Simvastatin may induce insulin resistance through a novel fatty acid mediated cholesterol independent mechanism.

abstract：:Licorice-induced pseudoaldosteronism is a common adverse effect in traditional Japanese Kampo medicine, and 3-monoglucuronyl glycyrrhetinic acid (3MGA) was considered as a causative agent of it. Previously, we found 22α-hydroxy-18β-glycyrrhetyl-3-O-sulfate-30-glucuronide (1), one of the metabolites of glycyrrhizin (GL...

journal_title：Scientific reports

authors： Ishiuchi K,Morinaga O,Ohkita T,Tian C,Hirasawa A,Mitamura M,Maki Y,Kondo T,Yasujima T,Yuasa H,Minamizawa K,Namiki T,Makino T

更新日期：2019-02-07 00:00:00

abstract：:Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made relatively easily. Technologies that facilitate specific and precise genome editing, such as knock-in, are critica...

journal_title：Scientific reports

authors： Wu M,Wei C,Lian Z,Liu R,Zhu C,Wang H,Cao J,Shen Y,Zhao F,Zhang L,Mu Z,Wang Y,Wang X,Du L,Wang C

更新日期：2016-04-11 00:00:00

abstract：:The Monte Carlo (MC) method is widely used to solve various problems in radiotherapy. There has been an impetus to accelerate MC simulation on GPUs whereas thread divergence remains a major issue for MC codes based on acceptance-rejection sampling. Inverse transform sampling has the potential to eliminate thread diver...

journal_title：Scientific reports

authors： Liang Y,Muhammad W,Hart GR,Nartowt BJ,Chen ZJ,Yu JB,Roberts KB,Duncan JS,Deng J

更新日期：2020-06-17 00:00:00

abstract：:The impact of statin therapy on plasma asymmetric dimethylarginine (ADMA) levels has not been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of statins on circulating ADMA levels. We searched selected databases (up to August 2014) to identify randomized controlled trials (RCTs) t...

journal_title：Scientific reports

authors： Serban C,Sahebkar A,Ursoniu S,Mikhailidis DP,Rizzo M,Lip GY,Kees Hovingh G,Kastelein JJ,Kalinowski L,Rysz J,Banach M

更新日期：2015-05-13 00:00:00

abstract：:Memristive systems have gained considerable attention in the field of neuromorphic engineering, because they allow the emulation of synaptic functionality in solid state nano-physical systems. In this study, we show that memristive behavior provides a broad working framework for the phenomenological modelling of cellu...

journal_title：Scientific reports

authors： Diederich N,Bartsch T,Kohlstedt H,Ziegler M

更新日期：2018-06-19 00:00:00

abstract：:Our study purpose was to evaluate mitochondrial (mt)DNA and RNA in peripheral blood mononuclear cells (PBMCs) and body shape changes (BSC) in HBV-infected patients. mtDNA and mtRNA were measured in PBMCs. The presence of BSC was evaluated through a questionnaire and clinical evaluation. A total of 157 subjects were en...

journal_title：Scientific reports

authors： Madeddu G,Fiore V,Melis M,Ortu S,Mannu F,Muredda AA,Garrucciu G,Bandiera F,Zaru S,Bagella P,Calvisi DF,Babudieri S

更新日期：2020-02-06 00:00:00

abstract：:Society's increasing interactions with technology are creating extensive "digital traces" of our collective human behavior. These new data sources are fuelling the rapid development of the new field of computational social science. To investigate user attention to the Hurricane Sandy disaster in 2012, we analyze data ...

journal_title：Scientific reports

authors： Preis T,Moat HS,Bishop SR,Treleaven P,Stanley HE

更新日期：2013-11-05 00:00:00

abstract：:Broadband on-chip optical frequency combs (OFCs) are important for expanding the functionality of photonic integrated circuits. Here, we demonstrate a huge local optical nonlinearity enhancement using graphene. A waveguide is decorated with graphene by precisely manipulating graphene's area and position. Our approach ...

journal_title：Scientific reports

authors： Ishizawa A,Kou R,Goto T,Tsuchizawa T,Matsuda N,Hitachi K,Nishikawa T,Yamada K,Sogawa T,Gotoh H

更新日期：2017-04-12 00:00:00

abstract：:Because of its novel physical properties, two-dimensional materials have attracted great attention. From first-principle calculations and vibration frequencies analysis, we predict a new family of two-dimensional materials based on the idea of octet stability: honeycomb lattices of pnictogens (N, P, As, Sb, Bi). The b...

journal_title：Scientific reports

authors： Lee J,Tian WC,Wang WL,Yao DX

更新日期：2015-06-30 00:00:00

abstract：:Selective enhancement of GABAergic inhibition is thought to impact many vital brain functions and interferes with the genesis and/or progression of numerous brain disorders. Here, we show that selectively increasing NMDA receptor activity in inhibitory neurons using an NMDAR positive allosteric modulator (PAM) elevate...

