Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars.

Abstract:

:The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had shown that PFH of the cultivar Giza 9 (PFH-G9) contains the highest concentration of SDG (81.64 mg/g). The in vitro cytotoxic potentiality of PFH's of six flaxseed cultivars was screened against a panel of human cancer cell lines. PFH -G9 showed the most significant cytotoxic activity against ER-receptor positive breast cell lines MCF7 and T47D with IC50 13.8 and 15.8 µg/ml, respectively. Moreover, PFH-G9 reduced the expression of the metastasis marker, 1-α, metalloproteinases and vascular endothelial growth factor (VEGF), one of the most potent stimulators of angiogenesis, while it increased the caspase-3 dependent apoptosis. Our study also showed that dietary intake of 10% of Giza 9 Flaxseeds (FS), fixed oil (FSO) or Flax meal (FSM) twice daily for 3 weeks in mice-bearing solid Ehrlich ascites carcinoma (EAC) resulted in reducing the tumor volume, the expression of estrogen, insulin growth factor, progesterone, VEGF and MMP-2, but enhanced expression of caspase-3.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ezzat SM,Shouman SA,Elkhoely A,Attia YM,Elsesy MS,El Senousy AS,Choucry MA,El Gayed SH,El Sayed AA,Sattar EA,El Tanbouly N

doi

10.1038/s41598-017-18944-0

subject

Has Abstract

pub_date

2018-01-11 00:00:00

pages

544

issue

1

issn

2045-2322

pii

10.1038/s41598-017-18944-0

journal_volume

8

pub_type

杂志文章
  • HIV-1 Tat-induced diarrhea evokes an enteric glia-dependent neuroinflammatory response in the central nervous system.

    abstract::Despite the effectiveness of combined anti-retroviral therapy, human immunodeficiency virus (HIV) infected-patients frequently report diarrhea and neuropsychological deficits. It is claimed that the viral HIV-1 Trans activating factor (HIV-1 Tat) protein is responsible for both diarrhea and neurotoxic effects, but the...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-05245-9

    authors: Esposito G,Capoccia E,Gigli S,Pesce M,Bruzzese E,D'Alessandro A,Cirillo C,di Cerbo A,Cuomo R,Seguella L,Steardo L,Sarnelli G

    更新日期:2017-08-10 00:00:00

  • Optimal architectures for long distance quantum communication.

    abstract::Despite the tremendous progress of quantum cryptography, efficient quantum communication over long distances (≥ 1000 km) remains an outstanding challenge due to fiber attenuation and operation errors accumulated over the entire communication distance. Quantum repeaters (QRs), as a promising approach, can overcome both...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20463

    authors: Muralidharan S,Li L,Kim J,Lütkenhaus N,Lukin MD,Jiang L

    更新日期:2016-02-15 00:00:00

  • Validation of multiplex immunofluorescence panels using multispectral microscopy for immune-profiling of formalin-fixed and paraffin-embedded human tumor tissues.

    abstract::Immune-profiling is becoming an important tool to identify predictive markers for the response to immunotherapy. Our goal was to validate multiplex immunofluorescence (mIF) panels to apply to formalin-fixed and paraffin-embedded tissues using a set of immune marker antibodies, with the Opal™ 7 color Kit (PerkinElmer) ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13942-8

    authors: Parra ER,Uraoka N,Jiang M,Cook P,Gibbons D,Forget MA,Bernatchez C,Haymaker C,Wistuba II,Rodriguez-Canales J

    更新日期:2017-10-17 00:00:00

  • Tumor cell secretion of soluble factor(s) for specific immunosuppression.

    abstract::Studies of tumor models using syngeneic transplantation have advanced our understanding of tumor immunity, including both immune surveillance and evasion. Murine mammary carcinoma 4T1 cells secrete immunosuppressive soluble factors as demonstrated in splenocyte culture. Cultured primary splenocytes secrete IFN-γ, whic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08913

    authors: Kano A

    更新日期:2015-03-09 00:00:00

  • Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin.

    abstract::Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-15901-9

    authors: Wang AS,Ong PF,Chojnowski A,Clavel C,Dreesen O

    更新日期:2017-11-15 00:00:00

  • Macroalgal browsing on a heavily degraded, urbanized equatorial reef system.

    abstract::The removal of macroalgal biomass is critical to the health of coral reef ecosystems. Previous studies on relatively intact reefs with diverse and abundant fish communities have quantified rapid removal of macroalgae by herbivorous fishes, yet how these findings relate to degraded reef systems where fish diversity and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08873-3

    authors: Bauman AG,Hoey AS,Dunshea G,Feary DA,Low J,Todd PA

    更新日期:2017-08-21 00:00:00

  • Prognostic Factors and Visual Outcomes of Pyogenic Liver Abscess-Related Endogenous Klebsiella pneumoniae Endophthalmitis: A 20-year retrospective review.

