Isolated pores dissected from human two-pore channel 2 are functional.

abstract：:This study measured the effects of vitamin D (VD) supplementation on the underlying molecular pathways involved in renal and testicular damage induced by lead (Pb) toxicity. Thirty two adult male Wistar rats were divided equally into four groups that were treated individually or simultaneously, except the negative con...

journal_title：Scientific reports

authors： BaSalamah MA,Abdelghany AH,El-Boshy M,Ahmad J,Idris S,Refaat B

更新日期：2018-03-19 00:00:00

abstract：:Seasonal influenza virus infections cause hundreds of thousands of deaths annually while viral mutation raises the threat of a novel pandemic strain. Antiviral drugs exhibit limited efficacy unless administered early and may induce viral resistance. Thus, targeting the host response directly has been proposed as a nov...

journal_title：Scientific reports

authors： Sugiyama MG,Armstrong SM,Wang C,Hwang D,Leong-Poi H,Advani A,Advani S,Zhang H,Szaszi K,Tabuchi A,Kuebler WM,Van Slyke P,Dumont DJ,Lee WL

更新日期：2015-06-05 00:00:00

abstract：:Chronic sleep fragmentation (SF) commonly occurs in human populations, and although it does not involve circadian shifts or sleep deprivation, it markedly alters feeding behaviors ultimately promoting obesity and insulin resistance. These symptoms are known to be related to the host gut microbiota. Mice were exposed t...

journal_title：Scientific reports

authors： Poroyko VA,Carreras A,Khalyfa A,Khalyfa AA,Leone V,Peris E,Almendros I,Gileles-Hillel A,Qiao Z,Hubert N,Farré R,Chang EB,Gozal D

更新日期：2016-10-14 00:00:00

abstract：:Orb2 is a functional amyloid that plays a key role in Drosophila long-term memory formation. Orb2 has two isoforms that differ in their N-termini. The N-terminus of the A isoform (Orb2A) that precedes its Q-rich prion-like domain has been shown to be important for Orb2 aggregation and long-term memory. However, beside...

journal_title：Scientific reports

authors： Cervantes SA,Bajakian TH,Soria MA,Falk AS,Service RJ,Langen R,Siemer AB

更新日期：2016-12-06 00:00:00

abstract：:We report the phonon and magnetic properties of various well-stabilized Co3O4 nanoparticles. The net valence in cobalt (II)/(III) cation can be obtained by subtracting the Co2+ ions in tetrahedral interstices and Co3+ ions in the octahedral interstices, respectively, which will possess spatial inhomogeneity of its mag...

journal_title：Scientific reports

authors： Gawali SR,Gandhi AC,Gaikwad SS,Pant J,Chan TS,Cheng CL,Ma YR,Wu SY

更新日期：2018-01-10 00:00:00

abstract：:Gliomas are the most common brain tumors affecting the central nervous system and are associated with a high mortality rate. DCF1 is a membrane protein that was previously found to play a role in neural stem cell differentiation. In the present study, we found that overexpression of dcf1 significantly inhibited cell p...

journal_title：Scientific reports

authors： Xie Y,Li Q,Yang Q,Yang M,Zhang Z,Zhu L,Yan H,Feng R,Zhang S,Huang C,Liu Z,Wen T

更新日期：2014-01-15 00:00:00

abstract：:The current study aimed to formulate Selenium-Chitosan-Mupirocin (M-SeNPs-CCH) complex. The nanohybrid system was prepared using chitosan-cetyltrimethylammonium bromide (CTAB)-based hydrogel (CCH) that entrapped mupirocin (M) and selenium nanoparticles (SeNPs). The in vitro studies were performed by evaluation of the ...

journal_title：Scientific reports

authors： Golmohammadi R,Najar-Peerayeh S,Tohidi Moghadam T,Hosseini SMJ

更新日期：2020-02-18 00:00:00

abstract：:In dividing animal cells the endoplasmic reticulum (ER) concentrates around the poles of the spindle apparatus by associating with astral microtubules (MTs), and this association is essential for proper ER partitioning to progeny cells. The mechanisms that associate the ER with astral MTs are unknown. Because astral M...

journal_title：Scientific reports

authors： Karabasheva D,Smyth JT

更新日期：2019-08-28 00:00:00

abstract：:A combination of techniques from 3D printing, tissue engineering and biomaterials has yielded a new class of engineered biological robots that could be reliably controlled via applied signals. These machines are powered by a muscle strip composed of differentiated skeletal myofibers in a matrix of natural proteins, in...

journal_title：Scientific reports

authors： Cvetkovic C,Ferrall-Fairbanks MC,Ko E,Grant L,Kong H,Platt MO,Bashir R

更新日期：2017-06-19 00:00:00

abstract：:Living organisms have to adjust to their surrounding in order to survive in stressful conditions. We study this mechanism in one of most primitive creatures - photosynthetic green sulfur bacteria. These bacteria absorb photons very efficiently using the chlorosome antenna complexes and perform photosynthesis in extrem...

