EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression.

abstract：:Multi-domain voltage-gated ion channels appear to have evolved through sequential rounds of intragenic duplication from a primordial one-domain precursor. Whereas modularity within one-domain symmetrical channels is established, little is known about the roles of individual regions within more complex asymmetrical cha...

journal_title：Scientific reports

authors： Penny CJ,Rahman T,Sula A,Miles AJ,Wallace BA,Patel S

更新日期：2016-12-12 00:00:00

abstract：:Chemokine receptor 5 (CCR5) belongs to G protein coupled receptors (GPCRs) and plays an important role in treatment of human immunodeficiency virus (HIV) infection since HIV uses CCR5 protein as a co-receptor. Recently, the crystal structure of CCR5-bound complex with an approved anti-retroviral drug (maroviroc) was r...

journal_title：Scientific reports

authors： Salmas RE,Yurtsever M,Durdagi S

更新日期：2015-08-24 00:00:00

abstract：:Phase modulators are one of the key components of many applications in electromagnetic and opto-electric wave propagations. Phase-shifters play an integral role in communications, imaging and in coherent material excitations. In order to realize the terahertz (THz) electromagnetic spectrum as a fully-functional bandwi...

journal_title：Scientific reports

authors： Dutta M,Betal S,Peralta XG,Bhalla AS,Guo R

更新日期：2016-11-30 00:00:00

abstract：:Angiogenin (hANG), a member of the Ribonuclease A superfamily has angiogenic, neurotrophic and neuroprotective activities. Mutations in hANG have been found in patients with Amyotrophic lateral sclerosis (ALS). The zebrafish (Danio rerio) rnasel-1, 2 and 3 are orthologues of hANG and of these only Rnasel-1 and Rnasel-...

journal_title：Scientific reports

authors： Ferguson R,Holloway DE,Chandrasekhar A,Acharya KR,Subramanian V

更新日期：2019-02-01 00:00:00

abstract：:Dietary exposure of insects to a feeding deterrent substance for hours to days can induce habituation and concomitant desensitization of the response of peripheral gustatory neurons to such a substance. In the present study, larvae of the herbivore Helicoverpa armigera were fed on diets containing either a high, mediu...

journal_title：Scientific reports

authors： Ma Y,Li J,Tang Q,Zhang X,Zhao X,Yan F,van Loon JJ

更新日期：2016-12-14 00:00:00

abstract：:The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary a...

journal_title：Scientific reports

authors： Liu W,Ling S,Sun W,Liu T,Li Y,Zhong G,Zhao D,Zhang P,Song J,Jin X,Xu Z,Song H,Li Q,Liu S,Chai M,Dai Q,He Y,Fan Z,Zhou YJ,Li Y

更新日期：2015-11-05 00:00:00

abstract：:Intrinsically disordered proteins are abundant in the eukaryotic proteome, and they are implicated in a range of different diseases. However, there is a paucity of experimental data on molecular details of the coupled binding and folding of such proteins. Two interacting and relatively well studied disordered protein ...

journal_title：Scientific reports

authors： Dogan J,Mu X,Engström Å,Jemth P

更新日期：2013-01-01 00:00:00

abstract：:Neuronal activity-dependent synaptic plasticity, a basis for learning and memory, is tightly correlated with the pattern of increase in intracellular Ca(2+) concentration ([Ca(2+)](i)). Here, using combined application of electrophysiological experiments and systems biological simulation, we show that such a correlati...

journal_title：Scientific reports

authors： Kawaguchi SY,Nagasaki N,Hirano T

更新日期：2011-01-01 00:00:00

abstract：:We analyze a transition from single peaked to bimodal velocity distribution in a relativistic fluid under increasing temperature, in contrast with a non-relativistic gas, where only a monotonic broadening of the bell-shaped distribution is observed. Such transition results from the interplay between the raise in therm...

journal_title：Scientific reports

authors： Mendoza M,Araújo NA,Succi S,Herrmann HJ

更新日期：2012-01-01 00:00:00

abstract：:In surface science and model catalysis, cerium oxide (ceria) is mostly grown as an ultra-thin film on a metal substrate in the ultra-high vacuum to understand fundamental mechanisms involved in diverse surface chemistry processes. However, such ultra-thin films do not have the contribution of a bulk ceria underneath, ...

journal_title：Scientific reports

authors： Barth C,Laffon C,Olbrich R,Ranguis A,Parent P,Reichling M

更新日期：2016-02-16 00:00:00

abstract：:The dynamics of networks of neuronal cultures has been recently shown to be strongly dependent on the network geometry and in particular on their dimensionality. However, this phenomenon has been so far mostly unexplored from the theoretical point of view. Here we reveal the rich interplay between network geometry and...