    abstract::Endogenous K. pneumoniae endophthalmitis (EKE) has a higher incidence among East Asians, and the most common infectious source of EKE is pyogenic liver abscess (PLA). We investigate the risk factors for poor visual outcomes in patients with PLA-related EKE. The retrospective medical records of 104 patients (120 eyes) ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37643-y

    authors: Chen YH,Li YH,Lin YJ,Chen YP,Wang NK,Chao AN,Liu L,Wu WC,Lai CC,Chen TL,Chen KJ

    更新日期:2019-01-31 00:00:00

  • Resolving single membrane fusion events on planar pore-spanning membranes.

    abstract::Even though a number of different in vitro fusion assays have been developed to analyze protein mediated fusion, they still only partially capture the essential features of the in vivo situation. Here we established an in vitro fusion assay that mimics the fluidity and planar geometry of the cellular plasma membrane t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12006

    authors: Schwenen LL,Hubrich R,Milovanovic D,Geil B,Yang J,Kros A,Jahn R,Steinem C

    更新日期:2015-07-13 00:00:00

  • Effect of hardening and sealing on color of chemically colored stainless steel.

    abstract::A light reflection device combined with visible light spectrophotometer was used to measure the reflectance-wavelength curves of colored stainless steel after coloring, hardening and sealing. After these processes, the coordinate in CIE 1931 color coordinate system and brightness of samples were confirmed by chromatom...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70359-6

    authors: Ji K,Ju H,Xun J,Su Y,Zhang K,Liu P,Xue Y

    更新日期:2020-08-11 00:00:00

  • Engineering of Baeyer-Villiger monooxygenase-based Escherichia coli biocatalyst for large scale biotransformation of ricinoleic acid into (Z)-11-(heptanoyloxy)undec-9-enoic acid.

    abstract::Baeyer-Villiger monooxygenases (BVMOs) are able to catalyze regiospecific Baeyer-Villiger oxygenation of a variety of cyclic and linear ketones to generate the corresponding lactones and esters, respectively. However, the enzymes are usually difficult to express in a functional form in microbial cells and are rather u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28223

    authors: Seo JH,Kim HH,Jeon EY,Song YH,Shin CS,Park JB

    更新日期:2016-06-17 00:00:00

  • See-through observation of malaria parasite behaviors in the mosquito vector.

    abstract::Although it is known that malaria parasites proliferate in the midgut of mosquito vector, their detailed behaviors, from gamete maturation to formation of next generation sporozoite, have not been fully understood at cellular or molecular level. This is mainly attributed to technical difficulties of dissection and who...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-38529-3

    authors: Mori T,Hirai M,Mita T

    更新日期:2019-02-11 00:00:00

  • Physico-chemical properties based differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated through oxidative stress.

    abstract::Graphene derivatives (GD) are currently being evaluated for technological and biomedical applications owing to their unique physico-chemical properties over other carbon allotrope such as carbon nanotubes (CNTs). But, the possible association of their properties with underlying in vitro effects have not fully examined...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39548

    authors: Mittal S,Kumar V,Dhiman N,Chauhan LK,Pasricha R,Pandey AK

    更新日期:2016-12-21 00:00:00

  • Heat Shock Protein 27 is down-regulated in Ballooned Hepatocytes of Patients with Nonalcoholic Steatohepatitis (NASH).

    abstract::Ballooning degeneration (BD) of hepatocytes is a distinguishing histological feature associated with the progression of nonalcoholic fatty liver disease (NAFLD). Under the assumption that NAFLD severity is associated with metabolic-stress we explored the hypothesis that heat shock 27 kDa protein 1 (HSP27), a protein c...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/srep22528

    authors: Sookoian S,Castaño GO,Scian R,San Martino J,Pirola CJ

    更新日期:2016-03-03 00:00:00

  • Complete genome sequence of the cellulose-producing strain Komagataeibacter nataicola RZS01.

    abstract::Komagataeibacter nataicola is an acetic acid bacterium (AAB) that can produce abundant bacterial cellulose and tolerate high concentrations of acetic acid. To globally understand its fermentation characteristics, we present a high-quality complete genome sequence of K. nataicola RZS01. The genome consists of a 3,485,1...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04589-6

    authors: Zhang H,Xu X,Chen X,Yuan F,Sun B,Xu Y,Yang J,Sun D

    更新日期:2017-06-30 00:00:00

  • Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation.