journal_title：Scientific reports

authors： Deng D,Masri S,Yao L,Ma X,Cao X,Yang S,Bao S,Zhou Q

更新日期：2020-07-20 00:00:00

abstract：:Capacitive, inductive and resistive loads of an ion-trap system, which can be modelled as LCR circuits, are important to know for building a high accuracy experiment. Accurate estimation of these loads is necessary for delivering the desired radio frequency (RF) signal to an ion trap via an RF resonator. Of particular...

journal_title：Scientific reports

authors： Sharma L,Roy A,Panja S,Ojha VN,De S

更新日期：2018-11-15 00:00:00

abstract：:Sauropodomorpha were herbivorous saurischian dinosaurs that incorporate Sauropoda and early-diverging sauropodomorphs. The oldest sauropodomorph remains are known from Late Triassic deposits, most of them Gondwanan. The Laurasian record comprises some Triassic forms, but the bulk is Jurassic in age. Among the 14 Juras...

journal_title：Scientific reports

authors： Peyre de Fabrègues C,Bi S,Li H,Li G,Yang L,Xu X

更新日期：2020-07-03 00:00:00

abstract：:Belgian Malinois (BM), one of the excellent military dog breeds in South Korea, is usually castrated before sexual maturation. Therefore, the transfer of their genetic features to the next generation is difficult. To overcome this, testicular cells from 4-month-old BMs were frozen. Testicular cells were thawed after 3...

journal_title：Scientific reports

authors： Lee KH,Lee WY,Kim DH,Lee SH,Do JT,Park C,Kim JH,Choi YS,Song H

更新日期：2016-02-24 00:00:00

abstract：:Sunflower see/ds (Helianthus annuus L.) were roasted in an electric forced air oven for 15, 30, 45, and 60 min at 125, 135 and 145 °C. The effect of temperature and time on the flavor profile of the samples were evaluated by headspace solid-phase microextraction coupled with gas chromatography-mass spectroscopy (HS-SP...

journal_title：Scientific reports

authors： Guo S,Na Jom K,Ge Y

更新日期：2019-08-05 00:00:00

abstract：:Threat detection is essential for protecting individuals from adverse situations, in which a network of amygdala, limbic regions and dorsomedial prefrontal cortex (dmPFC) regions are involved in fear processing. Excitability regulation in the dmPFC might be crucial for fear processing, while abnormal patterns could le...

journal_title：Scientific reports

authors： Gonzalez-Escamilla G,Chirumamilla VC,Meyer B,Bonertz T,von Grotthus S,Vogt J,Stroh A,Horstmann JP,Tüscher O,Kalisch R,Muthuraman M,Groppa S

更新日期：2018-09-28 00:00:00

abstract：:Busulfan (Bu) is an alkylating agent commonly used in preparative regimens for hematologic malignant and non-malignant patients undergoing hematopoietic stem cell transplantation (HSCT). The objective of the present study was to develop an UPLC-MS/MS method for quantification of Bu in human plasma. A total of 55 patie...

journal_title：Scientific reports

authors： Matar KM,Alshemmari SH,Refaat S,Anwar A

更新日期：2020-06-02 00:00:00

abstract：:The overpopulation of abandoned and stray companion animals has become a global crisis. The main purpose of this study was to develop a novel nanomedicine-based antifertility compound for non-surgical castration of male animals. Mangosteen (Garcinia mangostana L) pericarp extract has been shown to exhibit anti-fertili...

journal_title：Scientific reports

authors： Yostawonkul J,Surassmo S,Namdee K,Khongkow M,Boonthum C,Pagseesing S,Saengkrit N,Ruktanonchai UR,Chatdarong K,Ponglowhapan S,Yata T

更新日期：2017-11-24 00:00:00

abstract：:Humans, like all organisms, are subject to fundamental biophysical laws. Van Valen predicted that, because of zero-sum dynamics, all populations of all species in a given environment flux the same amount of energy on average. Damuth's 'energetic equivalence rule' supported Van Valen´s conjecture by showing a tradeoff ...

journal_title：Scientific reports

authors： Burger JR,Weinberger VP,Marquet PA

更新日期：2017-03-02 00:00:00

abstract：:The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a "glymphatic system" where metabolites are removed from the brain's extracellular space by convective exchange between interstitial fluid (ISF) and cerebrospinal fluid (CSF) along the paravascular spaces (PVS) around cerebral bl...

journal_title：Scientific reports

authors： Kedarasetti RT,Drew PJ,Costanzo F

更新日期：2020-06-22 00:00:00

abstract：:Recent breakthrough of novel hierarchic materials, orchestrated through oriented attachment of crystal subunits, opened questions on what is the mechanism of their self-assembly. Using rutile-type TiO2, synthesized by hydrothermal reaction of Ti(IV)-butoxide in highly acidic aqueous medium, we uncovered the key proces...

