Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.

abstract：:Although recovery following a stroke is limited, undamaged neurons under the right conditions can establish new connections and take on-board lost functions. Sonic hedgehog (Shh) signaling is integral for developmental axon growth, but its role after injury has not been fully examined. To investigate the effects of Sh...

journal_title：Scientific reports

authors： Berretta A,Gowing EK,Jasoni CL,Clarkson AN

更新日期：2016-02-23 00:00:00

abstract：:Here, we report results on systematic analysis of DNA substrate preferences of three N6-adenine β-class DNA methyltransferases that are part of the type II restriction-modification systems. The studied enzymes were: M.EcoVIII, M.HindIII and M.LlaCI, which although found in phylogenetically distant bacteria (γ-proteoba...

journal_title：Scientific reports

authors： Wons E,Mruk I,Kaczorowski T

更新日期：2018-05-29 00:00:00

abstract：:Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escheric...

journal_title：Scientific reports

authors： Denkovskienė E,Paškevičius Š,Misiūnas A,Stočkūnaitė B,Starkevič U,Vitkauskienė A,Hahn-Löbmann S,Schulz S,Giritch A,Gleba Y,Ražanskienė A

更新日期：2019-10-28 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Brill R,Brill E,Uller W,Teusch V,Gufler H,Hammer S,Fellner C,Evert K,Goldann C,Helm M,Rosendahl J,Wohlgemuth WA

更新日期：2020-02-07 00:00:00

abstract：:Salix matsudana is a deciduous, rapidly growing willow species commonly cultivated in China, which can tolerate drought, salt, and heavy metal stress conditions. Selection of suitable reference genes for quantitative real-time PCR is important for normalizing the expression of the key genes associated with various str...

journal_title：Scientific reports

authors： Zhang Y,Han X,Chen S,Zheng L,He X,Liu M,Qiao G,Wang Y,Zhuo R

更新日期：2017-01-25 00:00:00

abstract：:This research utilized an external longitudinal dataset of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) to compare and validate various predictive models that support the current recommendations to select the most effective predictive risk models to estimate short- and long-term mortality and fa...

journal_title：Scientific reports

authors： Shen Y,Wang X,Zhang S,Qin G,Liu Y,Lu Y,Liang F,Zhuang X

更新日期：2016-09-16 00:00:00

abstract：:Layered Li2RuO3 is an important candidate cathode material in rechargeable lithium ion batteries because of its novel anionic redox process and high reversible capacity. Atomistic scale simulations are used to calculate the intrinsic defect process, favourable dopants and migration energies of lithium ion diffusions t...

journal_title：Scientific reports

authors： Kuganathan N,Kordatos A,Chroneos A

更新日期：2019-01-24 00:00:00

abstract：:Fractal behavior is scale-invariant and widely characterized by fractal dimension. However, the cor-respondence between them is that fractal behavior uniquely determines a fractal dimension while a fractal dimension can be related to many possible fractal behaviors. Therefore, fractal behavior is independent of the fr...

journal_title：Scientific reports

authors： Jin Y,Wu Y,Li H,Zhao M,Pan J

更新日期：2017-04-24 00:00:00

abstract：:Assembly of nanowires into ordered macroscopic structures with new functionalities has been a recent focus. In this Letter, we report a new route for ordering hydrophilic Ag nanowires with high aspect ratio by flowing through a glass capillary. The present glass capillary with well-defined silver nanowire films inside...

journal_title：Scientific reports

authors： Liu JW,Wang JL,Huang WR,Yu L,Ren XF,Wen WC,Yu SH

更新日期：2012-01-01 00:00:00

abstract：:We present a new class of TiBw/Ti6Al4V composites with a network reinforcement architecture that exhibits a significant creep resistance compared to monolithic Ti6Al4V alloys. Creep tests performed at temperatures between 773 K and 923 K and stress range of 100 MPa-300 MPa indicate both a significant improvement of th...

journal_title：Scientific reports

authors： Wang S,Huang LJ,Geng L,Scarpa F,Jiao Y,Peng HX

更新日期：2017-01-17 00:00:00

abstract：:Since the advent of graphene, a variety of studies have been performed to elucidate its fundamental physics, or to explore its practical applications. Gate-tunable resistance is one of the most important properties of graphene and has been studied in 1-3 layer graphene in a number of efforts to control the band gap to...

journal_title：Scientific reports

authors： Hirahara T,Ebisuoka R,Oka T,Nakasuga T,Tajima S,Watanabe K,Taniguchi T,Yagi R