    abstract::Hepatitis C virus (HCV) has long been observed to take advantage of the host mitochondria to support viral replication and assembly. The HCV core protein has been implicated to fragment host mitochondria. In this report, we have discovered that the non-structural protein 5A (NS5A) plays an instructive role in attachin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23464

    authors: Siu GK,Zhou F,Yu MK,Zhang L,Wang T,Liang Y,Chen Y,Chan HC,Yu S

    更新日期:2016-03-24 00:00:00

  • Tick receptor for outer surface protein A from Ixodes ricinus - the first intrinsically disordered protein involved in vector-microbe recognition.

    abstract::The tick receptor for outer surface protein A (TROSPA) is the only identified factor involved in tick gut colonization by various Borrelia species. TROSPA is localized in the gut epithelium and can recognize and bind the outer surface bacterial protein OspA via an unknown mechanism. Based on earlier reports and our la...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep25205

    authors: Urbanowicz A,Lewandowski D,Szpotkowski K,Figlerowicz M

    更新日期:2016-04-26 00:00:00

  • Photoinduced Strain Release and Phase Transition Dynamics of Solid-Supported Ultrathin Vanadium Dioxide.

    abstract::The complex phase transitions of vanadium dioxide (VO2) have drawn continual attention for more than five decades. Dynamically, ultrafast electron diffraction (UED) with atomic-scale spatiotemporal resolution has been employed to study the reaction pathway in the photoinduced transition of VO2, using bulk and strain-f...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10217-0

    authors: He X,Punpongjareorn N,Liang W,Lin Y,Chen C,Jacobson AJ,Yang DS

    更新日期:2017-08-30 00:00:00

  • Early changes in corticospinal excitability when seeing fearful body expressions.

    abstract::Quick inhibition of approach tendencies in response to signals of potential threats is thought to promote survival. However, little is known about the effect of viewing fearful expressions on the early dynamics of the human motor system. We used the high temporal resolution of single-pulse and paired-pulse transcrania...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14122

    authors: Borgomaneri S,Vitale F,Avenanti A

    更新日期:2015-09-21 00:00:00

  • Complex inheritance in Pulmonary Arterial Hypertension patients with several mutations.

    abstract::Pulmonary Arterial Hypertension (PAH) is a rare and progressive disease with low incidence and prevalence, and elevated mortality. PAH is characterized by increased mean pulmonary artery pressure. The aim of this study was to analyse patients with combined mutations in BMPR2, ACVRL1, ENG and KCNA5 genes and to establi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33570

    authors: Pousada G,Baloira A,Valverde D

    更新日期:2016-09-15 00:00:00

  • Atmosphere-Ocean Coupling Effect on Intense Tropical Cyclone Distribution and its Future Change with 60 km-AOGCM.

    abstract::Atmosphere-ocean coupling effect on the frequency distribution of tropical cyclones (TCs) and its future change is studied using an atmosphere and ocean coupled general circulation model (AOGCM). In the present climate simulation, the atmosphere-ocean coupling in the AOGCM improves biases in the AGCM such as the polew...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29800

    authors: Ogata T,Mizuta R,Adachi Y,Murakami H,Ose T

    更新日期:2016-07-15 00:00:00

  • A millisecond micro-RNA separation technique by a hybrid structure of nanopillars and nanoslits.

    abstract::A millisecond micro-RNA separation of a mixture of total RNA and genomic DNA, extracted from cultured HeLa cells, was successfully achieved using a hybrid structure of nanopillars and nanoslits contained inside a microchannel. The nanopillars, 250-nm in diameter and 100-nm in height, were fabricated with a 750-nm spac...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43877

    authors: Wu Q,Kaji N,Yasui T,Rahong S,Yanagida T,Kanai M,Nagashima K,Tokeshi M,Kawai T,Baba Y

    更新日期:2017-03-08 00:00:00

  • Formants provide honest acoustic cues to body size in American alligators.

    abstract::In many vertebrates, acoustic cues to body size are encoded in resonance frequencies of the vocal tract ("formants"), rather than in the rate of tissue vibration in the sound source ("pitch"). Anatomical constraints on the vocal tract's size render formants honest cues to size in many bird and mammal species, but it i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01948-1

    authors: Reber SA,Janisch J,Torregrosa K,Darlington J,Vliet KA,Fitch WT

    更新日期:2017-05-12 00:00:00

  • Focused Ultrasound-enabled Brain Tumor Liquid Biopsy.