journal_title：Scientific reports

authors： Jordan V,Javornik U,Plavec J,Podgornik A,Rečnik A

更新日期：2016-04-11 00:00:00

abstract：:Experimental evidence has shown that some of the human endogenous hormones significantly affect drug efficacy. Since hormone status varies with individual physiological states, it is essential to understand the interplay of hormones and drugs for precision medicine. Here, we developed an in silico method to predict in...

journal_title：Scientific reports

authors： Kwon M,Jung J,Yu H,Lee D

更新日期：2017-11-30 00:00:00

abstract：:Hyperuricemia is an abnormal metabolic condition characterized by an increase in uric acid levels in the blood. It is the cause of gout, manifested by inflammatory arthritis, pain and disability. This study examined the possible ameliorative impacts of parsley (PAR) and celery (CEL) as hypouricemic agents at biochemic...

journal_title：Scientific reports

authors： Soliman MM,Nassan MA,Aldhahrani A,Althobaiti F,Mohamed WA

更新日期：2020-06-11 00:00:00

abstract：:To determine factors associated with delayed discharge of hospitalized patients with coronavirus disease (COVID-19). This retrospective cohort study included 47 patients with COVID-19 admitted to three hospitals in Quanzhou City, Fujian Province, China, between January 21, 2020 and March 6, 2020. Univariate and multiv...

journal_title：Scientific reports

authors： Lin P,Chen W,Huang H,Lin Y,Cai M,Lin D,Cai H,Su Z,Zhuang X,Yu X

更新日期：2021-01-13 00:00:00

abstract：:Type 2 innate lymphoid cells (ILC2) potentiate immune responses, however, their role in mediating adaptive immunity in cancer has not been assessed. Here, we report that mice genetically lacking ILC2s have significantly increased tumour growth rates and conspicuously higher frequency of circulating tumour cells (CTCs)...

journal_title：Scientific reports

authors： Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA

更新日期：2018-02-13 00:00:00

abstract：:Difficulties in the production of lignin from rice straw because of high silica content in the recovered lignin reduce its recovery yield and applications as bio-fuel and aromatic chemicals. Therefore, the objective of this study is to develop a novel method to reduce the silica content in lignin from rice straw more ...

journal_title：Scientific reports

authors： Do NH,Pham HH,Le TM,Lauwaert J,Diels L,Verberckmoes A,Do NHN,Tran VT,Le PK

更新日期：2020-12-04 00:00:00

abstract：:Due to the limitations of current imaging techniques, visualization of lymphatic capillaries within tissue in vivo has been challenging. Here, we present a label-free high resolution optical coherence tomography (OCT) based lymphangiography (OLAG) within human skin in vivo. OLAG enables rapid (~seconds) mapping of lym...

journal_title：Scientific reports

authors： Baran U,Qin W,Qi X,Kalkan G,Wang RK

更新日期：2016-02-19 00:00:00

abstract：:It has been reported that the ATM kinase inhibitor KU60019 preferentially radiosensitizes orthotopic high grade gliomas (HGG) driven by established U87 and U1242 cell lines bearing specific TP53 mutations. We wished to determine whether those results could be extended to tumors driven by primary glioma initiating cell...

journal_title：Scientific reports

authors： Frosina G,Ravetti JL,Corvò R,Fella M,Garrè ML,Levrero F,Marcello D,Marubbi D,Morana G,Mussap M,Neumaier CE,Profumo A,Raso A,Rosa F,Vagge S,Vecchio D,Verrico A,Zona G,Daga A

更新日期：2018-09-21 00:00:00

abstract：:In recent pioneer experiment, a strong spin-orbit coupling, with equal Rashba and Dresselhaus strengths, has been created in a trapped Bose-Einstein condensate. Moreover, many exotic superfluid phenomena induced by this strong spin-orbit coupling have been predicted. In this report, we show that this novel spin-orbit ...

journal_title：Scientific reports

authors： Lian J,Yu L,Liang JQ,Chen G,Jia S

更新日期：2013-11-07 00:00:00

abstract：:Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and between systems (or networks) in shaping pain experience and behavior, the intra-regional functional connectivity (FC) in the hub regions of the sy...

journal_title：Scientific reports

authors： Wu TH,Tu CH,Chao HT,Li WC,Low I,Chuang CY,Yeh TC,Cheng CM,Chou CC,Chen LF,Hsieh JC

更新日期：2016-04-19 00:00:00

abstract：:Engineered protein scaffolds are an alternative to monoclonal antibodies in research and drug design due to their small size, ease of production, versatility, and specificity for chosen targets. One key consideration when engineering such proteins is retaining the original scaffold structure and stability upon inserti...

journal_title：Scientific reports

authors： Zalar M,Indrakumar S,Levy CW,Tunnicliffe RB,Peters GHJ,Golovanov AP

更新日期：2019-06-21 00:00:00