Abstract:
:This research utilized an external longitudinal dataset of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) to compare and validate various predictive models that support the current recommendations to select the most effective predictive risk models to estimate short- and long-term mortality and facilitate decision-making about preferable therapeutics for HBV-ACLF patients. Twelve ACLF prognostic models were developed after a systematic literature search using the longitudinal data of 232 HBV-ACLF patients on the waiting list for liver transplantation (LT). Four statistical measures, the constant (A) and slope (B) of the fitted line, the area under the curve (C) and the net benefit (D), were calculated to assess and compare the calibration, discrimination and clinical usefulness of the 12 predictive models. According to the model calibration and discrimination, the logistic regression models (LRM2) and the United Kingdom model of end-stage liver disease(UKELD) were selected as the best predictive models for both 3-month and 5-year outcomes. The decision curve summarizes the benefits of intervention relative to the costs of unnecessary treatment. After the comprehensive validation and comparison of the currently used models, LRM2 was confirmed as a markedly effective prognostic model for LT-free HBV-ACLF patients for assisting targeted and standardized therapeutic decisions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shen Y,Wang X,Zhang S,Qin G,Liu Y,Lu Y,Liang F,Zhuang Xdoi
10.1038/srep33389subject
Has Abstractpub_date
2016-09-16 00:00:00pages
33389issn
2045-2322pii
srep33389journal_volume
6pub_type
杂志文章abstract::Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17997
更新日期:2015-12-09 00:00:00
abstract::Inertial and deformability- based particles separations gradually attract more significant attentions. In this work, we present a hybrid chip by combining the advantages of inertial and deformability -based principle. The chip is a triplet parallelizing spiral inertial microfluidic chip interconnected with numerable t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22348-z
更新日期:2018-03-06 00:00:00
abstract::There is an increased need for improved and affordable insect repellents to reduce transmission of rapidly spreading diseases with high mortality rates. Natural products are often used when DEET cannot be afforded or accessed and when consumers choose not to use a synthetic repellent. The essential oils from two newly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36814-1
更新日期:2019-02-06 00:00:00
abstract::Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their mechanism of action a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09253
更新日期:2015-03-19 00:00:00
abstract::Although the link between sleep disturbances and dopamine (DA)-related neurological and neuropsychiatric disorders is well established, the impact of sleep alterations on neuronal activity of midbrain DA-ergic structures is currently unknown. Here, using wildtype C57Bl mice, we investigated the circadian- and sleep-re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25770-5
更新日期:2018-05-17 00:00:00
abstract::Understanding the behaviour of humpback whale mother-calf pairs and the acoustic environment on their breeding grounds is fundamental to assessing the biological and ecological requirements needed to ensure a successful migration and survival of calves. Therefore, on a breeding/resting ground, Exmouth Gulf, Western Au...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36870-7
更新日期:2019-01-25 00:00:00
abstract::Method for production of alpha emitter 149Tb by irradiation of 151Eu with 70 MeV 3He nuclei is proposed. For the first time, the cross sections for the formation of isotopes 149,150,151,152Tb were measured experimentally using a stack foil technique in the 3He particles energy range 70 → 12 MeV. The thick target yield...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57436-6
更新日期:2020-01-16 00:00:00
abstract::Post-operative pancreatic fistula (POPF) following pancreatic resection is a life-threatening surgical complication. Cell sheets were prepared and harvested using temperature-responsive culture dishes and transplanted as patches to seal POPF. Two different mesenchymal stem cell (MSC) sheets were compared in terms of t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18490-9
更新日期:2018-01-10 00:00:00
abstract::Although poaching (illegal killing) is an important cause of death for large carnivores globally, the effect of lethal management policies on poaching is unknown for many populations. Two opposing hypotheses have been proposed: liberalizing killing may decrease poaching incidence ('tolerance hunting') or increase it (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70837-x
更新日期:2020-08-17 00:00:00
abstract::The availability and spatial distribution of food resources affect animal behavior and survival. Black howler monkeys (Alouatta pigra) have a foraging strategy to balance their nutrient intake that involves mixing their consumption of leaves and fruits. The spatial aggregation of food items should impact this strategy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55932-y
更新日期:2019-12-19 00:00:00
abstract::We have investigated the emission from InGaN/GaN quantum disks grown on the tip of GaN nanorods. The emission at 3.21 eV from the InGaN quantum disk doesn't show a Stark shift, and it is linearly polarized when excited perpendicular to the growth direction. The degree of linear polarization is about 39.3% due to the a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26642-8
更新日期:2018-05-25 00:00:00
abstract::It has been contended that any observed difference of the corpus callosum (CC) size between men and women is not sex-related but brain-size-related. A recent report, however, showed that the midsagittal CC area was significantly larger in women in 37 brain-size-matched pairs of normal young adults. Since this constitu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39818
更新日期:2017-01-03 00:00:00
abstract::The accumulation of fat, especially in visceral sites, is a significant risk factor for several chronic diseases with altered cardiometabolic homeostasis. We studied how intensive long-term weight loss and subsequent weight regain affect physiological changes, by longitudinally interrogating the lipid metabolism and w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40107-6
更新日期:2019-03-05 00:00:00