    abstract::Although blood-based liquid biopsies have emerged as a promising non-invasive method to detect biomarkers in various cancers, limited progress has been made for brain tumors. One major obstacle is the blood-brain barrier (BBB), which hinders efficient passage of tumor biomarkers into the peripheral circulation. The ob...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24516-7

    authors: Zhu L,Cheng G,Ye D,Nazeri A,Yue Y,Liu W,Wang X,Dunn GP,Petti AA,Leuthardt EC,Chen H

    更新日期:2018-04-26 00:00:00

  • Defining Phenotypes in Diabetic Nephropathy: a novel approach using a cross-sectional analysis of a single centre cohort.

    abstract::The global increase in Diabetes Mellitus (DM) has led to an increase in DM-Chronic Kidney Disease (DM-CKD). In this cross-sectional observational study we aimed to define phenotypes for patients with DM-CKD that in future may be used to individualise treatment We report 4 DM-CKD phenotypes in 220 patients recruited fr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18595-1

    authors: Montero RM,Herath A,Qureshi A,Esfandiari E,Pusey CD,Frankel AH,Tam FWK

    更新日期:2018-01-08 00:00:00

  • Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression.

    abstract::Epithelial-mesenchymal transition (EMT) plays an important role in tumor invasion and metastasis. A comprehensive, bioinformatics analysis of CCLE and TCGA datasets of seven tumor types allowed us to identify a novel pan-cancer EMT-associated gene expression signature consisting of 16 epithelial and 4 mesenchymal stat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04234-2

    authors: Rokavec M,Kaller M,Horst D,Hermeking H

    更新日期:2017-07-05 00:00:00

  • Rigorous broadband study of the intrinsic ferromagnetic linewidth of monocrystalline garnet spheres.

    abstract::This work demonstrates the first application of direct broadband (1 GHz-30 GHz) quality (Q) factor measurements of the uniform precession mode in magnetised garnet spheres for the accurate determination of the room-temperature intrinsic ferromagnetic linewidth (ΔH). The spheres were enclosed in a subwavelength cavity,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45699-7

    authors: Pacewicz A,Krupka J,Salski B,Aleshkevych P,Kopyt P

    更新日期:2019-07-01 00:00:00

  • Verification of Type-A and Type-B-HC Blinking Mechanisms of Organic-Inorganic Formamidinium Lead Halide Perovskite Quantum Dots by FLID Measurements.

    abstract::Organic-inorganic halide perovskite nanocrystals or quantum dots (PQDs) are excellent candidates for optoelectronic applications, such as lasers, solar cells, light emitting diodes, and single photon sources. However, the potential applications of PQDs can expand once the photoluminescence, and in particular, the blin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58926-3

    authors: Trinh CT,Minh DN,Ahn KJ,Kang Y,Lee KG

    更新日期:2020-02-07 00:00:00

  • Arctic sea ice melt leads to atmospheric new particle formation.

    abstract::Atmospheric new particle formation (NPF) and growth significantly influences climate by supplying new seeds for cloud condensation and brightness. Currently, there is a lack of understanding of whether and how marine biota emissions affect aerosol-cloud-climate interactions in the Arctic. Here, the aerosol population ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03328-1

    authors: Dall Osto M,Beddows DCS,Tunved P,Krejci R,Ström J,Hansson HC,Yoon YJ,Park KT,Becagli S,Udisti R,Onasch T,O Dowd CD,Simó R,Harrison RM

    更新日期:2017-06-12 00:00:00

  • Screening of microalgae liquid extracts for their bio stimulant properties on plant growth, nutrient uptake and metabolite profile of Solanum lycopersicum L.

    abstract::The present study investigates the biostimulant effects of 18 Crude Bio-Extracts (CBEs) obtained from Microalgae and Cyanobacteria on tomato plant growth, chlorophyll content, nutrient uptake and metabolite profile. Significant root and shoot length improvement (112.65%, 53.70%); was recorded at treatment with Aphanot...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59840-4

    authors: Mutale-Joan C,Redouane B,Najib E,Yassine K,Lyamlouli K,Laila S,Zeroual Y,Hicham EA

    更新日期:2020-02-18 00:00:00

  • Exciton-like electromagnetic excitations in non-ideal microcavity supercrystals.

    abstract::We study localized photonic excitations in a quasi-two-dimensional non-ideal binary microcavity lattice with use of the virtual crystal approximation. The effect of point defects (vacancies) on the excitation spectrum is investigated by numerical modelling. We obtain the dispersion and the energy gap of the electromag...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06945

    authors: Rumyantsev V,Fedorov S,Gumennyk K,Sychanova M,Kavokin A

    更新日期:2014-11-06 00:00:00