Abstract:
:The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were characterized with coronary artery calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels of clinical matched 11 CAC (CACS > 100) and 6 non-CAC (CACS = 0) subjects by microarray profile. Microarray analysis identified 34 differentially expressed miRNAs between CAC and non CAC groups. Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. Validation test in angiographic cohort showed that miR-134, miR-3135b and miR-2861 were significantly changed in patients with obstructive CAD . We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu W,Ling S,Sun W,Liu T,Li Y,Zhong G,Zhao D,Zhang P,Song J,Jin X,Xu Z,Song H,Li Q,Liu S,Chai M,Dai Q,He Y,Fan Z,Zhou YJ,Li Ydoi
10.1038/srep16099subject
Has Abstractpub_date
2015-11-05 00:00:00pages
16099issn
2045-2322pii
srep16099journal_volume
5pub_type
杂志文章abstract::Estrogen receptor-α (ERα) plays an important role in normal and abnormal physiology of the human reproductive system by interacting with the endogenous ligand estradiol (E2). However, other ligands, either analogous or dissimilar to E2, also bind to ERα. This may create unintentional activation of ER signaling in repr...
journal_title:Scientific reports
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journal_title:Scientific reports
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
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