journal_title：Scientific reports

authors： Saikin SK,Khin Y,Huh J,Hannout M,Wang Y,Zare F,Aspuru-Guzik A,Tang JK

更新日期：2014-05-27 00:00:00

abstract：:Microscopic swimming devices hold promise for radically new applications in lab-on-a-chip and microfluidic technology, diagnostics and drug delivery etc. In this paper, we demonstrate the experimental verification of a new class of autonomous ferromagnetic swimming devices, actuated and controlled solely by an oscilla...

journal_title：Scientific reports

authors： Hamilton JK,Petrov PG,Winlove CP,Gilbert AD,Bryan MT,Ogrin FY

更新日期：2017-03-09 00:00:00

abstract：:The genetics underlying autism spectrum disorder (ASD) are complex. Approximately 3-5% of ASD cases arise from maternally inherited duplications of 15q11.2-q13.1, termed Duplication 15q syndrome (Dup15q). 15q11.2-q13.1 includes the gene UBE3A which is believed to underlie ASD observed in Dup15q syndrome. UBE3A is an E...

journal_title：Scientific reports

authors： Hope KA,McGinn A,Reiter LT

更新日期：2019-02-20 00:00:00

abstract：:We study the entanglement structure and the topological edge states of the ground state of the spin-1/2 XXZ model with bond alternation. We employ parity-density matrix renormalization group with periodic boundary conditions. The finite-size scaling of Rényi entropies S2 and S∞ are used to construct the phase diagram ...

journal_title：Scientific reports

authors： Tzeng YC,Dai L,Chung MC,Amico L,Kwek LC

更新日期：2016-05-24 00:00:00

abstract：:Gaussia luciferase (GLuc) is a small luciferase (18.2 kDa; 168 residues) and is thus attracting much attention as a reporter protein, but the lack of structural information is hampering further application. Here, we report the first solution structure of a fully active, recombinant GLuc determined by heteronuclear mul...

journal_title：Scientific reports

authors： Wu N,Kobayashi N,Tsuda K,Unzai S,Saotome T,Kuroda Y,Yamazaki T

更新日期：2020-11-18 00:00:00

abstract：:We analyze a wide gravity low in the Campania Active Volcanic Area and interpret it by a large and deep source distribution of partially molten, low-density material from about 8 to 30 km depth. Given the complex spatial-temporal distribution of explosive volcanism in the area, we model the gravity data consistently w...

journal_title：Scientific reports

authors： Fedi M,Cella F,D'Antonio M,Florio G,Paoletti V,Morra V

更新日期：2018-05-29 00:00:00

abstract：:Although most models suggest continental Antarctica was covered by ice during the Last Glacial Maximum (LGM) it has been speculated that endemic species of soil invertebrates could have survived the Pleistocene at high elevation habitats protruding above the ice sheets. We analyzed a series of soil samples from differ...

journal_title：Scientific reports

authors： Lyons WB,Deuerling K,Welch KA,Welch SA,Michalski G,Walters WW,Nielsen U,Wall DH,Hogg I,Adams BJ

更新日期：2016-05-18 00:00:00

abstract：:Enterovirus A89 (EV-A89) is a novel member of the EV-A species. To date, only one full-length genome sequence (the prototype strain) has been published. Here, we report the molecular identification and genomic characterization of a Chinese EV-A89 strain, KSYPH-TRMH22F/XJ/CHN/2011, isolated in 2011 from a contact of an...

journal_title：Scientific reports

authors： Fan Q,Zhang Y,Hu L,Sun Q,Cui H,Yan D,Sikandaner H,Tang H,Wang D,Zhu Z,Zhu S,Xu W

更新日期：2015-12-21 00:00:00

abstract：:Fatty acid oxidation is the major energy pathway used by the kidney, although glycolysis becomes more important in the low oxygen environment of the medulla. Fatty acid oxidation appears to be reduced in renal fibrosis, and drugs that reverse this improve fibrosis. Expression of glycolytic genes is more variable, but ...

journal_title：Scientific reports

authors： Lee M,Harley G,Katerelos M,Gleich K,Sullivan MA,Laskowski A,Coughlan M,Fraser SA,Mount PF,Power DA

更新日期：2020-09-03 00:00:00

abstract：:Although numerous reports on nonprecious metal catalysts for replacing expensive Pt-based catalysts have been published, few of these studies have demonstrated their practical application in fuel cells. In this work, we report graphitic carbon nitride and carbon nanofiber hybrid materials synthesized by a facile and g...

journal_title：Scientific reports

authors： Kim OH,Cho YH,Chung DY,Kim MJ,Yoo JM,Park JE,Choe H,Sung YE

更新日期：2015-03-02 00:00:00

abstract：:To determine the association of birth weight (BW) and waist circumference (WC) on cardiovascular disease (CVD). The longitudinal cohort study consisted of 745 participants who were able to provide their birth weight information and were followed from 2002 to 2014. During the follow-up, 83 events of CVD were confirmed....

journal_title：Scientific reports

authors： Tian J,Qiu M,Li Y,Zhang X,Wang H,Sun S,Sharp NS,Tong W,Zeng H,Zheng S,Song X,Wang W,Ning G