abstract::Schizophrenia is a highly heritable disorder with multiple susceptibility genes. Previously, we identified CACNA1C rs2007044 as a new risk locus for schizophrenia, with the minor allele G as risk allele. This association was recently validated by a powerful genome-wide association study. However, the underlying neural...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34298
更新日期:2016-09-29 00:00:00
abstract::Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37255
更新日期:2016-11-17 00:00:00
abstract::Developing effective treatment strategies for neurodegenerative diseases require an understanding of the underlying cellular pathways that lead to neuronal vulnerability and progressive degeneration. To date, numerous mutations in 147 distinct genes are identified to be "associated" with, "modifier" or "causative" of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32902-4
更新日期:2018-10-03 00:00:00
abstract::Paclitaxel drug coated balloons (DCBs) should provide optimal drug transfer exclusively to the target tissue. The aim of this study was to evaluate the particle loss by handling during angioplasty. A robotic arm was developed for systematic and reproducible drug abrasion experiments. The contact force on eight differe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74227-1
更新日期:2020-10-14 00:00:00
abstract::Raman spectroscopy is a powerful analytical method that allows deposited and/or immobilized cells to be evaluated without complex sample preparation or labeling. However, a main limitation of Raman spectroscopy in cell analysis is the extremely weak Raman intensity that results in low signal to noise ratios. Therefore...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13150
更新日期:2015-08-27 00:00:00
abstract::Long-term all-cause mortality and dependency after complex surgical procedures have not been assessed in the framework of value-based medicine. The aim of this study was to investigate the postoperative and long-term outcomes after surgical procedures lasting for more than six hours. Retrospective cohort study of pati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09833-7
更新日期:2017-08-23 00:00:00
abstract::In this work, we introduce a novel and facile method of exfoliating large-area, single-layer graphene oxide using a shearing stress. The shearing stress reactor consists of two concentric cylinders, where the inner cylinder rotates at controlled speed while the outer cylinder is kept stationary. We found that the form...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16649-y
更新日期:2017-11-27 00:00:00
abstract::Water Droplet Erosion (WDE) as a material degradation phenomenon has been a concern in power generation industries for decades. Steam turbine blades and the compressor blades of gas turbines that use water injection usually suffer from WDE. The present work focuses on studying erosion resistance of TiAl as a potential...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14182
更新日期:2015-09-22 00:00:00
abstract::A nanotechnology-based approach for the inhibition of breast cancer cell proliferation is proposed. The innovative solution consists in a platform based on biocompatible piezoelectric nanoparticles able to target and remotely stimulate HER2-positive breast cancer cells. The anti-proliferative effects of the ultrasound...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24697-1
更新日期:2018-04-19 00:00:00
abstract::Phototherapy was introduced in the early 1950's, and is the primary treatment of severe neonatal jaundice or Crigler-Najjar syndrome. Nevertheless, the potential biological effects of the products generated from the photodegradation of bilirubin during phototherapy remain unknown. This is very relevant in light of rec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25684-2
更新日期:2018-05-10 00:00:00
abstract::The nutritional alarmones ppGpp and pppGpp (collectively: (p)ppGpp) are nucleotide-based second messengers enabling bacteria to respond to environmental and stress conditions. Several bacterial species contain two highly homologous (p)ppGpp synthetases named RelP (SAS2, YwaC) and RelQ (SAS1, YjbM). It is established t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20634-4
更新日期:2018-02-01 00:00:00
abstract::Nanoparticles are widely used in commodities, and pregnant women are inevitably exposed to these particles. The placenta protects the growing fetus from foreign or toxic materials, and provides energy and oxygen. Here we report that autophagy, a cellular mechanism to maintain homeostasis, engulfs platinum nanoparticle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41927-2
更新日期:2019-04-02 00:00:00
abstract::Saccharomyces cerevisiae is used as a host strain in bioproduction, because of its rapid growth, ease of genetic manipulation, and high reducing capacity. However, the heat produced during the fermentation processes inhibits the biological activities and growth of the yeast cells. We performed whole-genome sequencing ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23157
更新日期:2016-03-17 00:00:00
abstract::The number and subtype composition of N-methyl-d-aspartate receptor (NMDAR) at synapses determines their functional properties and role in learning and memory. Genetically increased or decreased amount of GluN2B affects hippocampus-dependent memory in the adult brain. But in some experimental conditions (e.g., memory ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30743
更新日期:2016-08-04 00:00:00
abstract::The sinusoidal endothelial cells present in the liver (LSECs) are tipically characterized by the presence of pores (fenestrae). During some pathological conditions LSECs undergo "capillarization", a process characterized by loss of fenestrations and acquisition of a vascular phenotype. In chronic liver disease capilla...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-45114-1
更新日期:2019-06-19 00:00:00
abstract::Delivering gene constructs into the dorsal root ganglia (DRG) is a powerful but challenging therapeutic strategy for sensory disorders affecting the DRG and their peripheral processes. The current delivery methods of direct intra-DRG injection and intrathecal injection have several disadvantages, including potential i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35612
更新日期:2016-10-17 00:00:00
abstract::Despite its intrinsic advantages, translation of laser induced breakdown spectroscopy for material identification has been often impeded by the lack of robustness of developed classification models, often due to the presence of spurious correlations. While a number of classifiers exhibiting high discriminatory power h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13169
更新日期:2015-08-19 00:00:00