journal_title：Scientific reports

authors： Millán AP,Torres JJ,Bianconi G

更新日期：2018-07-02 00:00:00

abstract：:Campylobacteriosis typically manifests as a short-lived, self-limiting gastrointestinal infection in humans, however prolonged infection can be seen in cases with underlying immunodeficiency. Public Health England received 25 isolates of Campylobacter jejuni from an individual with combined variable immunodeficiency o...

journal_title：Scientific reports

authors： Barker CR,Painset A,Swift C,Jenkins C,Godbole G,Maiden MCJ,Dallman TJ

更新日期：2020-06-22 00:00:00

abstract：:Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities for laboratory characterization. By incorporating functional annotations as predictors, stati...

journal_title：Scientific reports

authors： Gagliano SA,Ravji R,Barnes MR,Weale ME,Knight J

更新日期：2015-08-24 00:00:00

abstract：:Wave propagation is an important characteristic for pattern formation and pattern dynamics. To date, various waves in homogeneous media have been investigated extensively and have been understood to a great extent. However, the wave behaviors in heterogeneous media have been studied and understood much less. In this w...

journal_title：Scientific reports

authors： Cui X,Huang X,Hu G

更新日期：2016-05-04 00:00:00

abstract：:One of the most important goals of condensed matter physics is materials by design, i.e. the ability to reliably predict and design materials with a set of desired properties. A striking example is the deterministic enhancement of the superconducting properties of materials. Recent experiments have demonstrated that t...

journal_title：Scientific reports

authors： Smolyaninova VN,Jensen C,Zimmerman W,Prestigiacomo JC,Osofsky MS,Kim H,Bassim N,Xing Z,Qazilbash MM,Smolyaninov II

更新日期：2016-09-23 00:00:00

abstract：:Cytometric studies utilizing flow cytometry or multi-well culture plate fluorometry are often limited by a deficit in temporal resolution and a lack of single cell consideration. Unfortunately, many cellular processes, including signaling, motility, and molecular transport, occur transiently over relatively short peri...

journal_title：Scientific reports

authors： Byrd TF 4th,Hoang LT,Kim EG,Pfister ME,Werner EM,Arndt SE,Chamberlain JW,Hughey JJ,Nguyen BA,Schneibel EJ,Wertz LL,Whitfield JS,Wikswo JP,Seale KT

更新日期：2014-05-30 00:00:00

abstract：:Direct growth of MoS2 nanowalls on vapor grown carbon nanofibers (VGCNFs) has been achieved using a microwave-assisted hydrothermal (MAH) method under an acidic condition. The acidic condition was obtained through the addition of an HCl aqueous solution. We demonstrate that the HCl not only modifies the pH value for l...

journal_title：Scientific reports

authors： Sari FNI,Ting JM

更新日期：2017-07-20 00:00:00

abstract：:Heterostructures of oxides have been widely investigated in optical, catalytic and electrochemical applications, because the heterostructured interfaces exhibit pronouncedly different transport, charge, and reactivity characteristics compared to the bulk of the oxides. Here we fabricated a three-dimensional (3D) heter...

journal_title：Scientific reports

authors： Zhou W,Liang F,Shao Z,Chen J,Zhu Z

更新日期：2011-01-01 00:00:00

abstract：:Despite aggressive antimicrobial therapy, many respiratory pathogens persist in the lung, underpinning the chronic inflammation and eventual lung decline that are characteristic of respiratory disease. Recently, bile acid aspiration has emerged as a major comorbidity associated with a range of lung diseases, shaping t...

journal_title：Scientific reports

authors： Reen FJ,Flynn S,Woods DF,Dunphy N,Chróinín MN,Mullane D,Stick S,Adams C,O'Gara F

更新日期：2016-07-19 00:00:00

abstract：:Functional diversity is thought to enhance ecosystem resilience, driving research focused on trends in the functional composition of fisheries, most recently with new reconstructions of global catch data. However, there is currently little understanding of how accounting for unreported catches (e.g. small-scale and il...

journal_title：Scientific reports

authors： Nash KL,Watson RA,Halpern BS,Fulton EA,Blanchard JL

更新日期：2017-09-06 00:00:00

abstract：:China's reported cases of Human Immunodeficiency Virus (HIV) and AIDS increased from over 50000 in 2011 to more than 130000 in 2017, while AIDS related search indices on Baidu from 2.1 million to 3.7 million in the same time periods. In China, people seek AIDS related knowledge from Baidu which one of the world's larg...

