-06-17 00:00:00

abstract：:Based on a hybrid pumping method consisting of a 1150 nm continuous-wave pump source and a 1950 nm pulsed pump source, we demonstrate a power controllable gain-switched fiber laser in dual wavebands at ~ 3 μm and ~ 2.1 μm. Different pumping schemes for pumping a Ho3+-doped ZBLAN fiber are studied. Using only the 1950 ...

journal_title：Scientific reports

authors： Shi Y,Li J,Lai C,Peng H,Zhu C,Liu Y

更新日期：2021-01-13 00:00:00

abstract：:Extremely low frequency magnetic fields (ELF-MF) could be an alternative neuroprotective approach for ischemic stroke because preclinical studies have demonstrated their effects on the mechanisms underlying ischemic damage. The purpose of this open-label, one arm, dose-escalation, exploratory study is to evaluate the ...

journal_title：Scientific reports

authors： Capone F,Liberti M,Apollonio F,Camera F,Setti S,Cadossi R,Quattrocchi CC,Di Lazzaro V

更新日期：2017-09-22 00:00:00