更新日期：2018-09-18 00:00:00

abstract：:Literacy success is critical to unlocking a child's potential and enhancing their future wellbeing. Thus, the early identification and redressing of literacy needs is vital. Pacific children have, on average, the lowest literacy achievement levels in New Zealand. However, this population is very diverse. This study so...

journal_title：Scientific reports

authors： Schluter PJ,Kokaua J,Tautolo ES,Richards R,Taleni T,Kim HM,Audas R,McNeill B,Taylor B,Gillon G

更新日期：2018-08-17 00:00:00

abstract：:The natural alkaloid berberine has several pharmacological properties and recently received attention as a potential anticancer agent. In this work, we investigated the molecular mechanisms underlying the anti-tumor effect of berberine on glioblastoma U343 and pancreatic carcinoma MIA PaCa-2 cells. Human dermal fibrob...

journal_title：Scientific reports

authors： Agnarelli A,Natali M,Garcia-Gil M,Pesi R,Tozzi MG,Ippolito C,Bernardini N,Vignali R,Batistoni R,Bianucci AM,Marracci S

更新日期：2018-07-13 00:00:00

abstract：:Dynamic Nuclear Polarization (DNP) has been introduced to overcome the sensitivity limitations of nuclear magnetic resonance (NMR) spectroscopy also of supported lipid bilayers. When investigated by solid-state NMR techniques the approach typically involves doping the samples with biradicals and their investigation at...

journal_title：Scientific reports

authors： Salnikov ES,Aisenbrey C,Aussenac F,Ouari O,Sarrouj H,Reiter C,Tordo P,Engelke F,Bechinger B

更新日期：2016-02-15 00:00:00

abstract：:Chronic hepatitis B infection remains a serious public health issue worldwide. Hepatitis B virus (HBV) reactivation is commonly reported in patients receiving anticancer therapy, immunosuppressive therapy, or organ and tissue transplantation. However, the precise mechanisms underlying chemotherapeutic agent-related HB...

journal_title：Scientific reports

authors： Li X,Pan E,Zhu J,Xu L,Chen X,Li J,Liang L,Hu Y,Xia J,Chen J,Chen W,Hu J,Wang K,Tang N,Huang A

更新日期：2018-02-22 00:00:00

abstract：:Smad1, Smad5 and Smad9 (also known as Smad8) are activated by phosphorylation by bone morphogenetic protein (BMP)-bound type I receptor kinases. We examined the role of Smad1, Smad5, and Smad9 by creating constitutively active forms (Smad(DVD)). Transcriptional activity of Smad9(DVD) was lower than that of Smad1(DVD) ...

journal_title：Scientific reports

authors： Tsukamoto S,Mizuta T,Fujimoto M,Ohte S,Osawa K,Miyamoto A,Yoneyama K,Murata E,Machiya A,Jimi E,Kokabu S,Katagiri T

更新日期：2014-12-23 00:00:00

abstract：:Exposure to an adverse early-life environment leads to long-term health problems, many of which are recapitulated in subsequent generations. The female reproductive tract is particularly sensitive to early-life influences, and plays a pivotal role in programming the conceptus. We examine the influence of suboptimal gr...

journal_title：Scientific reports

authors： Aiken CE,Tarry-Adkins JL,Ozanne SE

更新日期：2015-11-03 00:00:00

abstract：:Graft contracture is a common problem associated with the regeneration processes of tissue-engineered bladders. Currently, most strategies used for incorporating bioactive molecules into biomaterial designs do not work during all phases of tissue regeneration. In this study, we used a growth factor-PLGA nanoparticle t...

journal_title：Scientific reports

authors： Jiang X,Lin H,Jiang D,Xu G,Fang X,He L,Xu M,Tang B,Wang Z,Cui D,Chen F,Geng H

更新日期：2016-02-08 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Tätte K,Pagani L,Pathak AK,Kõks S,Ho Duy B,Ho XD,Sultana GNN,Sharif MI,Asaduzzaman M,Behar DM,Hadid Y,Villems R,Chaubey G,Kivisild T,Metspalu M

更新日期：2019-04-10 00:00:00

abstract：:In a standard semiconductor laser, electrons and holes recombine via stimulated emission to emit coherent light, in a process that is far from thermal equilibrium. Exciton-polariton condensates-sharing the same basic device structure as a semiconductor laser, consisting of quantum wells coupled to a microcavity-have b...

journal_title：Scientific reports

authors： Horikiri T,Yamaguchi M,Kamide K,Matsuo Y,Byrnes T,Ishida N,Löffler A,Höfling S,Shikano Y,Ogawa T,Forchel A,Yamamoto Y