更新日期：2017-08-29 00:00:00

abstract：:Flotation of small solid objects and liquid droplets on water is critical to natural and industrial activities. This paper reports the floating mechanism of liquid marbles, or liquid droplets coated with hydrophobic microparticles. We used X-ray computed tomography (XCT) to acquire cross-sectional images of the floati...

journal_title：Scientific reports

authors： Ooi CH,Plackowski C,Nguyen AV,Vadivelu RK,St John JA,Dao DV,Nguyen NT

更新日期：2016-02-23 00:00:00

abstract：:Coastal zones constitute one of the most heavily populated and developed land zones in the world. Despite the utility and economic benefits that coasts provide, there is no reliable global-scale assessment of historical shoreline change trends. Here, via the use of freely available optical satellite images captured si...

journal_title：Scientific reports

authors： Luijendijk A,Hagenaars G,Ranasinghe R,Baart F,Donchyts G,Aarninkhof S

更新日期：2018-04-27 00:00:00

abstract：:Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clini...

journal_title：Scientific reports

authors： Ferreira AC,Zaverucha-do-Valle C,Reis PA,Barbosa-Lima G,Vieira YR,Mattos M,Silva PP,Sacramento C,de Castro Faria Neto HC,Campanati L,Tanuri A,Brüning K,Bozza FA,Bozza PT,Souza TML

更新日期：2017-08-25 00:00:00

abstract：:This work reports the remarkable effect of reversible gas molecular sieving for high temperature gas separation from cobalt doped ethoxy polysiloxane (CoES40) membranes. This effect stemmed from alternating the reducing and oxidising (redox) state of the cobalt particles embedded in the ES40 matrix. The reduced membra...

journal_title：Scientific reports

authors： Miller CR,Wang DK,Smart S,Diniz da Costa JC

更新日期：2013-01-01 00:00:00

abstract：:Width-controlled M-type hexagonal SrFe12O19 nanoribbons were synthesized for the first time via polyvinylpyrrolidone (PVP) sol assisted electrospinning followed by heat treatment in air, and their chemical composition, microstructure and magnetic performance were investigated. Results demonstrated that as-obtained SrF...

journal_title：Scientific reports

authors： Jing P,Du J,Wang J,Wei J,Pan L,Li J,Liu Q

更新日期：2015-10-14 00:00:00

abstract：:Anatomically incomplete spinal cord injuries can be followed by functional recovery mediated, in part, by the formation of intraspinal detour circuits. Here, we show that adult mice recover tactile and proprioceptive function following a unilateral dorsal column lesion. We therefore investigated the basis of this reco...

journal_title：Scientific reports

authors： Granier C,Schwarting J,Fourli E,Laage-Gaupp F,Hennrich AA,Schmalz A,Jacobi A,Wesolowski M,Conzelmann KK,Bareyre FM

更新日期：2020-07-02 00:00:00

abstract：:Effects of elevated seawater temperatures on deep-water benthos has been poorly studied, despite reports of increased seawater temperature (up to 4 °C over 24 hrs) coinciding with mass mortality events of the sponge Geodia barretti at Tisler Reef, Norway. While the mechanisms driving these mortality events are unclear...

journal_title：Scientific reports

authors： Strand R,Whalan S,Webster NS,Kutti T,Fang JKH,Luter HM,Bannister RJ

更新日期：2017-05-22 00:00:00

abstract：:First discovered in rural areas of middle-eastern China in 2009, severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis affecting hundreds of cases reported in China each year. Using the national surveillance data from 2010 to 2013, we conducted this retrospective epidemiological study a...

journal_title：Scientific reports

authors： Liu K,Zhou H,Sun RX,Yao HW,Li Y,Wang LP,Di Mu,Li XL,Yang Y,Gray GC,Cui N,Yin WW,Fang LQ,Yu HJ,Cao WC

更新日期：2015-04-23 00:00:00

abstract：:Chronic myeloid leukemia (CML) is characterized in the majority of cases by a t(9;22)(q34;q11) translocation, also called the Philadelphia chromosome, giving rise to the BCR-ABL1 fusion protein. Current treatment with tyrosine kinase inhibitors is directed against the constitutively active ABL1 domain of the fusion pr...

journal_title：Scientific reports

authors： Löf L,Arngården L,Olsson-Strömberg U,Siart B,Jansson M,Dahlin JS,Thörn I,Christiansson L,Hermansson M,Larsson A,Ahlstrand E,Wålinder G,Söderberg O,Rosenquist R,Landegren U,Kamali-Moghaddam M

更新日期：2017-04-04 00:00:00

abstract：:Multiple applications of genome editing by CRISPR-Cas9 necessitate stringent regulation and Cas9 variants have accordingly been generated whose activity responds to small ligands, temperature or light. However, these approaches are often impracticable, for example in clinical therapeutic genome editing in situ or gene...

journal_title：Scientific reports

authors： Suzuki T,Asami M,Patel SG,Luk LYP,Tsai YH,Perry ACF

更新日期：2018-07-03 00:00:00