journal_title：Scientific reports

authors： Li K,Liu M,Feng Y,Ning C,Ou W,Sun J,Wei W,Liang H,Shao Y

更新日期：2019-01-23 00:00:00

abstract：:In contrast to annual plants, in perennial plants, the shoot apical meristem (SAM) can undergo seasonal transitions between dormancy and activity; understanding this transition is crucial for understanding growth in perennial plants. However, little is known about the molecular mechanisms of SAM development in trees. ...

journal_title：Scientific reports

authors： Xu H,Cao D,Chen Y,Wei D,Wang Y,Stevenson RA,Zhu Y,Lin J

更新日期：2016-02-02 00:00:00

abstract：:Norovirus is one of the most common causes of gastroenteritis. Following infection, anti-norovirus salivary immunoglobulin G (IgG) rises steeply within 2 weeks and remains elevated for several months; this immunoconversion can serve as an indicator of infection. We used a multiplex salivary immunoassay to study norovi...

journal_title：Scientific reports

authors： Wade TJ,Griffin SM,Egorov AI,Sams E,Hudgens E,Augustine S,DeFlorio-Barker S,Plunkett T,Dufour AP,Styles JN,Oshima K

更新日期：2019-12-20 00:00:00

abstract：:2-hydroxy-1,4 naphthoquinone (lawsone) is widely used and induces environmental pollutions during its production and application. In the present study, a lawsone-degrading bacterium strain, LH-3 was successfully isolated from the activated sludge. Based on the 16S rRNA gene analysis, the strain LH-3 phylogenetically b...

journal_title：Scientific reports

authors： Yang L,Cai T,Ding D,Cai T,Jiang C,Li H,Yang Q,Chen L

更新日期：2017-07-28 00:00:00

abstract：:The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had s...

journal_title：Scientific reports

authors： Ezzat SM,Shouman SA,Elkhoely A,Attia YM,Elsesy MS,El Senousy AS,Choucry MA,El Gayed SH,El Sayed AA,Sattar EA,El Tanbouly N

更新日期：2018-01-11 00:00:00

abstract：:In this decade coherent X-ray diffraction imaging has been demonstrated to reveal internal structures of whole biological cells and organelles. However, the spatial resolution is limited to several tens of nanometers due to the poor scattering power of biological samples. The challenge is to recover correct phase info...

journal_title：Scientific reports

authors： Takayama Y,Maki-Yonekura S,Oroguchi T,Nakasako M,Yonekura K

更新日期：2015-01-28 00:00:00

abstract：:Statins are a class of oral drugs that are widely used for treatment of hypercholesterolemia. Recent clinical data suggest that chronic use of these drugs increases the frequency of new onset diabetes. Studies to define the risks of statin-induced diabetes and its underlying mechanisms are clearly necessary. We explor...

journal_title：Scientific reports

authors： Kain V,Kapadia B,Misra P,Saxena U

更新日期：2015-09-08 00:00:00

abstract：:Teleost fish exhibit a remarkable diversity in the control of sex determination, offering the opportunity to identify novel differentiation mechanisms and their ecological consequences. Here, we perform GWAS using 4715 fish and 46,501 SNP to map sex determination to three separate genomic locations in Atlantic salmon ...

journal_title：Scientific reports

authors： Kijas J,McWilliam S,Naval Sanchez M,Kube P,King H,Evans B,Nome T,Lien S,Verbyla K

更新日期：2018-04-04 00:00:00

abstract：:The spread of multidrug resistance via mobile genetic elements is a major clinical and veterinary concern. Pathogenic Escherichia coli harbour antibiotic resistance and virulence genes mainly on plasmids, but also bacteriophages and hybrid phage-like plasmids. In this study, the genomes of three E. coli phage-like pla...

journal_title：Scientific reports

authors： Venturini C,Zingali T,Wyrsch ER,Bowring B,Iredell J,Partridge SR,Djordjevic SP

更新日期：2019-12-11 00:00:00

abstract：:Genetic polymorphisms in drug metabolizing enzymes and drug transporters may affect irinotecan toxicity. Although genetic polymorphisms have been shown to influence the irinotecan toxicity, data are limited in Thai population. Thus, the aim of this study was to assess the allele and genotype frequencies and the relati...

journal_title：Scientific reports

authors： Atasilp C,Chansriwong P,Sirachainan E,Reungwetwattana T,Sirilerttrakul S,Chamnanphon M,Puangpetch A,Sukasem C

更新日期：2020-08-10 00:00:00