更新日期：2016-05-19 00:00:00

abstract：:Metastasis of head and neck tumors is responsible for a high mortality rate. Understanding its biochemistry may allow insights into tumorigenesis. To that end we carried out RNA-Seq analyses of 5 SCC9 derived oral cancer cell lines displaying increased invasive potential. Differentially expressed genes (DEGs) were ann...

journal_title：Scientific reports

authors： Pérez-Valencia JA,Prosdocimi F,Cesari IM,da Costa IR,Furtado C,Agostini M,Rumjanek FD

更新日期：2018-01-31 00:00:00

abstract：:Flat optics, which could planarize and miniaturize the traditional optical elements, possesses the features of extremely low profile and high integration for advanced manipulation of light. Here we proposed and experimentally demonstrated a planar metalens to realize an ultra-long focal length of ~240λ with a large de...

journal_title：Scientific reports

authors： Qin F,Huang K,Wu J,Jiao J,Luo X,Qiu C,Hong M

更新日期：2015-05-06 00:00:00

abstract：:Meckel syndrome (MKS) is an inherited autosomal recessive hepatorenal fibrocystic syndrome, caused by mutations in TMEM67, characterized by occipital encephalocoele, renal cysts, hepatic fibrosis, and polydactyly. Here we describe an ovine model of MKS, with kidney and liver abnormalities, without polydactyly or occip...

journal_title：Scientific reports

authors： Stayner C,Poole CA,McGlashan SR,Pilanthananond M,Brauning R,Markie D,Lett B,Slobbe L,Chae A,Johnstone AC,Jensen CG,McEwan JC,Dittmer K,Parker K,Wiles A,Blackburne W,Leichter A,Leask M,Pinnapureddy A,Jennings M,Hor

更新日期：2017-05-09 00:00:00

abstract：:We demonstrate application of the method of higher-order operators to nonlinear standard optomechanics. It is shown that a symmetry breaking in frequency shifts exists, corresponding to inequivalency of red and blue side-bands. This arises from nonlinear higher-order processes leading to inequal detunings. Similarly, ...

journal_title：Scientific reports

authors： Khorasani S

更新日期：2018-08-01 00:00:00

abstract：:Angiosperm mitochondrial genomes (mtDNA) exhibit variable quantities of alien sequences. Many of these sequences are acquired by intracellular gene transfer (IGT) from the plastid. In addition, frequent events of horizontal gene transfer (HGT) between mitochondria of different species also contribute to their expanded...

journal_title：Scientific reports

authors： Gandini CL,Sanchez-Puerta MV

更新日期：2017-03-06 00:00:00

abstract：:The live attenuated yellow fever (YF) vaccine is a highly effective human vaccine and induces long-term protective neutralizing antibodies directed against the viral envelope protein E. The generation of such antibodies requires the help of CD4 T cells which recognize peptides derived from proteins in virus particles ...

journal_title：Scientific reports

authors： Koblischke M,Mackroth MS,Schwaiger J,Fae I,Fischer G,Stiasny K,Heinz FX,Aberle JH

更新日期：2017-08-21 00:00:00

abstract：:Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-an...

journal_title：Scientific reports

authors： Wei YY,Lin WF,Zhang TH,Tang YX,Wang JJ,Zhong MF

更新日期：2018-04-18 00:00:00

abstract：:Genome-wide studies on high-altitude adaptation have received increased attention as a classical case of organismal evolution under extreme environment. However, the current genetic understanding of high-altitude adaptation emanated mainly from autosomal analyses. Only a few earlier genomic studies paid attention to t...

journal_title：Scientific reports

authors： Wu H,Liu YH,Wang GD,Yang CT,Otecko NO,Liu F,Wu SF,Wang L,Yu L,Zhang YP

更新日期：2016-10-07 00:00:00

abstract：:Interaction between the epithelium and mesenchyme coordinates patterning and differentiation of oral cavity structures including teeth, palatal rugae and tongue papillae. SHH is one of the key signaling molecules for this interaction. Epithelial expression of Shh in the tooth buds and tongue papillae is regulated by a...

journal_title：Scientific reports

authors： Sagai T,Amano T,Maeno A,Kiyonari H,Seo H,Cho SW,Shiroishi T

更新日期：2017-10-11 00:00:00

abstract：:In this report, spherical silver nanoparticle (AgNP-sp) and rod-shaped silver nanoparticle (AgNR) were prepared by chemical reduction method and their antibacterial activity against various Gram-positive and Gram-negative bacteria had been evaluated for their efficiency. Minimal inhibitory concentration (MIC) tests we...

journal_title：Scientific reports

authors： Acharya D,Singha KM,Pandey P,Mohanta B,Rajkumari J,Singha LP

更新日期：2018-01-09 00:00:00